# Table S4. Comprehensive list of cancer-associated loci with African allele frequencies and PBS scores. # This tab-delimited dataset includes a total of 2,477 unique markers yielding 3,557 disease or trait associations. chr pos_hg38 rsID MADCaP_Allele1 MADCaP_Allele2 MILITARY_A1freq KBTH_A1freq UCH_A1freq HOGGY_A1freq SU_A1freq WITS_A1freq UATH_A1freq SENEGAL_PBS S_AFRICA_PBS GHANA_NIGERIA_PBS LINK STUDY DISEASE_TRAIT 1 959193 rs13303010 A G 0.119 0.081 0.13 0.178 0.117 0.119 0.155 0.0166 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 1 8035440 rs225132 G T 0.333 0.385 0.392 0.391 0.523 0.487 0.441 0 0.0276 0.0019 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 8424763 rs301807 A G 0.314 0.297 0.29 0.339 0.275 0.271 0.274 0.0067 0.0021 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 1 8424763 rs301807 A G 0.314 0.297 0.29 0.339 0.275 0.271 0.274 0.0067 0.0021 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 10226118 rs17396340 A G 0.047 0.027 0.031 0.083 0.072 0.053 0.04 0.0141 0 0.0207 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 10226118 rs17396340 A G 0.047 0.027 0.031 0.083 0.072 0.053 0.04 0.0141 0 0.0207 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 10325413 rs17401966 G A 0.043 0.059 0.058 0.044 0.027 0.037 0.044 0 0.0015 0.0015 www.ncbi.nlm.nih.gov/pubmed/29246937 Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma. Hepatitis B virus-related hepatocellular carcinoma 1 10325413 rs17401966 G A 0.043 0.059 0.058 0.044 0.027 0.037 0.044 0 0.0015 0.0015 www.ncbi.nlm.nih.gov/pubmed/20676096 Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Hepatocellular carcinoma 1 10496040 rs636291 A G 0.144 0.135 0.165 0.244 0.38 0.336 0.188 0 0.0586 0.0649 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 1 10496040 rs636291 A G 0.144 0.135 0.165 0.244 0.38 0.336 0.188 0 0.0586 0.0649 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 1 10503552 rs10864459 G A 0.352 0.374 0.429 0.444 0.5 0.521 0.416 0 0.0158 0.0145 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 1 10503552 rs10864459 G A 0.352 0.374 0.429 0.444 0.5 0.521 0.416 0 0.0158 0.0145 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 1 10506158 rs616488 G A 0.051 0.054 0.067 0.078 0.117 0.107 0.066 0 0.0107 0.0089 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 1 10506158 rs616488 G A 0.051 0.054 0.067 0.078 0.117 0.107 0.066 0 0.0107 0.0089 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 1 10506158 rs616488 G A 0.051 0.054 0.067 0.078 0.117 0.107 0.066 0 0.0107 0.0089 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 1 10506158 rs616488 G A 0.051 0.054 0.067 0.078 0.117 0.107 0.066 0 0.0107 0.0089 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 10506158 rs616488 G A 0.051 0.054 0.067 0.078 0.117 0.107 0.066 0 0.0107 0.0089 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 1 10535965 rs2506889 T C 0.017 0.045 0.018 0.074 0.068 0.07 0.035 0.01 0 0.0305 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 10736809 rs880315 C T 0.103 0.136 0.155 0.174 0.139 0.109 0.159 0.0071 0.0017 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 1 10736809 rs880315 C T 0.103 0.136 0.155 0.174 0.139 0.109 0.159 0.0071 0.0017 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 1 11802721 rs17367504 G A 0.111 0.099 0.08 0.057 0.063 0.111 0.084 0.0077 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 1 11802721 rs17367504 G A 0.111 0.099 0.08 0.057 0.063 0.111 0.084 0.0077 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 1 14338636 rs11803759 T C 0.394 0.368 0.366 0.244 0.297 0.299 0.403 0.0257 0 0.0363 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 1 15013464 rs6429703 T C 0.191 0.15 0.136 0.178 0.239 0.287 0.201 0 0.0243 0.0046 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) 1 16981663 rs9435732 T C 0.144 0.144 0.205 0.206 0.243 0.23 0.257 0 0.0033 0.0033 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 16981663 rs9435732 T C 0.144 0.144 0.205 0.206 0.243 0.23 0.257 0 0.0033 0.0033 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 16981663 rs9435732 T C 0.144 0.144 0.205 0.206 0.243 0.23 0.257 0 0.0033 0.0033 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 1 17395867 rs7538876 A G 0.377 0.409 0.33 0.3 0.351 0.295 0.341 0.0042 0 0.007 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 1 17395867 rs7538876 A G 0.377 0.409 0.33 0.3 0.351 0.295 0.341 0.0042 0 0.007 www.ncbi.nlm.nih.gov/pubmed/24403052 Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Basal cell carcinoma 1 17395867 rs7538876 A G 0.377 0.409 0.33 0.3 0.351 0.295 0.341 0.0042 0 0.007 www.ncbi.nlm.nih.gov/pubmed/18849993 Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. Basal cell carcinoma 1 17967993 rs16861326 A G 0.093 0.131 0.094 0.087 0.095 0.053 0.089 0 0.0019 0.0019 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 1 18351676 rs16861827 T C 0.148 0.135 0.116 0.117 0.059 0.053 0.093 0.0003 0.0268 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 1 18480845 rs2992756 C T 0.456 0.447 0.438 0.451 0.539 0.547 0.473 0 0.0161 0.0001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 21058943 rs12125335 C T 0 0.005 0 0 0.005 0 0.004 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 21511262 rs16825455 G A 0.339 0.36 0.304 0.409 0.245 0.295 0.425 0.0175 0.028 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) 1 23617245 rs34676223 A C 0.44 0.46 0.5 0.344 0.288 0.377 0.415 0.0022 0 0.0329 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 1 24171333 rs6698365 T G 0.377 0.336 0.401 0.36 0.401 0.446 0.366 0.0007 0.006 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 1 24179559 rs3893319 G A 0.373 0.355 0.384 0.335 0.333 0.414 0.366 0.0011 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 1 25861484 rs12067275 C T 0.352 0.367 0.366 0.383 0.414 0.422 0.384 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 1 26811902 rs12748152 T C 0 0.005 0.013 0.03 0.005 0.016 0 0.0295 0 0.0217 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 1 26854576 rs41307935 T C 0.013 0.014 0.022 0.018 0.009 0.025 0.023 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 1 28334563 rs139242087 T C 0.008 0.009 0.004 0.004 0 0.008 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 1 30094749 rs910696 A G 0.182 0.216 0.205 0.191 0.176 0.18 0.221 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 1 31730218 rs1889571 G T 0.008 0.032 0.031 0.013 0.027 0.041 0.013 0.002 0.0044 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 1 31730218 rs1889571 G T 0.008 0.032 0.031 0.013 0.027 0.041 0.013 0.002 0.0044 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 33588629 rs1417965 G A 0.203 0.185 0.288 0.204 0.158 0.217 0.192 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 1 34012883 rs4653367 T G 0.119 0.212 0.165 0.13 0.14 0.143 0.196 0.0025 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 1 35222214 rs673604 T C 0.342 0.342 0.33 0.491 0.266 0.303 0.381 0.0774 0.023 0 www.ncbi.nlm.nih.gov/pubmed/21499250 Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Endometrial cancer 1 38291565 rs2637869 A G 0.214 0.225 0.214 0.187 0.216 0.262 0.214 0.0036 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 1 38291565 rs2637869 A G 0.214 0.225 0.214 0.187 0.216 0.262 0.214 0.0036 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 40386710 rs1391315 G T 0.013 0.018 0.004 0.043 0 0 0.004 0.0573 0.0143 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 1 40914768 rs4233486 C T 0.246 0.297 0.214 0.213 0.327 0.279 0.199 0.0048 0.0143 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 41486926 rs3754287 T C 0.242 0.23 0.221 0.191 0.104 0.131 0.204 0 0.0294 0.01 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 1 41671640 rs79724016 G T 0.008 0.009 0.009 0.017 0.018 0 0.004 0.0027 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 43634413 rs11210892 A G 0.051 0.054 0.041 0.1 0.158 0.127 0.058 0 0.0175 0.0419 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 1 46135245 rs1707302 A G 0.403 0.419 0.42 0.421 0.293 0.364 0.36 0.0035 0.0137 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 49124175 rs657452 G A 0.443 0.349 0.486 0.405 0.37 0.363 0.386 0 0.0024 0.002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 49124175 rs657452 G A 0.443 0.349 0.486 0.405 0.37 0.363 0.386 0 0.0024 0.002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 50094148 rs11583200 T C 0.178 0.234 0.13 0.287 0.311 0.287 0.173 0.0042 0 0.0493 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 50094148 rs11583200 T C 0.178 0.234 0.13 0.287 0.311 0.287 0.173 0.0042 0 0.0493 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 53909897 rs2235544 A C 0.182 0.191 0.138 0.233 0.2 0.176 0.124 0.0143 0 0.012 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 1 54638272 rs10736390 A G 0.297 0.315 0.223 0.27 0.32 0.225 0.394 0.0002 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 1 59655756 rs72666268 G A 0.013 0 0.009 0.004 0 0.017 0.004 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 1 62129005 rs2481665 C T 0.055 0.036 0.058 0.035 0.005 0.025 0.054 0 0.0115 0.006 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 62129005 rs2481665 C T 0.055 0.036 0.058 0.035 0.005 0.025 0.054 0 0.0115 0.006 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 64073289 rs1747924 A C 0.42 0.409 0.393 0.326 0.473 0.529 0.447 0.0382 0.029 0 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 1 64370963 rs1514964 C T 0.039 0.11 0.063 0.125 0.089 0.076 0.054 0.0213 0 0.0134 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 66223426 rs17423910 G A 0.051 0.059 0.041 0.178 0.054 0.086 0.097 0.0957 0 0.0307 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 66296783 rs546784 C T 0.15 0.155 0.161 0.083 0.081 0.094 0.116 0.004 0 0.0189 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 66303417 rs6683977 C G 0.021 0.014 0.027 0.061 0.009 0 0.009 0.0618 0.0149 0 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 67639770 rs344924 G A 0.424 0.477 0.487 0.452 0.277 0.385 0.474 0 0.0337 0.0034 www.ncbi.nlm.nih.gov/pubmed/23478653 A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy. Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer 1 67729450 rs3753366 G C 0.312 0.332 0.33 0.376 0.277 0.355 0.295 0.0074 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 1 70421416 rs672203 G A 0.352 0.356 0.371 0.37 0.356 0.299 0.239 0.0022 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) 1 72285502 rs3101336 C T 0.539 0.536 0.464 0.622 0.423 0.426 0.46 0.0577 0.0259 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 72285502 rs3101336 C T 0.539 0.536 0.464 0.622 0.423 0.426 0.46 0.0577 0.0259 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 1 72285502 rs3101336 C T 0.539 0.536 0.464 0.622 0.423 0.426 0.46 0.0577 0.0259 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 73359226 rs10789369 A G 0.315 0.271 0.318 0.315 0.222 0.19 0.344 0.0018 0.0323 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 1 73359226 rs10789369 A G 0.315 0.271 0.318 0.315 0.222 0.19 0.344 0.0018 0.0323 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 74527379 rs1514174 T C 0.165 0.18 0.201 0.239 0.306 0.277 0.188 0 0.0138 0.0221 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 1 74536509 rs12566985 A G 0.136 0.106 0.113 0.162 0.3 0.267 0.103 0 0.0679 0.0405 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 74536509 rs12566985 A G 0.136 0.106 0.113 0.162 0.3 0.267 0.103 0 0.0679 0.0405 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 76306643 rs10873876 T C 0.496 0.487 0.433 0.465 0.451 0.471 0.46 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 76987908 rs2143582 T C 0.369 0.405 0.41 0.478 0.315 0.303 0.464 0.0269 0.0388 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 1 77981077 rs12401738 A G 0.009 0.023 0.045 0.048 0.054 0.058 0.055 0 0.0018 0.0045 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 77981077 rs12401738 A G 0.009 0.023 0.045 0.048 0.054 0.058 0.055 0 0.0018 0.0045 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 78512030 rs6700362 T C 0.282 0.282 0.304 0.348 0.213 0.244 0.283 0.0198 0.0172 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 1 83784252 rs10430064 T G 0.072 0.099 0.152 0.096 0.108 0.107 0.165 0.0011 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 84156830 rs903263 T G 0.335 0.343 0.347 0.311 0.577 0.549 0.414 0.0256 0.112 0 www.ncbi.nlm.nih.gov/pubmed/23001122 Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Breast cancer (male) 1 87147675 rs7553864 C T 0.5 0.505 0.554 0.544 0.446 0.393 0.558 0.0034 0.0288 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 1 87313534 rs12118297 T G 0.229 0.185 0.162 0.222 0.158 0.143 0.195 0.0063 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/27354352 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Breast cancer 1 87691240 rs17426269 A G 0.123 0.108 0.107 0.122 0.041 0.066 0.08 0.0086 0.0252 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 87963341 rs11583393 A C 0.131 0.144 0.147 0.204 0.261 0.186 0.181 0 0.0022 0.0157 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 89431556 rs12095604 C T 0.193 0.191 0.156 0.114 0.114 0.157 0.136 0.006 0 0.009 www.ncbi.nlm.nih.gov/pubmed/29356057 Genetic risk of prostate cancer in Ugandan men. Prostate cancer 1 89557237 rs922107 G A 0.504 0.473 0.46 0.5 0.608 0.554 0.394 0 0.0199 0.0114 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) 1 90724174 rs1008078 T C 0.008 0.014 0.027 0.048 0.014 0.016 0.031 0.0212 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 1 90724174 rs1008078 T C 0.008 0.014 0.027 0.048 0.014 0.016 0.031 0.0212 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 90730619 rs12042107 T C 0.136 0.189 0.203 0.161 0.153 0.127 0.243 0 0.0034 0.0057 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 1 91555907 rs12134245 T C 0.026 0.023 0.045 0.035 0.032 0.07 0.04 0 0.0019 0.0015 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 94615889 rs4474258 T C 0.352 0.342 0.415 0.287 0.185 0.266 0.412 0 0.0191 0.0378 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) 1 96458541 rs11165643 T C 0.115 0.123 0.08 0.104 0.064 0.057 0.08 0.0016 0.0109 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 96458541 rs11165643 T C 0.115 0.123 0.08 0.104 0.064 0.057 0.08 0.0016 0.0109 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 100414772 rs612683 T A 0.297 0.288 0.223 0.3 0.082 0.205 0.266 0.0178 0.0622 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 101777361 rs6668441 G A 0.373 0.342 0.357 0.365 0.369 0.418 0.332 0 0.0015 0.0015 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 1 102955788 rs2622849 T C 0.144 0.144 0.121 0.183 0.131 0.123 0.124 0.0118 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/29266176 Bone mineral density in children with acute lymphoblastic leukemia. Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia 1 107760300 rs12142335 A G 0.229 0.207 0.241 0.322 0.167 0.225 0.19 0.0441 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) 1 107816883 rs4915076 C T 0.038 0.032 0.032 0.031 0.077 0.054 0.062 0.0023 0.0075 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 1 107816883 rs4915076 C T 0.038 0.032 0.032 0.031 0.077 0.054 0.062 0.0023 0.0075 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Papillary thyroid cancer 1 108850215 rs1277203 T C 0.275 0.221 0.232 0.261 0.144 0.115 0.226 0.0125 0.0528 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 1 109612066 rs17024393 C T 0.064 0.05 0.103 0.074 0.068 0.111 0.08 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 109612066 rs17024393 C T 0.064 0.05 0.103 0.074 0.068 0.111 0.08 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 110716148 rs343604 T C 0.178 0.131 0.134 0.157 0.162 0.172 0.116 0 0.0008 0.0008 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 112503773 rs351365 T C 0.335 0.36 0.277 0.357 0.259 0.198 0.292 0.0138 0.0306 0 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 1 112503773 rs351365 T C 0.335 0.36 0.277 0.357 0.259 0.198 0.292 0.0138 0.0306 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 1 114128347 rs2774307 A G 0.034 0.036 0.08 0.083 0.063 0.049 0.049 0.0083 0 0.0048 www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 1 116927159 rs2806864 C G 0.453 0.487 0.5 0.416 0.459 0.376 0.433 0.0006 0 0.005 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 1 117470700 rs3820500 G A 0.12 0.16 0.131 0.209 0.137 0.171 0.161 0.0158 0 0.0074 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 117687599 rs7529522 C T 0.402 0.403 0.388 0.435 0.436 0.398 0.336 0.0026 0 0.0036 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 118111143 rs1962373 A G 0.039 0.028 0.041 0.018 0.019 0.034 0.009 0.0004 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 118310352 rs12731372 T C 0.059 0.059 0.063 0.117 0.023 0.037 0.062 0.0494 0.0242 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 1 118321979 rs7536458 G T 0.151 0.138 0.149 0.184 0.077 0.127 0.137 0.015 0.0142 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 118321979 rs7536458 G T 0.151 0.138 0.149 0.184 0.077 0.127 0.137 0.015 0.0142 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 118488075 rs10923574 A C 0.261 0.23 0.232 0.322 0.252 0.275 0.186 0.0188 0 0.0152 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 118954531 rs12143789 C G 0 0 0 0.004 0.005 0 0 0.006 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 1 118962811 rs10923712 A G 0.428 0.41 0.344 0.474 0.378 0.339 0.389 0.0226 0.0059 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 118962811 rs10923712 A G 0.428 0.41 0.344 0.474 0.378 0.339 0.389 0.0226 0.0059 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 119031964 rs2645294 C T 0.373 0.409 0.432 0.311 0.491 0.397 0.406 0.0303 0.0063 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 1 119031964 rs2645294 C T 0.373 0.409 0.432 0.311 0.491 0.397 0.406 0.0303 0.0063 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 1 119714487 rs637868 T C 0.475 0.419 0.424 0.548 0.491 0.488 0.456 0.0161 0 0.0146 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 1 119716347 rs666930 T C 0.39 0.323 0.308 0.527 0.419 0.43 0.381 0.0522 0 0.0431 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 121538815 rs11249433 G A 0.038 0.027 0.071 0.104 0.036 0.012 0.063 0.0513 0.0219 0 www.ncbi.nlm.nih.gov/pubmed/19330030 A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Breast cancer 1 121538815 rs11249433 G A 0.038 0.027 0.071 0.104 0.036 0.012 0.063 0.0513 0.0219 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 1 121538815 rs11249433 G A 0.038 0.027 0.071 0.104 0.036 0.012 0.063 0.0513 0.0219 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 1 121538815 rs11249433 G A 0.038 0.027 0.071 0.104 0.036 0.012 0.063 0.0513 0.0219 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 145790097 rs12405132 A G 0.085 0.118 0.063 0.104 0.073 0.12 0.08 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 1 145790097 rs12405132 A G 0.085 0.118 0.063 0.104 0.073 0.12 0.08 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 147513925 rs12057959 C T 0.137 0.151 0.138 0.057 0.072 0.07 0.115 0.0107 0 0.0318 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 1 147548685 rs594206 G A 0.381 0.261 0.321 0.309 0.257 0.291 0.31 0 0.0018 0.0018 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) 1 149934520 rs11205303 C T 0 0.005 0.005 0.022 0.014 0.02 0.009 0.0094 0 0.0182 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 150685811 rs17599629 G A 0 0.023 0.054 0.022 0.018 0.012 0.053 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 1 150685811 rs17599629 G A 0 0.023 0.054 0.022 0.018 0.012 0.053 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 1 150685811 rs17599629 G A 0 0.023 0.054 0.022 0.018 0.012 0.053 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 1 150887995 rs7412746 T C 0.064 0.099 0.112 0.117 0.064 0.053 0.097 0.0099 0.0144 0 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 1 150887995 rs7412746 T C 0.064 0.099 0.112 0.117 0.064 0.053 0.097 0.0099 0.0144 0 www.ncbi.nlm.nih.gov/pubmed/21983785 Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Melanoma 1 150989393 rs1722784 G A 0.046 0.105 0.115 0.096 0.032 0.021 0.102 0.0101 0.0449 0 www.ncbi.nlm.nih.gov/pubmed/21926416 Genome-wide association study identifies novel loci predisposing to cutaneous melanoma. Melanoma 1 153668351 rs7536700 T C 0.343 0.302 0.339 0.365 0.5 0.488 0.336 0 0.0467 0.014 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 1 154861707 rs1218582 A G 0.373 0.275 0.232 0.396 0.305 0.281 0.252 0.0332 0 0.009 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 1 154861707 rs1218582 A G 0.373 0.275 0.232 0.396 0.305 0.281 0.252 0.0332 0 0.009 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 1 155018913 rs905938 C T 0.288 0.252 0.25 0.222 0.302 0.283 0.31 0.0098 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 1 155061442 rs41264285 T C 0.203 0.209 0.152 0.209 0.185 0.16 0.177 0.001 0.0009 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 155176305 rs4971059 A G 0.162 0.122 0.138 0.222 0.177 0.184 0.165 0.0142 0 0.0146 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 155212052 rs2974935 G T 0.373 0.425 0.469 0.425 0.257 0.246 0.327 0.0126 0.064 0 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer 1 155212373 rs2075570 C T 0.355 0.407 0.458 0.44 0.238 0.233 0.29 0.0347 0.073 0 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 1 155302483 rs7524950 C T 0 0 0 0 0 0.012 0.004 0 0.0031 0.0008 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 155697170 rs348196 T C 0.339 0.286 0.263 0.422 0.221 0.303 0.327 0.0517 0.0097 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 159711078 rs2808630 C T 0.064 0.117 0.162 0.149 0.149 0.107 0.146 0.0013 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/18385676 Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Lung cancer 1 162851501 rs1912453 A G 0.376 0.487 0.46 0.447 0.473 0.537 0.522 0.0007 0.0039 0 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 1 164720525 rs1387389 A G 0.441 0.41 0.414 0.399 0.414 0.298 0.393 0 0.0044 0.0027 www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 1 168528503 rs78663305 G A 0.051 0.041 0.04 0.083 0.149 0.123 0.053 0 0.0275 0.0331 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 1 168535779 rs77045810 C A 0.038 0.032 0.018 0.058 0.09 0.094 0.04 0 0.0163 0.0224 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 1 171387110 rs10912872 G T 0.36 0.351 0.33 0.422 0.437 0.422 0.35 0.0007 0 0.0147 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 1 172361919 rs1894633 A G 0.418 0.432 0.424 0.352 0.523 0.48 0.354 0.0177 0.0286 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 172383850 rs714515 A G 0.076 0.059 0.085 0.074 0.086 0.098 0.058 0 0.0012 0.0012 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 1 172383850 rs714515 A G 0.076 0.059 0.085 0.074 0.086 0.098 0.058 0 0.0012 0.0012 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 1 177920345 rs543874 G A 0.297 0.284 0.228 0.197 0.225 0.231 0.25 0.0068 0 0.0091 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 177920345 rs543874 G A 0.297 0.284 0.228 0.197 0.225 0.231 0.25 0.0068 0 0.0091 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 1 177920345 rs543874 G A 0.297 0.284 0.228 0.197 0.225 0.231 0.25 0.0068 0 0.0091 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 177930963 rs575908 C T 0.299 0.282 0.241 0.187 0.306 0.314 0.261 0.0318 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 183004356 rs10752881 G A 0.364 0.225 0.326 0.27 0.482 0.434 0.286 0.0115 0.0677 0 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 1 184051811 rs2274432 A G 0.131 0.092 0.091 0.196 0.105 0.092 0.08 0.0557 0 0.0108 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 184051811 rs2274432 A G 0.131 0.092 0.091 0.196 0.105 0.092 0.08 0.0557 0 0.0108 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 185426050 rs10911725 A G 0.343 0.41 0.384 0.325 0.441 0.406 0.414 0.0142 0.0053 0 www.ncbi.nlm.nih.gov/pubmed/29971594 Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. Lung cancer x radon exposure interaction (1df) 1 186763038 rs56160832 A G 0.042 0.027 0.045 0.075 0.036 0.053 0.071 0.008 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 196875463 rs6428370 A G 0.275 0.315 0.306 0.339 0.387 0.466 0.314 0 0.0253 0.012 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 196973530 rs115105970 T C 0.114 0.14 0.103 0.106 0.149 0.115 0.111 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 1 197483784 rs114143322 A G 0.017 0.023 0.031 0.017 0.014 0.025 0.035 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29195075 An Unexpectedly Complex Architecture for Skin Pigmentation in Africans. Tanning 1 200038304 rs3790844 G A 0.102 0.118 0.063 0.1 0.072 0.082 0.128 0 0.0015 0.001 www.ncbi.nlm.nih.gov/pubmed/20101243 "A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33." Pancreatic cancer 1 200038304 rs3790844 G A 0.102 0.118 0.063 0.1 0.072 0.082 0.128 0 0.0015 0.001 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 1 200038304 rs3790844 G A 0.102 0.118 0.063 0.1 0.072 0.082 0.128 0 0.0015 0.001 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 1 201815159 rs2820292 C A 0.292 0.261 0.313 0.309 0.369 0.377 0.327 0 0.0099 0.0028 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 1 201815159 rs2820292 C A 0.292 0.261 0.313 0.309 0.369 0.377 0.327 0 0.0099 0.0028 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 1 202209914 rs17489300 C A 0.077 0.055 0.036 0.043 0.027 0.025 0.053 0 0.0061 0.0035 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 1 202209914 rs17489300 C A 0.077 0.055 0.036 0.043 0.027 0.025 0.053 0 0.0061 0.0035 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 1 202218048 rs6678914 A G 0.322 0.293 0.33 0.291 0.221 0.176 0.376 0 0.0344 0.0122 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 1 202218048 rs6678914 A G 0.322 0.293 0.33 0.291 0.221 0.176 0.376 0 0.0344 0.0122 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 1 203797203 rs4951011 G A 0.055 0.055 0.027 0.039 0.083 0.05 0.035 0 0.004 0.0001 www.ncbi.nlm.nih.gov/pubmed/25038754 "Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1." Breast cancer 1 204375629 rs112725747 T C 0.03 0.063 0.045 0.03 0.114 0.119 0.04 0.0029 0.0456 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 1 204546897 rs2290854 G A 0.195 0.279 0.147 0.165 0.194 0.197 0.168 0.0013 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/23544013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. Breast Cancer in BRCA1 mutation carriers 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/24325915 Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. "Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)" 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 1 204549714 rs4245739 C A 0.203 0.207 0.188 0.348 0.203 0.197 0.204 0.0763 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 1 207903511 rs2724379 C A 0.06 0.086 0.067 0.161 0.041 0.045 0.089 0.0782 0.0221 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 208545327 rs1891196 G A 0.208 0.261 0.255 0.235 0.171 0.161 0.23 0 0.0149 0.0007 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 1 208545327 rs1891196 G A 0.208 0.261 0.255 0.235 0.171 0.161 0.23 0 0.0149 0.0007 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 1 208834717 rs34763909 C T 0.068 0.032 0.027 0.026 0.023 0.004 0.027 0 0.0065 0.0047 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in never smokers 1 210316066 rs34585985 G A 0.034 0.041 0.027 0.022 0 0.004 0.022 0.0008 0.0213 0 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease 1 210504207 rs4537555 G A 0.009 0.028 0.009 0.052 0.014 0.021 0.009 0.0371 0 0.0159 www.ncbi.nlm.nih.gov/pubmed/30068317 Genome-wide association study of lung function and clinical implication in heavy smokers. Post bronchodilator FEV1/FVC ratio in smoking 1 210504207 rs4537555 G A 0.009 0.028 0.009 0.052 0.014 0.021 0.009 0.0371 0 0.0159 www.ncbi.nlm.nih.gov/pubmed/30068317 Genome-wide association study of lung function and clinical implication in heavy smokers. Post bronchodilator percent predicted FEV1 in smoking 1 210816167 rs11119608 G T 0.17 0.136 0.113 0.096 0.045 0.07 0.134 0 0.0173 0.0174 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer 1 213369363 rs17020562 C T 0.148 0.189 0.263 0.174 0.158 0.129 0.115 0 0.0022 0.0013 www.ncbi.nlm.nih.gov/pubmed/29059430 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. Breast cancer in childhood cancer survivors 1 213369363 rs17020562 C T 0.148 0.189 0.263 0.174 0.158 0.129 0.115 0 0.0022 0.0013 www.ncbi.nlm.nih.gov/pubmed/29059430 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. Breast cancer in childhood cancer survivors treated with less than 10 gray radiotherapy 1 213850882 rs4342822 G T 0.114 0.193 0.125 0.121 0.128 0.122 0.1 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059430 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy 1 216684671 rs4085154 G A 0.394 0.351 0.402 0.37 0.293 0.256 0.341 0 0.0218 0.0006 www.ncbi.nlm.nih.gov/pubmed/27670397 Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Pre-treatment pain in head and neck squamous cell carcinoma 1 217047232 rs11117758 A G 0.133 0.127 0.147 0.183 0.086 0.103 0.107 0.0241 0.0126 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 1 218423955 rs12048049 C G 0.47 0.569 0.487 0.535 0.3 0.344 0.478 0.0174 0.0848 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 218423955 rs12048049 C G 0.47 0.569 0.487 0.535 0.3 0.344 0.478 0.0174 0.0848 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 219495884 rs765751 T C 0.432 0.446 0.402 0.478 0.248 0.303 0.465 0.0212 0.0763 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 1 219495884 rs765751 T C 0.432 0.446 0.402 0.478 0.248 0.303 0.465 0.0212 0.0763 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 1 219580167 rs2820443 C T 0.009 0.005 0.027 0.065 0.036 0.025 0.04 0.033 0 0.0196 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 1 219580167 rs2820443 C T 0.009 0.005 0.027 0.065 0.036 0.025 0.04 0.033 0 0.0196 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 1 219586391 rs3897379 A G 0.195 0.342 0.348 0.23 0.383 0.361 0.27 0.0205 0.0271 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 219586391 rs3897379 A G 0.195 0.342 0.348 0.23 0.383 0.361 0.27 0.0205 0.0271 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 221136075 rs12127195 A G 0.398 0.378 0.313 0.439 0.451 0.508 0.398 0 0.0071 0.0183 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 1 221136075 rs12127195 A G 0.398 0.378 0.313 0.439 0.451 0.508 0.398 0 0.0071 0.0183 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 1 221872104 rs6691170 T G 0.305 0.324 0.299 0.352 0.302 0.328 0.32 0.0016 0 0.0014 www.ncbi.nlm.nih.gov/pubmed/20972440 "Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33." Colorectal cancer 1 221989031 rs6691195 A C 0.085 0.122 0.125 0.161 0.109 0.098 0.137 0.0126 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 1 221991606 rs6687758 G A 0.124 0.149 0.176 0.209 0.135 0.152 0.186 0.0127 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 1 221991606 rs6687758 G A 0.124 0.149 0.176 0.209 0.135 0.152 0.186 0.0127 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/20972440 "Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33." Colorectal cancer 1 221991606 rs6687758 G A 0.124 0.149 0.176 0.209 0.135 0.152 0.186 0.0127 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 1 221991606 rs6687758 G A 0.124 0.149 0.176 0.209 0.135 0.152 0.186 0.0127 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 1 221991606 rs6687758 G A 0.124 0.149 0.176 0.209 0.135 0.152 0.186 0.0127 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 1 225711351 rs55894909 T G 0.246 0.266 0.29 0.239 0.391 0.336 0.297 0.0096 0.0262 0 www.ncbi.nlm.nih.gov/pubmed/30219690 GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort. Depression in smokers 1 225904035 rs360071 T C 0.534 0.468 0.442 0.422 0.392 0.348 0.456 0 0.0105 0.0135 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. "Response to radiotherapy in prostate cancer (toxicity, rectal bleeding)" 1 226376990 rs3219090 C T 0.379 0.419 0.401 0.509 0.383 0.322 0.473 0.0345 0.0201 0 www.ncbi.nlm.nih.gov/pubmed/21983785 Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Melanoma 1 228744549 rs41271473 A G 0.167 0.156 0.174 0.101 0.128 0.142 0.173 0.0118 0 0.0116 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 1 228858641 rs12070203 T C 0.229 0.266 0.21 0.2 0.158 0.246 0.177 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 1 228862088 rs801114 T G 0.161 0.158 0.161 0.139 0.122 0.127 0.181 0 0.0022 0.0034 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 1 228862088 rs801114 T G 0.161 0.158 0.161 0.139 0.122 0.127 0.181 0 0.0022 0.0034 www.ncbi.nlm.nih.gov/pubmed/24403052 Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Basal cell carcinoma 1 228862088 rs801114 T G 0.161 0.158 0.161 0.139 0.122 0.127 0.181 0 0.0022 0.0034 www.ncbi.nlm.nih.gov/pubmed/18849993 Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. Basal cell carcinoma 1 230289344 rs16851421 G A 0.381 0.387 0.344 0.309 0.378 0.439 0.323 0.0114 0.01 0 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 1 230712956 rs2004776 C T 0.543 0.559 0.397 0.596 0.473 0.409 0.46 0.0395 0.012 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 1 230712956 rs2004776 C T 0.543 0.559 0.397 0.596 0.473 0.409 0.46 0.0395 0.012 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 1 230811394 rs1202519 T C 0.106 0.104 0.089 0.109 0.176 0.152 0.12 0 0.013 0.0028 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 1 233276815 rs12129938 G A 0.171 0.158 0.134 0.2 0.14 0.194 0.15 0.0051 0 0.0045 www.ncbi.nlm.nih.gov/pubmed/28195142 A genome-wide association study yields five novel thyroid cancer risk loci. Thyroid cancer 1 233280792 rs4649295 C T 0.409 0.398 0.383 0.396 0.255 0.237 0.313 0.0084 0.0492 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 1 233280792 rs4649295 C T 0.409 0.398 0.383 0.396 0.255 0.237 0.313 0.0084 0.0492 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Papillary thyroid cancer 1 236276616 rs6662005 A G 0.309 0.359 0.339 0.287 0.234 0.298 0.354 0 0.0025 0.0096 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 1 237103303 rs7554607 G A 0.403 0.307 0.33 0.378 0.478 0.418 0.31 0 0.0154 0.0106 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 237688783 rs876793 C T 0 0.005 0 0.017 0 0 0 0.0351 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 1 237688783 rs876793 C T 0 0.005 0 0.017 0 0 0 0.0351 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 1 238128048 rs6684897 C G 0.14 0.18 0.156 0.114 0.113 0.111 0.15 0.0004 0 0.008 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 1 239918447 rs2184857 A C 0.28 0.275 0.317 0.387 0.355 0.369 0.341 0.0075 0 0.0148 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 1 241715245 rs12569163 G T 0.025 0.054 0.018 0.071 0.023 0.025 0.04 0.0263 0.0036 0 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 1 243199378 rs10436951 G A 0.237 0.203 0.196 0.197 0.099 0.152 0.248 0 0.0248 0.0059 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 1 244201577 rs76327975 G C 0.06 0.05 0.08 0.039 0.023 0.053 0.044 0 0.0001 0.0028 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 1 244369912 rs3101457 G A 0.339 0.324 0.246 0.204 0.212 0.242 0.321 0.0106 0 0.0269 www.ncbi.nlm.nih.gov/pubmed/22832964 Genome-wide meta-analyses of smoking behaviors in African Americans. Smoking behavior 1 247526230 rs1881797 T C 0.402 0.391 0.437 0.413 0.414 0.384 0.438 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 1 247618267 rs1144815 T C 0.521 0.491 0.545 0.509 0.41 0.385 0.553 0 0.0309 0.0055 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 1 247702471 rs3862188 T C 0.047 0.045 0.036 0.061 0.045 0.037 0.062 0.001 0.0007 0 www.ncbi.nlm.nih.gov/pubmed/27670397 Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Pre-treatment pain in head and neck squamous cell carcinoma 2 6015425 rs10929925 C A 0.487 0.432 0.384 0.425 0.491 0.475 0.423 0.0001 0.0042 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 2 6015425 rs10929925 C A 0.487 0.432 0.384 0.425 0.491 0.475 0.423 0.0001 0.0042 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 2 6637697 rs17815605 A C 0.06 0.09 0.085 0.017 0.171 0.143 0.084 0.059 0.048 0 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 2 6637860 rs11692570 T C 0.389 0.374 0.393 0.361 0.257 0.291 0.376 0 0.0219 0.0053 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 2 7377100 rs13429103 A G 0.237 0.33 0.277 0.313 0.168 0.172 0.237 0.0199 0.044 0 www.ncbi.nlm.nih.gov/pubmed/29551738 Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barretts Esophagus. Esophageal adenocarcinoma x smoking interaction 2 8456993 rs62106670 T C 0.093 0.081 0.071 0.122 0.091 0.094 0.053 0.0102 0 0.009 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 9977740 rs11902236 C T 0.352 0.333 0.362 0.43 0.284 0.316 0.292 0.0328 0.0062 0 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 2 9977740 rs11902236 C T 0.352 0.333 0.362 0.43 0.284 0.316 0.292 0.0328 0.0062 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 11895429 rs6432241 G C 0.225 0.188 0.176 0.18 0.108 0.082 0.164 0 0.0353 0.0004 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 15369022 rs7572081 G A 0.199 0.168 0.174 0.157 0.207 0.23 0.173 0.0032 0.0074 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 2 16280877 rs57244888 C T 0.182 0.173 0.228 0.165 0.207 0.223 0.266 0.0067 0 0.001 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 2 17602890 rs13031455 C T 0.004 0.005 0.023 0.013 0.041 0.016 0.009 0 0.006 0.0037 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 2 18106253 rs12467348 T C 0.094 0.099 0.076 0.161 0.068 0.07 0.089 0.0441 0.0062 0 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 2 18313189 rs10495672 C G 0.208 0.198 0.282 0.174 0.185 0.25 0.212 0.0064 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 2 19111157 rs11684853 T G 0.42 0.338 0.351 0.378 0.329 0.307 0.424 0 0.0075 0.0015 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 19121042 rs12710696 C T 0.47 0.374 0.397 0.457 0.356 0.369 0.46 0.005 0.0125 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 2 19121042 rs12710696 C T 0.47 0.374 0.397 0.457 0.356 0.369 0.46 0.005 0.0125 0 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 2 19121042 rs12710696 C T 0.47 0.374 0.397 0.457 0.356 0.369 0.46 0.005 0.0125 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 2 19121042 rs12710696 C T 0.47 0.374 0.397 0.457 0.356 0.369 0.46 0.005 0.0125 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 19121042 rs12710696 C T 0.47 0.374 0.397 0.457 0.356 0.369 0.46 0.005 0.0125 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 2 19121042 rs12710696 C T 0.47 0.374 0.397 0.457 0.356 0.369 0.46 0.005 0.0125 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 2 19429543 rs13398721 C T 0.305 0.284 0.281 0.23 0.293 0.307 0.279 0.0102 0.0004 0 www.ncbi.nlm.nih.gov/pubmed/23478653 A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy. Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer 2 20678393 rs9306895 C T 0.064 0.054 0.049 0.083 0.117 0.107 0.049 0 0.0094 0.0158 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 20688505 rs13385191 G A 0.008 0.009 0.009 0.026 0.009 0 0 0.0228 0 0.0024 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 2 20688505 rs13385191 G A 0.008 0.009 0.009 0.026 0.009 0 0 0.0228 0 0.0024 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 2 20935927 rs76588427 A G 0.055 0.045 0.063 0.052 0.05 0.053 0.049 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25569183 A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Marginal zone lymphoma 2 21354871 rs219553 G A 0.267 0.23 0.228 0.222 0.191 0.197 0.248 0 0.0031 0.0031 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 22360096 rs61533748 C T 0.034 0.032 0.009 0.022 0.077 0.057 0.009 0 0.0256 0.0058 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 2 24471603 rs79480871 T C 0.127 0.203 0.179 0.148 0.162 0.258 0.142 0.002 0.01 0 www.ncbi.nlm.nih.gov/pubmed/25261932 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Diffuse large B cell lymphoma 2 24705710 rs2289393 C T 0.121 0.181 0.177 0.198 0.216 0.227 0.138 0 0.0038 0.0123 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 2 24744855 rs2083389 C T 0.056 0.126 0.098 0.139 0.185 0.164 0.103 0 0.0095 0.021 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 2 24927427 rs10182181 A G 0.102 0.063 0.063 0.13 0.023 0.037 0.049 0.0563 0.0356 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 2 24927427 rs10182181 A G 0.102 0.063 0.063 0.13 0.023 0.037 0.049 0.0563 0.0356 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 2 25263901 rs12991495 C T 0.102 0.077 0.098 0.074 0.149 0.103 0.08 0.0029 0.0089 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 2 25263901 rs12991495 C T 0.102 0.077 0.098 0.074 0.149 0.103 0.08 0.0029 0.0089 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 2 25263901 rs12991495 C T 0.102 0.077 0.098 0.074 0.149 0.103 0.08 0.0029 0.0089 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 2 25390277 rs7577599 C T 0.393 0.455 0.392 0.474 0.329 0.271 0.442 0.0225 0.0496 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 2 25390277 rs7577599 C T 0.393 0.455 0.392 0.474 0.329 0.271 0.442 0.0225 0.0496 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 2 25410373 rs10180663 T C 0.17 0.14 0.112 0.213 0.122 0.172 0.137 0.0212 0 0.0075 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 2 25431180 rs7605235 A G 0.085 0.086 0.089 0.109 0.099 0.139 0.084 0 0.0018 0.004 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 2 25436375 rs6746082 C A 0.525 0.532 0.505 0.557 0.437 0.41 0.509 0.0103 0.0269 0 www.ncbi.nlm.nih.gov/pubmed/22120009 Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Multiple myeloma 2 26691496 rs1275988 T C 0.09 0.141 0.161 0.149 0.122 0.107 0.106 0.0024 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 2 26691496 rs1275988 T C 0.09 0.141 0.161 0.149 0.122 0.107 0.106 0.0024 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 2 28097166 rs7572644 C T 0.102 0.118 0.125 0.157 0.09 0.067 0.121 0.0178 0.0162 0 www.ncbi.nlm.nih.gov/pubmed/27047539 "Genome-Wide Study of Response to Platinum, Taxane, and Combination Therapy in Ovarian Cancer: In vitro Phenotypes, Inherited Variation, and Disease Recurrence." Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50) 2 28896719 rs67073037 T A 0.141 0.162 0.196 0.178 0.104 0.176 0.189 0.0002 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 2 28896719 rs67073037 T A 0.141 0.162 0.196 0.178 0.104 0.176 0.189 0.0002 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 2 28897867 rs4577244 T C 0.165 0.185 0.201 0.23 0.171 0.225 0.217 0.0023 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 2 29074892 rs17007554 T C 0.131 0.113 0.054 0.126 0.122 0.115 0.075 0.0022 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in never smokers 2 30666058 rs12464483 A G 0.093 0.135 0.116 0.152 0.072 0.076 0.111 0.0177 0.0175 0 www.ncbi.nlm.nih.gov/pubmed/27670397 Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Pre-treatment pain in head and neck squamous cell carcinoma 2 30763879 rs78355147 C T 0 0 0.005 0.004 0 0 0 0.0031 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 2 33154196 rs6715793 T C 0.242 0.216 0.237 0.202 0.2 0.242 0.225 0.0004 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 2 33154196 rs6715793 T C 0.242 0.216 0.237 0.202 0.2 0.242 0.225 0.0004 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 2 37376658 rs888096 G A 0.004 0.005 0.004 0.048 0.018 0.004 0.009 0.0626 0 0.0321 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 2 38049406 rs6750047 A G 0.269 0.271 0.243 0.182 0.214 0.235 0.301 0.0141 0 0.0155 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 2 38049406 rs6750047 A G 0.269 0.271 0.243 0.182 0.214 0.235 0.301 0.0141 0 0.0155 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 2 38050689 rs6741148 T G 0.297 0.302 0.281 0.257 0.252 0.258 0.33 0.0004 0 0.0048 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 39720581 rs2716734 T C 0.326 0.383 0.348 0.33 0.545 0.484 0.434 0.0159 0.0563 0 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 43088349 rs62137541 C T 0.36 0.329 0.38 0.333 0.369 0.402 0.341 0.0012 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 2 43088710 rs7578467 C T 0.309 0.275 0.241 0.317 0.266 0.225 0.257 0.0086 0.0034 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 2 43091570 rs7562946 G A 0.329 0.291 0.315 0.261 0.333 0.36 0.283 0.0086 0.0072 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 2 43092840 rs3179891 A G 0.203 0.198 0.205 0.152 0.23 0.279 0.19 0.0157 0.0159 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 2 43093990 rs12615153 G T 0.284 0.279 0.295 0.196 0.277 0.32 0.27 0.0273 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 2 43326810 rs1465618 T C 0.038 0.099 0.071 0.074 0.063 0.053 0.084 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 2 43326810 rs1465618 T C 0.038 0.099 0.071 0.074 0.063 0.053 0.084 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 44478476 rs698813 A G 0.047 0.054 0.094 0.104 0.063 0.057 0.075 0.0126 0.0001 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) 2 44962598 rs79368540 T C 0.013 0.018 0.027 0.035 0.032 0.02 0.031 0.0013 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 2 45181130 rs6720296 C A 0.28 0.347 0.362 0.339 0.342 0.406 0.348 0 0.0014 0.0014 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 2 45606937 rs7591446 C T 0.353 0.352 0.421 0.369 0.362 0.446 0.404 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 2 47009297 rs61571577 T C 0.22 0.225 0.192 0.183 0.212 0.172 0.23 0.0011 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 2 47012873 rs10194115 T G 0.254 0.277 0.243 0.237 0.239 0.188 0.261 0 0.0025 0.0025 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 47248996 rs12620038 G C 0.301 0.324 0.304 0.383 0.405 0.406 0.288 0 0.0024 0.0216 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 2 48950462 rs7591064 C T 0.013 0.014 0.027 0.013 0 0 0.018 0.0028 0.0163 0 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 2 48974189 rs2268363 G A 0.39 0.527 0.531 0.465 0.473 0.463 0.487 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 49917183 rs12465974 C T 0.441 0.414 0.464 0.448 0.5 0.492 0.389 0 0.0054 0.0035 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 2 55798738 rs74760234 T C 0.136 0.197 0.15 0.126 0.116 0.088 0.125 0 0.0047 0.0057 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 2 55869757 rs3791679 G A 0.026 0.05 0.018 0.048 0.023 0.012 0.013 0.0128 0.0041 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 2 55869757 rs3791679 G A 0.026 0.05 0.018 0.048 0.023 0.012 0.013 0.0128 0.0041 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 2 55869757 rs3791679 G A 0.026 0.05 0.018 0.048 0.023 0.012 0.013 0.0128 0.0041 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 2 58795075 rs17616642 G A 0.089 0.117 0.076 0.096 0.068 0.09 0.044 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 2 59272212 rs10490113 C A 0.157 0.117 0.196 0.165 0.077 0.074 0.168 0.006 0.0393 0 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 2 60816699 rs13034020 G A 0.089 0.081 0.152 0.122 0.176 0.143 0.093 0 0.0086 0.0056 www.ncbi.nlm.nih.gov/pubmed/24920014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Hodgkins lymphoma 2 60839531 rs1432295 G A 0.148 0.131 0.183 0.139 0.153 0.178 0.103 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/24149102 Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkins lymphoma. Hodgkins lymphoma 2 60839531 rs1432295 G A 0.148 0.131 0.183 0.139 0.153 0.178 0.103 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/21037568 "A genome-wide association study of Hodgkins lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)." Hodgkins lymphoma 2 61245497 rs4671400 G A 0 0.005 0 0 0.005 0 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 2 62904596 rs721048 A G 0 0 0 0.017 0.014 0.004 0.013 0.0107 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/18264098 Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Prostate cancer 2 62904596 rs721048 A G 0 0 0 0.017 0.014 0.004 0.013 0.0107 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 63074029 rs6545977 G A 0.539 0.569 0.405 0.496 0.347 0.338 0.522 0 0.0564 0.0042 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 2 65293011 rs1039766 T C 0.085 0.036 0.067 0.091 0.081 0.119 0.053 0 0.0013 0.0102 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 2 65293011 rs1039766 T C 0.085 0.036 0.067 0.091 0.081 0.119 0.053 0 0.0013 0.0102 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 2 65973514 rs1385167 G A 0.288 0.296 0.255 0.222 0.176 0.252 0.248 0 0.0002 0.0074 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 2 66593583 rs55767876 G T 0.081 0.086 0.09 0.088 0.095 0.041 0.08 0 0.0005 0.0002 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 2 66738934 rs2901879 C T 0.352 0.391 0.41 0.314 0.423 0.443 0.443 0.0247 0.0056 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 2 67075611 rs17032980 G A 0.496 0.509 0.46 0.408 0.441 0.504 0.527 0.0145 0 0.0077 www.ncbi.nlm.nih.gov/pubmed/25710658 Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia 2 67366671 rs962856 C T 0.203 0.198 0.15 0.277 0.122 0.104 0.161 0.0664 0.0388 0 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 2 67412637 rs1486134 G T 0.17 0.176 0.063 0.17 0.146 0.143 0.155 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 2 67412637 rs1486134 G T 0.17 0.176 0.063 0.17 0.146 0.143 0.155 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 2 68971256 rs4254535 C T 0.403 0.432 0.388 0.357 0.311 0.295 0.429 0 0.012 0.0153 www.ncbi.nlm.nih.gov/pubmed/19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Lung cancer 2 69207095 rs12474538 A C 0.081 0.072 0.103 0.096 0.068 0.086 0.133 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 69832692 rs4853036 G A 0.377 0.412 0.408 0.443 0.445 0.384 0.464 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 2 69945455 rs6756513 A G 0.275 0.248 0.227 0.23 0.275 0.328 0.286 0.0042 0.0071 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 73525241 rs10469966 A G 0.377 0.387 0.487 0.417 0.333 0.357 0.383 0.0008 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 74107335 rs828867 A G 0.131 0.141 0.174 0.212 0.086 0.103 0.208 0.0271 0.0372 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 75642702 rs12105510 C T 0.186 0.155 0.121 0.248 0.23 0.211 0.159 0.0142 0 0.0283 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 2 77701188 rs7598757 G A 0.517 0.482 0.424 0.474 0.482 0.467 0.496 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 79716982 rs13025833 A G 0.299 0.333 0.33 0.361 0.333 0.307 0.344 0.0013 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/25824743 A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia. Breast cancer 2 79729424 rs1567532 T C 0.131 0.126 0.13 0.126 0.104 0.074 0.115 0 0.006 0.0002 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 2 85567174 rs10187424 T C 0.318 0.293 0.308 0.33 0.333 0.332 0.27 0 0.0002 0.0014 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 2 85567174 rs10187424 T C 0.318 0.293 0.308 0.33 0.333 0.332 0.27 0 0.0002 0.0014 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer 2 85567174 rs10187424 T C 0.318 0.293 0.308 0.33 0.333 0.332 0.27 0 0.0002 0.0014 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 85787998 rs13402783 G A 0.091 0.046 0.078 0.065 0.145 0.132 0.078 0.0006 0.0257 0 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 2 96835063 rs9948 G C 0.309 0.336 0.357 0.478 0.568 0.623 0.412 0 0.0559 0.0753 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 97707918 rs12999616 T C 0.004 0.014 0.013 0.026 0.005 0.004 0.013 0.0145 0.0058 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 2 98688331 rs885036 A G 0.161 0.18 0.167 0.18 0.162 0.127 0.173 0.0006 0.0018 0 www.ncbi.nlm.nih.gov/pubmed/26222057 "Genome Wide Association Study for Predictors of Progression Free Survival in Patients on Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in First-Line Therapy of Metastatic Colorectal Cancer." Progression free survival in metastatic colorectal cancer (chemotherapy interaction) 2 100975599 rs60866311 G T 0.256 0.207 0.23 0.178 0.269 0.244 0.248 0.0138 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 2 102090719 rs10199359 C T 0.242 0.257 0.223 0.283 0.359 0.328 0.255 0 0.0141 0.0114 www.ncbi.nlm.nih.gov/pubmed/27670397 Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Pre-treatment pain in head and neck squamous cell carcinoma 2 104762499 rs12615966 T C 0.14 0.113 0.121 0.165 0.162 0.098 0.133 0.005 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 2 110858527 rs13401811 A G 0.157 0.138 0.165 0.122 0.135 0.152 0.156 0.0019 0 0.0019 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 110970905 rs4849303 T C 0.509 0.464 0.442 0.509 0.446 0.451 0.558 0.001 0.0039 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 2 111039881 rs17483466 G A 0.047 0.018 0.045 0.035 0.014 0.012 0.027 0.0012 0.0093 0 www.ncbi.nlm.nih.gov/pubmed/22700719 Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 111039881 rs17483466 G A 0.047 0.018 0.045 0.035 0.014 0.012 0.027 0.0012 0.0093 0 www.ncbi.nlm.nih.gov/pubmed/18758461 A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 111039881 rs17483466 G A 0.047 0.018 0.045 0.035 0.014 0.012 0.027 0.0012 0.0093 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 111074216 rs58055674 C T 0.03 0.051 0.027 0.044 0.028 0.033 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 2 111074216 rs58055674 C T 0.03 0.051 0.027 0.044 0.028 0.033 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 111114320 rs1439287 A G 0.335 0.392 0.321 0.387 0.279 0.299 0.363 0.0071 0.0141 0 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 111150685 rs9308731 G A 0.148 0.14 0.125 0.18 0.14 0.156 0.177 0.0022 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 112482606 rs3811038 C T 0.225 0.168 0.211 0.33 0.293 0.348 0.274 0.0096 0 0.0384 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 2 112482606 rs3811038 C T 0.225 0.168 0.211 0.33 0.293 0.348 0.274 0.0096 0 0.0384 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 114456179 rs17048372 T G 0.102 0.104 0.063 0.148 0.108 0.074 0.111 0.0182 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer 2 114456179 rs17048372 T G 0.102 0.104 0.063 0.148 0.108 0.074 0.111 0.0182 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 2 116151675 rs11123333 T C 0.309 0.27 0.321 0.3 0.248 0.23 0.301 0 0.0086 0.0006 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 2 116321325 rs1505758 A G 0.441 0.536 0.554 0.448 0.55 0.508 0.469 0.0082 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 2 118661291 rs144104656 G A 0 0.005 0.018 0 0.005 0.012 0.018 0.0055 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 2 119990995 rs11685222 G A 0.013 0.009 0.023 0.013 0.009 0.013 0.009 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 2 120330606 rs11903787 A G 0.517 0.509 0.441 0.566 0.421 0.467 0.523 0.0182 0.0112 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 2 120330606 rs11903787 A G 0.517 0.509 0.441 0.566 0.421 0.467 0.523 0.0182 0.0112 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 2 120481784 rs4848599 T C 0.36 0.378 0.326 0.326 0.275 0.328 0.354 0 0.0025 0.0026 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 120487546 rs4849887 T C 0.36 0.383 0.313 0.33 0.279 0.357 0.353 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 2 120487546 rs4849887 T C 0.36 0.383 0.313 0.33 0.279 0.357 0.353 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 2 120487546 rs4849887 T C 0.36 0.383 0.313 0.33 0.279 0.357 0.353 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 120487546 rs4849887 T C 0.36 0.383 0.313 0.33 0.279 0.357 0.353 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 2 122533446 rs1527243 T C 0.178 0.171 0.25 0.287 0.275 0.295 0.288 0.0025 0 0.0133 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 130967332 rs4377367 C T 0.465 0.431 0.468 0.374 0.398 0.441 0.473 0.01 0 0.0099 www.ncbi.nlm.nih.gov/pubmed/26222057 "Genome Wide Association Study for Predictors of Progression Free Survival in Patients on Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in First-Line Therapy of Metastatic Colorectal Cancer." Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) 2 132466818 rs6753618 A C 0.097 0.108 0.094 0.127 0.162 0.148 0.102 0 0.0055 0.0086 www.ncbi.nlm.nih.gov/pubmed/30068317 Genome-wide association study of lung function and clinical implication in heavy smokers. Post bronchodilator FEV1/FVC ratio in smoking 2 132466818 rs6753618 A C 0.097 0.108 0.094 0.127 0.162 0.148 0.102 0 0.0055 0.0086 www.ncbi.nlm.nih.gov/pubmed/30068317 Genome-wide association study of lung function and clinical implication in heavy smokers. Post bronchodilator percent predicted FEV1 in smoking 2 133680388 rs1901440 A C 0.271 0.311 0.321 0.278 0.482 0.443 0.31 0.008 0.0671 0 www.ncbi.nlm.nih.gov/pubmed/22293537 A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. Response to gemcitabine in pancreatic cancer 2 136240824 rs4954585 T C 0.348 0.396 0.353 0.352 0.396 0.43 0.398 0.0017 0.004 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 2 136797654 rs1427593 T C 0.237 0.211 0.246 0.254 0.162 0.178 0.223 0.0058 0.016 0 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 2 137384594 rs13405020 C G 0.124 0.095 0.094 0.1 0.027 0.07 0.08 0.002 0.0181 0 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 2 141038051 rs10210358 G A 0.462 0.441 0.353 0.426 0.369 0.439 0.389 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 2 141414797 rs4954702 A G 0.14 0.113 0.103 0.161 0.189 0.156 0.143 0 0.0012 0.0073 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 2 143491193 rs35825582 A G 0.424 0.469 0.433 0.404 0.455 0.335 0.388 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 146327302 rs16855418 C G 0.013 0.023 0.004 0.013 0.018 0.008 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 2 149540704 rs7578361 T G 0.292 0.261 0.205 0.252 0.171 0.16 0.235 0.0015 0.0225 0 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 2 149601110 rs10170236 A G 0.36 0.284 0.295 0.357 0.329 0.275 0.274 0.006 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 2 150254516 rs62170035 A C 0.087 0.064 0.085 0.08 0.023 0.059 0.057 0.0025 0.0102 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 2 151397404 rs10197940 C T 0.369 0.365 0.33 0.391 0.27 0.324 0.327 0.0089 0.0099 0 www.ncbi.nlm.nih.gov/pubmed/23143601 Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Lung cancer 2 151677702 rs202124287 T C 0.009 0.009 0.009 0.026 0.023 0.029 0.013 0.0026 0 0.0103 www.ncbi.nlm.nih.gov/pubmed/27114598 Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia. Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) 2 152100897 rs3820706 C T 0.267 0.221 0.272 0.25 0.23 0.281 0.221 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) 2 152124821 rs16830728 T G 0.195 0.186 0.219 0.189 0.194 0.231 0.177 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) 2 153074663 rs1367374 C G 0.3 0.342 0.295 0.257 0.338 0.287 0.301 0.0062 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/27207650 Genome-wide association study of colorectal cancer in Hispanics. Colorectal cancer 2 158326236 rs12617237 C T 0.275 0.314 0.33 0.296 0.315 0.282 0.314 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in estrogen receptor negative breast cancer 2 159042977 rs7582141 T G 0.314 0.329 0.286 0.387 0.437 0.41 0.354 0 0.0056 0.0182 www.ncbi.nlm.nih.gov/pubmed/24974847 A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1. Response to radiotherapy in prostate cancer (toxicity) 2 161244750 rs11678980 A G 0.188 0.198 0.179 0.122 0.221 0.182 0.199 0.0218 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 2 161244750 rs11678980 A G 0.188 0.198 0.179 0.122 0.221 0.182 0.199 0.0218 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 163470244 rs13014982 A G 0.131 0.159 0.103 0.18 0.279 0.23 0.173 0 0.0266 0.019 www.ncbi.nlm.nih.gov/pubmed/25823687 Genome-wide association study of myelosuppression in non-small-cell lung cancer patients with platinum-based chemotherapy. Platinum-induced myelosuppression in non-small cell lung cancer 2 163711179 rs1460676 C T 0.284 0.173 0.246 0.261 0.224 0.256 0.29 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 2 163711179 rs1460676 C T 0.284 0.173 0.246 0.261 0.224 0.256 0.29 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 2 164656581 rs10195252 T C 0.186 0.193 0.25 0.23 0.171 0.172 0.226 0.0024 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 2 164656581 rs10195252 T C 0.186 0.193 0.25 0.23 0.171 0.172 0.226 0.0024 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 2 164656581 rs10195252 T C 0.186 0.193 0.25 0.23 0.171 0.172 0.226 0.0024 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 2 164656581 rs10195252 T C 0.186 0.193 0.25 0.23 0.171 0.172 0.226 0.0024 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 2 164672114 rs1128249 G T 0.188 0.2 0.248 0.23 0.171 0.172 0.228 0.0021 0.0072 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 2 164672114 rs1128249 G T 0.188 0.2 0.248 0.23 0.171 0.172 0.228 0.0021 0.0072 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 2 164697799 rs12692737 C A 0.311 0.294 0.347 0.295 0.355 0.325 0.333 0.0009 0.0009 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 2 164701742 rs12692738 T C 0.339 0.342 0.371 0.404 0.264 0.283 0.381 0.0146 0.0264 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 2 164701742 rs12692738 T C 0.339 0.342 0.371 0.404 0.264 0.283 0.381 0.0146 0.0264 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 2 165696408 rs34462569 A G 0 0 0 0.004 0.005 0.004 0 0.0042 0 0.0097 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 2 171665317 rs7600835 A G 0.415 0.437 0.411 0.474 0.505 0.418 0.416 0.0023 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 2 171665317 rs7600835 A G 0.415 0.437 0.411 0.474 0.505 0.418 0.416 0.0023 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 173211033 rs1866631 A G 0.373 0.441 0.446 0.447 0.432 0.441 0.376 0.0009 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 2 173348166 rs1550623 G A 0.331 0.309 0.299 0.351 0.365 0.289 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 2 173348166 rs1550623 G A 0.331 0.309 0.299 0.351 0.365 0.289 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 2 173348166 rs1550623 G A 0.331 0.309 0.299 0.351 0.365 0.289 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 173369819 rs34925593 C T 0.186 0.131 0.153 0.148 0.177 0.152 0.152 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 173640196 rs13028485 A G 0.14 0.086 0.063 0.122 0.132 0.119 0.08 0 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 2 174729547 rs77530448 G A 0.121 0.098 0.173 0.123 0.041 0.066 0.131 0.0005 0.0334 0 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Response to radiotherapy in prostate cancer (overall toxicity) 2 180594207 rs16867335 T C 0.051 0.045 0.054 0.061 0.036 0.041 0.04 0.0015 0.0014 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 2 181286781 rs2119148 G A 0.398 0.288 0.268 0.317 0.32 0.281 0.354 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 2 187250671 rs1569135 A G 0.386 0.312 0.326 0.387 0.376 0.393 0.33 0.0008 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 2 189205442 rs73034872 C A 0.128 0.122 0.127 0.109 0.083 0.103 0.117 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 191099907 rs7574865 T G 0.144 0.117 0.086 0.096 0.086 0.139 0.115 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/23242368 Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Hepatocellular carcinoma in hepatitis B infection 2 191584116 rs62179734 T C 0.148 0.198 0.205 0.213 0.257 0.209 0.155 0 0.0025 0.0068 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 191722478 rs11903757 C T 0.201 0.13 0.121 0.142 0.11 0.12 0.132 0 0.0017 0.0013 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 2 192049560 rs10497720 T C 0.229 0.216 0.266 0.248 0.18 0.275 0.217 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 198658398 rs17229285 T C 0.047 0.067 0.06 0.112 0.106 0.076 0.036 0.0155 0 0.0275 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 2 198658398 rs17229285 T C 0.047 0.067 0.06 0.112 0.106 0.076 0.036 0.0155 0 0.0275 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 200157231 rs1569175 T C 0.203 0.252 0.259 0.17 0.171 0.221 0.214 0.0063 0 0.0085 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 2 200849597 rs5837757 C A 0.102 0.1 0.118 0.114 0.081 0.064 0.136 0.0001 0.0093 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 201044792 rs13015798 G A 0 0.009 0 0.009 0.009 0 0 0.0033 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 201159226 rs7558911 G A 0.326 0.365 0.402 0.422 0.35 0.295 0.381 0.0124 0.0093 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 2 201246657 rs3769825 G A 0.275 0.329 0.353 0.339 0.315 0.275 0.363 0.0003 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 201258272 rs3769823 A G 0.517 0.509 0.446 0.414 0.342 0.393 0.42 0 0.0083 0.0148 www.ncbi.nlm.nih.gov/pubmed/28177523 Association between genetic variation within vitamin D receptor-DNA binding sites and risk of basal cell carcinoma. Basal cell carcinoma 2 201258272 rs3769823 A G 0.517 0.509 0.446 0.414 0.342 0.393 0.42 0 0.0083 0.0148 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 2 201258707 rs3769821 T C 0.352 0.347 0.396 0.378 0.329 0.348 0.372 0.0002 0.0004 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 201258757 rs59308963 ATTCTGTC T 0.282 0.223 0.183 0.161 0.203 0.238 0.181 0.011 0 0.0016 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 201298088 rs13016963 A G 0.483 0.5 0.451 0.417 0.387 0.385 0.416 0 0.004 0.0076 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 2 201298088 rs13016963 A G 0.483 0.5 0.451 0.417 0.387 0.385 0.416 0 0.004 0.0076 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 2 201298088 rs13016963 A G 0.483 0.5 0.451 0.417 0.387 0.385 0.416 0 0.004 0.0076 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 2 201350769 rs13014235 C G 0.254 0.207 0.196 0.161 0.243 0.242 0.19 0.0139 0.0051 0 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 2 212432139 rs13393577 C T 0.135 0.1 0.107 0.177 0.179 0.127 0.146 0.0073 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/22452962 A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. Breast cancer 2 212548507 rs7599312 A G 0.47 0.391 0.371 0.474 0.329 0.322 0.429 0.0199 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 2 212548507 rs7599312 A G 0.47 0.391 0.371 0.474 0.329 0.322 0.429 0.0199 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 2 213169380 rs72949976 T C 0.025 0.032 0.045 0.061 0.077 0.046 0.022 0.0029 0 0.0138 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 2 213169380 rs72949976 T C 0.025 0.032 0.045 0.061 0.077 0.046 0.022 0.0029 0 0.0138 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 2 216883915 rs4674124 T C 0.034 0.027 0.022 0.022 0.032 0.045 0.035 0.0009 0.0009 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 217029040 rs12998806 A G 0.161 0.144 0.116 0.144 0.077 0.103 0.102 0.003 0.0104 0 www.ncbi.nlm.nih.gov/pubmed/28171663 Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor positive) 2 217041109 rs13387042 G A 0.22 0.261 0.174 0.213 0.158 0.193 0.179 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 2 217041109 rs13387042 G A 0.22 0.261 0.174 0.213 0.158 0.193 0.179 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/20872241 A combined analysis of genome-wide association studies in breast cancer. Breast cancer 2 217041109 rs13387042 G A 0.22 0.261 0.174 0.213 0.158 0.193 0.179 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 2 217041109 rs13387042 G A 0.22 0.261 0.174 0.213 0.158 0.193 0.179 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/19330030 A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Breast cancer 2 217041109 rs13387042 G A 0.22 0.261 0.174 0.213 0.158 0.193 0.179 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/17529974 Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Breast cancer 2 217041109 rs13387042 G A 0.22 0.261 0.174 0.213 0.158 0.193 0.179 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 2 217041109 rs13387042 G A 0.22 0.261 0.174 0.213 0.158 0.193 0.179 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 2 217056046 rs4442975 T G 0.314 0.347 0.29 0.287 0.252 0.303 0.274 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 217056046 rs4442975 T G 0.314 0.347 0.29 0.287 0.252 0.303 0.274 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 2 217406996 rs6759952 C T 0.359 0.405 0.33 0.4 0.374 0.41 0.266 0.0022 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/23894154 Genome-wide association study on differentiated thyroid cancer. Thyroid cancer 2 217429494 rs12990503 G C 0.479 0.46 0.451 0.457 0.518 0.492 0.465 0 0.002 0.0001 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 2 217429494 rs12990503 G C 0.479 0.46 0.451 0.457 0.518 0.492 0.465 0 0.002 0.0001 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Papillary thyroid cancer 2 217431785 rs16857609 T C 0.157 0.234 0.223 0.335 0.158 0.149 0.243 0.0771 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 2 217431785 rs16857609 T C 0.157 0.234 0.223 0.335 0.158 0.149 0.243 0.0771 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 2 217431785 rs16857609 T C 0.157 0.234 0.223 0.335 0.158 0.149 0.243 0.0771 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 2 217431785 rs16857609 T C 0.157 0.234 0.223 0.335 0.158 0.149 0.243 0.0771 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 217431785 rs16857609 T C 0.157 0.234 0.223 0.335 0.158 0.149 0.243 0.0771 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 2 217445617 rs966423 T C 0.157 0.185 0.165 0.174 0.171 0.127 0.142 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22267200 Discovery of common variants associated with low TSH levels and thyroid cancer risk. Thyroid cancer 2 217858732 rs6436017 A G 0.102 0.095 0.085 0.087 0.131 0.131 0.115 0.0016 0.0057 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 218290058 rs992157 A G 0.11 0.146 0.174 0.142 0.18 0.209 0.155 0 0.0082 0.0003 www.ncbi.nlm.nih.gov/pubmed/28960316 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. Colorectal cancer 2 218290058 rs992157 A G 0.11 0.146 0.174 0.142 0.18 0.209 0.155 0 0.0082 0.0003 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 2 221684477 rs10209697 A G 0.004 0 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. "Response to radiotherapy in prostate cancer (toxicity, urinary frequency)" 2 223053265 rs12621643 G T 0.496 0.5 0.491 0.461 0.496 0.508 0.505 0.0011 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 2 225467317 rs4674993 G A 0.124 0.14 0.138 0.204 0.104 0.168 0.094 0.027 0 0.0114 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 2 225467317 rs4674993 G A 0.124 0.14 0.138 0.204 0.104 0.168 0.094 0.027 0 0.0114 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 2 225488082 rs6436559 G T 0.28 0.333 0.29 0.304 0.257 0.291 0.261 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 2 226228086 rs2176040 A G 0.288 0.259 0.272 0.352 0.239 0.307 0.243 0.0192 0 0.0063 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 2 226228086 rs2176040 A G 0.288 0.259 0.272 0.352 0.239 0.307 0.243 0.0192 0 0.0063 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 2 226362236 rs12479355 G A 0.275 0.213 0.241 0.211 0.18 0.161 0.239 0 0.0083 0.0072 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 226474745 rs13008686 G T 0.385 0.282 0.38 0.319 0.23 0.312 0.313 0 0.0064 0.0038 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 2 228150003 rs4438470 T C 0 0.005 0.004 0.017 0.009 0 0 0.0195 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 2 228777706 rs11679180 A G 0.11 0.108 0.094 0.065 0.126 0.09 0.066 0.0071 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/24096698 Genome-wide association study of endometrial cancer in E2C2. Endometrial cancer 2 230179539 rs2396718 C T 0.038 0.018 0.014 0.035 0.023 0.029 0.031 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 2 232320342 rs6437061 A C 0.127 0.104 0.113 0.13 0.162 0.153 0.102 0 0.0045 0.0045 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 2 232320342 rs6437061 A C 0.127 0.104 0.113 0.13 0.162 0.153 0.102 0 0.0045 0.0045 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 2 232561816 rs1656402 T C 0.39 0.37 0.405 0.396 0.463 0.463 0.396 0 0.0088 0.0017 www.ncbi.nlm.nih.gov/pubmed/21079520 Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. Non-small cell lung cancer (survival) 2 233656637 rs11892031 C A 0.191 0.234 0.212 0.187 0.18 0.246 0.177 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 2 233656637 rs11892031 C A 0.191 0.234 0.212 0.187 0.18 0.246 0.177 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 2 234701030 rs7606512 T C 0.339 0.329 0.313 0.322 0.324 0.328 0.266 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 2 236277682 rs1453308 A G 0.394 0.437 0.438 0.439 0.338 0.381 0.394 0.0031 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 2 237478585 rs7584330 A G 0.203 0.212 0.21 0.283 0.122 0.123 0.226 0.0431 0.0531 0 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer 2 237534583 rs2292884 A G 0.386 0.342 0.357 0.339 0.523 0.48 0.381 0.0082 0.0474 0 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 2 237534583 rs2292884 A G 0.386 0.342 0.357 0.339 0.523 0.48 0.381 0.0082 0.0474 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 2 238729659 rs4545955 T C 0 0 0 0.004 0.014 0.008 0.004 0 0.0042 0.0061 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 2 239001819 rs3935695 T C 0.242 0.302 0.257 0.2 0.302 0.279 0.332 0.0222 0 0.0019 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 2 241297557 rs6743226 C T 0.178 0.241 0.21 0.246 0.469 0.418 0.235 0 0.1115 0.0241 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 2 241297557 rs6743226 C T 0.178 0.241 0.21 0.246 0.469 0.418 0.235 0 0.1115 0.0241 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 2 241443449 rs3771570 T C 0 0 0 0.013 0.014 0 0 0.0189 0 0.0279 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 2 241443449 rs3771570 T C 0 0 0 0.013 0.014 0 0 0.0189 0 0.0279 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 3 2005081 rs13067896 A G 0.055 0.041 0.045 0.03 0.018 0.02 0.031 0 0.0036 0.0041 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 3 2006661 rs73807529 A G 0.055 0.041 0.045 0.03 0.018 0.008 0.031 0 0.01 0.0042 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 3 3313860 rs770996 T C 0.475 0.436 0.464 0.448 0.396 0.463 0.496 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 3 3314490 rs9874556 A G 0.479 0.446 0.478 0.457 0.455 0.525 0.496 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23180869 Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Pancreatic cancer 3 3314490 rs9874556 A G 0.479 0.446 0.478 0.457 0.455 0.525 0.496 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 3 3685905 rs1485272 C T 0.314 0.311 0.326 0.213 0.268 0.312 0.314 0.0254 0 0.0111 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 4614354 rs72622154 G A 0.102 0.171 0.13 0.152 0.239 0.23 0.146 0 0.0277 0.008 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 3 4686890 rs6787391 T C 0.017 0.018 0.018 0.057 0.027 0.029 0.04 0.0185 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 4700592 rs6762644 A G 0.496 0.487 0.563 0.478 0.437 0.398 0.522 0 0.0123 0.0085 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 3 4700592 rs6762644 A G 0.496 0.487 0.563 0.478 0.437 0.398 0.522 0 0.0123 0.0085 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 3 4700592 rs6762644 A G 0.496 0.487 0.563 0.478 0.437 0.398 0.522 0 0.0123 0.0085 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 4751322 rs17041333 G T 0.184 0.203 0.188 0.217 0.232 0.217 0.192 0 0.0007 0.0013 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 3 8822123 rs17049612 G T 0.123 0.165 0.147 0.135 0.113 0.091 0.133 0 0.0048 0.0017 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 3 9844668 rs6788400 G A 0.309 0.339 0.376 0.386 0.397 0.366 0.35 0.0009 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 3 12293492 rs2960422 G A 0.376 0.365 0.433 0.425 0.496 0.406 0.381 0 0.0026 0.0041 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 3 12293492 rs2960422 G A 0.376 0.365 0.433 0.425 0.496 0.406 0.381 0 0.0026 0.0041 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 3 12447843 rs17819328 G T 0.144 0.158 0.152 0.17 0.131 0.131 0.19 0.0007 0.0029 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 12447843 rs17819328 G T 0.144 0.158 0.152 0.17 0.131 0.131 0.19 0.0007 0.0029 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 3 13029299 rs361052 G A 0.534 0.505 0.522 0.588 0.329 0.324 0.54 0.0382 0.1157 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 3 16737360 rs1375631 G A 0.331 0.297 0.239 0.333 0.324 0.266 0.252 0.0043 0 0.0035 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 16809700 rs748832 A G 0.403 0.401 0.429 0.483 0.392 0.36 0.496 0.0116 0.012 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 3 16809700 rs748832 A G 0.403 0.401 0.429 0.483 0.392 0.36 0.496 0.0116 0.012 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 16818207 rs6779302 T G 0.496 0.487 0.473 0.465 0.338 0.397 0.522 0 0.0264 0.0077 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 3 20671102 rs56168640 T G 0.008 0 0 0.017 0 0 0 0.0287 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 20984460 rs73188336 T C 0.259 0.234 0.228 0.204 0.207 0.152 0.208 0 0.0037 0.0045 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 3 25064946 rs6804842 G A 0.373 0.279 0.357 0.348 0.207 0.238 0.35 0.0035 0.0381 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 3 25064946 rs6804842 G A 0.373 0.279 0.357 0.348 0.207 0.238 0.35 0.0035 0.0381 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 3 25064946 rs6804842 G A 0.373 0.279 0.357 0.348 0.207 0.238 0.35 0.0035 0.0381 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 3 27145111 rs1357245 T C 0.009 0.005 0.004 0.035 0.018 0.021 0.009 0.0212 0 0.0255 www.ncbi.nlm.nih.gov/pubmed/19330027 Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Breast cancer 3 27285723 rs481519 C T 0.013 0.014 0.004 0.018 0.023 0.012 0.004 0.0006 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 3 27290919 rs60936670 TCAAAACA C 0.013 0.014 0.004 0.022 0.023 0.012 0.004 0.0035 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 27302153 rs653465 C T 0.017 0.018 0.009 0.027 0.028 0.016 0.005 0.0031 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 3 27374522 rs4973768 T C 0.423 0.315 0.375 0.365 0.35 0.306 0.283 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 3 27374522 rs4973768 T C 0.423 0.315 0.375 0.365 0.35 0.306 0.283 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 3 27374522 rs4973768 T C 0.423 0.315 0.375 0.365 0.35 0.306 0.283 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/19330027 Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Breast cancer 3 27374522 rs4973768 T C 0.423 0.315 0.375 0.365 0.35 0.306 0.283 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 3 27374522 rs4973768 T C 0.423 0.315 0.375 0.365 0.35 0.306 0.283 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 3 27374522 rs4973768 T C 0.423 0.315 0.375 0.365 0.35 0.306 0.283 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 27404794 rs13063291 A T 0.022 0.027 0.055 0.066 0.064 0.074 0.018 0.0032 0 0.022 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) 3 27404794 rs13063291 A T 0.022 0.027 0.055 0.066 0.064 0.074 0.018 0.0032 0 0.022 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) 3 27404794 rs13063291 A T 0.022 0.027 0.055 0.066 0.064 0.074 0.018 0.0032 0 0.022 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 3 27404794 rs13063291 A T 0.022 0.027 0.055 0.066 0.064 0.074 0.018 0.0032 0 0.022 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 3 27496418 rs13082711 C T 0.004 0.005 0.036 0.053 0.068 0.07 0.018 0 0.0015 0.0459 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 3 27496418 rs13082711 C T 0.004 0.005 0.036 0.053 0.068 0.07 0.018 0 0.0015 0.0459 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 3 27723132 rs3806624 A G 0.102 0.099 0.076 0.148 0.09 0.119 0.089 0.0152 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/24149102 Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkins lymphoma. Hodgkins lymphoma 3 28290744 rs73822569 G A 0.186 0.117 0.192 0.136 0.194 0.211 0.13 0.0035 0.0101 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 29533972 rs1530057 T G 0.004 0 0.018 0 0.009 0 0 0.0015 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Lung cancer 3 30643415 rs17838698 T C 0.309 0.317 0.353 0.361 0.158 0.193 0.354 0.0181 0.0843 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 32978543 rs4678680 T G 0.352 0.327 0.402 0.47 0.386 0.434 0.336 0.0195 0 0.0212 www.ncbi.nlm.nih.gov/pubmed/21105107 Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma. Hepatocellular carcinoma 3 34938860 rs6789440 A T 0.42 0.468 0.438 0.421 0.55 0.496 0.429 0.0028 0.0167 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 37954986 rs9311171 T G 0.475 0.478 0.451 0.47 0.333 0.303 0.443 0.0034 0.0492 0 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Prostate cancer 3 39805581 rs17079534 A G 0.055 0.063 0.058 0.03 0.063 0.049 0.062 0.0075 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 3 41744517 rs6599175 T C 0.178 0.243 0.21 0.381 0.122 0.182 0.204 0.1346 0.0256 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 3 41883906 rs1052501 T C 0.225 0.264 0.223 0.383 0.142 0.182 0.201 0.1123 0.0336 0 www.ncbi.nlm.nih.gov/pubmed/22120009 Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Multiple myeloma 3 41954644 rs2272007 C T 0.191 0.212 0.205 0.348 0.131 0.176 0.204 0.0994 0.0196 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 3 42691976 rs123509 T C 0.038 0.104 0.054 0.065 0.122 0.086 0.084 0 0.0067 0.0002 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 3 46825376 rs6796502 A G 0.225 0.23 0.179 0.27 0.239 0.193 0.12 0.017 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 3 46825376 rs6796502 A G 0.225 0.23 0.179 0.27 0.239 0.193 0.12 0.017 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 47347457 rs8180040 A T 0.292 0.257 0.179 0.178 0.225 0.193 0.248 0.0069 0 0.0094 www.ncbi.nlm.nih.gov/pubmed/23350875 A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. Colorectal cancer 3 48694054 rs3172494 T G 0.138 0.156 0.162 0.2 0.117 0.136 0.168 0.0131 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 3 48694054 rs3172494 T G 0.138 0.156 0.162 0.2 0.117 0.136 0.168 0.0131 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 51341843 rs1031925 T C 0.06 0.068 0.059 0.026 0.018 0.02 0.049 0 0.0023 0.016 www.ncbi.nlm.nih.gov/pubmed/24980573 Identification of a melanoma susceptibility locus and somatic mutation in TET2. Melanoma 3 52502498 rs731831 A G 0.042 0.032 0.031 0.057 0.036 0.029 0.031 0.0065 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 3 52532998 rs12489828 T G 0.462 0.398 0.449 0.4 0.346 0.279 0.464 0 0.0267 0.013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 3 52532998 rs12489828 T G 0.462 0.398 0.449 0.4 0.346 0.279 0.464 0 0.0267 0.013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 3 52532998 rs12489828 T G 0.462 0.398 0.449 0.4 0.346 0.279 0.464 0 0.0267 0.013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 52603470 rs2276824 C G 0.203 0.185 0.196 0.32 0.158 0.148 0.19 0.0779 0.0146 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 52615732 rs13083798 A G 0.53 0.455 0.388 0.487 0.414 0.414 0.429 0.0043 0.0046 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 54866828 rs1880828 A G 0.203 0.261 0.201 0.248 0.252 0.221 0.17 0.0017 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 3 54983722 rs3773582 G A 0.074 0.069 0.058 0.114 0.05 0.058 0.064 0.0242 0.0018 0 www.ncbi.nlm.nih.gov/pubmed/24096698 Genome-wide association study of endometrial cancer in E2C2. Endometrial cancer 3 55773227 rs6445754 T C 0.246 0.248 0.272 0.317 0.194 0.238 0.288 0.0155 0.0117 0 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 3 58041470 rs1623879 G A 0.428 0.491 0.518 0.425 0.369 0.447 0.46 0 0.0014 0.0061 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 3 58566602 rs11539086 G C 0.214 0.203 0.302 0.281 0.185 0.221 0.288 0.0056 0.01 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 3 59448694 rs1910236 G A 0.047 0.045 0.067 0.044 0.068 0.021 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 3 59448694 rs1910236 G A 0.047 0.045 0.067 0.044 0.068 0.021 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 59559604 rs9858271 G A 0.059 0.059 0.058 0.065 0.081 0.082 0.027 0 0.0036 0.0041 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 3 59559604 rs9858271 G A 0.059 0.059 0.058 0.065 0.081 0.082 0.027 0 0.0036 0.0041 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Papillary thyroid cancer 3 60951377 rs9849262 T C 0.114 0.059 0.103 0.096 0.068 0.103 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27114598 Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia. Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) 3 61250788 rs2365389 C T 0.097 0.081 0.116 0.161 0.171 0.148 0.097 0.0051 0 0.0231 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 3 61250788 rs2365389 C T 0.097 0.081 0.116 0.161 0.171 0.148 0.097 0.0051 0 0.0231 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 3 61250788 rs2365389 C T 0.097 0.081 0.116 0.161 0.171 0.148 0.097 0.0051 0 0.0231 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 3 63956021 rs3821902 G T 0.013 0.023 0.009 0.013 0.009 0.021 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 63982224 rs1053338 G A 0.008 0.018 0 0.009 0.009 0.004 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 3 63982224 rs1053338 G A 0.008 0.018 0 0.009 0.009 0.004 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 64074452 rs1450985 A G 0.483 0.496 0.505 0.565 0.455 0.439 0.522 0.0168 0.0118 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 64715470 rs9860730 A G 0.102 0.126 0.121 0.161 0.077 0.078 0.08 0.0269 0.0118 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 3 64715470 rs9860730 A G 0.102 0.126 0.121 0.161 0.077 0.078 0.08 0.0269 0.0118 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 3 64732582 rs2371767 G C 0.381 0.405 0.317 0.352 0.297 0.336 0.279 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 64732582 rs2371767 G C 0.381 0.405 0.317 0.352 0.297 0.336 0.279 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 3 64732582 rs2371767 G C 0.381 0.405 0.317 0.352 0.297 0.336 0.279 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI in smokers 3 66392011 rs812481 C G 0.051 0.05 0.013 0.126 0.018 0.041 0.066 0.0835 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 3 66392011 rs812481 C G 0.051 0.05 0.013 0.126 0.018 0.041 0.066 0.0835 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 3 66475539 rs3845905 C T 0.348 0.401 0.339 0.365 0.383 0.291 0.323 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) 3 66475539 rs3845905 C T 0.348 0.401 0.339 0.365 0.383 0.291 0.323 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 3 67392218 rs76010824 A G 0.072 0.09 0.116 0.07 0.158 0.176 0.106 0.0106 0.0322 0 www.ncbi.nlm.nih.gov/pubmed/26307654 Genome-wide association study of prostate cancer-specific survival. Prostate cancer (survival) 3 70210551 rs17006842 T C 0.026 0.018 0.027 0.031 0.05 0.029 0.027 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 3 72406204 rs12330322 T C 0.31 0.257 0.335 0.3 0.275 0.316 0.313 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 3 84402361 rs6794880 G A 0.326 0.347 0.286 0.196 0.173 0.194 0.354 0.0025 0 0.0582 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 3 84402361 rs6794880 G A 0.326 0.347 0.286 0.196 0.173 0.194 0.354 0.0025 0 0.0582 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 3 85625640 rs62263923 G A 0.182 0.211 0.196 0.261 0.167 0.115 0.174 0.0326 0.0203 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 85758440 rs13078960 G T 0.03 0.036 0.04 0.039 0.014 0.016 0.04 0.002 0.0094 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 3 85758440 rs13078960 G T 0.03 0.036 0.04 0.039 0.014 0.016 0.04 0.002 0.0094 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 3 86109735 rs2324999 T C 0.297 0.239 0.259 0.296 0.185 0.248 0.23 0.0079 0.0075 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 3 86154659 rs9833726 T G 0.021 0.018 0.009 0.009 0.014 0.033 0.009 0.0012 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 86988393 rs13066793 G A 0.021 0.023 0.022 0.043 0.009 0.033 0.04 0.0058 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 87061524 rs2660753 C T 0.39 0.369 0.464 0.374 0.333 0.381 0.474 0 0.0015 0.0068 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 3 87061524 rs2660753 C T 0.39 0.369 0.464 0.374 0.333 0.381 0.474 0 0.0015 0.0068 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 3 87061524 rs2660753 C T 0.39 0.369 0.464 0.374 0.333 0.381 0.474 0 0.0015 0.0068 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 3 87085650 rs17023900 G A 0.043 0.028 0.036 0.022 0.059 0.033 0.049 0.0046 0.0007 0 www.ncbi.nlm.nih.gov/pubmed/22923026 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Prostate cancer 3 87085650 rs17023900 G A 0.043 0.028 0.036 0.022 0.059 0.033 0.049 0.0046 0.0007 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 3 87103019 rs9284813 G A 0.492 0.428 0.46 0.535 0.446 0.48 0.504 0.009 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 3 87124174 rs17181170 A G 0.127 0.176 0.147 0.165 0.171 0.094 0.128 0.0011 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 3 87192347 rs7629490 T C 0.171 0.216 0.162 0.196 0.307 0.198 0.146 0 0.0124 0.0067 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 3 88708681 rs11927424 G A 0.496 0.468 0.487 0.389 0.473 0.558 0.531 0.0328 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 3 89093025 rs2173039 C G 0.216 0.198 0.219 0.257 0.185 0.201 0.174 0.0106 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 3 89093025 rs2173039 C G 0.216 0.198 0.219 0.257 0.185 0.201 0.174 0.0106 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 3 89096190 rs12629427 C T 0.216 0.181 0.22 0.264 0.177 0.184 0.173 0.0193 0.0014 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 3 89096190 rs12629427 C T 0.216 0.181 0.22 0.264 0.177 0.184 0.173 0.0193 0.0014 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 3 95905623 rs9825648 C T 0.396 0.382 0.395 0.322 0.436 0.463 0.386 0.0204 0.0148 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 3 100004736 rs9833888 T G 0.059 0.072 0.08 0.052 0.068 0.033 0.062 0 0.0006 0.0012 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 100105841 rs9837602 A G 0.042 0.045 0.058 0.017 0.063 0.037 0.049 0.014 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 101881880 rs651907 T C 0.422 0.5 0.518 0.526 0.467 0.517 0.491 0.0017 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 3 104161190 rs1920324 C T 0.357 0.481 0.396 0.394 0.449 0.363 0.344 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 3 107243674 rs1283104 C G 0.534 0.5 0.55 0.589 0.383 0.438 0.407 0.0374 0.0298 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 3 107594133 rs670752 A G 0.271 0.306 0.326 0.378 0.369 0.398 0.248 0.0025 0 0.0247 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 107746970 rs6437740 C T 0.301 0.302 0.308 0.274 0.234 0.217 0.305 0 0.0095 0.0061 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 3 108980663 rs73200691 T C 0.114 0.072 0.094 0.127 0.077 0.082 0.071 0.0112 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 108984178 rs2593957 T C 0.513 0.505 0.442 0.522 0.284 0.357 0.474 0.0176 0.0733 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 3 109132637 rs4855695 C T 0.123 0.073 0.08 0.152 0.099 0.086 0.089 0.0221 0 0.005 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 3 113409144 rs16845107 A C 0.089 0.095 0.089 0.104 0.086 0.103 0.106 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 3 113931599 rs114780919 C T 0 0.009 0.009 0.018 0.009 0.013 0 0.0072 0 0.0091 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 3 114402172 rs10511330 C T 0.555 0.464 0.46 0.426 0.36 0.401 0.482 0 0.0082 0.0172 www.ncbi.nlm.nih.gov/pubmed/29942513 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses. Mucinous adenocarcinoma in colorectal cancer 3 114451425 rs6438208 G A 0.402 0.351 0.41 0.396 0.378 0.422 0.478 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 3 115605505 rs1438356 A G 0.017 0.036 0.04 0.013 0.082 0.094 0.044 0.0143 0.0361 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 115931601 rs4378954 T C 0.394 0.342 0.348 0.409 0.405 0.389 0.407 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 3 119542528 rs7648642 A C 0.534 0.509 0.518 0.465 0.454 0.397 0.531 0 0.0066 0.0138 www.ncbi.nlm.nih.gov/pubmed/24080446 Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study. Lobular breast cancer (menopausal hormone therapy interaction) 3 121435346 rs6800901 T C 0.064 0.104 0.054 0.122 0.077 0.066 0.12 0.0124 0.0027 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 3 122098766 rs2681416 A G 0.174 0.225 0.125 0.213 0.162 0.115 0.084 0.0193 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/25261932 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Diffuse large B cell lymphoma 3 122098766 rs2681416 A G 0.174 0.225 0.125 0.213 0.162 0.115 0.084 0.0193 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 3 127231283 rs4234284 A G 0.212 0.257 0.183 0.136 0.279 0.347 0.279 0.0563 0.0344 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) 3 127621197 rs144122212 C T 0.008 0 0 0.013 0 0.012 0 0.0084 0 0.0096 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 3 128169224 rs872267 G A 0.161 0.185 0.223 0.209 0.14 0.152 0.173 0.0043 0.0085 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 3 128169224 rs872267 G A 0.161 0.185 0.223 0.209 0.14 0.152 0.173 0.0043 0.0085 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 3 128319530 rs10934853 C A 0.174 0.176 0.223 0.217 0.153 0.152 0.168 0.0067 0.0067 0 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 3 128319530 rs10934853 C A 0.174 0.176 0.223 0.217 0.153 0.152 0.168 0.0067 0.0067 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 3 129615390 rs10804591 A C 0.28 0.248 0.205 0.421 0.176 0.139 0.186 0.1628 0.044 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 132198152 rs9836270 A C 0.397 0.369 0.482 0.361 0.478 0.439 0.415 0.0114 0.0067 0 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 3 134484505 rs6772896 C T 0.335 0.396 0.341 0.307 0.279 0.23 0.344 0 0.0122 0.0119 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 3 134484505 rs6772896 C T 0.335 0.396 0.341 0.307 0.279 0.23 0.344 0 0.0122 0.0119 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 3 140450815 rs6439924 C A 0.346 0.36 0.357 0.344 0.27 0.422 0.412 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24920014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Hodgkins lymphoma 3 141383991 rs6763931 G A 0.106 0.126 0.094 0.145 0.063 0.098 0.093 0.0146 0.0066 0 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer 3 141383991 rs6763931 G A 0.106 0.126 0.094 0.145 0.063 0.098 0.093 0.0146 0.0066 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 3 141406344 rs1344674 A G 0.097 0.099 0.08 0.122 0.036 0.053 0.084 0.0192 0.028 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 3 141406344 rs1344674 A G 0.097 0.099 0.08 0.122 0.036 0.053 0.084 0.0192 0.028 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 3 141406344 rs1344674 A G 0.097 0.099 0.08 0.122 0.036 0.053 0.084 0.0192 0.028 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 3 141658488 rs868767 G A 0.047 0.054 0.018 0.061 0.027 0.025 0.027 0.0122 0.0037 0 www.ncbi.nlm.nih.gov/pubmed/28935272 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin 3 144621363 rs800082 T C 0.165 0.164 0.201 0.226 0.2 0.225 0.255 0.0008 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 3 144658358 rs1164302 C T 0 0.005 0 0.004 0.005 0.008 0 0 0.0009 0.0029 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 3 145456001 rs345013 G A 0.03 0.086 0.081 0.048 0.064 0.087 0.059 0.002 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Prostate cancer 3 147808253 rs72995528 G A 0.108 0.126 0.041 0.185 0.05 0.038 0.055 0.1016 0.0313 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 3 150750021 rs6788895 G T 0.449 0.378 0.415 0.36 0.365 0.401 0.5 0.0056 0 0.0102 www.ncbi.nlm.nih.gov/pubmed/30323354 "BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts." BRCA1/2-negative high-risk breast cancer 3 150750021 rs6788895 G T 0.449 0.378 0.415 0.36 0.365 0.401 0.5 0.0056 0 0.0102 www.ncbi.nlm.nih.gov/pubmed/22951594 A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. Breast cancer 3 151958534 rs2723362 C A 0.352 0.382 0.299 0.43 0.342 0.381 0.341 0.0151 0 0.0075 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 3 156645453 rs2136690 G A 0.17 0.141 0.144 0.154 0.293 0.213 0.097 0 0.0376 0.0094 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 156800879 rs78579487 TT G 0.297 0.288 0.29 0.344 0.441 0.328 0.239 0 0.0067 0.0193 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 156927968 rs7637701 A G 0.103 0.064 0.077 0.065 0.2 0.16 0.053 0 0.0584 0.0018 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 157079820 rs17451107 C T 0.364 0.347 0.302 0.291 0.378 0.336 0.336 0.0061 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 3 157079820 rs17451107 C T 0.364 0.347 0.302 0.291 0.378 0.336 0.336 0.0061 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 3 157079820 rs17451107 C T 0.364 0.347 0.302 0.291 0.378 0.336 0.336 0.0061 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 3 157429779 rs2120243 A C 0.377 0.297 0.366 0.3 0.252 0.336 0.345 0 0 0.0049 www.ncbi.nlm.nih.gov/pubmed/26870257 Nine susceptibility loci for hepatitis B virus-related hepatocellular carcinoma identified by a pilot two-stage genome-wide association study. Hepatocellular carcinoma in hepatitis B infection 3 159723391 rs17807116 G A 0.004 0.009 0 0.031 0.009 0 0.004 0.0396 0 0.0123 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 3 169043635 rs75316749 G A 0.026 0.009 0.005 0.026 0.068 0.079 0.04 0 0.0309 0.0111 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer 3 169198452 rs9864370 C T 0.043 0.059 0.063 0.035 0.135 0.12 0.058 0.009 0.0427 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 3 169383098 rs419076 C T 0.478 0.433 0.444 0.452 0.449 0.479 0.451 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 3 169383098 rs419076 C T 0.478 0.433 0.444 0.452 0.449 0.479 0.451 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 3 169747154 rs13097028 T C 0.445 0.5 0.438 0.487 0.541 0.521 0.469 0 0.0047 0.0038 www.ncbi.nlm.nih.gov/pubmed/24980573 Identification of a melanoma susceptibility locus and somatic mutation in TET2. Melanoma 3 169759718 rs12638862 G A 0.073 0.131 0.13 0.117 0.207 0.201 0.153 0 0.0273 0.0014 www.ncbi.nlm.nih.gov/pubmed/28112199 "Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci." "B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)" 3 169759718 rs12638862 G A 0.073 0.131 0.13 0.117 0.207 0.201 0.153 0 0.0273 0.0014 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 3 169763483 rs12696304 C G 0.415 0.356 0.405 0.487 0.307 0.328 0.366 0.0426 0.0224 0 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 3 169763483 rs12696304 C G 0.415 0.356 0.405 0.487 0.307 0.328 0.366 0.0426 0.0224 0 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 3 169774313 rs10936599 T C 0.008 0.018 0.005 0.022 0.041 0.029 0.013 0 0.0053 0.0094 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 3 169774313 rs10936599 T C 0.008 0.018 0.005 0.022 0.041 0.029 0.013 0 0.0053 0.0094 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 3 169774313 rs10936599 T C 0.008 0.018 0.005 0.022 0.041 0.029 0.013 0 0.0053 0.0094 www.ncbi.nlm.nih.gov/pubmed/20972440 "Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33." Colorectal cancer 3 169774313 rs10936599 T C 0.008 0.018 0.005 0.022 0.041 0.029 0.013 0 0.0053 0.0094 www.ncbi.nlm.nih.gov/pubmed/23955597 "Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk." Multiple myeloma 3 170281428 rs71277158 G T 0.009 0.005 0.009 0.022 0.009 0 0.018 0.0098 0.0042 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 3 171840746 rs3914272 A G 0.203 0.203 0.234 0.235 0.135 0.131 0.181 0.011 0.0277 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 3 172204265 rs12493901 A G 0 0.009 0.027 0.026 0.018 0.008 0.013 0.0051 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 3 172204265 rs12493901 A G 0 0.009 0.027 0.026 0.018 0.008 0.013 0.0051 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 3 172204265 rs12493901 A G 0 0.009 0.027 0.026 0.018 0.008 0.013 0.0051 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 3 172550013 rs13074711 C T 0.352 0.333 0.315 0.378 0.275 0.307 0.308 0.0104 0.0058 0 www.ncbi.nlm.nih.gov/pubmed/28171663 Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Breast cancer 3 172550013 rs13074711 C T 0.352 0.333 0.315 0.378 0.275 0.307 0.308 0.0104 0.0058 0 www.ncbi.nlm.nih.gov/pubmed/28171663 Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 3 173635949 rs16828799 T G 0.03 0.032 0.009 0.013 0.032 0.045 0.018 0.0029 0.0066 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 3 177768082 rs7430456 G A 0.195 0.185 0.17 0.23 0.077 0.107 0.137 0.0374 0.0492 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 178712151 rs9290663 T A 0.314 0.284 0.326 0.365 0.4 0.375 0.354 0 0.0025 0.0072 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 3 181213607 rs2718791 C T 0 0.005 0 0.017 0.005 0 0.004 0.023 0 0.008 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 3 181487805 rs12485391 A C 0.144 0.122 0.156 0.074 0.113 0.143 0.173 0.0241 0 0.0103 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 3 181691269 rs7631379 T C 0.246 0.212 0.21 0.287 0.167 0.234 0.23 0.0168 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 3 185904041 rs6444087 G A 0.284 0.273 0.306 0.283 0.324 0.369 0.297 0.0003 0.0073 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 3 186106215 rs1516725 T C 0.148 0.146 0.196 0.148 0.234 0.269 0.195 0.0059 0.0269 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 3 186106215 rs1516725 T C 0.148 0.146 0.196 0.148 0.234 0.269 0.195 0.0059 0.0269 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 3 186106215 rs1516725 T C 0.148 0.146 0.196 0.148 0.234 0.269 0.195 0.0059 0.0269 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 3 187075454 rs2239612 A G 0.335 0.327 0.321 0.23 0.383 0.377 0.323 0.0394 0.014 0 www.ncbi.nlm.nih.gov/pubmed/22960999 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Esophageal cancer (squamous cell) 3 187681148 rs79592764 T C 0.123 0.113 0.094 0.126 0.14 0.176 0.089 0 0.0071 0.0065 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 3 187931631 rs6773854 C T 0.331 0.311 0.339 0.219 0.315 0.307 0.29 0.0266 0 0.0064 www.ncbi.nlm.nih.gov/pubmed/23749188 Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. B cell non-Hodgkin lymphoma 3 188236626 rs4459895 A C 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/28112199 "Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci." "B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)" 3 188236626 rs4459895 A C 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Hodgkins lymphoma 3 188236626 rs4459895 A C 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nodular sclerosis Hodgkin lymphoma 3 188370330 rs11715549 G C 0.161 0.072 0.098 0.209 0.214 0.192 0.093 0.0138 0 0.0544 www.ncbi.nlm.nih.gov/pubmed/27424798 Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Cutaneous squamous cell carcinoma 3 188582114 rs6444305 A G 0.509 0.436 0.585 0.391 0.478 0.537 0.518 0.035 0 0.0071 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 3 188701738 rs1254774 A G 0.275 0.288 0.335 0.3 0.323 0.381 0.347 0.0005 0.0035 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 3 189487243 rs6791479 A T 0.318 0.342 0.295 0.357 0.275 0.32 0.266 0.0062 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/26829030 Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. Squamous cell carcinoma 3 189638472 rs4488809 C T 0.309 0.323 0.29 0.268 0.318 0.328 0.326 0.0047 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/21725308 A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Lung cancer 3 189638472 rs4488809 C T 0.309 0.323 0.29 0.268 0.318 0.328 0.326 0.0047 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/23143601 Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Lung cancer 3 189639152 rs7636839 G A 0.309 0.32 0.29 0.263 0.32 0.324 0.31 0.0052 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/27501781 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. EGFR mutation-positive lung adenocarcinoma 3 189639410 rs13080835 T G 0.309 0.32 0.29 0.261 0.315 0.316 0.304 0.0048 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 3 189639410 rs13080835 T G 0.309 0.32 0.29 0.261 0.315 0.316 0.304 0.0048 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 3 189639813 rs13314271 C T 0.309 0.323 0.295 0.263 0.347 0.369 0.31 0.0102 0.0097 0 www.ncbi.nlm.nih.gov/pubmed/24880342 Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Lung cancer 3 189665394 rs10937405 T C 0.286 0.27 0.241 0.235 0.432 0.406 0.297 0.0153 0.0634 0 www.ncbi.nlm.nih.gov/pubmed/22797724 A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Lung adenocarcinoma 3 189665394 rs10937405 T C 0.286 0.27 0.241 0.235 0.432 0.406 0.297 0.0153 0.0634 0 www.ncbi.nlm.nih.gov/pubmed/20871597 Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Lung adenocarcinoma 3 189683987 rs17505102 C G 0.034 0.063 0.04 0.017 0.064 0.115 0.04 0.0188 0.0265 0 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 3 189790682 rs9854771 A G 0.267 0.266 0.205 0.239 0.35 0.312 0.212 0 0.0205 0.0017 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 3 189790682 rs9854771 A G 0.267 0.266 0.205 0.239 0.35 0.312 0.212 0 0.0205 0.0017 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 3 189928144 rs710521 C T 0.17 0.171 0.201 0.157 0.252 0.176 0.261 0.0075 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 3 189928144 rs710521 C T 0.17 0.171 0.201 0.157 0.252 0.176 0.261 0.0075 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 3 189928144 rs710521 C T 0.17 0.171 0.201 0.157 0.252 0.176 0.261 0.0075 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/20348956 A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Urinary bladder cancer 3 189928144 rs710521 C T 0.17 0.171 0.201 0.157 0.252 0.176 0.261 0.0075 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/18794855 Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Urinary bladder cancer 3 190056667 rs9882792 T C 0.11 0.153 0.116 0.123 0.176 0.172 0.124 0 0.0084 0.0006 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 3 190632672 rs7626795 G A 0.458 0.477 0.455 0.491 0.491 0.439 0.491 0 0 0 www.ncbi.nlm.nih.gov/pubmed/18385676 Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Lung cancer 3 195137645 rs2131877 A G 0.216 0.159 0.201 0.23 0.243 0.209 0.23 0.0004 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/20876614 A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Non-small cell lung cancer 3 195778256 rs73085315 C G 0.492 0.464 0.446 0.37 0.356 0.299 0.345 0 0.0083 0.0186 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 4 1732512 rs798766 T C 0.292 0.347 0.321 0.265 0.203 0.197 0.345 0 0.0212 0.0209 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 4 1732512 rs798766 T C 0.292 0.347 0.321 0.265 0.203 0.197 0.345 0 0.0212 0.0209 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 4 1732512 rs798766 T C 0.292 0.347 0.321 0.265 0.203 0.197 0.345 0 0.0212 0.0209 www.ncbi.nlm.nih.gov/pubmed/20348956 A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Urinary bladder cancer 4 4677180 rs7675915 A G 0 0 0.004 0.017 0 0 0 0.0351 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 4 4774436 rs12108538 A G 0.17 0.148 0.165 0.11 0.189 0.136 0.195 0.0136 0 0.0045 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 4 6274903 rs62283056 C G 0.164 0.221 0.189 0.157 0.261 0.244 0.191 0.0096 0.0172 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 4 9717524 rs7683574 T C 0.513 0.481 0.537 0.54 0.369 0.462 0.549 0.0044 0.0267 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 4 11854239 rs35523062 T C 0.22 0.225 0.25 0.287 0.32 0.258 0.27 0.0006 0 0.0053 www.ncbi.nlm.nih.gov/pubmed/28662289 Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma. Familial hepatitis B virus-related hepatocellular carcinoma 4 14294676 rs1426107 T C 0.085 0.077 0.076 0.087 0.077 0.041 0.102 0.0001 0.0042 0 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 4 14775070 rs28479566 T C 0.203 0.167 0.196 0.23 0.122 0.156 0.204 0.0123 0.0175 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 4 15456801 rs2215810 T A 0.369 0.369 0.353 0.413 0.225 0.25 0.31 0.0293 0.0497 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 4 17433467 rs2518590 A T 0.093 0.095 0.135 0.148 0.153 0.148 0.146 0.0001 0 0.004 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 4 18793707 rs4147045 C T 0.042 0.045 0.036 0.039 0.086 0.07 0.049 0 0.0108 0.0005 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 4 18864546 rs6845621 A G 0.329 0.41 0.374 0.383 0.662 0.549 0.425 0.0002 0.1055 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) 4 20444567 rs11933090 G C 0.107 0.077 0.099 0.061 0.109 0.103 0.053 0.006 0.0045 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 4 20778692 rs16869961 G A 0.055 0.032 0.04 0.061 0.072 0.066 0.036 0 0.0014 0.006 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 4 27184810 rs4692174 C T 0.008 0.009 0.04 0.017 0.082 0.07 0.04 0 0.0337 0.0012 www.ncbi.nlm.nih.gov/pubmed/29367611 Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer. Carboplatin disposition in epthelial ovarian cancer 4 28244427 rs59537158 T C 0.22 0.252 0.246 0.209 0.189 0.189 0.261 0 0.0028 0.0055 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 4 28244427 rs59537158 T C 0.22 0.252 0.246 0.209 0.189 0.189 0.261 0 0.0028 0.0055 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 4 29737677 rs10939276 T C 0.131 0.185 0.183 0.27 0.198 0.164 0.12 0.0447 0 0.022 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 4 31181708 rs7679162 G T 0.093 0.105 0.083 0.091 0.2 0.175 0.097 0 0.0388 0.0028 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 4 34529002 rs28649461 C G 0.14 0.144 0.125 0.091 0.198 0.258 0.155 0.0266 0.0417 0 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 4 35474678 rs1022261 A C 0.392 0.395 0.436 0.451 0.454 0.446 0.414 0.0003 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 4 37181024 rs7678296 C T 0.136 0.131 0.121 0.122 0.072 0.09 0.146 0 0.0102 0.0028 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 4 38814717 rs6815814 A C 0.098 0.135 0.078 0.039 0.059 0.016 0.128 0.0023 0 0.039 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 39618250 rs12500234 G T 0.174 0.135 0.107 0.213 0.131 0.135 0.084 0.0343 0 0.0106 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 4 43211547 rs75790006 G T 0 0 0 0.004 0 0.004 0 0.006 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/28081215 Genome-Wide Association Studies of Multiple Keratinocyte Cancers. Multiple keratinocyte cancers 4 45180510 rs10938397 G A 0.162 0.164 0.243 0.241 0.156 0.194 0.177 0.0119 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 4 45180510 rs10938397 G A 0.162 0.164 0.243 0.241 0.156 0.194 0.177 0.0119 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 4 45180510 rs10938397 G A 0.162 0.164 0.243 0.241 0.156 0.194 0.177 0.0119 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 4 58637561 rs282708 G A 0.509 0.527 0.496 0.416 0.355 0.388 0.478 0 0.0086 0.0276 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 4 60971415 rs1906073 C A 0.095 0.079 0.079 0.09 0.023 0.048 0.071 0.0062 0.0235 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 4 60987687 rs13148643 G T 0.025 0.027 0.018 0.061 0.014 0.016 0.04 0.0291 0.0081 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 4 62558371 rs11944965 T C 0.267 0.252 0.237 0.348 0.159 0.256 0.329 0.0316 0.0215 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) 4 67215843 rs62315512 A G 0.089 0.086 0.068 0.035 0.045 0.025 0.049 0.0013 0 0.0144 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 72649596 rs7697556 C T 0.153 0.131 0.152 0.093 0.126 0.131 0.128 0.0084 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 4 72649596 rs7697556 C T 0.153 0.131 0.152 0.093 0.126 0.131 0.128 0.0084 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 4 72989536 rs10009409 T C 0.318 0.302 0.388 0.43 0.374 0.418 0.381 0.008 0 0.0125 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 4 72989536 rs10009409 T C 0.318 0.302 0.388 0.43 0.374 0.418 0.381 0.008 0 0.0125 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 4 73483441 rs1894292 A G 0.208 0.282 0.317 0.307 0.273 0.34 0.283 0 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 4 73483441 rs1894292 A G 0.208 0.282 0.317 0.307 0.273 0.34 0.283 0 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 4 74821455 rs6854845 T G 0.259 0.218 0.228 0.248 0.287 0.25 0.223 0 0.001 0.001 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 4 76208415 rs17001654 G C 0.157 0.167 0.201 0.278 0.09 0.107 0.177 0.0785 0.0535 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 4 76208415 rs17001654 G C 0.157 0.167 0.201 0.278 0.09 0.107 0.177 0.0785 0.0535 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 4 76842845 rs10518159 T C 0 0 0.005 0.018 0.05 0.075 0 0 0.0373 0.0591 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 4 76936952 rs1874564 G A 0.271 0.311 0.281 0.291 0.302 0.213 0.261 0.0001 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 4 76936952 rs1874564 G A 0.271 0.311 0.281 0.291 0.302 0.213 0.261 0.0001 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Papillary thyroid cancer 4 79409589 rs28459916 A C 0.131 0.14 0.152 0.239 0.216 0.246 0.106 0.0129 0 0.0511 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 4 80243569 rs1458038 T C 0.03 0.023 0.036 0.013 0.018 0.021 0.035 0.0026 0 0.0037 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 4 80243569 rs1458038 T C 0.03 0.023 0.036 0.013 0.018 0.021 0.035 0.0026 0 0.0037 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 4 81239194 rs2197271 C G 0.246 0.225 0.156 0.217 0.14 0.164 0.208 0.0016 0.0117 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 4 81239194 rs2197271 C G 0.246 0.225 0.156 0.217 0.14 0.164 0.208 0.0016 0.0117 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 4 81772382 rs6853410 G A 0.461 0.491 0.505 0.416 0.509 0.529 0.562 0.0212 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 4 82591688 rs72909131 T A 0.076 0.064 0.063 0.061 0.108 0.098 0.084 0.0016 0.0072 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 4 87750786 rs11733008 T C 0.081 0.125 0.158 0.127 0.093 0.103 0.12 0.0004 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/25145502 Genome-wide association study of survival in early-stage non-small cell lung cancer. Non-small cell lung cancer (survival) 4 88175489 rs7658584 A G 0.521 0.555 0.571 0.491 0.329 0.414 0.589 0 0.046 0.0283 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 4 88322666 rs10022462 T C 0.441 0.473 0.491 0.4 0.324 0.254 0.474 0 0.0455 0.0284 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 88791970 rs9991328 C T 0.394 0.386 0.366 0.357 0.365 0.381 0.389 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 4 88791970 rs9991328 C T 0.394 0.386 0.366 0.357 0.365 0.381 0.389 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 4 89007338 rs6849143 C T 0.407 0.336 0.347 0.378 0.414 0.348 0.385 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27612410 Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A. Pre bronchodilator FEV1/FVC ratio in never-smokers 4 90992579 rs72665486 T G 0 0 0 0.004 0 0 0.004 0.0031 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 4 91117856 rs6855885 A G 0.398 0.383 0.418 0.425 0.329 0.339 0.425 0.0031 0.0137 0 www.ncbi.nlm.nih.gov/pubmed/25192705 No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. Colorectal cancer (calcium intake interaction) 4 93965880 rs13130787 C T 0.093 0.09 0.116 0.178 0.126 0.176 0.13 0.0124 0 0.0214 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 4 94593458 rs12500426 A C 0.398 0.356 0.366 0.348 0.396 0.328 0.385 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 4 94641726 rs17021918 T C 0.209 0.196 0.207 0.154 0.239 0.231 0.203 0.0138 0.0057 0 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 4 94641726 rs17021918 T C 0.209 0.196 0.207 0.154 0.239 0.231 0.203 0.0138 0.0057 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 4 101816093 rs10028805 G A 0.384 0.344 0.304 0.408 0.36 0.369 0.292 0.0087 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 4 101819845 rs71597109 T C 0.233 0.284 0.196 0.268 0.239 0.246 0.223 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 4 103999322 rs41427747 T G 0.212 0.185 0.214 0.257 0.153 0.213 0.235 0.01 0.0045 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 4 105140377 rs7679673 C A 0.373 0.423 0.38 0.291 0.248 0.291 0.363 0 0.0021 0.0282 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 4 105140377 rs7679673 C A 0.373 0.423 0.38 0.291 0.248 0.291 0.363 0 0.0021 0.0282 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 4 105140377 rs7679673 C A 0.373 0.423 0.38 0.291 0.248 0.291 0.363 0 0.0021 0.0282 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 4 105140377 rs7679673 C A 0.373 0.423 0.38 0.291 0.248 0.291 0.363 0 0.0021 0.0282 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 4 105140377 rs7679673 C A 0.373 0.423 0.38 0.291 0.248 0.291 0.363 0 0.0021 0.0282 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 4 105143597 rs17035310 T C 0.161 0.146 0.17 0.2 0.297 0.213 0.195 0 0.0134 0.0106 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 4 105147856 rs62331150 T G 0 0 0 0.004 0.018 0 0 0.0007 0 0.0132 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 105163621 rs9790517 T C 0.034 0.027 0.045 0.03 0.036 0.033 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 4 105163621 rs9790517 T C 0.034 0.027 0.045 0.03 0.036 0.033 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 4 105163621 rs9790517 T C 0.034 0.027 0.045 0.03 0.036 0.033 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 105218230 rs4698934 C T 0.025 0.059 0.049 0.065 0.127 0.103 0.031 0 0.0257 0.0214 www.ncbi.nlm.nih.gov/pubmed/24980573 Identification of a melanoma susceptibility locus and somatic mutation in TET2. Melanoma 4 105274384 rs2726492 T C 0.042 0.032 0.05 0.035 0.018 0.008 0.036 0 0.0111 0.0009 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 105435604 rs77928427 A C 0.144 0.095 0.151 0.189 0.064 0.067 0.117 0.0444 0.0431 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 108104709 rs7690934 T C 0.432 0.423 0.42 0.374 0.221 0.328 0.403 0 0.0323 0.0146 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 4 113625548 rs10023113 G A 0.356 0.315 0.383 0.296 0.356 0.279 0.332 0.0027 0 0.0035 www.ncbi.nlm.nih.gov/pubmed/25145502 Genome-wide association study of survival in early-stage non-small cell lung cancer. Non-small cell lung cancer (survival) 4 113762688 rs6858698 C G 0.303 0.288 0.272 0.361 0.387 0.357 0.272 0.0005 0 0.0184 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 4 113777540 rs1476569 G A 0.441 0.451 0.415 0.426 0.423 0.504 0.469 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 4 123145793 rs303084 A G 0.239 0.3 0.29 0.309 0.185 0.236 0.279 0.008 0.0178 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 4 125510764 rs950063 C T 0.11 0.09 0.04 0.144 0.14 0.139 0.089 0.0062 0 0.0243 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 4 132819226 rs151170584 T A 0.051 0.095 0.08 0.052 0.063 0.09 0.08 0.0031 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 134859217 rs10029269 G T 0.254 0.216 0.255 0.2 0.171 0.156 0.181 0 0.0069 0.0054 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 4 137213427 rs10519410 G A 0.322 0.296 0.281 0.335 0.392 0.324 0.235 0 0.0026 0.0096 www.ncbi.nlm.nih.gov/pubmed/23719583 Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. Adverse response to radiation therapy 4 138910418 rs4616695 T G 0.373 0.369 0.402 0.425 0.505 0.517 0.394 0 0.0226 0.0121 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 4 139501980 rs17050782 G A 0.106 0.095 0.112 0.174 0.109 0.123 0.102 0.0233 0 0.0106 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 4 141788570 rs17007695 C T 0.017 0.005 0 0.004 0.005 0 0.009 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 4 142581918 rs1019643 A G 0.411 0.427 0.487 0.53 0.441 0.496 0.482 0.0108 0 0.0058 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 4 144510345 rs1512282 G A 0.081 0.108 0.13 0.148 0.063 0.09 0.099 0.0184 0.0093 0 www.ncbi.nlm.nih.gov/pubmed/27612410 Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A. Pre bronchodilator FEV1/FVC ratio in never-smokers 4 144585304 rs13141641 C T 0.03 0.023 0.027 0.079 0.032 0.029 0.035 0.0382 0 0.0109 www.ncbi.nlm.nih.gov/pubmed/27669027 Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Emphysema distribution in smoking 4 144653692 rs1812175 A G 0.343 0.333 0.297 0.435 0.266 0.265 0.297 0.0544 0.0164 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 4 144653692 rs1812175 A G 0.343 0.333 0.297 0.435 0.266 0.265 0.297 0.0544 0.0164 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 4 149751362 rs17026425 A G 0.051 0.086 0.045 0.061 0.014 0.02 0.031 0.0076 0.0242 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 4 155724361 rs13139571 A C 0.186 0.171 0.134 0.2 0.212 0.165 0.12 0.0033 0 0.0065 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 4 155724361 rs13139571 A C 0.186 0.171 0.134 0.2 0.212 0.165 0.12 0.0033 0 0.0065 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 4 163148970 rs2320614 C T 0.239 0.236 0.204 0.162 0.299 0.288 0.266 0.031 0.0171 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 4 164402797 rs79669866 A G 0.047 0.077 0.067 0.065 0.158 0.112 0.049 0 0.0306 0.0072 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 4 166075994 rs17047225 G A 0.161 0.177 0.188 0.174 0.209 0.2 0.168 0 0.001 0.0009 www.ncbi.nlm.nih.gov/pubmed/29266176 Bone mineral density in children with acute lymphoblastic leukemia. Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia 4 173734763 rs4521323 C A 0.292 0.284 0.353 0.237 0.387 0.299 0.33 0.0225 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 4 174701439 rs12646911 G A 0.328 0.315 0.311 0.322 0.373 0.422 0.329 0 0.0122 0.0011 www.ncbi.nlm.nih.gov/pubmed/25963547 Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort. Obesity in adult survivors of childhood cancer exposed to cranial radiation 4 174906885 rs7697216 T C 0.504 0.495 0.481 0.464 0.491 0.565 0.45 0.0016 0.0047 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 174925275 rs6828523 A C 0.448 0.422 0.42 0.415 0.383 0.413 0.383 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 4 174925275 rs6828523 A C 0.448 0.422 0.42 0.415 0.383 0.413 0.383 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 4 174925275 rs6828523 A C 0.448 0.422 0.42 0.415 0.383 0.413 0.383 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 4 180047278 rs1994816 G A 0.432 0.446 0.54 0.409 0.518 0.504 0.464 0.0137 0.0067 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 4 181038635 rs55656647 C T 0.026 0.005 0.027 0.017 0.068 0.061 0.022 0 0.0272 0.0037 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 4 181276794 rs1454694 C T 0.102 0.104 0.13 0.105 0.072 0.082 0.071 0.0001 0.0023 0 www.ncbi.nlm.nih.gov/pubmed/24737549 Genetic variations associated with postoperative recurrence in stage I non-small cell lung cancer. Non-small cell lung cancer (recurrence rate) 4 181371930 rs6552496 A C 0.42 0.387 0.384 0.374 0.347 0.332 0.38 0 0.0026 0.0026 www.ncbi.nlm.nih.gov/pubmed/28317148 Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients. Bortezomib-induced peripheral neuropathy in multiple myeloma 4 181486725 rs17198973 C T 0.311 0.382 0.412 0.429 0.323 0.306 0.375 0.0163 0.0132 0 www.ncbi.nlm.nih.gov/pubmed/30161160 A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study. Response to tamoxifen in oestrogen receptor positive/HER2 negative breast cancer 4 181490427 rs4861477 C A 0.195 0.218 0.203 0.178 0.122 0.115 0.241 0 0.0218 0.0111 www.ncbi.nlm.nih.gov/pubmed/30161160 A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study. Response to tamoxifen in oestrogen receptor positive/HER2 negative breast cancer 4 181892145 rs1028166 G A 0.142 0.147 0.131 0.235 0.165 0.189 0.153 0.0247 0 0.0199 www.ncbi.nlm.nih.gov/pubmed/25192705 No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. Colorectal cancer (calcium intake interaction) 4 184333619 rs57214277 T C 0.009 0.019 0.033 0.077 0.014 0.042 0.04 0.0415 0 0.0145 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 4 188094248 rs10031466 G A 0.275 0.266 0.257 0.278 0.162 0.153 0.266 0.0066 0.0421 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 5 609978 rs924607 T C 0.042 0.054 0.058 0.074 0.05 0.037 0.062 0.0052 0.0023 0 www.ncbi.nlm.nih.gov/pubmed/25710658 Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia 5 851467 rs3810859 A G 0.326 0.315 0.397 0.39 0.359 0.332 0.482 0.0003 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 5 1004587 rs79398649 T G 0.15 0.209 0.185 0.199 0.164 0.157 0.164 0.0014 0.0014 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 5 1128621 rs12517665 A G 0.076 0.05 0.058 0.061 0.063 0.086 0.044 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28171663 Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Breast cancer 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22037553 A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Breast cancer 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24325915 Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. "Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)" 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28171663 Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast Cancer in BRCA1 mutation carriers 5 1279675 rs10069690 C T 0.339 0.356 0.335 0.339 0.338 0.332 0.319 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28195142 A genome-wide association study yields five novel thyroid cancer risk loci. Thyroid cancer 5 1279913 rs2242652 A G 0.102 0.091 0.121 0.139 0.153 0.16 0.106 0 0.0029 0.0093 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 5 1279913 rs2242652 A G 0.102 0.091 0.121 0.139 0.153 0.16 0.106 0 0.0029 0.0093 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 5 1279913 rs2242652 A G 0.102 0.091 0.121 0.139 0.153 0.16 0.106 0 0.0029 0.0093 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer 5 1279913 rs2242652 A G 0.102 0.091 0.121 0.139 0.153 0.16 0.106 0 0.0029 0.0093 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 5 1282204 rs7726159 A C 0.123 0.149 0.147 0.17 0.198 0.209 0.146 0 0.0066 0.0079 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 5 1282204 rs7726159 A C 0.123 0.149 0.147 0.17 0.198 0.209 0.146 0 0.0066 0.0079 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 5 1282299 rs7725218 A G 0.407 0.451 0.446 0.491 0.414 0.41 0.474 0.0074 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 5 1282299 rs7725218 A G 0.407 0.451 0.446 0.491 0.414 0.41 0.474 0.0074 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 5 1285859 rs7705526 A C 0.103 0.139 0.142 0.149 0.183 0.183 0.13 0 0.0064 0.0051 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 5 1285859 rs7705526 A C 0.103 0.139 0.142 0.149 0.183 0.183 0.13 0 0.0064 0.0051 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 5 1285859 rs7705526 A C 0.103 0.139 0.142 0.149 0.183 0.183 0.13 0 0.0064 0.0051 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in never smokers 5 1286401 rs2736100 C A 0.403 0.441 0.429 0.474 0.446 0.426 0.465 0.0012 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/27501781 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. EGFR mutation-positive lung adenocarcinoma 5 1286401 rs2736100 C A 0.403 0.441 0.429 0.474 0.446 0.426 0.465 0.0012 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/20871597 Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Lung adenocarcinoma 5 1286401 rs2736100 C A 0.403 0.441 0.429 0.474 0.446 0.426 0.465 0.0012 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/19836008 A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Lung adenocarcinoma 5 1286401 rs2736100 C A 0.403 0.441 0.429 0.474 0.446 0.426 0.465 0.0012 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/20700438 The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. Lung adenocarcinoma 5 1286401 rs2736100 C A 0.403 0.441 0.429 0.474 0.446 0.426 0.465 0.0012 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/21725308 A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Lung cancer 5 1286401 rs2736100 C A 0.403 0.441 0.429 0.474 0.446 0.426 0.465 0.0012 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/23143601 Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Lung cancer 5 1287079 rs2853677 G A 0.246 0.248 0.205 0.178 0.36 0.303 0.274 0.0286 0.0326 0 www.ncbi.nlm.nih.gov/pubmed/22797724 A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Lung adenocarcinoma 5 1287079 rs2853677 G A 0.246 0.248 0.205 0.178 0.36 0.303 0.274 0.0286 0.0326 0 www.ncbi.nlm.nih.gov/pubmed/27393504 Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung adenocarcinoma 5 1287079 rs2853677 G A 0.246 0.248 0.205 0.178 0.36 0.303 0.274 0.0286 0.0326 0 www.ncbi.nlm.nih.gov/pubmed/27393504 Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung cancer 5 1295234 rs2853669 G A 0.056 0.054 0.063 0.113 0.108 0.078 0.063 0.0121 0 0.0202 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 1295258 rs35226131 T C 0.021 0.014 0.013 0.022 0.005 0 0.004 0.0087 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 5 1295258 rs35226131 T C 0.021 0.014 0.013 0.022 0.005 0 0.004 0.0087 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/27579533 "Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21." Pancreatic cancer 5 1296371 rs2735940 G A 0.424 0.5 0.482 0.548 0.338 0.389 0.465 0.0346 0.039 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 5 1297373 rs2736108 T C 0.064 0.054 0.063 0.113 0.104 0.078 0.071 0.0107 0 0.0151 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 5 1297373 rs2736108 T C 0.064 0.054 0.063 0.113 0.104 0.078 0.071 0.0107 0 0.0151 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 5 1297373 rs2736108 T C 0.064 0.054 0.063 0.113 0.104 0.078 0.071 0.0107 0 0.0151 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 5 1315545 rs4975616 A G 0.174 0.198 0.223 0.274 0.207 0.25 0.199 0.0123 0 0.0112 www.ncbi.nlm.nih.gov/pubmed/19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Lung cancer 5 1320132 rs380286 G A 0.343 0.335 0.392 0.37 0.311 0.389 0.357 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 5 1320132 rs380286 G A 0.343 0.335 0.392 0.37 0.311 0.389 0.357 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 5 1320607 rs402710 C T 0.492 0.482 0.518 0.487 0.509 0.545 0.46 0 0.0012 0.0007 www.ncbi.nlm.nih.gov/pubmed/18978790 Lung cancer susceptibility locus at 5p15.33. Lung cancer 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24403052 Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Basal cell carcinoma 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19151717 Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Basal cell carcinoma 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/18978787 Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Lung cancer 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20101243 "A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33." Pancreatic cancer 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 5 1321972 rs401681 C T 0.364 0.378 0.415 0.357 0.342 0.414 0.372 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 5 1325475 rs421284 T C 0.364 0.383 0.411 0.339 0.338 0.402 0.375 0.0018 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 5 1342599 rs31489 C A 0.475 0.478 0.509 0.465 0.473 0.553 0.447 0.0004 0.002 0 www.ncbi.nlm.nih.gov/pubmed/19836008 A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Lung adenocarcinoma 5 1453229 rs2617583 A C 0.14 0.162 0.167 0.122 0.248 0.184 0.168 0.0123 0.0169 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 1518964 rs4406174 T C 0.004 0 0.009 0.009 0 0.008 0 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 5 1895715 rs12653946 T C 0.403 0.409 0.477 0.461 0.487 0.454 0.416 0 0.0008 0.002 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 5 1895715 rs12653946 T C 0.403 0.409 0.477 0.461 0.487 0.454 0.416 0 0.0008 0.002 www.ncbi.nlm.nih.gov/pubmed/22923026 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Prostate cancer 5 1895715 rs12653946 T C 0.403 0.409 0.477 0.461 0.487 0.454 0.416 0 0.0008 0.002 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 5 2109787 rs6879627 T C 0.034 0.023 0.032 0.074 0.072 0.049 0.027 0.0137 0 0.0266 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 5 2777197 rs7709328 G A 0.473 0.463 0.472 0.426 0.408 0.435 0.496 0.0001 0 0.005 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 3727065 rs1566691 A G 0.377 0.351 0.357 0.317 0.365 0.332 0.323 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 5 6353702 rs10040610 C T 0.254 0.257 0.241 0.265 0.266 0.205 0.261 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 5 7983139 rs13170463 A G 0.021 0.014 0.018 0.009 0.018 0.02 0.018 0.001 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 5 9557490 rs17264034 A G 0.093 0.127 0.085 0.096 0.117 0.103 0.115 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease 5 9978972 rs553169 T C 0.449 0.405 0.38 0.465 0.368 0.365 0.387 0.0131 0.0066 0 www.ncbi.nlm.nih.gov/pubmed/23577725 Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. Age-related macular degeneration (smoking status interaction) 5 10240437 rs2607324 A G 0.208 0.216 0.183 0.204 0.185 0.205 0.252 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 5 10467590 rs1092913 A G 0.289 0.225 0.297 0.386 0.198 0.238 0.283 0.0558 0.0196 0 www.ncbi.nlm.nih.gov/pubmed/21424380 Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. Breast cancer 5 14071948 rs163818 T C 0.106 0.126 0.122 0.091 0.059 0.061 0.097 0 0.0103 0.006 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) 5 16187315 rs342563 G A 0.377 0.4 0.357 0.33 0.541 0.574 0.33 0.0164 0.0961 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 5 16881981 rs16869212 A G 0.297 0.365 0.432 0.325 0.333 0.361 0.42 0.003 0 0.0036 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease 5 22642425 rs66783663 T C 0.068 0.054 0.063 0.048 0.054 0.029 0.049 0 0.0009 0.0009 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 22812155 rs780179 T C 0.352 0.339 0.329 0.325 0.321 0.269 0.385 0 0.0034 0.0034 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 5 26389153 rs969088 C G 0.242 0.266 0.237 0.183 0.207 0.193 0.226 0.0043 0 0.0085 www.ncbi.nlm.nih.gov/pubmed/22872573 Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Response to platinum-based chemotherapy in non-small-cell lung cancer 5 31804244 rs17416314 A G 0.013 0.036 0.031 0.035 0.009 0.016 0.031 0.0033 0.0071 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 5 32567626 rs2012709 T C 0.085 0.105 0.099 0.125 0.162 0.157 0.075 0 0.0095 0.015 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 5 32567626 rs2012709 T C 0.085 0.105 0.099 0.125 0.162 0.157 0.075 0 0.0095 0.015 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 32814922 rs1173771 A G 0.175 0.212 0.188 0.178 0.091 0.123 0.168 0 0.0224 0.001 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 5 32814922 rs1173771 A G 0.175 0.212 0.188 0.178 0.091 0.123 0.168 0 0.0224 0.001 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 5 33946466 rs35407 G A 0.265 0.23 0.272 0.217 0.296 0.312 0.274 0.0096 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 5 33946466 rs35407 G A 0.265 0.23 0.272 0.217 0.296 0.312 0.274 0.0096 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/27424798 Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Cutaneous squamous cell carcinoma 5 33946466 rs35407 G A 0.265 0.23 0.272 0.217 0.296 0.312 0.274 0.0096 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 5 33951588 rs16891982 G C 0 0.005 0 0.009 0.009 0 0 0.0066 0 0.0076 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Low tan response 5 33951588 rs16891982 G C 0 0.005 0 0.009 0.009 0 0 0.0066 0 0.0076 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 5 33951588 rs16891982 G C 0 0.005 0 0.009 0.009 0 0 0.0066 0 0.0076 www.ncbi.nlm.nih.gov/pubmed/17999355 A genomewide association study of skin pigmentation in a South Asian population. Skin pigmentation 5 33951588 rs16891982 G C 0 0.005 0 0.009 0.009 0 0 0.0066 0 0.0076 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 5 33951588 rs16891982 G C 0 0.005 0 0.009 0.009 0 0 0.0066 0 0.0076 www.ncbi.nlm.nih.gov/pubmed/30166351 Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Skin pigmentation traits 5 33951588 rs16891982 G C 0 0.005 0 0.009 0.009 0 0 0.0066 0 0.0076 www.ncbi.nlm.nih.gov/pubmed/26829030 Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. Squamous cell carcinoma 5 33955221 rs35390 C A 0.453 0.478 0.432 0.478 0.523 0.413 0.429 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 5 33955568 rs35391 T C 0.453 0.477 0.429 0.478 0.518 0.41 0.429 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 5 33964105 rs183671 G T 0.15 0.202 0.174 0.132 0.144 0.131 0.173 0.0017 0 0.0057 www.ncbi.nlm.nih.gov/pubmed/25963972 Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up. Skin colour saturation 5 33964105 rs183671 G T 0.15 0.202 0.174 0.132 0.144 0.131 0.173 0.0017 0 0.0057 www.ncbi.nlm.nih.gov/pubmed/30166351 Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Skin pigmentation traits 5 33967040 rs35412 C G 0.462 0.451 0.491 0.491 0.541 0.446 0.478 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25963972 Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up. Perceived skin darkness 5 34718238 rs1545348 G T 0.119 0.122 0.08 0.078 0.135 0.164 0.093 0.008 0.0151 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 5 34718238 rs1545348 G T 0.119 0.122 0.08 0.078 0.135 0.164 0.093 0.008 0.0151 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 5 35799892 rs3822735 A G 0.322 0.288 0.281 0.257 0.315 0.348 0.317 0.0082 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 5 36137518 rs267759 A G 0.108 0.144 0.094 0.17 0.059 0.066 0.12 0.0352 0.0349 0 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 5 43410515 rs73098691 A G 0.153 0.185 0.21 0.226 0.149 0.197 0.204 0.0057 0.001 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 43891334 rs35029702 A G 0 0 0 0.009 0.005 0 0 0.0154 0 0.015 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 44365443 rs2121875 A C 0.178 0.198 0.214 0.23 0.162 0.16 0.217 0.0059 0.009 0 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer 5 44365443 rs2121875 A C 0.178 0.198 0.214 0.23 0.162 0.16 0.217 0.0059 0.009 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 5 44662413 rs4415084 C T 0.335 0.347 0.277 0.352 0.297 0.279 0.288 0.0054 0.0023 0 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 5 44874903 rs7716600 A C 0.137 0.127 0.161 0.202 0.168 0.172 0.107 0.0111 0 0.0152 www.ncbi.nlm.nih.gov/pubmed/20872241 A combined analysis of genome-wide association studies in breast cancer. Breast cancer 5 45074531 rs13183434 A G 0.064 0.068 0.08 0.083 0.054 0.07 0.062 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 45265666 rs13180087 C T 0.099 0.079 0.063 0.101 0.05 0.062 0.055 0.0087 0.0051 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer 5 45265666 rs13180087 C T 0.099 0.079 0.063 0.101 0.05 0.062 0.055 0.0087 0.0051 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 5 45285616 rs981782 C A 0 0 0.004 0.022 0.005 0 0.004 0.0336 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/17529967 Genome-wide association study identifies novel breast cancer susceptibility loci. Breast cancer 5 45333758 rs55821517 C T 0 0 0 0.017 0 0 0.004 0.0351 0 0.0085 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 50324716 rs72749828 T C 0 0 0 0.004 0 0.004 0 0.006 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 5 51032423 rs11960470 A C 0.521 0.536 0.5 0.571 0.428 0.458 0.447 0.0199 0.0133 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 52724562 rs830884 C T 0.246 0.191 0.152 0.209 0.173 0.16 0.155 0.0019 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/22020760 "Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients." Response to platinum-based agents 5 53399007 rs4254863 C T 0.004 0 0.004 0.017 0.05 0.012 0.009 0 0.0055 0.0211 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 56361879 rs7378815 T C 0 0.005 0.004 0.004 0 0 0 0.002 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 56505512 rs29999 A G 0.008 0 0.004 0 0.005 0.004 0.004 0.001 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in never smokers 5 56507706 rs30000 A G 0.093 0.135 0.17 0.17 0.099 0.086 0.128 0.0148 0.0144 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 5 56507706 rs30000 A G 0.093 0.135 0.17 0.17 0.099 0.086 0.128 0.0148 0.0144 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (smoking interaction) 5 56510924 rs459193 A G 0.453 0.413 0.397 0.496 0.64 0.508 0.455 0 0.0207 0.0217 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 5 56510924 rs459193 A G 0.453 0.413 0.397 0.496 0.64 0.508 0.455 0 0.0207 0.0217 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 5 56510924 rs459193 A G 0.453 0.413 0.397 0.496 0.64 0.508 0.455 0 0.0207 0.0217 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (smoking interaction) 5 56565039 rs3936510 T G 0.271 0.279 0.205 0.248 0.23 0.143 0.243 0 0.0113 0.0007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 5 56565532 rs13173241 A G 0.271 0.279 0.205 0.248 0.218 0.143 0.239 0 0.0137 0.0003 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 5 56565532 rs13173241 A G 0.271 0.279 0.205 0.248 0.218 0.143 0.239 0 0.0137 0.0003 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 5 56566067 rs9687846 A G 0.271 0.279 0.205 0.248 0.227 0.149 0.243 0 0.0106 0.0007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 5 56699208 rs16886113 G T 0.131 0.135 0.125 0.165 0.117 0.098 0.106 0.0112 0.0027 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56733416 rs16886181 C T 0.178 0.171 0.147 0.213 0.216 0.148 0.155 0.0057 0 0.0051 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56736057 rs889312 C A 0.343 0.324 0.33 0.365 0.482 0.439 0.319 0 0.0269 0.0115 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 5 56736057 rs889312 C A 0.343 0.324 0.33 0.365 0.482 0.439 0.319 0 0.0269 0.0115 www.ncbi.nlm.nih.gov/pubmed/17529967 Genome-wide association study identifies novel breast cancer susceptibility loci. Breast cancer 5 56736057 rs889312 C A 0.343 0.324 0.33 0.365 0.482 0.439 0.319 0 0.0269 0.0115 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 5 56736057 rs889312 C A 0.343 0.324 0.33 0.365 0.482 0.439 0.319 0 0.0269 0.0115 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 5 56736057 rs889312 C A 0.343 0.324 0.33 0.365 0.482 0.439 0.319 0 0.0269 0.0115 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56737113 rs1862626 G T 0.343 0.315 0.33 0.361 0.473 0.439 0.319 0 0.0266 0.0107 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 5 56826517 rs16886364 G A 0.038 0.027 0.018 0.026 0.027 0.02 0.013 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56838449 rs16886397 G A 0.038 0.032 0.018 0.026 0.027 0.021 0.013 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56857565 rs1017226 C T 0.038 0.027 0.018 0.026 0.027 0.02 0.013 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56872885 rs2229882 T C 0.025 0.023 0.013 0.022 0.027 0.02 0.013 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56882284 rs3822625 G A 0.138 0.131 0.067 0.124 0.102 0.07 0.068 0.0039 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56899963 rs12655019 G A 0.102 0.09 0.049 0.109 0.086 0.053 0.062 0.0085 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56960656 rs7726354 T C 0.017 0.014 0.018 0.022 0.041 0.025 0.009 0 0.0036 0.0037 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 5 56964779 rs6890270 G A 0.038 0.032 0.018 0.048 0.041 0.02 0.009 0.0075 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 57890836 rs35100619 A G 0.285 0.338 0.272 0.31 0.327 0.4 0.348 0 0.0052 0.0008 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 59111944 rs10052657 A C 0.089 0.095 0.125 0.096 0.122 0.156 0.103 0.0005 0.0062 0 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 5 59180291 rs9292195 T C 0.186 0.221 0.107 0.183 0.108 0.119 0.143 0.0048 0.0146 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 61565295 rs10042706 G A 0.225 0.205 0.29 0.196 0.207 0.156 0.261 0 0.0021 0.0098 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 5 64771925 rs2042329 G T 0.432 0.436 0.406 0.422 0.541 0.545 0.394 0 0.0318 0.0019 www.ncbi.nlm.nih.gov/pubmed/27206850 Genome-Wide Association Study of Bladder Cancer in a Chinese Cohort Reveals a New Susceptibility Locus at 5q12.3. Bladder cancer 5 65152843 rs6885147 C T 0.348 0.342 0.365 0.409 0.365 0.459 0.372 0 0 0.0063 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease 5 67215707 rs1697139 A G 0.47 0.491 0.522 0.504 0.338 0.475 0.393 0.006 0.0111 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 67999079 rs157411 G A 0.373 0.374 0.36 0.298 0.396 0.34 0.345 0.01 0 0.0016 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 5 68315658 rs184886 T C 0.182 0.18 0.188 0.265 0.225 0.23 0.186 0.0126 0 0.0164 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 73010019 rs258892 A C 0.424 0.441 0.482 0.404 0.455 0.413 0.464 0.0023 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 5 73943871 rs157554 T C 0.178 0.259 0.171 0.091 0.23 0.197 0.212 0.0587 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 75719417 rs2112347 T G 0.417 0.355 0.38 0.5 0.613 0.55 0.5 0 0.0254 0.0353 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 5 75719417 rs2112347 T G 0.417 0.355 0.38 0.5 0.613 0.55 0.5 0 0.0254 0.0353 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 5 76143375 rs6453204 A G 0.081 0.117 0.138 0.122 0.091 0.057 0.173 0 0.0139 0.0009 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer (hypertension) (bevacizumab) 5 76143375 rs6453204 A G 0.081 0.117 0.138 0.122 0.091 0.057 0.173 0 0.0139 0.0009 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 5 78888580 rs6893857 T C 0.284 0.279 0.275 0.387 0.419 0.34 0.348 0.0057 0 0.0208 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 5 81187755 rs716897 C T 0.186 0.221 0.25 0.374 0.189 0.234 0.221 0.0826 0 0.0109 www.ncbi.nlm.nih.gov/pubmed/29942513 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses. Mucinous adenocarcinoma in colorectal cancer 5 82340549 rs2407156 G A 0.059 0.045 0.058 0.1 0.054 0.066 0.031 0.022 0 0.012 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 83122237 rs28745309 T G 0.008 0.009 0.005 0 0 0.008 0.004 0.0021 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 5 83523300 rs310518 A G 0.008 0.005 0.018 0.009 0 0.008 0.009 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/25194280 Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Laryngeal squamous cell carcinoma 5 86878330 rs1493354 G A 0.326 0.323 0.308 0.335 0.32 0.295 0.341 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) 5 86881956 rs2471042 A G 0.292 0.284 0.196 0.257 0.095 0.107 0.181 0.0176 0.084 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) 5 87315172 rs35148638 C A 0.072 0.05 0.085 0.035 0.09 0.094 0.12 0.0233 0.0009 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer aggressiveness 5 90931162 rs74501188 A G 0.076 0.09 0.063 0.061 0.014 0.012 0.089 0 0.0431 0.001 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 5 91280462 rs13355819 A G 0.008 0.005 0 0.057 0.005 0.008 0.013 0.0853 0 0.0259 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 5 91436408 rs10474352 T C 0.411 0.46 0.411 0.272 0.293 0.414 0.407 0.0378 0 0.0312 www.ncbi.nlm.nih.gov/pubmed/25038754 "Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1." Breast cancer 5 91436408 rs10474352 T C 0.411 0.46 0.411 0.272 0.293 0.414 0.407 0.0378 0 0.0312 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 91466931 rs933688 G A 0.199 0.155 0.23 0.248 0.168 0.172 0.201 0.0136 0.0046 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 5 91979496 rs421379 C T 0.207 0.211 0.236 0.191 0.246 0.207 0.25 0.0018 0 0.001 www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 5 91979496 rs421379 C T 0.207 0.211 0.236 0.191 0.246 0.207 0.25 0.0018 0 0.001 www.ncbi.nlm.nih.gov/pubmed/25526632 A genome wide meta-analysis study for identification of common variation associated with breast cancer prognosis. Breast cancer (survival) 5 94862585 rs42417 C T 0.39 0.405 0.393 0.361 0.279 0.242 0.336 0 0.0297 0.0051 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 5 94862585 rs42417 C T 0.39 0.405 0.393 0.361 0.279 0.242 0.336 0 0.0297 0.0051 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 5 94862585 rs42417 C T 0.39 0.405 0.393 0.361 0.279 0.242 0.336 0 0.0297 0.0051 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 5 95907227 rs56219066 C T 0.453 0.428 0.424 0.29 0.432 0.434 0.474 0.0594 0 0.0135 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma 5 95907227 rs56219066 C T 0.453 0.428 0.424 0.29 0.432 0.434 0.474 0.0594 0 0.0135 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma and monoclonal gammopathy 5 96700607 rs72772090 C G 0 0 0 0.004 0 0 0.004 0.0031 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 5 96766240 rs27524 A G 0.504 0.496 0.505 0.487 0.468 0.406 0.509 0 0.0058 0.0029 www.ncbi.nlm.nih.gov/pubmed/22286212 Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. Hodgkins lymphoma 5 97197765 rs1000083 T C 0.114 0.108 0.161 0.109 0.167 0.156 0.146 0.0041 0.0051 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 5 107084888 rs4957528 A C 0.043 0.059 0.041 0.096 0.036 0.064 0.036 0.0265 0 0.0102 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 5 108016378 rs288175 A G 0.182 0.225 0.176 0.168 0.158 0.157 0.155 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 5 108816727 rs10041657 A G 0.259 0.266 0.308 0.355 0.246 0.246 0.319 0.0205 0.0096 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 5 108816727 rs10041657 A G 0.259 0.266 0.308 0.355 0.246 0.246 0.319 0.0205 0.0096 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 5 108816727 rs10041657 A G 0.259 0.266 0.308 0.355 0.246 0.246 0.319 0.0205 0.0096 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 5 115054424 rs10077885 C A 0.246 0.288 0.293 0.313 0.257 0.24 0.275 0.0055 0.0033 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 5 115054424 rs10077885 C A 0.246 0.288 0.293 0.313 0.257 0.24 0.275 0.0055 0.0033 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 5 115188701 rs7736737 A G 0.216 0.225 0.228 0.144 0.248 0.203 0.181 0.0201 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 5 119393591 rs1045241 T C 0.415 0.347 0.433 0.37 0.36 0.398 0.416 0.0005 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 5 120081372 rs255788 A G 0.084 0.149 0.082 0.244 0.082 0.12 0.147 0.0932 0 0.0068 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 5 122582513 rs7712513 G T 0.271 0.25 0.284 0.239 0.122 0.115 0.297 0 0.067 0.0108 www.ncbi.nlm.nih.gov/pubmed/26460308 Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy. Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy 5 123338869 rs75887402 C T 0.035 0.075 0.073 0.057 0.123 0.115 0.072 0.0001 0.021 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 123800962 rs6891344 G A 0.303 0.324 0.313 0.314 0.306 0.246 0.304 0 0.0014 0.0004 www.ncbi.nlm.nih.gov/pubmed/29971594 Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. Lung cancer x radon exposure interaction (1df) 5 124400713 rs6878727 A G 0.381 0.44 0.378 0.439 0.23 0.295 0.456 0.0115 0.0636 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 124688588 rs4285214 T G 0.288 0.315 0.25 0.382 0.505 0.451 0.317 0 0.0358 0.0443 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 5 125030274 rs6862844 C A 0.288 0.284 0.36 0.294 0.27 0.258 0.283 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 5 128098106 rs1112956 A G 0 0 0.004 0.017 0.023 0 0 0.0167 0 0.027 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 128227188 rs36715 G A 0.466 0.469 0.536 0.43 0.419 0.365 0.469 0 0.006 0.0122 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 132342304 rs272869 A G 0.22 0.203 0.219 0.226 0.356 0.324 0.239 0 0.035 0.0041 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 5 132342304 rs272869 A G 0.22 0.203 0.219 0.226 0.356 0.324 0.239 0 0.035 0.0041 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 5 132497907 rs736801 T C 0.051 0.054 0.036 0.074 0.041 0.058 0.044 0.0061 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 132660272 rs20541 A G 0.157 0.176 0.174 0.091 0.282 0.275 0.177 0.0543 0.0576 0 www.ncbi.nlm.nih.gov/pubmed/22286212 Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. Hodgkins lymphoma 5 132662721 rs2069757 A G 0.03 0.005 0.004 0.009 0.018 0.025 0.018 0.001 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/24920014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Hodgkins lymphoma 5 133849844 rs1703426 T C 0.013 0.014 0.013 0.057 0.136 0.141 0.027 0 0.0669 0.0814 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 5 134529762 rs329124 A G 0.445 0.437 0.464 0.37 0.35 0.402 0.385 0.0022 0 0.0077 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 5 134529762 rs329124 A G 0.445 0.437 0.464 0.37 0.35 0.402 0.385 0.0022 0 0.0077 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 5 134529762 rs329124 A G 0.445 0.437 0.464 0.37 0.35 0.402 0.385 0.0022 0 0.0077 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 5 135163402 rs647161 C A 0.39 0.414 0.419 0.456 0.577 0.689 0.42 0 0.0882 0.0217 www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 5 135163402 rs647161 C A 0.39 0.414 0.419 0.456 0.577 0.689 0.42 0 0.0882 0.0217 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 5 135163402 rs647161 C A 0.39 0.414 0.419 0.456 0.577 0.689 0.42 0 0.0882 0.0217 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 5 136245971 rs11740657 A G 0.136 0.162 0.138 0.196 0.122 0.131 0.155 0.0141 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 5 136997105 rs6876032 C G 0.201 0.149 0.179 0.217 0.311 0.422 0.243 0 0.0726 0.0164 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 5 141655607 rs79464052 C G 0.13 0.158 0.098 0.148 0.09 0.111 0.128 0.0032 0.0056 0 www.ncbi.nlm.nih.gov/pubmed/25261932 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Diffuse large B cell lymphoma 5 142066209 rs252152 G A 0.461 0.446 0.402 0.457 0.271 0.267 0.402 0.0138 0.0723 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 5 142290274 rs10051199 T G 0.203 0.225 0.165 0.239 0.153 0.143 0.128 0.0202 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 143376439 rs2963155 G A 0.233 0.257 0.272 0.291 0.23 0.25 0.327 0.0016 0.0029 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 148793365 rs9285673 A C 0.496 0.464 0.433 0.487 0.41 0.368 0.455 0.0043 0.0152 0 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 5 149053986 rs250677 C T 0.36 0.423 0.397 0.434 0.329 0.339 0.416 0.007 0.014 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 149816671 rs251464 G C 0.428 0.514 0.469 0.509 0.293 0.373 0.363 0.0269 0.0411 0 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Low tan response 5 149816671 rs251464 G C 0.428 0.514 0.469 0.509 0.293 0.373 0.363 0.0269 0.0411 0 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 5 149831285 rs32579 C T 0.381 0.496 0.441 0.435 0.427 0.426 0.415 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 5 153611838 rs1493383 T C 0.085 0.063 0.063 0.065 0.077 0.082 0.058 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 5 154130036 rs2033195 T C 0.43 0.414 0.406 0.457 0.288 0.353 0.407 0.0124 0.0282 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 5 154158333 rs7715256 G T 0.393 0.369 0.424 0.352 0.338 0.368 0.385 0.0003 0 0.0024 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 5 154158333 rs7715256 G T 0.393 0.369 0.424 0.352 0.338 0.368 0.385 0.0003 0 0.0024 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 5 155775518 rs11134474 G A 0.144 0.109 0.21 0.083 0.176 0.184 0.177 0.0369 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/22006218 Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Smoking behavior 5 155918211 rs2163746 G A 0.073 0.045 0.068 0.065 0.054 0.038 0.059 0.0001 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 5 158803005 rs11135046 T G 0.186 0.136 0.108 0.074 0.113 0.153 0.142 0.0236 0 0.0069 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 158817075 rs1432679 T C 0.186 0.135 0.103 0.074 0.113 0.16 0.133 0.0232 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 5 158817075 rs1432679 T C 0.186 0.135 0.103 0.074 0.113 0.16 0.133 0.0232 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 5 158817075 rs1432679 T C 0.186 0.135 0.103 0.074 0.113 0.16 0.133 0.0232 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 5 158817075 rs1432679 T C 0.186 0.135 0.103 0.074 0.113 0.16 0.133 0.0232 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 5 158817075 rs1432679 T C 0.186 0.135 0.103 0.074 0.113 0.16 0.133 0.0232 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 158817075 rs1432679 T C 0.186 0.135 0.103 0.074 0.113 0.16 0.133 0.0232 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 5 158905372 rs17543752 C T 0.246 0.185 0.112 0.13 0.239 0.258 0.186 0.0216 0.0228 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 159008453 rs11288072 C A 0.127 0.104 0.045 0.118 0.122 0.165 0.102 0 0.005 0.0071 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 159821007 rs17057166 T C 0.11 0.086 0.068 0.1 0.072 0.074 0.146 0 0.0032 0.001 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 5 162680373 rs6874604 T G 0.11 0.113 0.107 0.104 0.05 0.041 0.115 0.0005 0.0289 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 5 162680373 rs6874604 T G 0.11 0.113 0.107 0.104 0.05 0.041 0.115 0.0005 0.0289 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 5 163158639 rs12187751 G A 0.048 0.049 0.046 0.054 0.037 0.055 0.075 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 5 163660079 rs12655486 C T 0.312 0.218 0.272 0.23 0.338 0.307 0.204 0.0038 0.0158 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 5 164084868 rs13163167 C T 0.326 0.261 0.268 0.3 0.173 0.221 0.261 0.0058 0.0237 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 5 164462274 rs6556756 G T 0.051 0.068 0.018 0.048 0.064 0.041 0.049 0 0 0 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 5 165828980 rs248276 T C 0.102 0.117 0.094 0.178 0.095 0.082 0.084 0.0426 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 5 166636675 rs79476395 G A 0.081 0.104 0.067 0.115 0.113 0.115 0.076 0.0013 0 0.0064 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 5 166636675 rs79476395 G A 0.081 0.104 0.067 0.115 0.113 0.115 0.076 0.0013 0 0.0064 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 5 168484035 rs244899 C T 0.239 0.259 0.248 0.177 0.176 0.225 0.25 0.0071 0 0.0124 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 5 170164483 rs4562056 T G 0.265 0.3 0.313 0.217 0.262 0.314 0.329 0.018 0 0.0064 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 5 171470204 rs3097847 A G 0.123 0.14 0.126 0.105 0.045 0.053 0.189 0 0.033 0.0155 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 5 171470204 rs3097847 A G 0.123 0.14 0.126 0.105 0.045 0.053 0.189 0 0.033 0.0155 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 5 171854871 rs4868125 C G 0.36 0.428 0.362 0.5 0.473 0.426 0.403 0.0166 0 0.0206 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 5 171854871 rs4868125 C G 0.36 0.428 0.362 0.5 0.473 0.426 0.403 0.0166 0 0.0206 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 5 173223484 rs10440708 G A 0.145 0.117 0.099 0.134 0.171 0.205 0.106 0 0.0152 0.0065 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 5 173704454 rs4868304 T C 0.081 0.09 0.117 0.083 0.063 0.111 0.12 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 5 173893812 rs7705502 A G 0 0 0 0.004 0 0 0.004 0.0031 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 5 173921153 rs10516107 A G 0.021 0.036 0.022 0.022 0.009 0.016 0.022 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 5 173921153 rs10516107 A G 0.021 0.036 0.022 0.022 0.009 0.016 0.022 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 5 174280232 rs6878584 G A 0.487 0.491 0.491 0.474 0.518 0.484 0.415 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 5 174350517 rs12659144 C T 0.212 0.252 0.237 0.252 0.356 0.385 0.279 0 0.0373 0.0046 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 5 176485993 rs3888233 A G 0.076 0.041 0.036 0.065 0.05 0.057 0.035 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 5 177100576 rs6556301 T G 0.237 0.243 0.232 0.157 0.291 0.32 0.248 0.0399 0.0226 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 5 177100576 rs6556301 T G 0.237 0.243 0.232 0.157 0.291 0.32 0.248 0.0399 0.0226 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 5 177100576 rs6556301 T G 0.237 0.243 0.232 0.157 0.291 0.32 0.248 0.0399 0.0226 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 5 177100576 rs6556301 T G 0.237 0.243 0.232 0.157 0.291 0.32 0.248 0.0399 0.0226 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 5 177100576 rs6556301 T G 0.237 0.243 0.232 0.157 0.291 0.32 0.248 0.0399 0.0226 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 5 179335063 rs340417 A C 0.1 0.082 0.127 0.105 0.116 0.142 0.08 0 0.0022 0.0022 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 6 408079 rs1050976 T C 0 0 0 0.013 0.023 0.012 0.004 0.0041 0 0.0245 www.ncbi.nlm.nih.gov/pubmed/30213928 Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Multiple myeloma 6 409119 rs9391997 G A 0.068 0.077 0.089 0.063 0.059 0.053 0.081 0 0.0013 0.0015 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 410848 rs2316515 G A 0.335 0.324 0.297 0.3 0.336 0.353 0.277 0.0001 0.0018 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 6 411064 rs872071 G A 0 0 0 0.013 0.023 0.012 0.004 0.0041 0 0.0245 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 411064 rs872071 G A 0 0 0 0.013 0.023 0.012 0.004 0.0041 0 0.0245 www.ncbi.nlm.nih.gov/pubmed/22700719 Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 411064 rs872071 G A 0 0 0 0.013 0.023 0.012 0.004 0.0041 0 0.0245 www.ncbi.nlm.nih.gov/pubmed/18758461 A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 411064 rs872071 G A 0 0 0 0.013 0.023 0.012 0.004 0.0041 0 0.0245 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 412802 rs9392504 A G 0.246 0.273 0.268 0.283 0.162 0.201 0.235 0.0078 0.0224 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 6 417727 rs9378805 C A 0.051 0.027 0.054 0.017 0 0.008 0.027 0 0.0118 0.0124 www.ncbi.nlm.nih.gov/pubmed/21131588 Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Chronic lymphocytic leukemia 6 442357 rs9392017 A G 0.127 0.153 0.161 0.14 0.077 0.074 0.168 0 0.0263 0.002 www.ncbi.nlm.nih.gov/pubmed/28112199 "Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci." "B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)" 6 466033 rs1540771 T C 0.122 0.095 0.089 0.104 0.117 0.103 0.075 0 0 0 www.ncbi.nlm.nih.gov/pubmed/17952075 "Genetic determinants of hair, eye and skin pigmentation in Europeans." Freckles 6 471136 rs12202284 A C 0 0 0 0.009 0 0 0.004 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/23548203 Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. Non-melanoma skin cancer 6 484453 rs116446171 G C 0.017 0.018 0.031 0.018 0.018 0.029 0.022 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25261932 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Diffuse large B cell lymphoma 6 484453 rs116446171 G C 0.017 0.018 0.031 0.018 0.018 0.029 0.022 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30305637 Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenstršm macroglobulinemia. Waldenstršm macroglobulinemia / lymphoplasmacytic lymphoma 6 998578 rs845868 A G 0.051 0.054 0.049 0.052 0.032 0.045 0.035 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 6 1294916 rs6596805 A G 0.517 0.487 0.428 0.461 0.391 0.389 0.474 0 0.0119 0.0034 www.ncbi.nlm.nih.gov/pubmed/29942513 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses. Mucinous adenocarcinoma in colorectal cancer 6 1318643 rs11242675 T C 0.525 0.446 0.522 0.509 0.369 0.41 0.518 0.001 0.0278 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 6 1318643 rs11242675 T C 0.525 0.446 0.522 0.509 0.369 0.41 0.518 0.001 0.0278 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 6 1339954 rs9502893 T C 0.428 0.491 0.393 0.417 0.414 0.385 0.469 0 0.0016 0.0016 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 6 1402302 rs1711973 T C 0.081 0.063 0.098 0.157 0.214 0.26 0.093 0 0.0433 0.067 www.ncbi.nlm.nih.gov/pubmed/24662972 Genome-wide interaction study of smoking and bladder cancer risk. Bladder cancer (smoking interaction) 6 1573378 rs2338 A G 0.192 0.225 0.239 0.135 0.185 0.223 0.252 0.026 0 0.0107 www.ncbi.nlm.nih.gov/pubmed/22020760 "Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients." Response to platinum-based agents 6 2634705 rs6938753 G C 0.119 0.114 0.116 0.18 0.077 0.078 0.111 0.0378 0.0182 0 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in estrogen receptor positive breast cancer 6 3294794 rs4959799 C G 0.229 0.27 0.339 0.265 0.153 0.18 0.279 0 0.0332 0.0028 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 6 6550516 rs17142289 G A 0.22 0.252 0.17 0.174 0.185 0.098 0.173 0 0.0071 0.0067 www.ncbi.nlm.nih.gov/pubmed/24785509 A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. Response to radiotherapy in cancer (late toxicity) 6 6738519 rs1294410 T C 0.161 0.189 0.144 0.23 0.09 0.111 0.199 0.0329 0.0403 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 6 6911218 rs2249382 G A 0.237 0.279 0.223 0.193 0.155 0.18 0.239 0 0.0043 0.0131 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 6 7231610 rs9379084 A G 0 0.009 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 9015865 rs430329 A G 0.051 0.068 0.027 0.1 0.018 0.02 0.049 0.0513 0.0283 0 www.ncbi.nlm.nih.gov/pubmed/30573740 Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. Male-pattern baldness 6 9030103 rs438259 A G 0.259 0.293 0.219 0.235 0.216 0.252 0.217 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20732626 Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. Attention deficit hyperactivity disorder 6 9291650 rs72820264 C T 0.025 0.023 0.045 0.066 0.099 0.074 0.022 0 0.0054 0.0332 www.ncbi.nlm.nih.gov/pubmed/28468790 Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects. Left ventricular obstructive tract defect (inherited effect) 6 9304416 rs78576899 T C 0.017 0.009 0.009 0.009 0.005 0.012 0.004 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28196072 Genetic prediction of male pattern baldness. Male-pattern baldness 6 9320073 rs56409046 T C 0.165 0.171 0.203 0.174 0.297 0.25 0.248 0.0049 0.0219 0 www.ncbi.nlm.nih.gov/pubmed/28468790 Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects. Congenital heart disease (inherited effect) 6 9368285 rs2104455 G A 0.211 0.214 0.167 0.291 0.2 0.258 0.207 0.0206 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/30487263 Multiethnic Genome-wide Association Study of Diabetic Retinopathy using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetic retinopathy (all NPDR and PDR) 6 9389079 rs2294736 C T 0.22 0.162 0.214 0.196 0.189 0.238 0.15 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/28196072 Genetic prediction of male pattern baldness. Male-pattern baldness 6 9419866 rs6457977 A G 0.331 0.27 0.29 0.222 0.259 0.353 0.25 0.0155 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/28196072 Genetic prediction of male pattern baldness. Male-pattern baldness 6 9427283 rs9470710 T C 0.17 0.153 0.185 0.135 0.086 0.09 0.168 0 0.0173 0.0111 www.ncbi.nlm.nih.gov/pubmed/30019117 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. Adolescent idiopathic scoliosis 6 9450964 rs10484246 A T 0.097 0.081 0.04 0.113 0.167 0.184 0.044 0 0.0314 0.0392 www.ncbi.nlm.nih.gov/pubmed/17903295 Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. Morbidity-free survival 6 9464314 rs79032435 T C 0.03 0.063 0.058 0.061 0.068 0.066 0.049 0 0.0008 0.0008 www.ncbi.nlm.nih.gov/pubmed/28196072 Genetic prediction of male pattern baldness. Male-pattern baldness 6 9469005 rs9381107 A G 0.161 0.126 0.103 0.191 0.114 0.154 0.08 0.0218 0 0.0112 www.ncbi.nlm.nih.gov/pubmed/28232668 Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity. Nonsyndromic cleft lip with cleft palate 6 9481139 rs2876167 A G 0.254 0.27 0.268 0.278 0.257 0.176 0.301 0.0005 0.009 0 www.ncbi.nlm.nih.gov/pubmed/29146897 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. Male-pattern baldness 6 9509797 rs9463175 C T 0.335 0.315 0.263 0.3 0.293 0.225 0.283 0 0.0026 0.0007 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Body mass index 6 9940990 rs9396752 A G 0.017 0.027 0 0 0.018 0.012 0 0.0088 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/27612410 Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A. Pre bronchodilator FEV1/FVC ratio in never-smokers 6 10414773 rs654351 G C 0.085 0.054 0.063 0.061 0.045 0.033 0.049 0 0.0039 0.0008 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 6 11218797 rs4713266 T C 0.148 0.144 0.188 0.178 0.171 0.209 0.146 0 0.0016 0.0016 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 6 11218797 rs4713266 T C 0.148 0.144 0.188 0.178 0.171 0.209 0.146 0 0.0016 0.0016 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 11705467 rs742223 A G 0 0 0 0.009 0.018 0.02 0 0.0005 0.0003 0.0299 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 6 12217189 rs7356945 T C 0.42 0.414 0.348 0.313 0.27 0.246 0.279 0 0.0133 0.0145 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. "Response to radiotherapy in prostate cancer (toxicity, urinary frequency)" 6 13722291 rs204247 G A 0.285 0.333 0.339 0.344 0.332 0.307 0.31 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 6 13722291 rs204247 G A 0.285 0.333 0.339 0.344 0.332 0.307 0.31 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 6 13722291 rs204247 G A 0.285 0.333 0.339 0.344 0.332 0.307 0.31 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 14636732 rs707824 C T 0.129 0.236 0.212 0.298 0.336 0.265 0.237 0.0055 0 0.0325 www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 6 15691547 rs59112743 G A 0.44 0.482 0.478 0.474 0.5 0.496 0.563 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28081215 Genome-Wide Association Studies of Multiple Keratinocyte Cancers. Multiple keratinocyte cancers 6 16399326 rs3819405 T C 0.432 0.45 0.482 0.548 0.55 0.529 0.491 0.0041 0 0.0151 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 20723562 rs78489263 G A 0.097 0.077 0.073 0.058 0.036 0.029 0.04 0 0.0101 0.0041 www.ncbi.nlm.nih.gov/pubmed/30219690 GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort. Depression in smokers 6 20728282 rs6928012 T C 0.203 0.305 0.214 0.244 0.234 0.215 0.228 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 20751084 rs7747724 C T 0.398 0.414 0.482 0.37 0.315 0.406 0.474 0.0005 0 0.0131 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 6 20766466 rs4510656 A C 0.326 0.359 0.419 0.292 0.236 0.316 0.412 0 0.0005 0.0227 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 6 21330062 rs12198220 T G 0.212 0.149 0.158 0.148 0.182 0.189 0.147 0.0012 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 6 21648854 rs1740828 G A 0.267 0.286 0.275 0.235 0.158 0.131 0.219 0 0.036 0.007 www.ncbi.nlm.nih.gov/pubmed/27008869 GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer. Endometrial cancer 6 21648854 rs1740828 G A 0.267 0.286 0.275 0.235 0.158 0.131 0.219 0 0.036 0.007 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 6 21648854 rs1740828 G A 0.267 0.286 0.275 0.235 0.158 0.131 0.219 0 0.036 0.007 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 6 21905495 rs9350395 A G 0.28 0.241 0.304 0.278 0.27 0.295 0.226 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 24544739 rs16889440 T C 0.265 0.275 0.286 0.189 0.464 0.426 0.228 0.047 0.1077 0 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 6 24651092 rs3181245 G C 0.466 0.432 0.455 0.39 0.437 0.43 0.535 0.0087 0 0.0094 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 6 25513951 rs35789010 A G 0.009 0.009 0.009 0.035 0 0 0.009 0.0426 0.0139 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 25513951 rs35789010 A G 0.009 0.009 0.009 0.035 0 0 0.009 0.0426 0.0139 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 25513951 rs35789010 A G 0.009 0.009 0.009 0.035 0 0 0.009 0.0426 0.0139 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 6 25684378 rs13191296 T C 0.017 0.027 0.018 0.061 0.005 0 0.032 0.0549 0.0343 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 25684378 rs13191296 T C 0.017 0.027 0.018 0.061 0.005 0 0.032 0.0549 0.0343 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 6 26090951 rs1799945 G C 0.004 0.005 0.009 0 0.014 0.004 0 0.0028 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 6 26090951 rs1799945 G C 0.004 0.005 0.009 0 0.014 0.004 0 0.0028 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 6 26158765 rs1009181 C T 0.346 0.392 0.469 0.439 0.297 0.291 0.381 0.0142 0.0347 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 6 26171022 rs1059490 C T 0.28 0.311 0.371 0.355 0.198 0.209 0.292 0.0185 0.0462 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 6 26175638 rs17598658 C A 0.004 0 0.032 0.009 0 0 0.027 0 0.0116 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 26285639 rs3999544 C T 0.03 0.032 0.089 0.035 0.059 0.029 0.062 0.0013 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 26293110 rs7746807 A C 0.407 0.419 0.455 0.474 0.324 0.377 0.358 0.018 0.0139 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 6 26336344 rs34158769 A G 0.153 0.135 0.192 0.145 0.036 0.021 0.181 0.0104 0.1079 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 26402808 rs12200782 G C 0.025 0.005 0 0.017 0.009 0.02 0.004 0.0012 0 0.0016 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 6 26441412 rs13220495 T C 0.025 0.041 0.049 0.022 0.005 0.004 0.022 0 0.0161 0.0034 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 6 26463346 rs13195401 T G 0.03 0.037 0.046 0.027 0.009 0.004 0.023 0 0.015 0.0006 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 26568907 rs36162392 C T 0.043 0.054 0.077 0.026 0.018 0.004 0.044 0 0.0107 0.0154 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 26959823 rs80264589 A G 0.03 0.053 0.094 0.064 0.06 0.08 0.09 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 27307055 rs56114371 T C 0.026 0.032 0.049 0.022 0.023 0.004 0.066 0 0.0038 0.0105 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 27332531 rs13212562 G A 0.186 0.182 0.194 0.224 0.156 0.213 0.196 0.0024 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 28043738 rs149949 C T 0.165 0.108 0.108 0.144 0.099 0.082 0.146 0.0027 0.0107 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 6 28162011 rs1150668 T G 0 0.014 0.004 0.061 0.005 0.016 0 0.0988 0 0.0506 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 6 28162011 rs1150668 T G 0 0.014 0.004 0.061 0.005 0.016 0 0.0988 0 0.0506 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 6 28162011 rs1150668 T G 0 0.014 0.004 0.061 0.005 0.016 0 0.0988 0 0.0506 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 6 28282402 rs34878803 C T 0.085 0.041 0.04 0.07 0.009 0.008 0.031 0.0244 0.0467 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 6 28314117 rs34661125 A G 0.085 0.045 0.036 0.07 0.009 0.004 0.031 0.0276 0.0533 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 28336607 rs67340775 C A 0.085 0.045 0.036 0.057 0.009 0.004 0.035 0.0147 0.0448 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 28808340 rs4324798 A G 0.114 0.095 0.116 0.017 0.045 0.037 0.124 0.0255 0 0.0526 www.ncbi.nlm.nih.gov/pubmed/19836008 A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Lung adenocarcinoma 6 29388554 rs9257809 G A 0.013 0.018 0.009 0 0.005 0.012 0.013 0.0071 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 29509637 rs1233480 T C 0.157 0.216 0.259 0.165 0.257 0.213 0.266 0.0129 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 29723242 rs1362126 A G 0.136 0.182 0.13 0.239 0.176 0.16 0.093 0.0364 0 0.024 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 6 29739490 rs1633096 T G 0.297 0.252 0.246 0.174 0.261 0.32 0.235 0.0317 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Mixed cellularity Hodgkin lymphoma 6 29828908 rs1632941 T C 0.446 0.462 0.438 0.446 0.467 0.442 0.468 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 6 30003183 rs3094146 C G 0.004 0 0.004 0.017 0 0 0.022 0.0133 0.0133 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 30103160 rs1110446 T C 0.301 0.279 0.259 0.352 0.203 0.164 0.279 0.0379 0.0478 0 www.ncbi.nlm.nih.gov/pubmed/29784950 Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma. Hepatocellular carcinoma in hepatitis B infection 6 30105999 rs7767188 A G 0.102 0.104 0.125 0.117 0.104 0.103 0.111 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 30107326 rs2523992 G T 0.017 0.027 0.018 0.004 0.032 0.004 0.004 0.0048 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 30473526 rs3132615 T C 0.013 0.009 0.027 0.022 0.041 0.025 0.027 0 0.0014 0.0014 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 30576624 rs3132610 G A 0.017 0.014 0.018 0.013 0.032 0.016 0.04 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 30682249 rs9262142 A G 0 0 0.009 0.009 0.027 0.016 0.018 0 0.0056 0.0034 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 30793795 rs3129984 T C 0.013 0.014 0.013 0.026 0.027 0.016 0.018 0.0019 0 0.002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 31106253 rs6457327 A C 0.316 0.25 0.266 0.304 0.239 0.219 0.243 0.0063 0.0076 0 www.ncbi.nlm.nih.gov/pubmed/20639881 Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Follicular lymphoma 6 31106253 rs6457327 A C 0.316 0.25 0.266 0.304 0.239 0.219 0.243 0.0063 0.0076 0 www.ncbi.nlm.nih.gov/pubmed/19620980 Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Follicular lymphoma 6 31113428 rs2233956 C T 0.009 0.005 0.022 0.031 0.032 0.016 0.027 0.0034 0 0.0038 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 31113657 rs3094222 G A 0.097 0.104 0.071 0.052 0.144 0.127 0.075 0.0174 0.0197 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 31139481 rs2285803 T C 0.288 0.329 0.263 0.291 0.158 0.156 0.313 0.0013 0.0587 0 www.ncbi.nlm.nih.gov/pubmed/23955597 "Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk." Multiple myeloma 6 31148749 rs3132535 A G 0.292 0.329 0.284 0.317 0.194 0.172 0.336 0.0052 0.0499 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 6 31150734 rs130067 G T 0.212 0.18 0.188 0.222 0.198 0.156 0.155 0.0044 0 0 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer 6 31150734 rs130067 G T 0.212 0.18 0.188 0.222 0.198 0.156 0.155 0.0044 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 31268790 rs1049281 T C 0.284 0.291 0.228 0.239 0.346 0.295 0.27 0.0047 0.0095 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 6 31268790 rs1049281 T C 0.284 0.291 0.228 0.239 0.346 0.295 0.27 0.0047 0.0095 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 6 31277183 rs6919908 T C 0.161 0.158 0.103 0.174 0.168 0.16 0.138 0.0017 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma 6 31277183 rs6919908 T C 0.161 0.158 0.103 0.174 0.168 0.16 0.138 0.0017 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma and monoclonal gammopathy 6 31355013 rs2523607 A T 0.097 0.095 0.068 0.109 0.15 0.143 0.089 0 0.0105 0.0082 www.ncbi.nlm.nih.gov/pubmed/25261932 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Diffuse large B cell lymphoma 6 31356838 rs1050529 T C 0.147 0.17 0.176 0.12 0.173 0.226 0.194 0.0166 0.0054 0 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 6 31368124 rs2922994 G A 0.025 0.023 0.009 0.083 0.027 0.033 0.04 0.0515 0 0.0203 www.ncbi.nlm.nih.gov/pubmed/25569183 A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Marginal zone lymphoma 6 31398818 rs2596542 C T 0.432 0.418 0.411 0.557 0.496 0.488 0.383 0.028 0 0.0346 www.ncbi.nlm.nih.gov/pubmed/21499248 Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. Hepatocellular carcinoma 6 31479019 rs2248462 A G 0.131 0.141 0.121 0.165 0.032 0.054 0.156 0.0287 0.077 0 www.ncbi.nlm.nih.gov/pubmed/22286212 Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. Hodgkins lymphoma 6 31600692 rs2857595 A G 0.394 0.41 0.513 0.335 0.482 0.492 0.554 0.0506 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/25194280 Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Laryngeal squamous cell carcinoma 6 31652743 rs3117582 G T 0.017 0.05 0.071 0 0.045 0.078 0.049 0.0467 0.0046 0 www.ncbi.nlm.nih.gov/pubmed/19836008 A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Lung adenocarcinoma 6 31652743 rs3117582 G T 0.017 0.05 0.071 0 0.045 0.078 0.049 0.0467 0.0046 0 www.ncbi.nlm.nih.gov/pubmed/19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Lung cancer 6 31652743 rs3117582 G T 0.017 0.05 0.071 0 0.045 0.078 0.049 0.0467 0.0046 0 www.ncbi.nlm.nih.gov/pubmed/18978787 Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Lung cancer 6 31757508 rs3131378 G A 0.064 0.09 0.094 0.022 0.063 0.078 0.066 0.0298 0 0.0067 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 31857135 rs9267650 T A 0.138 0.176 0.104 0.11 0.122 0.161 0.111 0.0014 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 6 31915902 rs9267673 T C 0.25 0.257 0.225 0.202 0.257 0.176 0.19 0.0005 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/21105107 Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma. Hepatocellular carcinoma 6 32154695 rs3096696 A C 0.191 0.216 0.167 0.215 0.113 0.139 0.217 0.0061 0.024 0 www.ncbi.nlm.nih.gov/pubmed/25987655 Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Asparaginase hypersensitivity in acute lymphoblastic leukemia 6 32172710 rs3130284 C T 0.192 0.216 0.176 0.228 0.114 0.141 0.217 0.0104 0.028 0 www.ncbi.nlm.nih.gov/pubmed/25987655 Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Asparaginase hypersensitivity in acute lymphoblastic leukemia 6 32224554 rs3096702 A G 0.153 0.158 0.107 0.096 0.09 0.103 0.106 0.0008 0 0.0055 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 6 32224554 rs3096702 A G 0.153 0.158 0.107 0.096 0.09 0.103 0.106 0.0008 0 0.0055 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 32289789 rs926070 G A 0.25 0.264 0.33 0.461 0.171 0.225 0.345 0.1226 0.0593 0 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 32357594 rs13196329 C A 0.06 0.092 0.045 0.152 0.045 0.062 0.035 0.079 0 0.0135 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Mixed cellularity Hodgkin lymphoma 6 32400310 rs3817963 C T 0.119 0.14 0.103 0.339 0.108 0.061 0.106 0.255 0 0.0053 www.ncbi.nlm.nih.gov/pubmed/27501781 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. EGFR mutation-positive lung adenocarcinoma 6 32400310 rs3817963 C T 0.119 0.14 0.103 0.339 0.108 0.061 0.106 0.255 0 0.0053 www.ncbi.nlm.nih.gov/pubmed/22797724 A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Lung adenocarcinoma 6 32421528 rs9268557 C T 0.305 0.252 0.268 0.491 0.212 0.152 0.248 0.2024 0.0574 0 www.ncbi.nlm.nih.gov/pubmed/26272072 An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis (smoking interaction) 6 32433162 rs3129859 C G 0.195 0.176 0.205 0.304 0.212 0.238 0.12 0.0426 0 0.035 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 32446496 rs3129890 C T 0.509 0.437 0.353 0.226 0.419 0.496 0.398 0.1233 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/26272072 An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis (smoking interaction) 6 32447303 rs3129891 A G 0.269 0.25 0.201 0.122 0.32 0.332 0.177 0.0687 0.0498 0 www.ncbi.nlm.nih.gov/pubmed/26272072 An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis (smoking interaction) 6 32460508 rs6903608 C T 0.309 0.315 0.415 0.348 0.275 0.353 0.425 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/24149102 Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkins lymphoma. Hodgkins lymphoma 6 32460508 rs6903608 C T 0.309 0.315 0.415 0.348 0.275 0.353 0.425 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/21037568 "A genome-wide association study of Hodgkins lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)." Hodgkins lymphoma 6 32460508 rs6903608 C T 0.309 0.315 0.415 0.348 0.275 0.353 0.425 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/24920014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Hodgkins lymphoma 6 32461866 rs9268853 C T 0.177 0.198 0.188 0.222 0.255 0.164 0.204 0.0009 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 6 32465390 rs2395185 T G 0.174 0.198 0.188 0.219 0.246 0.15 0.204 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/22286212 Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. Hodgkins lymphoma 6 32465390 rs2395185 T G 0.174 0.198 0.188 0.219 0.246 0.15 0.204 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/23143601 Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Lung cancer 6 32473323 rs9269081 A C 0.254 0.257 0.384 0.326 0.288 0.357 0.416 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nodular sclerosis Hodgkin lymphoma 6 32476767 rs12195582 T C 0.216 0.252 0.21 0.344 0.302 0.225 0.217 0.0341 0 0.0219 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 6 32610305 rs674313 T C 0.38 0.387 0.339 0.57 0.387 0.402 0.339 0.0988 0 0.0333 www.ncbi.nlm.nih.gov/pubmed/21131588 Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Chronic lymphocytic leukemia 6 32610350 rs9271176 A G 0.309 0.333 0.313 0.104 0.306 0.365 0.354 0.1656 0 0.0123 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 6 32614112 rs4530903 T C 0.081 0.086 0.058 0.026 0.063 0.049 0.08 0.017 0 0.011 www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 6 32614873 rs3104413 G C 0.06 0.056 0.041 0.125 0.139 0.094 0.084 0.0114 0 0.0332 www.ncbi.nlm.nih.gov/pubmed/26272072 An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis (smoking interaction) 6 32615580 rs6931277 T A 0.06 0.054 0.04 0.133 0.155 0.105 0.084 0.0116 0 0.0449 www.ncbi.nlm.nih.gov/pubmed/26272072 An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis (smoking interaction) 6 32621489 rs35597309 A G 0.042 0.054 0.073 0.127 0.065 0.071 0.068 0.0358 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 6 32632222 rs9272105 G A 0.325 0.396 0.464 0.259 0.387 0.331 0.455 0.0439 0 0.0265 www.ncbi.nlm.nih.gov/pubmed/22807686 GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. Hepatocellular carcinoma 6 32658495 rs9273363 A C 0.085 0.059 0.094 0.088 0.18 0.074 0.066 0 0.0094 0.0048 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 32696681 rs2647012 T C 0.322 0.248 0.38 0.144 0.505 0.48 0.42 0.1842 0.0969 0 www.ncbi.nlm.nih.gov/pubmed/21533074 GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma. Follicular lymphoma 6 32697643 rs10484561 G T 0.131 0.153 0.149 0.239 0.132 0.141 0.173 0.0391 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/20639881 Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Follicular lymphoma 6 32700559 rs2647046 A C 0.314 0.25 0.371 0.13 0.482 0.463 0.42 0.1942 0.0824 0 www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 6 32703326 rs13192471 C T 0.222 0.305 0.237 0.304 0.252 0.279 0.23 0.0055 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 6 32711222 rs9275572 A G 0.407 0.401 0.46 0.196 0.609 0.598 0.478 0.2395 0.1238 0 www.ncbi.nlm.nih.gov/pubmed/21499248 Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. Hepatocellular carcinoma 6 32713706 rs7454108 C T 0.013 0.018 0.022 0.061 0.072 0.041 0.013 0.0148 0 0.0428 www.ncbi.nlm.nih.gov/pubmed/26272072 An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis (smoking interaction) 6 32774091 rs2621416 C T 0.171 0.135 0.183 0.087 0.177 0.197 0.137 0.033 0.0073 0 www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 6 32815309 rs7383287 G A 0.167 0.108 0.138 0.209 0.122 0.115 0.19 0.023 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 6 32819398 rs9784858 C G 0.254 0.252 0.149 0.408 0.162 0.219 0.212 0.1349 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/26272072 An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis (smoking interaction) 6 33020918 rs9296068 T G 0.267 0.275 0.362 0.378 0.527 0.541 0.438 0 0.0688 0.0211 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 33091097 rs2179920 T C 0.615 0.568 0.513 0.478 0.373 0.413 0.419 0 0.0235 0.016 www.ncbi.nlm.nih.gov/pubmed/27501781 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. EGFR mutation-positive lung adenocarcinoma 6 33093093 rs2295119 T G 0.125 0.1 0.138 0.144 0.236 0.221 0.133 0 0.0327 0.0106 www.ncbi.nlm.nih.gov/pubmed/29784950 Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma. Hepatocellular carcinoma in hepatitis B infection 6 33360927 rs114984535 C T 0.008 0.014 0.009 0.043 0.032 0.029 0.013 0.0169 0 0.0271 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 33572432 rs210134 A G 0.199 0.223 0.237 0.248 0.198 0.189 0.214 0.0039 0.003 0 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 34227234 rs1776897 G T 0.487 0.401 0.496 0.491 0.541 0.442 0.54 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 6 34227234 rs1776897 G T 0.487 0.401 0.496 0.491 0.541 0.442 0.54 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 6 34595387 rs205262 A G 0.312 0.315 0.29 0.329 0.225 0.283 0.301 0.0035 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 6 34595387 rs205262 A G 0.312 0.315 0.29 0.329 0.225 0.283 0.301 0.0035 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 6 34648545 rs3800461 C G 0.013 0.027 0.013 0.022 0.005 0.008 0.018 0.0024 0.0059 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 6 34956087 rs847845 G A 0.483 0.478 0.46 0.36 0.391 0.353 0.429 0.0064 0 0.0239 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 6 35037307 rs13210323 C A 0.407 0.387 0.339 0.326 0.32 0.316 0.381 0 0.0005 0.007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 6 35037307 rs13210323 C A 0.407 0.387 0.339 0.326 0.32 0.316 0.381 0 0.0005 0.007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 6 36655123 rs1321311 A C 0.394 0.446 0.433 0.435 0.46 0.402 0.424 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22634755 "Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk." Colorectal cancer 6 36676721 rs3829964 T C 0.227 0.189 0.147 0.087 0.059 0.078 0.125 0 0.0044 0.0446 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 37015416 rs12199978 T C 0.229 0.214 0.147 0.241 0.122 0.115 0.186 0.0234 0.0372 0 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in breast cancer 6 38179969 rs7742915 C T 0.551 0.5 0.536 0.422 0.396 0.475 0.513 0.0074 0 0.0228 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 6 40568389 rs2494938 G A 0.504 0.396 0.473 0.456 0.46 0.442 0.403 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23103227 Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. "Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma)" 6 41053183 rs2073016 C T 0 0 0 0 0.023 0.008 0.005 0 0.0135 0.0038 www.ncbi.nlm.nih.gov/pubmed/26222057 "Genome Wide Association Study for Predictors of Progression Free Survival in Patients on Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in First-Line Therapy of Metastatic Colorectal Cancer." Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) 6 41522750 rs2495239 A G 0.339 0.387 0.263 0.313 0.356 0.332 0.272 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/27501781 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. EGFR mutation-positive lung adenocarcinoma 6 41568689 rs1983891 C T 0.41 0.468 0.509 0.43 0.374 0.393 0.478 0 0.0069 0.0065 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 6 41654359 rs45483501 G C 0.106 0.063 0.107 0.061 0.099 0.119 0.08 0.0084 0.004 0 www.ncbi.nlm.nih.gov/pubmed/25261932 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Diffuse large B cell lymphoma 6 41725074 rs4711689 G A 0.021 0.032 0.045 0.07 0.023 0.016 0.031 0.0309 0.0067 0 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 6 43726861 rs4711748 C T 0.403 0.383 0.308 0.383 0.365 0.348 0.279 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 43790159 rs998584 A C 0.178 0.095 0.113 0.109 0.168 0.193 0.128 0.0045 0.0145 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 6 43790159 rs998584 A C 0.178 0.095 0.113 0.109 0.168 0.193 0.128 0.0045 0.0145 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 6 43796814 rs1358980 T C 0.119 0.072 0.08 0.109 0.05 0.045 0.102 0.0077 0.0228 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 6 43796814 rs1358980 T C 0.119 0.072 0.08 0.109 0.05 0.045 0.102 0.0077 0.0228 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 6 45538385 rs12209785 G A 0.021 0.032 0.036 0.026 0.005 0.008 0.036 0.0001 0.0136 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 6 50877777 rs2207139 G A 0.08 0.076 0.08 0.066 0.083 0.042 0.071 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 6 50877777 rs2207139 G A 0.08 0.076 0.08 0.066 0.083 0.042 0.071 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 6 50877777 rs2207139 G A 0.08 0.076 0.08 0.066 0.083 0.042 0.071 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 6 51271160 rs9370019 G A 0.076 0.059 0.089 0.074 0.063 0.09 0.08 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28081215 Genome-Wide Association Studies of Multiple Keratinocyte Cancers. Multiple keratinocyte cancers 6 52236941 rs763780 C T 0.093 0.09 0.085 0.144 0.059 0.078 0.08 0.029 0.005 0 www.ncbi.nlm.nih.gov/pubmed/22142827 A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Response to gemcitabine in pancreatic cancer 6 52236941 rs763780 C T 0.093 0.09 0.085 0.144 0.059 0.078 0.08 0.029 0.005 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 6 53312880 rs209489 C A 0 0 0 0.004 0.005 0 0.005 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/26586795 Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis. Survival in colorectal cancer (distant metastatic) 6 54400598 rs16885294 C T 0.174 0.234 0.196 0.204 0.171 0.18 0.199 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 6 54862053 rs924712 G A 0.496 0.446 0.411 0.561 0.347 0.357 0.527 0.0448 0.0523 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 54865546 rs1155750 A G 0.509 0.478 0.509 0.426 0.482 0.471 0.447 0.0054 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 6 56338876 rs9464379 T G 0.35 0.327 0.411 0.313 0.423 0.438 0.397 0.0158 0.0137 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 6 64722390 rs1889497 T A 0.402 0.369 0.388 0.347 0.387 0.373 0.394 0.0015 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/24980573 Identification of a melanoma susceptibility locus and somatic mutation in TET2. Melanoma 6 66290108 rs2214123 A G 0.229 0.268 0.17 0.27 0.356 0.34 0.235 0 0.0238 0.0171 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 6 68432116 rs9363918 G T 0.275 0.27 0.281 0.239 0.209 0.258 0.177 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 6 68812086 rs582962 A G 0.496 0.46 0.411 0.374 0.563 0.537 0.438 0.0312 0.0349 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 6 75528025 rs12207675 C T 0.072 0.108 0.049 0.088 0.135 0.061 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 6 75528025 rs12207675 C T 0.072 0.108 0.049 0.088 0.135 0.061 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 6 76693087 rs11753479 A G 0 0 0.004 0.004 0 0 0 0.0031 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 6 81418669 rs17529111 C T 0.047 0.059 0.036 0.043 0.018 0.02 0.044 0 0.0094 0.0003 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 6 81418669 rs17529111 C T 0.047 0.059 0.036 0.043 0.018 0.02 0.044 0 0.0094 0.0003 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 81418669 rs17529111 C T 0.047 0.059 0.036 0.043 0.018 0.02 0.044 0 0.0094 0.0003 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 6 81483392 rs17530068 C T 0.013 0.041 0.027 0.039 0.014 0.016 0.018 0.0072 0.0041 0 www.ncbi.nlm.nih.gov/pubmed/22976474 A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Breast cancer 6 81483392 rs17530068 C T 0.013 0.041 0.027 0.039 0.014 0.016 0.018 0.0072 0.0041 0 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 6 81483392 rs17530068 C T 0.013 0.041 0.027 0.039 0.014 0.016 0.018 0.0072 0.0041 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 6 81545215 rs9361840 G A 0.056 0.054 0.045 0.057 0.027 0.02 0.031 0.0044 0.0107 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 84379128 rs7768862 A T 0.326 0.339 0.315 0.272 0.38 0.413 0.397 0.0226 0.0122 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 85210757 rs6934651 C T 0.383 0.407 0.376 0.275 0.273 0.332 0.364 0.0111 0 0.0247 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 88856018 rs17503919 G A 0.017 0.018 0.022 0.053 0.005 0.008 0.022 0.0386 0.0146 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 6 91474644 rs73753762 G A 0.153 0.104 0.094 0.043 0.068 0.079 0.133 0.0197 0 0.0265 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 6 92812416 rs9445023 T G 0.513 0.509 0.54 0.342 0.487 0.446 0.396 0.0481 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/25194280 Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Laryngeal squamous cell carcinoma 6 93496526 rs9452333 C T 0.259 0.207 0.33 0.29 0.296 0.307 0.283 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 6 99880322 rs4840097 T C 0.424 0.396 0.46 0.322 0.532 0.48 0.482 0.0534 0.0191 0 www.ncbi.nlm.nih.gov/pubmed/23577725 Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. Age-related macular degeneration (smoking status interaction) 6 100057472 rs12209443 G A 0 0.005 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 6 103108352 rs9404319 C T 0.148 0.119 0.069 0.112 0.118 0.105 0.119 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 6 104949543 rs395962 T G 0.203 0.216 0.259 0.211 0.239 0.179 0.17 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 6 104949543 rs395962 T G 0.203 0.216 0.259 0.211 0.239 0.179 0.17 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 6 104949543 rs395962 T G 0.203 0.216 0.259 0.211 0.239 0.179 0.17 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 6 105883853 rs9689308 G A 0.047 0.054 0.049 0.139 0.117 0.143 0.04 0.0233 0 0.077 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in breast cancer 6 106219660 rs9372120 G T 0.093 0.077 0.036 0.048 0.018 0.008 0.035 0 0.0269 0.0013 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 6 108656460 rs9400239 C T 0.14 0.123 0.123 0.075 0.182 0.169 0.128 0.0272 0.0164 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 6 108963986 rs2273669 G A 0.36 0.338 0.353 0.283 0.482 0.467 0.332 0.028 0.0537 0 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 6 108963986 rs2273669 G A 0.36 0.338 0.353 0.283 0.482 0.467 0.332 0.028 0.0537 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 111672544 rs77437330 A G 0.056 0.05 0.036 0.093 0.081 0.116 0.027 0.0037 0 0.0336 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 6 113750518 rs7765004 C A 0.318 0.401 0.339 0.417 0.482 0.459 0.46 0 0.0092 0.0083 www.ncbi.nlm.nih.gov/pubmed/26460308 Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy. Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy 6 116888889 rs339331 C T 0.199 0.207 0.246 0.144 0.212 0.217 0.204 0.0181 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 6 116888889 rs339331 C T 0.199 0.207 0.246 0.144 0.212 0.217 0.204 0.0181 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 6 116888889 rs339331 C T 0.199 0.207 0.246 0.144 0.212 0.217 0.204 0.0181 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 6 116966680 rs72951719 T C 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 117465017 rs9387478 C A 0.081 0.05 0.058 0.083 0.09 0.057 0.053 0.0017 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/23143601 Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Lung cancer 6 117498194 rs2057314 A G 0.072 0.054 0.054 0.109 0.081 0.045 0.062 0.0192 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 6 117501830 rs4946260 C T 0.073 0.054 0.058 0.109 0.081 0.045 0.062 0.0183 0 0.0045 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 6 122394099 rs74392007 T C 0.085 0.068 0.049 0.061 0.131 0.103 0.049 0 0.0178 0.0017 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 122554525 rs76092474 T C 0.008 0.009 0 0.004 0.036 0.045 0.013 0 0.0273 0.0038 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 125688970 rs2797160 A G 0.323 0.302 0.32 0.389 0.396 0.369 0.388 0.002 0 0.0061 www.ncbi.nlm.nih.gov/pubmed/27008869 GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer. Endometrial cancer 6 125695434 rs13328298 G A 0.333 0.312 0.326 0.399 0.464 0.426 0.407 0 0.0079 0.0137 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial cancer 6 125695434 rs13328298 G A 0.333 0.312 0.326 0.399 0.464 0.426 0.407 0 0.0079 0.0137 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial endometrioid carcinoma 6 125701456 rs1777220 T G 0.487 0.5 0.469 0.43 0.323 0.34 0.405 0 0.029 0.0102 www.ncbi.nlm.nih.gov/pubmed/24096698 Genome-wide association study of endometrial cancer in E2C2. Endometrial cancer 6 127130971 rs1936805 C T 0.365 0.399 0.396 0.434 0.412 0.4 0.434 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 6 127130971 rs1936805 C T 0.365 0.399 0.396 0.434 0.412 0.4 0.434 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 6 127131790 rs2745353 C T 0.36 0.392 0.401 0.43 0.401 0.393 0.42 0.0009 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 6 127131790 rs2745353 C T 0.36 0.392 0.401 0.43 0.401 0.393 0.42 0.0009 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 6 127133993 rs7766106 T C 0.301 0.307 0.304 0.283 0.252 0.32 0.336 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 6 127133993 rs7766106 T C 0.301 0.307 0.304 0.283 0.252 0.32 0.336 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 6 127279485 rs2180341 G A 0.309 0.4 0.397 0.309 0.246 0.193 0.323 0 0.0326 0.0159 www.ncbi.nlm.nih.gov/pubmed/18326623 Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Breast cancer 6 130027974 rs6569648 C T 0 0.005 0 0.004 0 0.004 0 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 130027974 rs6569648 C T 0 0.005 0 0.004 0 0.004 0 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer 6 130027974 rs6569648 C T 0 0.005 0 0.004 0 0.004 0 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 6 130604622 rs1933755 C T 0.314 0.297 0.255 0.278 0.243 0.266 0.266 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/25192705 No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. Colorectal cancer (calcium intake interaction) 6 131242437 rs4629710 A G 0.025 0.023 0.014 0.022 0.027 0.033 0.009 0 0.0012 0.0012 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 6 131740280 rs17601580 A G 0.004 0.005 0.004 0.004 0.005 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer 6 133159801 rs1856293 A C 0.102 0.117 0.161 0.105 0.162 0.201 0.111 0.0036 0.0185 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 6 133287530 rs454953 A G 0.428 0.451 0.393 0.391 0.464 0.406 0.323 0 0.001 0.0001 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 6 133759717 rs76987554 T C 0.107 0.14 0.139 0.162 0.082 0.07 0.115 0.0182 0.0236 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 6 133759717 rs76987554 T C 0.107 0.14 0.139 0.162 0.082 0.07 0.115 0.0182 0.0236 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 6 134577318 rs228437 C T 0.159 0.164 0.154 0.164 0.136 0.148 0.173 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 6 135305210 rs6928977 T G 0.004 0.005 0 0.013 0.014 0 0 0.0086 0 0.0097 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Hodgkins lymphoma 6 135305210 rs6928977 T G 0.004 0.005 0 0.013 0.014 0 0 0.0086 0 0.0097 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nodular sclerosis Hodgkin lymphoma 6 137354404 rs13201877 G A 0 0.005 0 0.026 0 0.004 0.004 0.0443 0 0.0152 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 6 137354404 rs13201877 G A 0 0.005 0 0.026 0 0.004 0.004 0.0443 0 0.0152 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 6 138600907 rs7758889 A G 0.042 0.036 0.068 0.057 0.041 0.02 0.049 0.0021 0.0053 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 6 138600907 rs7758889 A G 0.042 0.036 0.068 0.057 0.041 0.02 0.049 0.0021 0.0053 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 6 138801103 rs10457678 G A 0.013 0.027 0.032 0.043 0.014 0.008 0.027 0.0146 0.0107 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 6 140848688 rs11155133 G A 0.331 0.234 0.255 0.274 0.286 0.262 0.323 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 6 142358435 rs6570507 G A 0.017 0.009 0.004 0.052 0.009 0 0.013 0.063 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 6 142358435 rs6570507 G A 0.017 0.009 0.004 0.052 0.009 0 0.013 0.063 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 6 142358435 rs6570507 G A 0.017 0.009 0.004 0.052 0.009 0 0.013 0.063 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 6 143337875 rs6901152 T C 0 0 0.018 0.035 0 0.008 0.018 0.0342 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 6 143412439 rs2496589 A C 0.059 0.108 0.045 0.117 0.072 0.094 0.066 0.0129 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 6 143622177 rs9390123 T C 0.301 0.282 0.335 0.257 0.383 0.353 0.443 0.0247 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/23108145 Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer. Lung Cancer (DNA repair capacity) 6 149287738 rs9485372 A G 0.203 0.194 0.214 0.209 0.135 0.119 0.195 0.003 0.0229 0 www.ncbi.nlm.nih.gov/pubmed/22383897 Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. Breast cancer 6 149287738 rs9485372 A G 0.203 0.194 0.214 0.209 0.135 0.119 0.195 0.003 0.0229 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 149598007 rs9322193 T G 0.165 0.09 0.103 0.113 0.077 0.111 0.115 0 0.0009 0.0009 www.ncbi.nlm.nih.gov/pubmed/27393504 Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung cancer 6 149977706 rs1853665 T C 0.466 0.482 0.473 0.447 0.59 0.463 0.469 0.0029 0.0072 0 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 6 150683634 rs17080102 C G 0.11 0.131 0.085 0.144 0.09 0.098 0.115 0.0081 0.0025 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 6 150683634 rs17080102 C G 0.11 0.131 0.085 0.144 0.09 0.098 0.115 0.0081 0.0025 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 6 150804007 rs10046301 C T 0.428 0.487 0.464 0.478 0.509 0.553 0.5 0 0.0053 0.002 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 6 151586613 rs4869742 C T 0.225 0.252 0.21 0.239 0.225 0.262 0.212 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21540461 A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. Chronic myeloid leukemia 6 151592978 rs3757318 A G 0.004 0.018 0.022 0.03 0.018 0.008 0 0.0116 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 6 151592978 rs3757318 A G 0.004 0.018 0.022 0.03 0.018 0.008 0 0.0116 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/27354352 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Breast cancer 6 151592978 rs3757318 A G 0.004 0.018 0.022 0.03 0.018 0.008 0 0.0116 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 6 151592978 rs3757318 A G 0.004 0.018 0.022 0.03 0.018 0.008 0 0.0116 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/24325915 Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. "Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)" 6 151618215 rs3734805 C A 0.013 0.054 0.04 0.043 0.086 0.053 0.009 0 0.0103 0.0101 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 6 151623479 rs9383936 A G 0.004 0.018 0.022 0.035 0.104 0.078 0.018 0 0.0437 0.0336 www.ncbi.nlm.nih.gov/pubmed/30323354 "BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts." BRCA1/2-negative high-risk breast cancer 6 151627231 rs2046210 G A 0.346 0.324 0.304 0.296 0.23 0.221 0.394 0 0.0206 0.0137 www.ncbi.nlm.nih.gov/pubmed/30323354 "BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts." BRCA1/2-negative high-risk breast cancer 6 151627231 rs2046210 G A 0.346 0.324 0.304 0.296 0.23 0.221 0.394 0 0.0206 0.0137 www.ncbi.nlm.nih.gov/pubmed/19219042 Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Breast cancer 6 151627231 rs2046210 G A 0.346 0.324 0.304 0.296 0.23 0.221 0.394 0 0.0206 0.0137 www.ncbi.nlm.nih.gov/pubmed/27354352 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Breast cancer 6 151627231 rs2046210 G A 0.346 0.324 0.304 0.296 0.23 0.221 0.394 0 0.0206 0.0137 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 6 151627231 rs2046210 G A 0.346 0.324 0.304 0.296 0.23 0.221 0.394 0 0.0206 0.0137 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 6 151627231 rs2046210 G A 0.346 0.324 0.304 0.296 0.23 0.221 0.394 0 0.0206 0.0137 www.ncbi.nlm.nih.gov/pubmed/23544013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. Breast Cancer in BRCA1 mutation carriers 6 151631197 rs9397437 A G 0.017 0.027 0.045 0.035 0.073 0.045 0.013 0 0.0094 0.0062 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 151631197 rs9397437 A G 0.017 0.027 0.045 0.035 0.073 0.045 0.013 0 0.0094 0.0062 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 6 151631197 rs9397437 A G 0.017 0.027 0.045 0.035 0.073 0.045 0.013 0 0.0094 0.0062 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast Cancer in BRCA1 mutation carriers 6 151634779 rs60954078 G A 0.348 0.383 0.393 0.474 0.482 0.434 0.374 0.0076 0 0.0219 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 151666222 rs9383938 T G 0.182 0.167 0.143 0.139 0.207 0.193 0.192 0.0062 0.0046 0 www.ncbi.nlm.nih.gov/pubmed/22976474 A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Breast cancer 6 151696556 rs1293936 T G 0.428 0.396 0.429 0.448 0.396 0.442 0.478 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27393504 Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Smoking status (current vs former) 6 151974478 rs9383951 C G 0.22 0.14 0.13 0.1 0.189 0.211 0.164 0.028 0.0095 0 www.ncbi.nlm.nih.gov/pubmed/22383897 Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. Breast cancer 6 152115881 rs2747652 T C 0.402 0.514 0.532 0.531 0.414 0.395 0.482 0.0132 0.0199 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 6 152115881 rs2747652 T C 0.402 0.514 0.532 0.531 0.414 0.395 0.482 0.0132 0.0199 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 6 153119944 rs1933488 G A 0.377 0.455 0.438 0.439 0.568 0.496 0.5 0 0.0157 0.0002 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 6 153119944 rs1933488 G A 0.377 0.455 0.438 0.439 0.568 0.496 0.5 0 0.0157 0.0002 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 154150090 rs4869818 G A 0.448 0.477 0.406 0.513 0.514 0.455 0.424 0.0058 0 0.0085 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 6 154157305 rs2236256 C A 0.466 0.514 0.455 0.522 0.478 0.475 0.447 0.0034 0 0.002 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 6 154800125 rs7740797 G C 0.021 0.027 0.04 0.013 0.077 0.09 0.053 0.0155 0.0306 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 6 155608667 rs35229355 T C 0.068 0.054 0.068 0.074 0.072 0.094 0.08 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 6 155876368 rs4269383 G A 0.339 0.368 0.473 0.329 0.259 0.279 0.363 0 0.015 0.0163 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 6 156266886 rs17087282 A G 0.28 0.216 0.241 0.165 0.333 0.295 0.31 0.0455 0.0146 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 6 158910228 rs78995442 T C 0.038 0.068 0.049 0.043 0.045 0.045 0.058 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 6 158947492 rs12216499 T G 0.059 0.05 0.058 0.07 0.122 0.087 0.044 0 0.0114 0.0088 www.ncbi.nlm.nih.gov/pubmed/24662972 Genome-wide interaction study of smoking and bladder cancer risk. Bladder cancer (smoking interaction) 6 160160342 rs651164 A G 0.292 0.284 0.241 0.187 0.302 0.23 0.252 0.0195 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 6 160160342 rs651164 A G 0.292 0.284 0.241 0.187 0.302 0.23 0.252 0.0195 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 6 160160511 rs4646284 G T 0.403 0.405 0.438 0.391 0.396 0.381 0.412 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 6 160412632 rs9364554 T C 0.013 0.005 0 0.009 0.014 0.008 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 6 160412632 rs9364554 T C 0.013 0.005 0 0.009 0.014 0.008 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 6 160412632 rs9364554 T C 0.013 0.005 0 0.009 0.014 0.008 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 6 160421505 rs3123636 C T 0.004 0 0.004 0.009 0.018 0.008 0.018 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/27262462 Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. Prostate cancer 6 161680146 rs9689649 C A 0.377 0.338 0.38 0.296 0.351 0.353 0.429 0.013 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/26908436 A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants. Squamous cell carcinoma 6 161798822 rs9458376 T C 0.292 0.314 0.342 0.352 0.321 0.357 0.419 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 6 161815043 rs3016539 C T 0.055 0.077 0.076 0.061 0.077 0.053 0.044 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 6 162612318 rs13191362 G A 0.034 0.059 0.054 0.03 0.077 0.07 0.031 0.0043 0.0108 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 6 162612318 rs13191362 G A 0.034 0.059 0.054 0.03 0.077 0.07 0.031 0.0043 0.0108 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 6 164192425 rs1034447 T C 0.568 0.555 0.572 0.404 0.35 0.405 0.545 0 0 0.0712 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 6 166922663 rs9459805 A G 0.284 0.338 0.383 0.33 0.293 0.299 0.31 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/24096698 Genome-wide association study of endometrial cancer in E2C2. Endometrial cancer 6 166976754 rs444210 G A 0.203 0.194 0.214 0.278 0.194 0.184 0.248 0.0187 0.0045 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 6 167093246 rs17615336 G A 0.12 0.113 0.116 0.209 0.136 0.131 0.146 0.0319 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 6 170017397 rs6940159 T C 0.407 0.396 0.473 0.465 0.365 0.451 0.429 0.0029 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 2750246 rs798502 C A 0.065 0.079 0.055 0.123 0.161 0.113 0.023 0.0027 0 0.0485 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 7 2750246 rs798502 C A 0.065 0.079 0.055 0.123 0.161 0.113 0.023 0.0027 0 0.0485 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 7 3520194 rs2705608 A C 0.161 0.155 0.179 0.23 0.18 0.197 0.168 0.0108 0 0.0085 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 7 5094305 rs12667108 T C 0 0.009 0.004 0.004 0 0 0 0.0015 0.0027 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 7 7867093 rs6463739 G C 0.256 0.273 0.284 0.364 0.356 0.332 0.348 0.0057 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 7 8512984 rs765855 A G 0.144 0.171 0.237 0.127 0.271 0.266 0.263 0.038 0.0236 0 www.ncbi.nlm.nih.gov/pubmed/23544013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. Breast Cancer in BRCA1 mutation carriers 7 12721416 rs7810893 C T 0.381 0.428 0.38 0.47 0.451 0.484 0.42 0.0018 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 14406292 rs6971925 T C 0.059 0.045 0.036 0.03 0.09 0.058 0.04 0.0049 0.0104 0 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 7 16822225 rs10253216 G A 0.368 0.404 0.391 0.354 0.351 0.379 0.358 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) 7 16944656 rs1636744 T C 0.077 0.055 0.04 0.031 0.069 0.064 0.104 0.0138 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 7 16944656 rs1636744 T C 0.077 0.055 0.04 0.031 0.069 0.064 0.104 0.0138 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 7 16944656 rs1636744 T C 0.077 0.055 0.04 0.031 0.069 0.064 0.104 0.0138 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 7 17014722 rs3944100 C T 0.042 0.045 0.04 0.03 0.059 0.09 0.062 0.0064 0.0102 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 7 17203933 rs145145722 C T 0.068 0.032 0.027 0.03 0.027 0.053 0.058 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 7 19121274 rs10275272 T C 0.407 0.441 0.436 0.373 0.505 0.475 0.464 0.0166 0.011 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 7 20353164 rs2214442 A G 0.314 0.315 0.362 0.344 0.432 0.389 0.319 0 0.0111 0.0039 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 7 20353164 rs2214442 A G 0.314 0.315 0.362 0.344 0.432 0.389 0.319 0 0.0111 0.0039 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 7 20786833 rs34863300 G T 0.099 0.093 0.15 0.146 0.123 0.124 0.093 0.0038 0 0.0038 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 7 20954872 rs12155172 A G 0.136 0.104 0.081 0.178 0.127 0.078 0.12 0.0284 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 7 20954872 rs12155172 A G 0.136 0.104 0.081 0.178 0.127 0.078 0.12 0.0284 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 7 20954872 rs12155172 A G 0.136 0.104 0.081 0.178 0.127 0.078 0.12 0.0284 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 7 21544470 rs2285947 A G 0.385 0.396 0.402 0.465 0.626 0.546 0.381 0 0.048 0.0341 www.ncbi.nlm.nih.gov/pubmed/23103227 Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. "Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma)" 7 21888461 rs57104699 A C 0.064 0.05 0.054 0.048 0.068 0.037 0.066 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma 7 21888461 rs57104699 A C 0.064 0.05 0.054 0.048 0.068 0.037 0.066 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma and monoclonal gammopathy 7 21901342 rs7971 G A 0.085 0.063 0.063 0.07 0.095 0.094 0.08 0 0.0016 0.0004 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 22699143 rs4722166 C A 0.064 0.045 0.036 0.057 0.05 0.041 0.031 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 7 25529928 rs289997 T C 0.004 0 0 0.013 0.005 0 0 0.0185 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 25817905 rs4141278 C T 0.004 0.005 0.004 0.067 0.041 0.008 0.023 0.0704 0 0.0522 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 7 25817905 rs4141278 C T 0.004 0.005 0.004 0.067 0.041 0.008 0.023 0.0704 0 0.0522 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 7 25818994 rs10245353 A C 0.004 0.009 0 0.087 0.041 0.008 0.035 0.1003 0 0.0536 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 7 25822019 rs3902751 A G 0.371 0.419 0.514 0.487 0.401 0.413 0.482 0.0063 0.0052 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 7 26357619 rs1534696 C A 0.339 0.356 0.339 0.377 0.356 0.418 0.367 0 0.0009 0.0009 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 7 26517999 rs886716 A G 0.424 0.309 0.392 0.382 0.491 0.454 0.342 0 0.0193 0.004 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 7 27936944 rs10486567 A G 0.233 0.243 0.321 0.183 0.171 0.238 0.292 0.0092 0 0.0205 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 7 27936944 rs10486567 A G 0.233 0.243 0.321 0.183 0.171 0.238 0.292 0.0092 0 0.0205 www.ncbi.nlm.nih.gov/pubmed/18264096 Multiple loci identified in a genome-wide association study of prostate cancer. Prostate cancer 7 27936944 rs10486567 A G 0.233 0.243 0.321 0.183 0.171 0.238 0.292 0.0092 0 0.0205 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 7 27937744 rs7808935 C T 0.233 0.243 0.321 0.183 0.171 0.242 0.292 0.0096 0 0.0201 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 7 28144083 rs849140 T C 0.517 0.581 0.469 0.439 0.432 0.5 0.5 0.0061 0 0.0097 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 7 28144083 rs849140 T C 0.517 0.581 0.469 0.439 0.432 0.5 0.5 0.0061 0 0.0097 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 7 28317270 rs17156577 C T 0.39 0.405 0.366 0.33 0.293 0.447 0.332 0.0024 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 28828469 rs77702473 G C 0.157 0.176 0.174 0.213 0.153 0.176 0.186 0.0056 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 28974579 rs2018683 T G 0.194 0.207 0.156 0.235 0.185 0.242 0.192 0.0036 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/23478653 A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy. Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer 7 29068376 rs34541550 G A 0.038 0.027 0.036 0.022 0.018 0 0.031 0 0.008 0.0042 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 7 29139570 rs9639594 A G 0.107 0.079 0.08 0.08 0.06 0.041 0.096 0 0.0087 0.0029 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 7 29416664 rs79489058 T C 0 0.005 0 0 0.005 0 0.004 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 7 31076553 rs12668955 A G 0.292 0.302 0.32 0.27 0.259 0.221 0.288 0 0.004 0.0047 www.ncbi.nlm.nih.gov/pubmed/27957625 A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants. Cluster headache 7 32307723 rs215614 G A 0.42 0.46 0.441 0.531 0.478 0.467 0.387 0.0162 0 0.0146 www.ncbi.nlm.nih.gov/pubmed/20418888 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Smoking behavior 7 34103644 rs1420338 A G 0.517 0.446 0.531 0.4 0.5 0.479 0.593 0.0285 0 0.0144 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 7 36645539 rs7794780 T C 0.271 0.297 0.339 0.287 0.323 0.271 0.336 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 7 36899717 rs59964204 A G 0.291 0.196 0.21 0.246 0.09 0.094 0.181 0.0218 0.0823 0 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Plasma androstenedione levels in resected early stage-receptor positive breast cancer 7 37006815 rs17170827 C T 0.352 0.396 0.402 0.386 0.392 0.344 0.301 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 7 37226747 rs4723619 C T 0.097 0.105 0.08 0.083 0.041 0.061 0.093 0 0.0091 0.0029 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 7 37522765 rs1425132 G A 0.314 0.315 0.335 0.377 0.338 0.353 0.305 0.0047 0 0.0051 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) 7 40322235 rs3857747 G C 0.318 0.275 0.321 0.465 0.3 0.291 0.375 0.0665 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 7 40442213 rs2329775 C A 0.392 0.355 0.4 0.496 0.408 0.41 0.451 0.0202 0 0.0063 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 7 40827064 rs17688601 A C 0.03 0.027 0.045 0.017 0.014 0.008 0.031 0 0.0029 0.0067 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 7 40827064 rs17688601 A C 0.03 0.027 0.045 0.017 0.014 0.008 0.031 0 0.0029 0.0067 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 7 40835593 rs17621345 C A 0.106 0.105 0.104 0.061 0.099 0.05 0.111 0.0048 0 0.0102 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 7 43004867 rs2877187 T C 0.097 0.146 0.098 0.135 0.059 0.061 0.08 0.0147 0.0225 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 7 43187042 rs73099645 G A 0.004 0 0 0.022 0.052 0.035 0.014 0 0.012 0.0341 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 7 47403036 rs7776701 C T 0.025 0.032 0.009 0.061 0.055 0.025 0.022 0.0179 0 0.0191 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 7 47448971 rs73328514 T A 0.263 0.284 0.25 0.239 0.36 0.314 0.255 0.0044 0.0175 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 7 50398606 rs11978267 G A 0.203 0.216 0.207 0.152 0.18 0.168 0.21 0.0051 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/29348612 GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Acute lymphoblastic leukemia (childhood) 7 50398606 rs11978267 G A 0.203 0.216 0.207 0.152 0.18 0.168 0.21 0.0051 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 7 50398606 rs11978267 G A 0.203 0.216 0.207 0.152 0.18 0.168 0.21 0.0051 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 7 50402283 rs11980379 C T 0.216 0.252 0.223 0.183 0.189 0.193 0.221 0.0019 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/23996088 Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Acute lymphoblastic leukemia (B-cell precursor) 7 50402283 rs11980379 C T 0.216 0.252 0.223 0.183 0.189 0.193 0.221 0.0019 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Acute lymphoblastic leukemia (B-cell precursor) 7 50402283 rs11980379 C T 0.216 0.252 0.223 0.183 0.189 0.193 0.221 0.0019 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Acute lymphoblastic leukemia in childhood (B cell precursor) 7 50402283 rs11980379 C T 0.216 0.252 0.223 0.183 0.189 0.193 0.221 0.0019 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia (hyperdiploid negative) 7 50402283 rs11980379 C T 0.216 0.252 0.223 0.183 0.189 0.193 0.221 0.0019 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia (normal cytogenetics) 7 50402283 rs11980379 C T 0.216 0.252 0.223 0.183 0.189 0.193 0.221 0.0019 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) 7 50402906 rs4132601 G T 0.216 0.252 0.223 0.183 0.189 0.196 0.221 0.0021 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/19684604 "Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia." Acute lymphoblastic leukemia (childhood) 7 50402906 rs4132601 G T 0.216 0.252 0.223 0.183 0.189 0.196 0.221 0.0021 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 7 50402906 rs4132601 G T 0.216 0.252 0.223 0.183 0.189 0.196 0.221 0.0021 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/29632299 Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia in childhood (B cell precursor) 7 50405553 rs6964969 G A 0.216 0.248 0.225 0.183 0.189 0.174 0.221 0.0004 0 0.006 www.ncbi.nlm.nih.gov/pubmed/23512250 Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. Acute lymphoblastic leukemia (childhood) 7 50410929 rs1110701 G A 0.295 0.336 0.306 0.195 0.422 0.401 0.304 0.0684 0.0448 0 www.ncbi.nlm.nih.gov/pubmed/25310577 "Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures." Acute lymphoblastic leukemia (childhood) 7 50498129 rs2167364 C T 0.197 0.214 0.228 0.165 0.113 0.157 0.199 0 0.0062 0.0121 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 7 51797912 rs4947642 A G 0.064 0.099 0.076 0.091 0.122 0.119 0.076 0 0.0058 0.0042 www.ncbi.nlm.nih.gov/pubmed/25189868 Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. Blood pressure (smoking interaction) 7 53059866 rs1174864 A G 0.504 0.5 0.487 0.544 0.419 0.43 0.46 0.0141 0.0145 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 7 55125270 rs12718945 G T 0.303 0.32 0.338 0.378 0.383 0.406 0.376 0 0.0017 0.0057 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 67594280 rs10263639 C T 0.186 0.207 0.165 0.135 0.198 0.143 0.239 0.0093 0 0.0091 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 7 69359109 rs2271032 G A 0.008 0.014 0.014 0.022 0.009 0.016 0 0.0043 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 75533848 rs1167827 A G 0.026 0.027 0.036 0.043 0.092 0.078 0.035 0 0.0213 0.0112 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 7 75533848 rs1167827 A G 0.026 0.027 0.036 0.043 0.092 0.078 0.035 0 0.0213 0.0112 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 7 76307732 rs2908197 A G 0.259 0.257 0.32 0.252 0.132 0.123 0.268 0 0.0638 0.0044 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 7 76978826 rs2245368 C T 0.164 0.173 0.143 0.126 0.297 0.321 0.137 0.0098 0.0876 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 7 76978826 rs2245368 C T 0.164 0.173 0.143 0.126 0.297 0.321 0.137 0.0098 0.0876 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 7 78053573 rs3807766 T C 0.119 0.14 0.156 0.11 0.189 0.16 0.15 0.0078 0.007 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 7 78702149 rs1496766 C T 0.157 0.149 0.17 0.139 0.05 0.049 0.124 0.0029 0.056 0 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 7 92001306 rs6964587 G T 0.478 0.468 0.523 0.465 0.422 0.459 0.456 0 0.001 0.001 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 7 92001306 rs6964587 G T 0.478 0.468 0.523 0.465 0.422 0.459 0.456 0 0.001 0.001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 92624658 rs10269774 A G 0.402 0.383 0.339 0.351 0.455 0.418 0.451 0.0071 0.0064 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 7 92624658 rs10269774 A G 0.402 0.383 0.339 0.351 0.455 0.418 0.451 0.0071 0.0064 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 7 93052129 rs2188179 A G 0.445 0.418 0.433 0.39 0.374 0.351 0.469 0 0.0037 0.0092 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 7 93568420 rs9641123 C G 0.008 0.009 0.009 0.017 0.018 0.049 0.031 0 0.0059 0.0033 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 7 93568420 rs9641123 C G 0.008 0.009 0.009 0.017 0.018 0.049 0.031 0 0.0059 0.0033 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 7 93719703 rs1858826 C T 0.144 0.095 0.147 0.132 0.108 0.078 0.133 0 0.006 0 www.ncbi.nlm.nih.gov/pubmed/29278617 Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci. Taxane-induced peripheral neuropathy in breast cancer 7 94758031 rs10269006 T G 0.282 0.23 0.309 0.348 0.252 0.261 0.279 0.0186 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 96952499 rs17598306 T C 0.106 0.099 0.076 0.096 0.032 0.049 0.115 0.0015 0.0258 0 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 7 98187015 rs6465657 T C 0.004 0.014 0.009 0.07 0.018 0.045 0.013 0.061 0 0.0603 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 7 98187015 rs6465657 T C 0.004 0.014 0.009 0.07 0.018 0.045 0.013 0.061 0 0.0603 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 7 98187015 rs6465657 T C 0.004 0.014 0.009 0.07 0.018 0.045 0.013 0.061 0 0.0603 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 7 98397243 rs79518236 A CT 0.161 0.207 0.259 0.239 0.114 0.18 0.27 0.0051 0.0231 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 101775373 rs73183643 A G 0.025 0.032 0.027 0.048 0.041 0.078 0.045 0 0.0032 0.0061 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 7 105115908 rs1144 C T 0.259 0.27 0.205 0.257 0.162 0.156 0.19 0.0076 0.0239 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 7 106650672 rs17507636 T C 0.106 0.113 0.094 0.126 0.126 0.189 0.106 0 0.0071 0.0065 www.ncbi.nlm.nih.gov/pubmed/30213928 Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Multiple myeloma 7 106650672 rs17507636 T C 0.106 0.113 0.094 0.126 0.126 0.189 0.106 0 0.0071 0.0065 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 7 106771412 rs17477177 C T 0.047 0.056 0.031 0.062 0.023 0.025 0.049 0.0081 0.0119 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 7 107142238 rs3752645 A G 0.073 0.072 0.089 0.078 0.032 0.053 0.128 0 0.0135 0.0031 www.ncbi.nlm.nih.gov/pubmed/24662972 Genome-wide interaction study of smoking and bladder cancer risk. Bladder cancer (smoking interaction) 7 108904404 rs1404697 C G 0.068 0.05 0.031 0.027 0.023 0.025 0.04 0 0.0006 0.0061 www.ncbi.nlm.nih.gov/pubmed/22006218 Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Smoking behavior 7 108908603 rs848353 G A 0.393 0.364 0.342 0.323 0.428 0.463 0.365 0.0113 0.021 0 www.ncbi.nlm.nih.gov/pubmed/22006218 Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Smoking behavior 7 111532578 rs2529491 T C 0.047 0.09 0.094 0.122 0.113 0.112 0.164 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 7 117299233 rs114167782 T C 0.021 0.027 0.018 0.044 0.018 0.016 0.031 0.0104 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 7 117883655 rs10233018 A G 0.401 0.432 0.433 0.348 0.477 0.467 0.425 0.0217 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 7 117883655 rs10233018 A G 0.401 0.432 0.433 0.348 0.477 0.467 0.425 0.0217 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 7 117883655 rs10233018 A G 0.401 0.432 0.433 0.348 0.477 0.467 0.425 0.0217 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 7 118351841 rs41997 G A 0.106 0.078 0.09 0.066 0.146 0.116 0.062 0.005 0.0156 0 www.ncbi.nlm.nih.gov/pubmed/22872573 Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Response to platinum-based chemotherapy in non-small-cell lung cancer 7 118519495 rs2106595 A G 0.034 0.027 0.036 0.044 0.036 0.004 0.009 0.0072 0.0021 0 www.ncbi.nlm.nih.gov/pubmed/23049750 Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. Smoking behavior 7 124752458 rs2267708 T C 0.487 0.482 0.469 0.491 0.514 0.5 0.491 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 7 124756591 rs4731207 G A 0.509 0.482 0.518 0.5 0.464 0.484 0.491 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 7 130900794 rs157935 G T 0.203 0.144 0.201 0.135 0.095 0.09 0.208 0 0.0163 0.0218 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 7 130900794 rs157935 G T 0.203 0.144 0.201 0.135 0.095 0.09 0.208 0 0.0163 0.0218 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 7 130900794 rs157935 G T 0.203 0.144 0.201 0.135 0.095 0.09 0.208 0 0.0163 0.0218 www.ncbi.nlm.nih.gov/pubmed/24403052 Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Basal cell carcinoma 7 130900794 rs157935 G T 0.203 0.144 0.201 0.135 0.095 0.09 0.208 0 0.0163 0.0218 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 7 130969092 rs2048672 C A 0.225 0.194 0.205 0.244 0.158 0.16 0.243 0.0067 0.0166 0 www.ncbi.nlm.nih.gov/pubmed/21908515 Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. Breast cancer 7 130982362 rs4593472 T C 0.292 0.275 0.221 0.257 0.149 0.194 0.248 0 0.0219 0.0003 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 7 130982362 rs4593472 T C 0.292 0.275 0.221 0.257 0.149 0.194 0.248 0 0.0219 0.0003 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 130983859 rs6957511 C T 0.42 0.423 0.438 0.413 0.55 0.545 0.425 0.003 0.0342 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 7 130989722 rs68056147 A G 0.059 0.072 0.067 0.065 0.09 0.082 0.084 0 0.0002 0.0001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 130995762 rs6971499 C T 0.178 0.185 0.113 0.11 0.218 0.209 0.19 0.024 0.014 0 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 7 130995762 rs6971499 C T 0.178 0.185 0.113 0.11 0.218 0.209 0.19 0.024 0.014 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 7 130995762 rs6971499 C T 0.178 0.185 0.113 0.11 0.218 0.209 0.19 0.024 0.014 0 www.ncbi.nlm.nih.gov/pubmed/25086665 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Pancreatic cancer 7 131036046 rs10265693 A G 0.381 0.455 0.393 0.344 0.518 0.433 0.5 0.0277 0.0081 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 7 140002794 rs17837497 A G 0.148 0.095 0.085 0.1 0.158 0.16 0.071 0 0.0147 0.0017 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 7 140242504 rs11977670 A G 0.233 0.262 0.259 0.226 0.159 0.139 0.173 0 0.021 0.0008 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 144351809 rs62485509 T G 0 0 0 0.027 0 0.008 0.004 0.0481 0 0.0282 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 144377836 rs720475 A G 0.047 0.086 0.085 0.12 0.036 0.078 0.058 0.0257 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 7 144377836 rs720475 A G 0.047 0.086 0.085 0.12 0.036 0.078 0.058 0.0257 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 7 144377836 rs720475 A G 0.047 0.086 0.085 0.12 0.036 0.078 0.058 0.0257 0.0006 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 7 148932667 rs822531 C T 0.009 0.009 0 0.017 0.023 0.004 0.009 0.0033 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 7 148932667 rs822531 C T 0.009 0.009 0 0.017 0.023 0.004 0.009 0.0033 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 7 151253854 rs7781265 A G 0.346 0.335 0.286 0.342 0.368 0.383 0.292 0 0.0038 0.0038 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 7 153928758 rs6464375 T C 0.11 0.09 0.121 0.091 0.113 0.098 0.124 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 7 154889200 rs12534701 T G 0.158 0.203 0.165 0.187 0.158 0.221 0.208 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 7 155109147 rs2969540 T C 0.492 0.478 0.455 0.422 0.451 0.447 0.416 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/24662972 Genome-wide interaction study of smoking and bladder cancer risk. Bladder cancer (smoking interaction) 7 155608201 rs6948772 C T 0.254 0.243 0.241 0.3 0.32 0.299 0.323 0 0.0008 0.0028 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 7 157662767 rs1270639 T C 0.123 0.104 0.107 0.161 0.144 0.094 0.128 0.0088 0 0.003 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 8 1925374 rs2272613 T C 0.004 0.009 0.009 0 0.014 0.008 0.009 0.0053 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 8 3372208 rs17393453 T A 0.008 0.027 0.022 0.031 0.005 0.025 0 0.0065 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/28081215 Genome-Wide Association Studies of Multiple Keratinocyte Cancers. Multiple keratinocyte cancers 8 4247625 rs1714746 A G 0.339 0.329 0.302 0.27 0.302 0.238 0.266 0.0001 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 8 5017650 rs10112481 G T 0.178 0.194 0.304 0.164 0.207 0.197 0.261 0.0098 0 0.0094 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) 8 5689302 rs17362923 G C 0.136 0.122 0.176 0.167 0.159 0.09 0.168 0.0021 0.0039 0 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. "Response to radiotherapy in prostate cancer (toxicity, decreased urine stream)" 8 6781719 rs2936519 A G 0.513 0.446 0.441 0.517 0.36 0.405 0.412 0.0192 0.0187 0 www.ncbi.nlm.nih.gov/pubmed/26222057 "Genome Wide Association Study for Predictors of Progression Free Survival in Patients on Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in First-Line Therapy of Metastatic Colorectal Cancer." Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) 8 8525195 rs7823056 A G 0.538 0.496 0.473 0.367 0.55 0.508 0.433 0.0466 0.0086 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) 8 8525195 rs7823056 A G 0.538 0.496 0.473 0.367 0.55 0.508 0.433 0.0466 0.0086 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) 8 8525195 rs7823056 A G 0.538 0.496 0.473 0.367 0.55 0.508 0.433 0.0466 0.0086 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 8 8525195 rs7823056 A G 0.538 0.496 0.473 0.367 0.55 0.508 0.433 0.0466 0.0086 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 8 9293541 rs62493780 T C 0 0 0 0.017 0.005 0 0.004 0.0294 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) 8 9293541 rs62493780 T C 0 0 0 0.017 0.005 0 0.004 0.0294 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) 8 9293541 rs62493780 T C 0 0 0 0.017 0.005 0 0.004 0.0294 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 8 9293541 rs62493780 T C 0 0 0 0.017 0.005 0 0.004 0.0294 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 8 9538022 rs6601327 A G 0.53 0.527 0.536 0.426 0.373 0.377 0.509 0 0.012 0.0367 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 8 9744189 rs12545912 G T 0.271 0.302 0.321 0.435 0.423 0.463 0.354 0.0041 0 0.045 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 8 9932039 rs11786541 T G 0.201 0.243 0.205 0.109 0.086 0.139 0.195 0.0074 0 0.0416 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 8 9935152 rs2055729 A G 0.239 0.288 0.219 0.13 0.126 0.184 0.221 0.0151 0 0.0375 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 8 9946202 rs13271489 C T 0.11 0.15 0.161 0.07 0.078 0.092 0.106 0.0074 0 0.0173 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) 8 9946202 rs13271489 C T 0.11 0.15 0.161 0.07 0.078 0.092 0.106 0.0074 0 0.0173 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) 8 9946202 rs13271489 C T 0.11 0.15 0.161 0.07 0.078 0.092 0.106 0.0074 0 0.0173 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 8 9946202 rs13271489 C T 0.11 0.15 0.161 0.07 0.078 0.092 0.106 0.0074 0 0.0173 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 8 10403043 rs1962073 G A 0.089 0.117 0.089 0.171 0.108 0.135 0.133 0.0177 0 0.0097 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 8 10829027 rs35660623 T C 0.064 0.059 0.049 0.083 0.023 0.053 0.098 0.0057 0.0127 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 8 10980951 rs11779675 A G 0.184 0.221 0.144 0.174 0.14 0.139 0.12 0.0002 0.0018 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 8 11427626 rs12156238 C G 0.068 0.042 0.045 0.1 0.059 0.066 0.036 0.0212 0 0.0137 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 8 11437742 rs2898279 C G 0.297 0.285 0.273 0.272 0.188 0.24 0.248 0 0.0081 0.0011 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 8 11576400 rs2898290 T C 0.504 0.386 0.375 0.469 0.473 0.43 0.465 0.0006 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 8 11576400 rs2898290 T C 0.504 0.386 0.375 0.469 0.473 0.43 0.465 0.0006 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 8 11802194 rs12056541 C T 0.097 0.14 0.107 0.13 0.225 0.279 0.137 0 0.0585 0.0111 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 8 12915246 rs6989010 T G 0.081 0.09 0.04 0.07 0.041 0.049 0.049 0.0005 0.0028 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 8 13035349 rs113367091 T G 0.042 0.045 0.018 0.03 0.077 0.111 0.031 0 0.034 0.0033 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 8 15643458 rs12541402 C T 0 0 0.004 0.013 0.045 0.012 0 0 0.0058 0.0321 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 8 17650455 rs4921799 A G 0.331 0.356 0.357 0.391 0.4 0.369 0.393 0.0004 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/26732429 Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Adenocarcinoma 8 17650455 rs4921799 A G 0.331 0.356 0.357 0.391 0.4 0.369 0.393 0.0004 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/26732429 Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Lung cancer 8 17926905 rs11779988 C T 0.22 0.271 0.241 0.268 0.324 0.269 0.194 0 0.0036 0.0066 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 18415371 rs1495741 G A 0.47 0.464 0.382 0.355 0.458 0.39 0.389 0.0104 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 8 18415371 rs1495741 G A 0.47 0.464 0.382 0.355 0.458 0.39 0.389 0.0104 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 8 19793650 rs920590 T C 0.492 0.491 0.509 0.535 0.455 0.484 0.473 0.0047 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 8 21974983 rs3816788 A C 0.216 0.223 0.198 0.296 0.221 0.258 0.217 0.0159 0 0.0108 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 8 22634616 rs6558174 A G 0.453 0.5 0.518 0.474 0.369 0.442 0.549 0 0.0131 0.0063 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 23579239 rs2314686 A C 0.379 0.369 0.396 0.333 0.277 0.271 0.297 0 0.0118 0.0054 www.ncbi.nlm.nih.gov/pubmed/29423119 Meta-analysis of three genome-wide association studies identifies two loci that predict survival and treatment outcome in breast cancer. Survival in breast cancer (estrogen-receptor positive) 8 23581462 rs2928679 A G 0.242 0.216 0.143 0.283 0.324 0.291 0.192 0 0.0026 0.0319 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 8 23668950 rs1512268 C T 0.288 0.306 0.339 0.335 0.329 0.303 0.354 0 0 0 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 8 23668950 rs1512268 C T 0.288 0.306 0.339 0.335 0.329 0.303 0.354 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22923026 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Prostate cancer 8 23668950 rs1512268 C T 0.288 0.306 0.339 0.335 0.329 0.303 0.354 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 8 23668950 rs1512268 C T 0.288 0.306 0.339 0.335 0.329 0.303 0.354 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 8 23668950 rs1512268 C T 0.288 0.306 0.339 0.335 0.329 0.303 0.354 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 8 23676505 rs10503733 T G 0.292 0.275 0.246 0.244 0.212 0.242 0.297 0 0.0019 0.0037 www.ncbi.nlm.nih.gov/pubmed/22923026 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Prostate cancer 8 23745811 rs7830933 G A 0.288 0.297 0.315 0.313 0.234 0.287 0.252 0.0019 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 8 23745811 rs7830933 G A 0.288 0.297 0.315 0.313 0.234 0.287 0.252 0.0019 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 8 23745811 rs7830933 G A 0.288 0.297 0.315 0.313 0.234 0.287 0.252 0.0019 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 8 23745811 rs7830933 G A 0.288 0.297 0.315 0.313 0.234 0.287 0.252 0.0019 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 8 23801998 rs310291 G A 0.462 0.414 0.402 0.448 0.351 0.398 0.401 0.003 0.006 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 25974262 rs13256025 T C 0.038 0.045 0.067 0.052 0.023 0.037 0.049 0.0004 0.004 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 26034626 rs11135910 T C 0.076 0.059 0.112 0.104 0.14 0.09 0.102 0 0.0014 0.0015 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 8 26034626 rs11135910 T C 0.076 0.059 0.112 0.104 0.14 0.09 0.102 0 0.0014 0.0015 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 8 27563265 rs2741348 G T 0.276 0.236 0.266 0.333 0.236 0.221 0.217 0.027 0.0017 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 8 27882900 rs11774576 C T 0.458 0.432 0.509 0.409 0.536 0.504 0.46 0.0132 0.0111 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) 8 29486945 rs12548021 G A 0.18 0.158 0.192 0.104 0.284 0.242 0.181 0.0429 0.0377 0 www.ncbi.nlm.nih.gov/pubmed/23350875 A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. Colorectal cancer 8 29652100 rs9693444 A C 0.348 0.383 0.406 0.461 0.369 0.463 0.381 0.0089 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 8 29652100 rs9693444 A C 0.348 0.383 0.406 0.461 0.369 0.463 0.381 0.0089 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 8 29652100 rs9693444 A C 0.348 0.383 0.406 0.461 0.369 0.463 0.381 0.0089 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 31469533 rs7004520 T C 0.22 0.286 0.275 0.219 0.191 0.238 0.266 0 0.0001 0.0045 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 8 32552592 rs4236709 G A 0.364 0.342 0.353 0.209 0.318 0.326 0.314 0.0469 0 0.0144 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 8 32574851 rs2439302 G C 0.504 0.468 0.402 0.439 0.46 0.488 0.403 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/22267200 Discovery of common variants associated with low TSH levels and thyroid cancer risk. Thyroid cancer 8 32575278 rs2466076 G T 0.513 0.477 0.405 0.439 0.496 0.488 0.429 0.001 0.002 0 www.ncbi.nlm.nih.gov/pubmed/28195142 A genome-wide association study yields five novel thyroid cancer risk loci. Thyroid cancer 8 36992428 rs4286946 G C 0.017 0.009 0.004 0.017 0.05 0.033 0 0 0.0165 0.0148 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 37000965 rs13365225 G A 0.466 0.536 0.414 0.461 0.408 0.353 0.46 0 0.0146 0.0022 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 8 37000965 rs13365225 G A 0.466 0.536 0.414 0.461 0.408 0.353 0.46 0 0.0146 0.0022 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 8 37000965 rs13365225 G A 0.466 0.536 0.414 0.461 0.408 0.353 0.46 0 0.0146 0.0022 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 37000965 rs13365225 G A 0.466 0.536 0.414 0.461 0.408 0.353 0.46 0 0.0146 0.0022 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 8 38611785 rs7832232 G A 0.339 0.347 0.321 0.196 0.255 0.303 0.367 0.0419 0 0.0325 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 8 41756985 rs7831492 A G 0.36 0.347 0.397 0.391 0.405 0.455 0.372 0 0.004 0.0035 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 8 42695355 rs6474412 T C 0.216 0.216 0.261 0.283 0.374 0.357 0.286 0 0.0242 0.0136 www.ncbi.nlm.nih.gov/pubmed/20418888 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Smoking behavior 8 59633105 rs4737547 A G 0.148 0.164 0.158 0.191 0.151 0.117 0.165 0.0068 0.0047 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 8 70255759 rs2926702 C T 0.021 0.036 0.045 0.048 0.023 0.053 0.013 0.0031 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 8 71601993 rs12679556 T G 0.339 0.297 0.299 0.378 0.332 0.306 0.323 0.0086 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 8 71601993 rs12679556 T G 0.339 0.297 0.299 0.378 0.332 0.306 0.323 0.0086 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 8 71601993 rs12679556 T G 0.339 0.297 0.299 0.378 0.332 0.306 0.323 0.0086 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 8 71601993 rs12679556 T G 0.339 0.297 0.299 0.378 0.332 0.306 0.323 0.0086 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 8 74567389 rs13260300 C T 0.072 0.095 0.085 0.128 0.091 0.086 0.097 0.0096 0 0.003 www.ncbi.nlm.nih.gov/pubmed/27758888 Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy. Breast cancer-free interval (treatment with aromatase inhibitor) 8 75318066 rs6472903 G T 0.065 0.097 0.119 0.159 0.095 0.038 0.081 0.044 0.0104 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 8 75318066 rs6472903 G T 0.065 0.097 0.119 0.159 0.095 0.038 0.081 0.044 0.0104 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 8 75318066 rs6472903 G T 0.065 0.097 0.119 0.159 0.095 0.038 0.081 0.044 0.0104 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 75393550 rs72658071 T A 0.064 0.055 0.045 0.048 0.027 0.041 0.027 0 0.0004 0.0004 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 75498626 rs2926585 G A 0.28 0.239 0.308 0.322 0.252 0.225 0.288 0.0091 0.0078 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 75894349 rs17405819 C T 0.013 0.005 0.009 0.048 0.077 0.079 0.013 0 0.0118 0.0674 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 8 75894349 rs17405819 C T 0.013 0.005 0.009 0.048 0.077 0.079 0.013 0 0.0118 0.0674 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 8 76566304 rs28727938 G C 0.184 0.248 0.181 0.283 0.153 0.147 0.185 0.0417 0.019 0 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 8 80443628 rs16907718 C T 0.25 0.293 0.237 0.217 0.41 0.393 0.255 0.0168 0.0643 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 80887958 rs6473252 T C 0.055 0.059 0.054 0.065 0.068 0.074 0.035 0 0.001 0.0015 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 81074718 rs5003154 T C 0.162 0.182 0.165 0.175 0.159 0.184 0.133 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 8 91665813 rs6471291 T G 0.547 0.496 0.486 0.348 0.536 0.557 0.451 0.0729 0.0132 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 8 92177786 rs9987376 T G 0.317 0.269 0.366 0.295 0.368 0.395 0.342 0.0045 0.0111 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 8 92177786 rs9987376 T G 0.317 0.269 0.366 0.295 0.368 0.395 0.342 0.0045 0.0111 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 8 95107844 rs4392868 A G 0.076 0.041 0.107 0.091 0.135 0.143 0.12 0 0.0122 0.0033 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 8 95114802 rs7000734 G A 0.038 0.027 0.054 0.083 0.023 0.008 0.054 0.0392 0.0289 0 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 8 95279813 rs55821258 G C 0.237 0.162 0.201 0.157 0.378 0.328 0.212 0.0233 0.0777 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 8 95280875 rs112505062 A G 0.109 0.047 0.083 0.077 0.176 0.132 0.067 0 0.0298 0.0035 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 8 95583508 rs3104964 A G 0.457 0.478 0.491 0.517 0.496 0.492 0.42 0.0032 0 0.0039 www.ncbi.nlm.nih.gov/pubmed/23350875 A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. Colorectal cancer 8 100012277 rs7006527 C A 0.305 0.315 0.295 0.252 0.185 0.217 0.314 0 0.0132 0.0165 www.ncbi.nlm.nih.gov/pubmed/24403052 Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Basal cell carcinoma 8 100012277 rs7006527 C A 0.305 0.315 0.295 0.252 0.185 0.217 0.314 0 0.0132 0.0165 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 8 102566646 rs2511714 G T 0.5 0.581 0.433 0.53 0.383 0.369 0.491 0.0091 0.0428 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 8 102566646 rs2511714 G T 0.5 0.581 0.433 0.53 0.383 0.369 0.491 0.0091 0.0428 0 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 8 115234438 rs16887197 A G 0.212 0.185 0.126 0.202 0.144 0.152 0.181 0.0037 0.0048 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 8 115667320 rs13277568 A G 0.131 0.135 0.147 0.078 0.099 0.094 0.094 0.0058 0 0.0091 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 116197325 rs13267382 G A 0 0.018 0 0.022 0.032 0.012 0.005 0.0044 0 0.0161 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 8 116197325 rs13267382 G A 0 0.018 0 0.022 0.032 0.012 0.005 0.0044 0 0.0161 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 116353176 rs11778307 A G 0.136 0.149 0.174 0.17 0.086 0.111 0.168 0.0045 0.0186 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 8 116611854 rs2450115 C T 0.157 0.149 0.174 0.178 0.176 0.153 0.164 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 8 116611854 rs2450115 C T 0.157 0.149 0.174 0.178 0.176 0.153 0.164 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 8 116618444 rs16892766 C A 0.148 0.126 0.138 0.118 0.099 0.12 0.147 0 0.0012 0.0017 www.ncbi.nlm.nih.gov/pubmed/18372905 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Colorectal cancer 8 116618444 rs16892766 C A 0.148 0.126 0.138 0.118 0.099 0.12 0.147 0 0.0012 0.0017 www.ncbi.nlm.nih.gov/pubmed/21761138 Meta-analysis of new genome-wide association studies of colorectal cancer risk. Colorectal cancer 8 116618444 rs16892766 C A 0.148 0.126 0.138 0.118 0.099 0.12 0.147 0 0.0012 0.0017 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 8 116618444 rs16892766 C A 0.148 0.126 0.138 0.118 0.099 0.12 0.147 0 0.0012 0.0017 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 8 116635549 rs6469656 G A 0.229 0.207 0.167 0.104 0.173 0.184 0.186 0.0317 0 0.0109 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 8 116635549 rs6469656 G A 0.229 0.207 0.167 0.104 0.173 0.184 0.186 0.0317 0 0.0109 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 8 117178381 rs16889471 G A 0.44 0.437 0.411 0.413 0.414 0.467 0.367 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 117869627 rs10103490 C T 0.094 0.136 0.125 0.074 0.277 0.244 0.084 0.0175 0.1005 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 120102785 rs1519814 T G 0 0.009 0.004 0.004 0.014 0.004 0.027 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 123597926 rs58847541 A G 0.398 0.351 0.348 0.313 0.248 0.279 0.35 0 0.0104 0.0124 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 123726378 rs970821 T C 0.309 0.248 0.284 0.357 0.305 0.275 0.221 0.0185 0 0.0097 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 123745421 rs17350191 T C 0.042 0.045 0.013 0.017 0.059 0.029 0.022 0.0047 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer 8 123745421 rs17350191 T C 0.042 0.045 0.013 0.017 0.059 0.029 0.022 0.0047 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 8 123753462 rs10088262 G A 0.097 0.167 0.116 0.13 0.176 0.221 0.128 0 0.0184 0.003 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 8 125465736 rs2001945 G C 0.161 0.099 0.179 0.167 0.311 0.275 0.15 0 0.0575 0.0139 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 8 125465736 rs2001945 G C 0.161 0.099 0.179 0.167 0.311 0.275 0.15 0 0.0575 0.0139 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 8 126999692 rs10086908 C T 0.153 0.203 0.214 0.244 0.221 0.217 0.205 0.0043 0 0.005 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 8 127057790 rs10113175 C G 0.295 0.329 0.299 0.265 0.259 0.266 0.292 0 0.0001 0.0028 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in never smokers 8 127081052 rs1016343 T C 0.22 0.239 0.232 0.265 0.185 0.176 0.239 0.0079 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 8 127081052 rs1016343 T C 0.22 0.239 0.232 0.265 0.185 0.176 0.239 0.0079 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 8 127081052 rs1016343 T C 0.22 0.239 0.232 0.265 0.185 0.176 0.239 0.0079 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 8 127082911 rs13252298 G A 0 0.005 0.009 0.03 0.005 0.004 0.031 0.0213 0.0055 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 8 127082911 rs13252298 G A 0 0.005 0.009 0.03 0.005 0.004 0.031 0.0213 0.0055 0 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 8 127091692 rs1456315 C T 0.428 0.419 0.388 0.478 0.5 0.447 0.407 0.0024 0 0.0093 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 8 127091692 rs1456315 C T 0.428 0.419 0.388 0.478 0.5 0.447 0.407 0.0024 0 0.0093 www.ncbi.nlm.nih.gov/pubmed/23023329 Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Prostate cancer 8 127092098 rs13254738 A C 0.344 0.313 0.275 0.396 0.327 0.317 0.25 0.0215 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/22923026 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Prostate cancer 8 127094539 rs12682344 G T 0.331 0.364 0.397 0.313 0.234 0.256 0.482 0 0.0216 0.0301 www.ncbi.nlm.nih.gov/pubmed/24753544 Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. Prostate cancer 8 127094635 rs6983561 A C 0.475 0.496 0.406 0.491 0.599 0.566 0.372 0 0.0268 0.0179 www.ncbi.nlm.nih.gov/pubmed/22923026 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Prostate cancer 8 127094635 rs6983561 A C 0.475 0.496 0.406 0.491 0.599 0.566 0.372 0 0.0268 0.0179 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 8 127112671 rs16901979 A C 0.479 0.478 0.549 0.509 0.387 0.418 0.611 0 0.0277 0.0056 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 8 127112671 rs16901979 A C 0.479 0.478 0.549 0.509 0.387 0.418 0.611 0 0.0277 0.0056 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 8 127112671 rs16901979 A C 0.479 0.478 0.549 0.509 0.387 0.418 0.611 0 0.0277 0.0056 www.ncbi.nlm.nih.gov/pubmed/17401366 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Prostate cancer 8 127112671 rs16901979 A C 0.479 0.478 0.549 0.509 0.387 0.418 0.611 0 0.0277 0.0056 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 8 127112950 rs10505483 T C 0.483 0.478 0.549 0.504 0.387 0.418 0.611 0 0.027 0.0069 www.ncbi.nlm.nih.gov/pubmed/22923026 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Prostate cancer 8 127119564 rs116041037 A G 0.051 0.05 0.049 0.035 0.045 0.033 0.035 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 8 127175774 rs2466024 G A 0.339 0.338 0.326 0.317 0.207 0.213 0.372 0 0.0386 0.007 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 8 127198984 rs2466035 T C 0.203 0.27 0.232 0.309 0.159 0.161 0.208 0.0409 0.0306 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 8 127210176 rs1948915 T C 0.246 0.279 0.201 0.357 0.261 0.275 0.257 0.0315 0 0.0137 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 8 127308101 rs16902094 G A 0.097 0.113 0.112 0.144 0.117 0.123 0.075 0.006 0 0.007 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 8 127310936 rs445114 T C 0.252 0.271 0.297 0.266 0.317 0.338 0.255 0 0.0074 0.0005 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 8 127310936 rs445114 T C 0.252 0.271 0.297 0.266 0.317 0.338 0.255 0 0.0074 0.0005 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 8 127343372 rs13281615 G A 0.462 0.455 0.424 0.465 0.423 0.418 0.482 0.0001 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/17529967 Genome-wide association study identifies novel breast cancer susceptibility loci. Breast cancer 8 127343372 rs13281615 G A 0.462 0.455 0.424 0.465 0.423 0.418 0.482 0.0001 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 8 127343372 rs13281615 G A 0.462 0.455 0.424 0.465 0.423 0.418 0.482 0.0001 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 8 127343372 rs13281615 G A 0.462 0.455 0.424 0.465 0.423 0.418 0.482 0.0001 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 127343372 rs13281615 G A 0.462 0.455 0.424 0.465 0.423 0.418 0.482 0.0001 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 8 127359926 rs10096351 A G 0.414 0.372 0.417 0.359 0.326 0.31 0.368 0 0.006 0.0059 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 127375606 rs1562430 C T 0.479 0.495 0.513 0.474 0.356 0.377 0.496 0 0.0295 0.006 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 8 127375606 rs1562430 C T 0.479 0.495 0.513 0.474 0.356 0.377 0.496 0 0.0295 0.006 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 8 127375779 rs2392780 A G 0.407 0.391 0.392 0.409 0.559 0.549 0.42 0 0.0467 0.0027 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 8 127395198 rs10505477 G A 0.076 0.1 0.063 0.174 0.072 0.053 0.097 0.0687 0.0063 0 www.ncbi.nlm.nih.gov/pubmed/24737748 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Colorectal cancer 8 127395198 rs10505477 G A 0.076 0.1 0.063 0.174 0.072 0.053 0.097 0.0687 0.0063 0 www.ncbi.nlm.nih.gov/pubmed/17618283 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Colorectal cancer 8 127395198 rs10505477 G A 0.076 0.1 0.063 0.174 0.072 0.053 0.097 0.0687 0.0063 0 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 8 127395198 rs10505477 G A 0.076 0.1 0.063 0.174 0.072 0.053 0.097 0.0687 0.0063 0 www.ncbi.nlm.nih.gov/pubmed/28960316 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. Colorectal cancer 8 127395198 rs10505477 G A 0.076 0.1 0.063 0.174 0.072 0.053 0.097 0.0687 0.0063 0 www.ncbi.nlm.nih.gov/pubmed/24740154 Genome-wide association scan for variants associated with early-onset prostate cancer. Prostate cancer (early onset) 8 127398703 rs12682374 G C 0.038 0.077 0.049 0.109 0.045 0.016 0.053 0.0459 0.0165 0 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/21242260 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/17618284 A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/28960316 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/18372905 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/24753544 Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. Prostate cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/17401363 Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Prostate cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/18264096 Multiple loci identified in a genome-wide association study of prostate cancer. Prostate cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 8 127401060 rs6983267 T G 0.008 0.018 0.013 0.03 0.023 0.012 0.031 0.0026 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/24740154 Genome-wide association scan for variants associated with early-onset prostate cancer. Prostate cancer (early onset) 8 127412547 rs7014346 A G 0.424 0.41 0.393 0.404 0.41 0.348 0.42 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 8 127412547 rs7014346 A G 0.424 0.41 0.393 0.404 0.41 0.348 0.42 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 8 127412547 rs7014346 A G 0.424 0.41 0.393 0.404 0.41 0.348 0.42 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/18372901 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Colorectal cancer 8 127472793 rs1447295 A C 0.352 0.405 0.464 0.309 0.378 0.43 0.42 0.0248 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/24753544 Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. Prostate cancer 8 127472793 rs1447295 A C 0.352 0.405 0.464 0.309 0.378 0.43 0.42 0.0248 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/17401363 Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Prostate cancer 8 127472793 rs1447295 A C 0.352 0.405 0.464 0.309 0.378 0.43 0.42 0.0248 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 8 127472793 rs1447295 A C 0.352 0.405 0.464 0.309 0.378 0.43 0.42 0.0248 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/17401366 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Prostate cancer 8 127472793 rs1447295 A C 0.352 0.405 0.464 0.309 0.378 0.43 0.42 0.0248 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 8 127472793 rs1447295 A C 0.352 0.405 0.464 0.309 0.378 0.43 0.42 0.0248 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 8 127505328 rs4242382 A G 0.364 0.333 0.411 0.4 0.239 0.275 0.341 0.0132 0.0374 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 8 127505328 rs4242382 A G 0.364 0.333 0.411 0.4 0.239 0.275 0.341 0.0132 0.0374 0 www.ncbi.nlm.nih.gov/pubmed/18264096 Multiple loci identified in a genome-wide association study of prostate cancer. Prostate cancer 8 127506309 rs4242384 C A 0.17 0.167 0.183 0.2 0.063 0.103 0.181 0.016 0.0515 0 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 8 127506309 rs4242384 C A 0.17 0.167 0.183 0.2 0.063 0.103 0.181 0.016 0.0515 0 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 8 127506309 rs4242384 C A 0.17 0.167 0.183 0.2 0.063 0.103 0.181 0.016 0.0515 0 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 8 127527115 rs7837688 T G 0.055 0.059 0.018 0.074 0.059 0.086 0.053 0.0017 0 0.0076 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 8 127705823 rs9642880 G T 0.212 0.144 0.21 0.122 0.185 0.184 0.204 0.0184 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 8 127705823 rs9642880 G T 0.212 0.144 0.21 0.122 0.185 0.184 0.204 0.0184 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 8 127705823 rs9642880 G T 0.212 0.144 0.21 0.122 0.185 0.184 0.204 0.0184 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/20348956 A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Urinary bladder cancer 8 127705823 rs9642880 G T 0.212 0.144 0.21 0.122 0.185 0.184 0.204 0.0184 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/18794855 Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Urinary bladder cancer 8 127707639 rs10094872 T A 0.233 0.216 0.214 0.304 0.23 0.289 0.257 0.0105 0 0.0096 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 8 127707639 rs10094872 T A 0.233 0.216 0.214 0.304 0.23 0.289 0.257 0.0105 0 0.0096 www.ncbi.nlm.nih.gov/pubmed/27579533 "Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21." Pancreatic cancer 8 127707639 rs10094872 T A 0.233 0.216 0.214 0.304 0.23 0.289 0.257 0.0105 0 0.0096 www.ncbi.nlm.nih.gov/pubmed/24861552 Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. Urinary bladder cancer 8 127884833 rs17775239 A T 0.107 0.09 0.085 0.157 0.1 0.083 0.12 0.0214 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 8 128064205 rs13254990 T C 0.021 0.032 0.031 0.044 0.072 0.033 0.027 0 0.0018 0.0059 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 8 128064327 rs13255292 T C 0.03 0.018 0.031 0.022 0.059 0.025 0.031 0.0007 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/25261932 Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Diffuse large B cell lymphoma 8 128102971 rs2720680 G A 0.186 0.189 0.192 0.239 0.203 0.266 0.204 0.0014 0 0.0062 www.ncbi.nlm.nih.gov/pubmed/28112199 "Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci." "B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)" 8 128126960 rs17382698 C T 0.008 0.009 0.009 0.009 0.027 0.033 0.009 0 0.0114 0.0032 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 8 128157880 rs2608029 G C 0.339 0.326 0.279 0.348 0.306 0.316 0.274 0.0021 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 8 128180025 rs2019960 C T 0.415 0.419 0.442 0.448 0.455 0.439 0.531 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24149102 Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkins lymphoma. Hodgkins lymphoma 8 128180025 rs2019960 C T 0.415 0.419 0.442 0.448 0.455 0.439 0.531 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21037568 "A genome-wide association study of Hodgkins lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)." Hodgkins lymphoma 8 128180025 rs2019960 C T 0.415 0.419 0.442 0.448 0.455 0.439 0.531 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24920014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Hodgkins lymphoma 8 128182395 rs11780156 T C 0.008 0.009 0 0.013 0.014 0 0 0.0034 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 8 128182395 rs11780156 T C 0.008 0.009 0 0.013 0.014 0 0 0.0034 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 8 128182395 rs11780156 T C 0.008 0.009 0 0.013 0.014 0 0 0.0034 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 128192016 rs7017073 C T 0.286 0.257 0.205 0.217 0.171 0.119 0.199 0 0.0234 0.0048 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 8 128523018 rs67824503 C T 0.212 0.185 0.239 0.193 0.214 0.215 0.283 0.0016 0 0.0016 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 8 128525500 rs17232730 C G 0.059 0.059 0.086 0.026 0.099 0.062 0.066 0.0225 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial cancer 8 128555832 rs1561927 T C 0.393 0.36 0.375 0.426 0.311 0.316 0.314 0.0178 0.0104 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 8 128555832 rs1561927 T C 0.393 0.36 0.375 0.426 0.311 0.316 0.314 0.0178 0.0104 0 www.ncbi.nlm.nih.gov/pubmed/25086665 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Pancreatic cancer 8 129143897 rs4617118 G A 0.409 0.311 0.338 0.332 0.408 0.441 0.324 0.0021 0.0152 0 www.ncbi.nlm.nih.gov/pubmed/29348612 GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Acute lymphoblastic leukemia (childhood) 8 129724451 rs6470765 A C 0.25 0.302 0.237 0.259 0.23 0.227 0.168 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 8 129724451 rs6470765 A C 0.25 0.302 0.237 0.259 0.23 0.227 0.168 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 8 131485703 rs12114496 A G 0.131 0.161 0.121 0.127 0.131 0.107 0.164 0 0.0008 0.0008 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 8 131922291 rs7004484 C A 0.297 0.279 0.284 0.278 0.346 0.262 0.357 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 8 132107714 rs7822239 A C 0.089 0.119 0.086 0.087 0.146 0.164 0.12 0.0035 0.0161 0 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 8 133471452 rs9643297 A G 0.373 0.428 0.415 0.317 0.387 0.295 0.394 0.0064 0 0.0141 www.ncbi.nlm.nih.gov/pubmed/26908436 A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants. Squamous cell carcinoma 8 136921226 rs1909481 T C 0.186 0.189 0.122 0.196 0.211 0.217 0.153 0 0.0024 0.0058 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 8 138596475 rs61496269 C G 0.158 0.185 0.174 0.17 0.126 0.128 0.217 0 0.0081 0.003 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 8 139983697 rs75755010 A G 0.14 0.155 0.147 0.165 0.086 0.116 0.134 0.0054 0.0125 0 www.ncbi.nlm.nih.gov/pubmed/27669027 Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Emphysema distribution in smoking 8 140646056 rs11166986 A G 0.174 0.136 0.174 0.191 0.149 0.098 0.137 0.0098 0.0086 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 8 141800605 rs10101158 A T 0.345 0.378 0.414 0.447 0.496 0.541 0.35 0 0.0203 0.0279 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. "Response to radiotherapy in prostate cancer (toxicity, urinary frequency)" 8 142610273 rs60275617 G A 0.345 0.312 0.286 0.268 0.18 0.18 0.239 0 0.0298 0.0074 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 8 142680513 rs2294008 T C 0.352 0.362 0.236 0.287 0.546 0.55 0.339 0.0181 0.1312 0 www.ncbi.nlm.nih.gov/pubmed/19648920 Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Bladder cancer 8 142680513 rs2294008 T C 0.352 0.362 0.236 0.287 0.546 0.55 0.339 0.0181 0.1312 0 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 8 142925688 rs6988985 T C 0.03 0.032 0.027 0.079 0.032 0.037 0.044 0.0289 0 0.0083 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Plasma androstenedione levels in resected early stage-receptor positive breast cancer 9 310970 rs10969557 C G 0.284 0.315 0.286 0.278 0.189 0.148 0.25 0.0001 0.0392 0 www.ncbi.nlm.nih.gov/pubmed/26732429 Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Lung cancer 9 2203938 rs6475600 T C 0.373 0.356 0.308 0.377 0.45 0.447 0.354 0 0.0152 0.0069 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) 9 3014254 rs4543592 T C 0.184 0.243 0.29 0.257 0.218 0.201 0.266 0.0008 0.0032 0 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 9 3014254 rs4543592 T C 0.184 0.243 0.29 0.257 0.218 0.201 0.266 0.0008 0.0032 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 9 3025368 rs3847244 C T 0.259 0.291 0.339 0.373 0.198 0.258 0.301 0.0306 0.0237 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 9 3025368 rs3847244 C T 0.259 0.291 0.339 0.373 0.198 0.258 0.301 0.0306 0.0237 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 9 3761909 rs954980 A G 0.153 0.162 0.098 0.233 0.198 0.18 0.168 0.0186 0 0.0213 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 9 4426631 rs10974531 A C 0.013 0.005 0.018 0.083 0 0.004 0.013 0.1313 0 0.0099 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 9 5956008 rs10975370 G A 0.127 0.138 0.103 0.061 0.133 0.164 0.112 0.0304 0.0081 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 6033278 rs12378118 A G 0.127 0.117 0.103 0.113 0.083 0.049 0.067 0.0029 0.0114 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 9 6227418 rs10118776 G A 0.068 0.068 0.077 0.065 0.023 0.004 0.066 0.0067 0.0423 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 9 6849317 rs4742269 A G 0.161 0.261 0.17 0.33 0.311 0.262 0.199 0.027 0 0.0479 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 9 7582632 rs7873807 A G 0.208 0.239 0.29 0.265 0.168 0.24 0.257 0.0022 0.0061 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 9 8211949 rs1416584 G A 0.246 0.264 0.277 0.136 0.136 0.172 0.288 0.0157 0 0.0543 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 9 8897187 rs60250264 A C 0.195 0.239 0.223 0.157 0.161 0.172 0.217 0.0038 0 0.0112 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 9 9668869 rs12378124 A G 0.199 0.22 0.272 0.281 0.202 0.225 0.234 0.0093 0.0014 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 9 10260263 rs2475335 T C 0.436 0.446 0.469 0.5 0.446 0.521 0.504 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/29608257 Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. Endometriosis or endometrial cancer (pleiotropy) 9 13704540 rs1998584 T C 0.326 0.365 0.241 0.322 0.168 0.182 0.279 0.0103 0.0557 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 9 13942941 rs77457752 A G 0.021 0.027 0.022 0.018 0.032 0.033 0.013 0 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 16864523 rs2153271 T C 0.114 0.072 0.125 0.187 0.095 0.061 0.093 0.0563 0.0076 0 www.ncbi.nlm.nih.gov/pubmed/20585627 "Web-based, participant-driven studies yield novel genetic associations for common traits." Freckling 9 16884588 rs10810657 A T 0.108 0.054 0.135 0.171 0.119 0.086 0.089 0.0308 0 0.0092 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 9 16884588 rs10810657 A T 0.108 0.054 0.135 0.171 0.119 0.086 0.089 0.0308 0 0.0092 www.ncbi.nlm.nih.gov/pubmed/27424798 Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Cutaneous squamous cell carcinoma 9 16884588 rs10810657 A T 0.108 0.054 0.135 0.171 0.119 0.086 0.089 0.0308 0 0.0092 www.ncbi.nlm.nih.gov/pubmed/30166351 Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Skin pigmentation traits 9 17934122 rs17185553 C G 0.017 0.036 0.013 0.043 0.032 0.02 0.027 0.006 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 9 18930224 rs1571228 G A 0.28 0.252 0.228 0.14 0.09 0.119 0.17 0 0.0123 0.045 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 9 19055967 rs1048169 T C 0.263 0.3 0.221 0.336 0.314 0.328 0.219 0.0069 0 0.0192 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 9 19055967 rs1048169 T C 0.263 0.3 0.221 0.336 0.314 0.328 0.219 0.0069 0 0.0192 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (early onset) 9 21816529 rs7023329 A G 0.462 0.5 0.414 0.439 0.532 0.5 0.438 0.0015 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 9 21816529 rs7023329 A G 0.462 0.5 0.414 0.439 0.532 0.5 0.438 0.0015 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 9 21816529 rs7023329 A G 0.462 0.5 0.414 0.439 0.532 0.5 0.438 0.0015 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/19578364 Genome-wide association study identifies three loci associated with melanoma risk. Melanoma 9 21830158 rs885518 G A 0.28 0.293 0.315 0.344 0.198 0.189 0.31 0.0198 0.046 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 9 21852182 rs7026112 T G 0.522 0.509 0.532 0.504 0.428 0.368 0.522 0 0.0281 0.0048 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 9 21984662 rs3731217 C A 0.051 0.068 0.08 0.088 0.036 0.049 0.124 0.0033 0.0143 0 www.ncbi.nlm.nih.gov/pubmed/23996088 Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Acute lymphoblastic leukemia (B-cell precursor) 9 21984662 rs3731217 C A 0.051 0.068 0.08 0.088 0.036 0.049 0.124 0.0033 0.0143 0 www.ncbi.nlm.nih.gov/pubmed/29632299 Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia in childhood (B cell precursor) 9 21991924 rs2811710 C T 0.268 0.284 0.243 0.317 0.165 0.167 0.273 0.0246 0.0478 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 9 21995942 rs78545330 A T 0.291 0.327 0.313 0.177 0.303 0.283 0.255 0.044 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/30323354 "BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts." BRCA1/2-negative high-risk breast cancer 9 21997016 rs61271866 A T 0 0.014 0 0.009 0.009 0 0 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 9 22006274 rs2069426 T G 0.102 0.126 0.121 0.048 0.126 0.176 0.111 0.0425 0.0133 0 www.ncbi.nlm.nih.gov/pubmed/29348612 GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Acute lymphoblastic leukemia (childhood) 9 22034720 rs2151280 A G 0.284 0.257 0.255 0.448 0.176 0.176 0.319 0.1371 0.0695 0 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 9 22034720 rs2151280 A G 0.284 0.257 0.255 0.448 0.176 0.176 0.319 0.1371 0.0695 0 www.ncbi.nlm.nih.gov/pubmed/24403052 Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Basal cell carcinoma 9 22041999 rs17694493 G C 0.114 0.149 0.138 0.048 0.113 0.172 0.122 0.0489 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 9 22041999 rs17694493 G C 0.114 0.149 0.138 0.048 0.113 0.172 0.122 0.0489 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 9 22052069 rs62560775 G A 0.199 0.162 0.156 0.122 0.108 0.094 0.19 0 0.0046 0.0191 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 9 22052069 rs62560775 G A 0.199 0.162 0.156 0.122 0.108 0.094 0.19 0 0.0046 0.0191 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer 9 22062135 rs1011970 T G 0.372 0.35 0.384 0.265 0.329 0.418 0.392 0.0323 0 0.005 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 9 22067594 rs10811650 G A 0.144 0.171 0.143 0.348 0.108 0.07 0.15 0.2088 0.0476 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 22083405 rs1333040 C T 0.355 0.333 0.357 0.325 0.46 0.406 0.341 0.0041 0.0195 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 9 22160088 rs72658409 T C 0.239 0.266 0.201 0.191 0.176 0.176 0.252 0 0.0021 0.0095 www.ncbi.nlm.nih.gov/pubmed/26732429 Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Adenocarcinoma 9 22160088 rs72658409 T C 0.239 0.266 0.201 0.191 0.176 0.176 0.252 0 0.0021 0.0095 www.ncbi.nlm.nih.gov/pubmed/26732429 Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Lung cancer 9 22206988 rs1679013 T C 0.261 0.318 0.272 0.288 0.306 0.283 0.237 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 9 22206988 rs1679013 T C 0.261 0.318 0.272 0.288 0.306 0.283 0.237 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 9 22207038 rs1679014 T C 0.076 0.054 0.08 0.074 0.054 0.061 0.076 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 9 22207038 rs1679014 T C 0.076 0.054 0.08 0.074 0.054 0.061 0.076 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 9 22336997 rs1359742 G C 0.398 0.336 0.415 0.443 0.473 0.488 0.429 0 0.0052 0.0098 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 9 23035988 rs12375901 T C 0.017 0.009 0.013 0.018 0 0.004 0.004 0.0058 0.0098 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 9 23426273 rs12000445 G A 0.427 0.387 0.429 0.491 0.441 0.422 0.464 0.0076 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/22872573 Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Response to platinum-based chemotherapy in non-small-cell lung cancer 9 26789942 rs1889899 G A 0.263 0.203 0.25 0.23 0.117 0.141 0.23 0.0003 0.0387 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 9 27170623 rs601359 G A 0.195 0.136 0.192 0.17 0.168 0.128 0.174 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 9 28024196 rs72724928 C A 0.004 0.009 0 0.009 0.005 0 0 0.0024 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 9 28414341 rs10968576 G A 0.157 0.117 0.121 0.096 0.15 0.107 0.124 0.004 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 9 28414341 rs10968576 G A 0.157 0.117 0.121 0.096 0.15 0.107 0.124 0.004 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 9 28587996 rs2891316 A G 0.034 0.027 0.049 0.052 0.036 0.025 0.053 0.0021 0.0023 0 www.ncbi.nlm.nih.gov/pubmed/24096698 Genome-wide association study of endometrial cancer in E2C2. Endometrial cancer 9 32867483 rs4463516 G C 0.539 0.563 0.446 0.496 0.432 0.463 0.412 0 0.002 0.0002 www.ncbi.nlm.nih.gov/pubmed/25710658 Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia 9 33283584 rs12336160 T G 0.233 0.266 0.201 0.257 0.117 0.23 0.27 0.0034 0.016 0 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 9 33421422 rs10758203 A G 0.195 0.217 0.205 0.28 0.142 0.118 0.155 0.0507 0.0322 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 9 34049781 rs10122495 T A 0.244 0.234 0.236 0.243 0.241 0.25 0.261 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 9 75081761 rs11144217 C T 0.222 0.236 0.241 0.322 0.293 0.303 0.27 0.0076 0 0.015 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 9 75927370 rs11144688 A G 0 0.005 0 0.013 0 0 0 0.0238 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 9 75927370 rs11144688 A G 0 0.005 0 0.013 0 0 0 0.0238 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 9 87620879 rs11141915 C A 0.381 0.351 0.374 0.209 0.414 0.377 0.27 0.0708 0.0133 0 www.ncbi.nlm.nih.gov/pubmed/22293537 A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. Response to gemcitabine in pancreatic cancer 9 94978992 rs3802458 G A 0.267 0.266 0.299 0.309 0.261 0.283 0.243 0.0019 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 9 95493953 rs473902 G T 0 0 0 0.009 0.005 0 0 0.0154 0 0.015 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 9 95493953 rs473902 G T 0 0 0 0.009 0.005 0 0 0.0154 0 0.015 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 9 95606163 rs2405064 T C 0 0.005 0 0 0.005 0 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 96267007 rs7042315 T C 0.22 0.176 0.223 0.126 0.14 0.111 0.164 0.0021 0 0.0204 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 9 96335245 rs6479272 T C 0.051 0.095 0.067 0.065 0.045 0.053 0.071 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 9 97775520 rs1588635 A C 0.178 0.203 0.143 0.17 0.105 0.157 0.155 0 0.0038 0.0006 www.ncbi.nlm.nih.gov/pubmed/28195142 A genome-wide association study yields five novel thyroid cancer risk loci. Thyroid cancer 9 97793827 rs965513 A G 0.14 0.176 0.116 0.154 0.072 0.103 0.128 0.0046 0.017 0 www.ncbi.nlm.nih.gov/pubmed/23894154 Genome-wide association study on differentiated thyroid cancer. Thyroid cancer 9 97793827 rs965513 A G 0.14 0.176 0.116 0.154 0.072 0.103 0.128 0.0046 0.017 0 www.ncbi.nlm.nih.gov/pubmed/25855579 Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations. Thyroid cancer 9 97793827 rs965513 A G 0.14 0.176 0.116 0.154 0.072 0.103 0.128 0.0046 0.017 0 www.ncbi.nlm.nih.gov/pubmed/19198613 Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Thyroid cancer 9 97793827 rs965513 A G 0.14 0.176 0.116 0.154 0.072 0.103 0.128 0.0046 0.017 0 www.ncbi.nlm.nih.gov/pubmed/20350937 The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. "Thyroid cancer (Papillary, radiation-related)" 9 97865986 rs10122541 G A 0.212 0.218 0.232 0.167 0.144 0.18 0.186 0.0001 0 0.0069 www.ncbi.nlm.nih.gov/pubmed/25855579 Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations. Thyroid cancer 9 97896036 rs7037324 A G 0.064 0.086 0.071 0.052 0.136 0.19 0.089 0.011 0.0495 0 www.ncbi.nlm.nih.gov/pubmed/25855579 Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations. Thyroid cancer 9 98882256 rs1407508 C T 0 0 0 0.004 0.005 0 0 0.006 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 9 101860586 rs10989661 A G 0.186 0.207 0.147 0.148 0.207 0.193 0.177 0.0048 0.0021 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 9 101900303 rs823920 G A 0.004 0 0 0.009 0.027 0.012 0.004 0 0.0066 0.0125 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 9 101901014 rs823918 G T 0.004 0 0 0.009 0.032 0.016 0.004 0 0.0113 0.0143 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 9 101910258 rs1630858 C A 0.004 0 0 0.009 0.032 0.016 0.004 0 0.0113 0.0143 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 9 103912867 rs718857 T C 0.388 0.339 0.326 0.301 0.271 0.299 0.406 0 0.0015 0.0129 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 104973639 rs10991437 A C 0.008 0.018 0.018 0.013 0.072 0.049 0.004 0 0.0354 0.0093 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 9 105051392 rs35440884 A G 0 0.005 0 0.022 0 0 0 0.0466 0 0.0126 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 9 106138768 rs9409082 T C 0.025 0.023 0.027 0.022 0.059 0.09 0.018 0 0.0319 0.0053 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 9 106914612 rs1858231 A G 0.352 0.378 0.317 0.341 0.332 0.316 0.347 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) 9 107394019 rs817826 C T 0.386 0.293 0.344 0.348 0.221 0.287 0.358 0.0004 0.0199 0 www.ncbi.nlm.nih.gov/pubmed/23023329 Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Prostate cancer 9 107936435 rs7041168 T G 0.274 0.284 0.239 0.283 0.468 0.459 0.283 0 0.0819 0.0092 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 9 108074895 rs13294895 T C 0.017 0.005 0.004 0.018 0.018 0.008 0.004 0.0025 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 108123199 rs630965 T C 0.53 0.487 0.509 0.415 0.469 0.5 0.496 0.0151 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 108133073 rs676256 C T 0.199 0.23 0.25 0.265 0.212 0.209 0.217 0.0056 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 112324847 rs1056107 G T 0.322 0.321 0.388 0.29 0.378 0.329 0.342 0.0072 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 9 114439119 rs10817611 C T 0.098 0.149 0.143 0.088 0.09 0.152 0.165 0.0093 0 0.0057 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 9 115006400 rs4979489 T C 0.195 0.194 0.192 0.17 0.189 0.213 0.23 0.0016 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 9 115233945 rs2989505 T C 0.178 0.209 0.185 0.209 0.185 0.127 0.199 0.0023 0.0061 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 9 115509305 rs2213920 G A 0.03 0.018 0.027 0.035 0.072 0.037 0.018 0 0.0071 0.0074 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 9 116142133 rs204517 G A 0.191 0.185 0.147 0.148 0.117 0.127 0.186 0 0.0045 0.0065 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in estrogen receptor positive breast cancer 9 116202676 rs1003858 C G 0.009 0.009 0.013 0.035 0.027 0 0.027 0.0134 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 9 116551207 rs1895062 G A 0.089 0.09 0.183 0.13 0.198 0.197 0.098 0 0.0218 0.0076 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 116672011 rs803903 A G 0.026 0.023 0.027 0.061 0.041 0.029 0.04 0.0134 0 0.0072 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 117616205 rs1928295 C T 0.581 0.482 0.388 0.53 0.324 0.361 0.351 0.0343 0.0438 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 9 117616205 rs1928295 C T 0.581 0.482 0.388 0.53 0.324 0.361 0.351 0.0343 0.0438 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 9 120963648 rs17612 G T 0.013 0.009 0.009 0.004 0.045 0.029 0.022 0.0049 0.0152 0 www.ncbi.nlm.nih.gov/pubmed/27670397 Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Pre-treatment pain in head and neck squamous cell carcinoma 9 126634155 rs10760444 A G 0.428 0.373 0.455 0.487 0.342 0.283 0.389 0.032 0.0386 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 9 126698635 rs10733682 A G 0.203 0.279 0.252 0.226 0.194 0.172 0.204 0 0.0053 0.0018 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 9 126698635 rs10733682 A G 0.203 0.279 0.252 0.226 0.194 0.172 0.204 0 0.0053 0.0018 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 9 129033082 rs7042889 C A 0.309 0.41 0.397 0.348 0.568 0.512 0.425 0.0141 0.0644 0 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease 9 129127015 rs17481720 T C 0 0 0.004 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 9 129168215 rs10819474 C T 0.148 0.168 0.147 0.096 0.09 0.103 0.128 0.0019 0 0.0132 www.ncbi.nlm.nih.gov/pubmed/29942513 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses. Mucinous adenocarcinoma in colorectal cancer 9 129813781 rs1182 A C 0.021 0.005 0.022 0.004 0.032 0.012 0.027 0.0075 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 9 129813781 rs1182 A C 0.021 0.005 0.022 0.004 0.032 0.012 0.027 0.0075 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) 9 129813781 rs1182 A C 0.021 0.005 0.022 0.004 0.032 0.012 0.027 0.0075 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (early onset) 9 131459201 rs34553878 G A 0.038 0.027 0.058 0.035 0.059 0.053 0.013 0 0.0035 0.0014 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 9 131459201 rs34553878 G A 0.038 0.027 0.058 0.035 0.059 0.053 0.013 0 0.0035 0.0014 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 9 133613233 rs3025343 A G 0 0.005 0 0.013 0 0 0 0.0238 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/20418890 Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Smoking behavior 9 133640119 rs1108581 A G 0.398 0.441 0.482 0.496 0.581 0.549 0.443 0 0.0166 0.0159 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 9 134233655 rs10785877 G A 0.261 0.243 0.308 0.193 0.266 0.203 0.274 0.0107 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) 9 135085187 rs28647734 A G 0.268 0.264 0.262 0.237 0.182 0.223 0.232 0 0.0037 0.0032 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 9 135086514 rs11103667 C T 0.372 0.368 0.38 0.404 0.341 0.354 0.383 0.0021 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 9 136462535 rs57994353 C T 0.229 0.176 0.223 0.217 0.279 0.281 0.195 0 0.012 0.0037 www.ncbi.nlm.nih.gov/pubmed/27424798 Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Cutaneous squamous cell carcinoma 9 138043623 rs7865267 C T 0.381 0.324 0.344 0.396 0.377 0.353 0.319 0.0034 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/25987655 Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Asparaginase hypersensitivity in acute lymphoblastic leukemia 10 791467 rs1555895 A G 0.428 0.405 0.446 0.377 0.41 0.376 0.451 0.0024 0 0.0045 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 10 4634004 rs7086888 G A 0.299 0.341 0.324 0.361 0.342 0.324 0.297 0.0024 0 0.0024 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 10 4918829 rs4453114 C T 0.004 0 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 10 4936227 rs10904377 T G 0.123 0.072 0.098 0.1 0.122 0.094 0.124 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 10 5752689 rs55910451 G A 0.042 0.036 0.031 0.078 0.09 0.045 0.035 0.0094 0 0.0194 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 5844771 rs2380205 C T 0.389 0.383 0.411 0.281 0.583 0.475 0.354 0.0604 0.0718 0 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 10 6195193 rs11257188 C A 0.483 0.383 0.415 0.626 0.383 0.361 0.42 0.1275 0.0152 0 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 10 7175017 rs2497442 G C 0.097 0.095 0.094 0.079 0.158 0.098 0.071 0.0015 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 10 7272478 rs7082321 C T 0.435 0.491 0.478 0.365 0.378 0.406 0.443 0.0085 0 0.0176 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in estrogen receptor positive breast cancer 10 8047173 rs4143094 G T 0.431 0.5 0.527 0.588 0.428 0.4 0.544 0.0355 0.0297 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 10 8059964 rs3781093 C T 0.271 0.286 0.241 0.316 0.155 0.164 0.15 0.0413 0.0376 0 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Hodgkins lymphoma 10 8059964 rs3781093 C T 0.271 0.286 0.241 0.316 0.155 0.164 0.15 0.0413 0.0376 0 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nodular sclerosis Hodgkin lymphoma 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/25468567 A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. Acute lymphoblastic leukemia (adolescents and young adults) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/23996088 Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Acute lymphoblastic leukemia (B-cell precursor) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Acute lymphoblastic leukemia (B-cell precursor) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29632299 Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia in childhood (B cell precursor) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia (abnormal cytogenetics) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia (hyperdiploid negative) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia (normal cytogenetics) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia in adulthood 10 8062245 rs3824662 A C 0.102 0.131 0.085 0.083 0.032 0.037 0.066 0 0.0265 0.0022 www.ncbi.nlm.nih.gov/pubmed/29296818 Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. B cell acute lymphoblastic leukaemia in young adulthood 10 8068061 rs444929 C T 0.216 0.209 0.214 0.222 0.105 0.112 0.252 0.004 0.0509 0 www.ncbi.nlm.nih.gov/pubmed/24920014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Hodgkins lymphoma 10 8282926 rs11255615 C T 0.076 0.036 0.036 0.057 0.023 0.049 0.04 0.0011 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) 10 8346355 rs7075481 G A 0.051 0.086 0.049 0.026 0.109 0.131 0.103 0.034 0.0241 0 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Plasma androstenedione levels in resected early stage-receptor positive breast cancer 10 8659256 rs10795668 A G 0.004 0.005 0 0.026 0.005 0 0.004 0.0385 0 0.0093 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 10 8659256 rs10795668 A G 0.004 0.005 0 0.026 0.005 0 0.004 0.0385 0 0.0093 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 10 8659256 rs10795668 A G 0.004 0.005 0 0.026 0.005 0 0.004 0.0385 0 0.0093 www.ncbi.nlm.nih.gov/pubmed/18372905 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Colorectal cancer 10 8689292 rs7912831 T C 0.017 0.041 0.04 0.126 0.104 0.139 0.08 0.0182 0 0.0682 www.ncbi.nlm.nih.gov/pubmed/28869801 Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. Colorectal cancer 10 8697617 rs11255841 A T 0.09 0.073 0.086 0.136 0.036 0.054 0.124 0.0298 0.0334 0 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 10 8697617 rs11255841 A T 0.09 0.073 0.086 0.136 0.036 0.054 0.124 0.0298 0.0334 0 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 10 8697617 rs11255841 A T 0.09 0.073 0.086 0.136 0.036 0.054 0.124 0.0298 0.0334 0 www.ncbi.nlm.nih.gov/pubmed/24737748 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Colorectal cancer 10 8697617 rs11255841 A T 0.09 0.073 0.086 0.136 0.036 0.054 0.124 0.0298 0.0334 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 10 8760949 rs11255908 T G 0.492 0.532 0.429 0.448 0.356 0.397 0.411 0 0.0123 0.0038 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 10 8760949 rs11255908 T G 0.492 0.532 0.429 0.448 0.356 0.397 0.411 0 0.0123 0.0038 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 10 8894035 rs73635312 A G 0.267 0.23 0.228 0.268 0.36 0.324 0.204 0 0.0201 0.0117 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 10 8894035 rs73635312 A G 0.267 0.23 0.228 0.268 0.36 0.324 0.204 0 0.0201 0.0117 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 10 8898991 rs76141549 A G 0.051 0.032 0.031 0.087 0.108 0.074 0.022 0.007 0 0.0399 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 10 9175196 rs68140948 T C 0.39 0.347 0.357 0.313 0.5 0.5 0.336 0.0178 0.0586 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 9602837 rs4749884 A C 0.038 0.032 0.009 0.052 0.063 0.025 0.018 0.0065 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 10 11806793 rs12358475 A G 0 0 0 0.009 0.005 0 0 0.0154 0 0.015 www.ncbi.nlm.nih.gov/pubmed/25526632 A genome wide meta-analysis study for identification of common variation associated with breast cancer prognosis. Breast cancer (survival) 10 13373961 rs61610071 G A 0.038 0.018 0.027 0.035 0.014 0.004 0.018 0.0065 0.0131 0 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 10 13490648 rs9329342 T C 0.111 0.153 0.188 0.132 0.122 0.094 0.226 0 0.005 0.0102 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 10 13495204 rs12770479 A G 0.131 0.153 0.216 0.162 0.155 0.115 0.239 0 0.0046 0.0041 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 10 13563982 rs6602665 C T 0.305 0.28 0.308 0.283 0.419 0.43 0.31 0.0044 0.0407 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 10 13564490 rs6602666 G A 0.314 0.284 0.306 0.283 0.441 0.447 0.31 0.0059 0.0525 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 10 13625731 rs7089227 T G 0.44 0.401 0.411 0.47 0.359 0.287 0.455 0.0142 0.0357 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) 10 13865236 rs10906522 T C 0.373 0.405 0.356 0.491 0.505 0.439 0.447 0.0077 0 0.0189 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 19031157 rs76225372 G A 0.068 0.045 0.049 0.096 0.027 0.029 0.04 0.0352 0.0156 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 10 21147293 rs12243039 A C 0.157 0.234 0.174 0.157 0.099 0.168 0.142 0 0.0026 0.0026 www.ncbi.nlm.nih.gov/pubmed/24785509 A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. Response to radiotherapy in cancer (late toxicity) 10 21545607 rs7098100 G A 0.475 0.469 0.478 0.491 0.347 0.385 0.394 0.0095 0.0233 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 21744013 rs7072776 G A 0.479 0.459 0.46 0.47 0.333 0.381 0.393 0.0046 0.0213 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 10 21744013 rs7072776 G A 0.479 0.459 0.46 0.47 0.333 0.381 0.393 0.0046 0.0213 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 10 21744013 rs7072776 G A 0.479 0.459 0.46 0.47 0.333 0.381 0.393 0.0046 0.0213 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 21744013 rs7072776 G A 0.479 0.459 0.46 0.47 0.333 0.381 0.393 0.0046 0.0213 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 10 21744013 rs7072776 G A 0.479 0.459 0.46 0.47 0.333 0.381 0.393 0.0046 0.0213 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 10 22089029 rs72810761 G A 0.119 0.15 0.125 0.161 0.099 0.131 0.124 0.0054 0.0014 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 10 22108073 rs72810771 T C 0.216 0.225 0.252 0.196 0.15 0.209 0.221 0 0.0019 0.004 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 22212015 rs16922097 C A 0.22 0.203 0.223 0.237 0.151 0.145 0.234 0.0053 0.022 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 22681806 rs370356098 C G 0.124 0.15 0.177 0.156 0.176 0.191 0.101 0 0.0037 0.0037 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 23061174 rs3858207 A C 0.39 0.41 0.317 0.435 0.446 0.508 0.341 0 0.008 0.0204 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 10 23876027 rs11812960 G A 0.081 0.027 0.064 0.031 0.104 0.103 0.053 0.0137 0.0228 0 www.ncbi.nlm.nih.gov/pubmed/29195075 An Unexpectedly Complex Architecture for Skin Pigmentation in Africans. Tanning 10 24068862 rs75984653 C G 0.004 0 0 0.013 0.009 0.008 0 0.0108 0 0.0178 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 10 26722183 rs1564271 A G 0.131 0.122 0.094 0.109 0.131 0.057 0.097 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/28935272 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin 10 27080233 rs7918232 T C 0.094 0.095 0.077 0.078 0.045 0.046 0.109 0 0.0121 0.0042 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 28348731 rs7900823 G A 0 0.005 0 0 0.005 0 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27393504 Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung cancer 10 29945261 rs35374984 C A 0.299 0.376 0.36 0.437 0.296 0.395 0.358 0.0196 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/27669027 Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Emphysema distribution in smoking 10 29945955 rs7897478 G A 0.106 0.054 0.071 0.101 0.036 0.074 0.04 0.0117 0.0025 0 www.ncbi.nlm.nih.gov/pubmed/30219690 GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort. Depression in smokers 10 30288009 rs12220014 A G 0.178 0.168 0.125 0.132 0.15 0.174 0.195 0.0026 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 10 34529060 rs563507 A G 0.212 0.207 0.219 0.191 0.086 0.082 0.243 0 0.0639 0.0064 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 10 35955481 rs10827565 G C 0.205 0.191 0.2 0.235 0.191 0.248 0.214 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/27492634 Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study. Bronchial neuroendocrine tumor 10 37101682 rs1200921 A C 0.314 0.374 0.335 0.339 0.311 0.336 0.371 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/24753544 Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/18264096 Multiple loci identified in a genome-wide association study of prostate cancer. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 10 46046326 rs10993994 G A 0.335 0.342 0.286 0.374 0.338 0.303 0.305 0.0064 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/24740154 Genome-wide association scan for variants associated with early-onset prostate cancer. Prostate cancer (early onset) 10 46057653 rs10763567 T G 0.324 0.34 0.315 0.282 0.308 0.281 0.347 0.002 0 0.004 www.ncbi.nlm.nih.gov/pubmed/27262462 Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. Prostate cancer 10 46070851 rs3123078 G A 0.5 0.5 0.446 0.344 0.487 0.516 0.478 0.0548 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 10 51918266 rs1937680 C A 0.272 0.268 0.264 0.394 0.319 0.233 0.285 0.0429 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 54444531 rs7476422 G T 0.14 0.167 0.183 0.189 0.086 0.094 0.168 0.0121 0.0353 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) 10 58811675 rs4948317 T C 0.018 0.028 0.04 0.079 0.037 0.049 0.059 0.0203 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 10 58811675 rs4948317 T C 0.018 0.028 0.04 0.079 0.037 0.049 0.059 0.0203 0 0.0101 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 10 61707795 rs4590817 C G 0.174 0.176 0.165 0.165 0.205 0.213 0.133 0 0.0053 0.0016 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 10 61707795 rs4590817 C G 0.174 0.176 0.165 0.165 0.205 0.213 0.133 0 0.0053 0.0016 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 10 61764833 rs1530440 T C 0.03 0.027 0.022 0.052 0.018 0.008 0.027 0.021 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 10 61764833 rs1530440 T C 0.03 0.027 0.022 0.052 0.018 0.008 0.027 0.021 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 10 61963136 rs4245595 C T 0.188 0.171 0.201 0.239 0.225 0.172 0.186 0.0067 0 0.0041 www.ncbi.nlm.nih.gov/pubmed/25310577 "Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures." Acute lymphoblastic leukemia (childhood) 10 61963818 rs10821936 C T 0.178 0.167 0.205 0.23 0.23 0.149 0.179 0.0061 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 10 61963818 rs10821936 C T 0.178 0.167 0.205 0.23 0.23 0.149 0.179 0.0061 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 10 61963818 rs10821936 C T 0.178 0.167 0.205 0.23 0.23 0.149 0.179 0.0061 0 0.0029 www.ncbi.nlm.nih.gov/pubmed/23512250 Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. Acute lymphoblastic leukemia (childhood) 10 61992400 rs7089424 G T 0.237 0.223 0.219 0.204 0.248 0.211 0.255 0.0005 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/29348612 GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Acute lymphoblastic leukemia (childhood) 10 61992400 rs7089424 G T 0.237 0.223 0.219 0.204 0.248 0.211 0.255 0.0005 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/19684604 "Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia." Acute lymphoblastic leukemia (childhood) 10 61992400 rs7089424 G T 0.237 0.223 0.219 0.204 0.248 0.211 0.255 0.0005 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/29632299 Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia in childhood (B cell precursor) 10 62492218 rs10822013 T C 0.203 0.189 0.112 0.2 0.176 0.148 0.111 0.0059 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/21908515 Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. Breast cancer 10 62518923 rs10995190 A G 0.119 0.155 0.219 0.213 0.212 0.205 0.168 0.0021 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 10 62518923 rs10995190 A G 0.119 0.155 0.219 0.213 0.212 0.205 0.168 0.0021 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 10 62518923 rs10995190 A G 0.119 0.155 0.219 0.213 0.212 0.205 0.168 0.0021 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 10 62518923 rs10995190 A G 0.119 0.155 0.219 0.213 0.212 0.205 0.168 0.0021 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 10 62518923 rs10995190 A G 0.119 0.155 0.219 0.213 0.212 0.205 0.168 0.0021 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 10 62518923 rs10995190 A G 0.119 0.155 0.219 0.213 0.212 0.205 0.168 0.0021 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 10 62637778 rs16917546 C T 0.068 0.059 0.072 0.026 0.109 0.124 0.054 0.0261 0.0287 0 www.ncbi.nlm.nih.gov/pubmed/28177523 Association between genetic variation within vitamin D receptor-DNA binding sites and risk of basal cell carcinoma. Basal cell carcinoma 10 62822722 rs61865900 C T 0 0.005 0.004 0.004 0 0.008 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 66659088 rs10997287 C T 0.004 0.009 0.009 0.026 0.009 0 0.004 0.0227 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 10 70281049 rs41322152 C G 0.148 0.122 0.098 0.165 0.072 0.078 0.106 0.0238 0.0216 0 www.ncbi.nlm.nih.gov/pubmed/23007406 Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 10 71007652 rs10509328 C T 0.114 0.171 0.161 0.122 0.14 0.124 0.17 0.0015 0 0.002 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 10 72046530 rs1678618 G A 0.157 0.177 0.17 0.209 0.122 0.116 0.243 0.0079 0.0251 0 www.ncbi.nlm.nih.gov/pubmed/22832964 Genome-wide meta-analyses of smoking behaviors in African Americans. Smoking behavior 10 79059375 rs704017 A G 0.441 0.428 0.505 0.422 0.46 0.488 0.504 0.0037 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 10 79059375 rs704017 A G 0.441 0.428 0.505 0.422 0.46 0.488 0.504 0.0037 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 10 79059375 rs704017 A G 0.441 0.428 0.505 0.422 0.46 0.488 0.504 0.0037 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 10 79059375 rs704017 A G 0.441 0.428 0.505 0.422 0.46 0.488 0.504 0.0037 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 10 79081391 rs704010 T C 0.017 0.014 0.009 0.035 0.014 0.012 0.022 0.0115 0 0.001 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 10 79081391 rs704010 T C 0.017 0.014 0.009 0.035 0.014 0.012 0.022 0.0115 0 0.001 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 10 79081391 rs704010 T C 0.017 0.014 0.009 0.035 0.014 0.012 0.022 0.0115 0 0.001 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 10 79081391 rs704010 T C 0.017 0.014 0.009 0.035 0.014 0.012 0.022 0.0115 0 0.001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 79092621 rs1268974 A G 0.185 0.246 0.219 0.222 0.311 0.325 0.217 0 0.0258 0.0034 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 80608465 rs17693104 T C 0.055 0.09 0.089 0.1 0.059 0.029 0.089 0.0094 0.019 0 www.ncbi.nlm.nih.gov/pubmed/28935272 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin 10 85651147 rs7899106 G A 0.136 0.104 0.134 0.183 0.122 0.074 0.12 0.0265 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 10 85651147 rs7899106 G A 0.136 0.104 0.134 0.183 0.122 0.074 0.12 0.0265 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 10 85725660 rs10159528 T C 0.064 0.104 0.103 0.148 0.104 0.103 0.08 0.0183 0 0.0107 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 10 85980996 rs10788473 T C 0.141 0.132 0.214 0.167 0.104 0.172 0.093 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/23180869 Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Pancreatic cancer 10 88820573 rs1661281 A G 0.081 0.108 0.098 0.091 0.05 0.107 0.084 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29942513 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses. Mucinous adenocarcinoma in colorectal cancer 10 88967577 rs1926203 C A 0.428 0.464 0.451 0.457 0.469 0.409 0.482 0 0 0 www.ncbi.nlm.nih.gov/pubmed/19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Lung cancer 10 88990206 rs1800682 A G 0.203 0.216 0.21 0.304 0.177 0.217 0.21 0.0341 0 0.002 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 10 91588363 rs1329650 T G 0.059 0.041 0.054 0.1 0.045 0.02 0.066 0.0323 0.0145 0 www.ncbi.nlm.nih.gov/pubmed/20418890 Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Smoking behavior 10 94306584 rs2274223 G A 0.36 0.346 0.406 0.365 0.414 0.361 0.335 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 10 96137995 rs10882723 G A 0.136 0.09 0.143 0.135 0.136 0.103 0.161 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 10 96663139 rs1023741 C T 0.186 0.179 0.203 0.193 0.23 0.24 0.173 0 0.0047 0.0022 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 10 96880089 rs17112190 A G 0.316 0.342 0.268 0.313 0.383 0.402 0.292 0 0.015 0.0028 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 10 99529178 rs12412391 G A 0.114 0.095 0.059 0.104 0.145 0.135 0.097 0 0.0076 0.0042 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 10 99529178 rs12412391 G A 0.114 0.095 0.059 0.104 0.145 0.135 0.097 0 0.0076 0.0042 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 10 99585609 rs1035209 T C 0.081 0.09 0.077 0.043 0.09 0.115 0.076 0.0171 0.0058 0 www.ncbi.nlm.nih.gov/pubmed/24737748 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Colorectal cancer 10 99585609 rs1035209 T C 0.081 0.09 0.077 0.043 0.09 0.115 0.076 0.0171 0.0058 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 10 99591947 rs11190164 G A 0.034 0.059 0.023 0.013 0.023 0.016 0.018 0.0031 0 0.0053 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 10 99591947 rs11190164 G A 0.034 0.059 0.023 0.013 0.023 0.016 0.018 0.0031 0 0.0053 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 10 99850776 rs8187707 T C 0.026 0.032 0.036 0.035 0.081 0.074 0.031 0 0.0199 0.0057 www.ncbi.nlm.nih.gov/pubmed/29367611 Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer. Carboplatin disposition in epthelial ovarian cancer 10 100186276 rs28372851 A G 0.131 0.153 0.156 0.226 0.14 0.115 0.173 0.0317 0.0066 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 10 100635683 rs17094222 C T 0 0.009 0.004 0.009 0.005 0.004 0 0.0013 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 10 100635683 rs17094222 C T 0 0.009 0.004 0.009 0.005 0.004 0 0.0013 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 10 102125800 rs10883710 C T 0.008 0.014 0.009 0.043 0.014 0.02 0.013 0.0281 0 0.0159 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 102567827 rs3862030 G A 0.491 0.5 0.496 0.457 0.373 0.41 0.469 0 0.0126 0.0067 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 10 102567827 rs3862030 G A 0.491 0.5 0.496 0.457 0.373 0.41 0.469 0 0.0126 0.0067 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 10 102653628 rs12764388 A G 0 0 0 0.013 0.014 0 0 0.0189 0 0.0279 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 10 102654464 rs3850699 G A 0.419 0.377 0.406 0.395 0.369 0.351 0.429 0 0.0019 0.0019 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 10 102654464 rs3850699 G A 0.419 0.377 0.406 0.395 0.369 0.351 0.429 0 0.0019 0.0019 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 10 102727686 rs7917772 G A 0.335 0.365 0.366 0.283 0.446 0.475 0.42 0.0388 0.0326 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 10 102835491 rs4919687 A G 0.081 0.086 0.156 0.222 0.243 0.184 0.124 0.0166 0 0.0607 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 10 103086421 rs11191548 C T 0.025 0.045 0.04 0.026 0.036 0.041 0.058 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 10 103086421 rs11191548 C T 0.025 0.045 0.04 0.026 0.036 0.041 0.058 0.0012 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 10 103095899 rs1926030 C T 0.366 0.36 0.369 0.435 0.46 0.405 0.438 0.0011 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 10 103109281 rs11191560 C T 0.021 0.023 0.018 0.013 0.032 0.037 0.04 0.0044 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 10 103109281 rs11191560 C T 0.021 0.023 0.018 0.013 0.032 0.037 0.04 0.0044 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 10 103934543 rs7902587 T C 0.182 0.23 0.203 0.113 0.194 0.194 0.164 0.0276 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 10 103934543 rs7902587 T C 0.182 0.23 0.203 0.113 0.194 0.194 0.164 0.0276 0 0.0043 www.ncbi.nlm.nih.gov/pubmed/28195142 A genome-wide association study yields five novel thyroid cancer risk loci. Thyroid cancer 10 103959483 rs4244255 C T 0.256 0.171 0.232 0.165 0.261 0.275 0.217 0.0178 0.0123 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 10 104319179 rs34970111 T C 0.369 0.351 0.38 0.417 0.306 0.283 0.323 0.0183 0.0165 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 10 104319179 rs34970111 T C 0.369 0.351 0.38 0.417 0.306 0.283 0.323 0.0183 0.0165 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 10 104612026 rs1855581 A G 0.348 0.311 0.268 0.309 0.275 0.275 0.327 0 0.0012 0.0012 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 105756594 rs17119461 C T 0.233 0.266 0.275 0.248 0.18 0.201 0.252 0 0.0096 0.0019 www.ncbi.nlm.nih.gov/pubmed/21706340 A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q. Melanoma 10 106677881 rs821931 C G 0.496 0.486 0.46 0.47 0.396 0.451 0.451 0 0.0025 0.0012 www.ncbi.nlm.nih.gov/pubmed/25987655 Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Asparaginase hypersensitivity in acute lymphoblastic leukemia 10 107773994 rs4285805 G C 0.445 0.4 0.415 0.409 0.55 0.537 0.388 0.0004 0.037 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 10 110277217 rs11195062 A C 0.405 0.44 0.46 0.518 0.487 0.492 0.442 0.0066 0 0.0112 www.ncbi.nlm.nih.gov/pubmed/23955597 "Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk." Multiple myeloma 10 112520943 rs12241008 C T 0.22 0.194 0.25 0.222 0.32 0.344 0.232 0 0.0312 0.0012 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 10 112520943 rs12241008 C T 0.22 0.194 0.25 0.222 0.32 0.344 0.232 0 0.0312 0.0012 www.ncbi.nlm.nih.gov/pubmed/25105248 Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Colorectal cancer 10 112738717 rs7086803 G A 0.331 0.338 0.304 0.374 0.365 0.357 0.288 0.0029 0 0.0065 www.ncbi.nlm.nih.gov/pubmed/23143601 Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Lung cancer 10 112967084 rs11196172 A G 0.059 0.045 0.058 0.043 0.082 0.061 0.049 0.0012 0.0029 0 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 10 112967084 rs11196172 A G 0.059 0.045 0.058 0.043 0.082 0.061 0.049 0.0012 0.0029 0 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 10 112967084 rs11196172 A G 0.059 0.045 0.058 0.043 0.082 0.061 0.049 0.0012 0.0029 0 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 10 112974337 rs11196174 G A 0 0.005 0 0.013 0.041 0.012 0.004 0 0.006 0.0229 www.ncbi.nlm.nih.gov/pubmed/23544013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. Breast Cancer in BRCA1 mutation carriers 10 113014168 rs7904519 A G 0.097 0.099 0.117 0.17 0.105 0.083 0.12 0.0265 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 10 113014168 rs7904519 A G 0.097 0.099 0.117 0.17 0.105 0.083 0.12 0.0265 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 10 113014168 rs7904519 A G 0.097 0.099 0.117 0.17 0.105 0.083 0.12 0.0265 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 113014168 rs7904519 A G 0.097 0.099 0.117 0.17 0.105 0.083 0.12 0.0265 0.0019 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 10 113017911 rs10885405 C T 0.165 0.167 0.182 0.188 0.236 0.199 0.174 0 0.0029 0.0029 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 113023044 rs6585202 T C 0.17 0.153 0.179 0.193 0.198 0.157 0.156 0.0009 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 10 113127459 rs7906315 A G 0.025 0.032 0.036 0.061 0.032 0.012 0.053 0.0147 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 113368732 rs12250948 C T 0.165 0.194 0.134 0.241 0.234 0.193 0.098 0.0152 0 0.03 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 113490891 rs58742730 G A 0.185 0.255 0.228 0.14 0.101 0.112 0.15 0 0.0106 0.0252 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 116727589 rs1665650 T C 0.398 0.414 0.482 0.435 0.387 0.443 0.434 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 10 117502854 rs2901157 G A 0.004 0.014 0 0.009 0.005 0 0.004 0.0012 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 117806027 rs10444039 A C 0.246 0.221 0.192 0.257 0.141 0.16 0.204 0.0147 0.0235 0 www.ncbi.nlm.nih.gov/pubmed/29895819 Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations. Freckles 10 118519432 rs12413624 A T 0.055 0.068 0.072 0.075 0.126 0.123 0.066 0 0.0174 0.0061 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 10 119607441 rs66696671 T G 0.329 0.311 0.281 0.244 0.261 0.18 0.323 0 0.0038 0.0181 www.ncbi.nlm.nih.gov/pubmed/27047539 "Genome-Wide Study of Response to Platinum, Taxane, and Combination Therapy in Ovarian Cancer: In vitro Phenotypes, Inherited Variation, and Disease Recurrence." Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) 10 121042949 rs748476 A C 0.441 0.41 0.478 0.452 0.315 0.393 0.518 0 0.0211 0.0025 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 121273005 rs11199874 A G 0.093 0.099 0.116 0.117 0.099 0.07 0.115 0.0014 0.0028 0 www.ncbi.nlm.nih.gov/pubmed/22130093 New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort. Prostate cancer 10 121334387 rs11199914 C T 0.377 0.46 0.464 0.413 0.514 0.521 0.474 0.0053 0.016 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 10 121334387 rs11199914 C T 0.377 0.46 0.464 0.413 0.514 0.521 0.474 0.0053 0.016 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 10 121334387 rs11199914 C T 0.377 0.46 0.464 0.413 0.514 0.521 0.474 0.0053 0.016 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 121568362 rs10510097 T C 0.415 0.356 0.335 0.439 0.428 0.43 0.397 0.0026 0 0.0075 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 121573063 rs3750817 T C 0.017 0.041 0.04 0.065 0.027 0.02 0.035 0.021 0.0028 0 www.ncbi.nlm.nih.gov/pubmed/22951594 A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. Breast cancer 10 121577603 rs2912780 T C 0.407 0.351 0.348 0.335 0.437 0.455 0.323 0.0045 0.0213 0 www.ncbi.nlm.nih.gov/pubmed/25956309 Genome-wide association study of susceptibility loci for breast cancer in Sardinian population. Breast cancer 10 121577821 rs2981579 G A 0.424 0.374 0.371 0.404 0.455 0.459 0.35 0 0.0076 0.0045 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 10 121577821 rs2981579 G A 0.424 0.374 0.371 0.404 0.455 0.459 0.35 0 0.0076 0.0045 www.ncbi.nlm.nih.gov/pubmed/27354352 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Breast cancer 10 121577821 rs2981579 G A 0.424 0.374 0.371 0.404 0.455 0.459 0.35 0 0.0076 0.0045 www.ncbi.nlm.nih.gov/pubmed/19330030 A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Breast cancer 10 121577821 rs2981579 G A 0.424 0.374 0.371 0.404 0.455 0.459 0.35 0 0.0076 0.0045 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 10 121577821 rs2981579 G A 0.424 0.374 0.371 0.404 0.455 0.459 0.35 0 0.0076 0.0045 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 10 121577821 rs2981579 G A 0.424 0.374 0.371 0.404 0.455 0.459 0.35 0 0.0076 0.0045 www.ncbi.nlm.nih.gov/pubmed/28864454 Genome-Wide Testing of Exonic Variants and Breast Cancer Risk in the California Teachers Study. Breast cancer (estrogen-receptor positive) 10 121580918 rs35054928 G C 0.42 0.356 0.353 0.344 0.432 0.471 0.336 0.0044 0.02 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 121586602 rs2981575 A G 0.428 0.405 0.366 0.37 0.365 0.381 0.363 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30323354 "BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts." BRCA1/2-negative high-risk breast cancer 10 121586602 rs2981575 A G 0.428 0.405 0.366 0.37 0.365 0.381 0.363 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21060860 Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. Breast cancer in BRCA2 mutation carriers 10 121586676 rs1219648 G A 0.364 0.451 0.473 0.465 0.36 0.316 0.447 0.0085 0.0276 0 www.ncbi.nlm.nih.gov/pubmed/27354352 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Breast cancer 10 121586676 rs1219648 G A 0.364 0.451 0.473 0.465 0.36 0.316 0.447 0.0085 0.0276 0 www.ncbi.nlm.nih.gov/pubmed/20872241 A combined analysis of genome-wide association studies in breast cancer. Breast cancer 10 121586676 rs1219648 G A 0.364 0.451 0.473 0.465 0.36 0.316 0.447 0.0085 0.0276 0 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 10 121586676 rs1219648 G A 0.364 0.451 0.473 0.465 0.36 0.316 0.447 0.0085 0.0276 0 www.ncbi.nlm.nih.gov/pubmed/17529973 A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Breast cancer 10 121591810 rs2420946 C T 0.492 0.451 0.441 0.448 0.428 0.447 0.443 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23544012 Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. Breast cancer in BRCA2 mutation carriers 10 121592706 rs3135724 T C 0.093 0.153 0.161 0.139 0.108 0.148 0.128 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27764800 GWAS in the SIGNAL/PHARE clinical cohort restricts the association between the FGFR2 locus and estrogen receptor status to HER2-negative breast cancer patients. Estrogen receptor status in HER2 negative breast cancer 10 121592803 rs2981582 A G 0.492 0.491 0.522 0.439 0.473 0.451 0.496 0.0035 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/27354352 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Breast cancer 10 121592803 rs2981582 A G 0.492 0.491 0.522 0.439 0.473 0.451 0.496 0.0035 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/17529967 Genome-wide association study identifies novel breast cancer susceptibility loci. Breast cancer 10 121594355 rs3135718 T C 0.432 0.405 0.371 0.37 0.327 0.348 0.372 0 0.003 0.003 www.ncbi.nlm.nih.gov/pubmed/27764800 GWAS in the SIGNAL/PHARE clinical cohort restricts the association between the FGFR2 locus and estrogen receptor status to HER2-negative breast cancer patients. Estrogen receptor status in breast cancer 10 121677436 rs1696803 T C 0.369 0.347 0.406 0.4 0.257 0.299 0.367 0.0074 0.0273 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 121865675 rs10510102 C T 0.148 0.171 0.183 0.217 0.122 0.148 0.199 0.0132 0.0116 0 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 10 122041907 rs2253762 C A 0.372 0.41 0.38 0.43 0.342 0.318 0.335 0.013 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 10 124604740 rs35837782 A G 0.41 0.346 0.292 0.384 0.314 0.378 0.375 0.0001 0.0001 0 www.ncbi.nlm.nih.gov/pubmed/29632299 Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia in childhood (B cell precursor) 10 124604740 rs35837782 A G 0.41 0.346 0.292 0.384 0.314 0.378 0.375 0.0001 0.0001 0 www.ncbi.nlm.nih.gov/pubmed/27694927 A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1. Acute lymphoblastic leukemia in childhood (B cell precursor) 10 124605598 rs3740540 A G 0.055 0.054 0.063 0.03 0.086 0.037 0.035 0.0061 0.001 0 www.ncbi.nlm.nih.gov/pubmed/29348612 GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Acute lymphoblastic leukemia (childhood) 10 125008303 rs4962416 C T 0.085 0.113 0.161 0.157 0.221 0.234 0.15 0 0.0256 0.0146 www.ncbi.nlm.nih.gov/pubmed/18264096 Multiple loci identified in a genome-wide association study of prostate cancer. Prostate cancer 10 125008303 rs4962416 C T 0.085 0.113 0.161 0.157 0.221 0.234 0.15 0 0.0256 0.0146 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 10 125227554 rs9422860 A G 0.123 0.104 0.116 0.087 0.126 0.139 0.12 0.006 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 10 126158100 rs12778749 T C 0.343 0.373 0.433 0.444 0.441 0.426 0.482 0.0007 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/24096698 Genome-wide association study of endometrial cancer in E2C2. Endometrial cancer 10 126642144 rs2842169 C T 0.093 0.05 0.067 0.057 0.05 0.045 0.049 0 0.0008 0.0008 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Response to radiotherapy in prostate cancer (overall toxicity) 10 126973570 rs115536975 T A 0.068 0.054 0.067 0.043 0.059 0.078 0.071 0.0033 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 10 128879482 rs1408536 A G 0.209 0.23 0.205 0.29 0.198 0.201 0.266 0.0176 0.0049 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 10 128882085 rs1408537 C A 0.178 0.185 0.152 0.213 0.14 0.148 0.204 0.0079 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 10 128884838 rs10741177 C T 0.212 0.221 0.205 0.307 0.153 0.189 0.257 0.0382 0.0192 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 10 128886296 rs2152155 C G 0.22 0.216 0.223 0.317 0.158 0.201 0.25 0.0412 0.016 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 10 128887811 rs10829514 T C 0.167 0.176 0.144 0.193 0.104 0.143 0.19 0.0056 0.0122 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 10 128888212 rs10764826 A G 0.225 0.221 0.207 0.313 0.185 0.213 0.27 0.0303 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 10 128890376 rs10734079 T C 0.22 0.216 0.205 0.3 0.153 0.189 0.257 0.0325 0.0192 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 10 128974127 rs10829534 T C 0.449 0.427 0.415 0.365 0.225 0.314 0.363 0 0.0311 0.0158 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 10 129467281 rs16906252 T C 0 0 0 0.004 0.014 0.008 0 0 0.0011 0.015 www.ncbi.nlm.nih.gov/pubmed/26183928 Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung. MGMT methylation in smokers 10 130032376 rs11017056 C A 0.294 0.252 0.229 0.214 0.229 0.212 0.282 0.0017 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 10 131698817 rs9419702 C T 0.517 0.46 0.505 0.465 0.505 0.521 0.469 0.001 0.001 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 11 1884062 rs661348 C T 0.103 0.113 0.152 0.091 0.081 0.09 0.121 0 0.0007 0.005 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 11 1884062 rs661348 C T 0.103 0.113 0.152 0.091 0.081 0.09 0.121 0 0.0007 0.005 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 11 1887776 rs3817198 C T 0.157 0.122 0.08 0.148 0.176 0.139 0.075 0 0.0007 0.0093 www.ncbi.nlm.nih.gov/pubmed/17529967 Genome-wide association study identifies novel breast cancer susceptibility loci. Breast cancer 11 1887776 rs3817198 C T 0.157 0.122 0.08 0.148 0.176 0.139 0.075 0 0.0007 0.0093 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 11 1887776 rs3817198 C T 0.157 0.122 0.08 0.148 0.176 0.139 0.075 0 0.0007 0.0093 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 11 1887776 rs3817198 C T 0.157 0.122 0.08 0.148 0.176 0.139 0.075 0 0.0007 0.0093 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 1899025 rs7483477 G T 0.242 0.252 0.228 0.261 0.234 0.227 0.217 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) 11 1899025 rs7483477 G T 0.242 0.252 0.228 0.261 0.234 0.227 0.217 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) 11 1899025 rs7483477 G T 0.242 0.252 0.228 0.261 0.234 0.227 0.217 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 11 1899025 rs7483477 G T 0.242 0.252 0.228 0.261 0.234 0.227 0.217 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 11 1920716 rs909116 C T 0.212 0.194 0.246 0.335 0.234 0.262 0.243 0.0327 0 0.0155 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 11 1995678 rs217727 A G 0.056 0.05 0.078 0.083 0.077 0.074 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 1995678 rs217727 A G 0.056 0.05 0.078 0.083 0.077 0.074 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 11 1995678 rs217727 A G 0.056 0.05 0.078 0.083 0.077 0.074 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 11 2207722 rs7126629 C A 0.397 0.464 0.367 0.473 0.546 0.508 0.4 0 0.0111 0.0192 www.ncbi.nlm.nih.gov/pubmed/24740154 Genome-wide association scan for variants associated with early-onset prostate cancer. Prostate cancer (early onset) 11 2289922 rs7944004 G T 0.483 0.46 0.397 0.478 0.311 0.348 0.54 0.003 0.0459 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 11 2300420 rs2651823 A G 0.107 0.073 0.079 0.135 0.09 0.112 0.055 0.0135 0 0.0128 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 11 2301599 rs11022157 A C 0.059 0.077 0.031 0.126 0.09 0.078 0.022 0.0367 0 0.0399 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 11 2369831 rs800132 G A 0.034 0.047 0.023 0.072 0.064 0.077 0.054 0.003 0 0.0127 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 3128167 rs1466045 A G 0.39 0.423 0.433 0.461 0.401 0.353 0.456 0.0056 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 11 7526356 rs61890184 A G 0.153 0.158 0.13 0.165 0.221 0.221 0.205 0 0.0097 0.0021 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) 11 7535346 rs12791447 G A 0.004 0 0 0.004 0.009 0.016 0 0 0.0063 0.0073 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 11 7929250 rs4523689 G A 0.229 0.207 0.218 0.309 0.261 0.266 0.23 0.014 0 0.0156 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 11 7929250 rs4523689 G A 0.229 0.207 0.218 0.309 0.261 0.266 0.23 0.014 0 0.0156 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 11 8652392 rs4256980 G C 0.453 0.469 0.487 0.522 0.365 0.34 0.491 0.0179 0.0462 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 11 8652392 rs4256980 G C 0.453 0.469 0.487 0.522 0.365 0.34 0.491 0.0179 0.0462 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 11 9907995 rs12362504 T C 0.394 0.437 0.415 0.448 0.509 0.541 0.407 0 0.0182 0.0088 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 9929710 rs1512829 G A 0.119 0.108 0.143 0.122 0.167 0.148 0.103 0 0.004 0.0017 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 11 9951515 rs10500715 G T 0.209 0.302 0.207 0.309 0.374 0.365 0.248 0 0.0165 0.0265 www.ncbi.nlm.nih.gov/pubmed/23180869 Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Pancreatic cancer 11 13272358 rs900145 T C 0.453 0.423 0.384 0.446 0.342 0.398 0.414 0.0032 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 11 13272358 rs900145 T C 0.453 0.423 0.384 0.446 0.342 0.398 0.414 0.0032 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 11 13401400 rs10500780 A C 0.017 0.005 0.022 0.017 0.014 0.02 0.035 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28935272 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel 11 13553087 rs10832063 C T 0.034 0.032 0.063 0.035 0.063 0.057 0.058 0.0017 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/28935272 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel 11 15367163 rs4622244 G A 0.496 0.487 0.523 0.469 0.365 0.426 0.553 0 0.0172 0.0119 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 11 15431096 rs4757319 A G 0.373 0.392 0.384 0.448 0.653 0.611 0.389 0 0.0981 0.0348 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 15709104 rs4477405 G A 0.436 0.401 0.313 0.478 0.387 0.405 0.407 0.0172 0 0.005 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 11 18335633 rs4150579 G A 0.342 0.329 0.344 0.374 0.387 0.41 0.367 0 0.0026 0.0027 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 18363391 rs9783347 G A 0.343 0.327 0.339 0.374 0.387 0.41 0.367 0 0.0027 0.0029 www.ncbi.nlm.nih.gov/pubmed/23180869 Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Pancreatic cancer 11 18372298 rs4757645 G C 0.191 0.207 0.165 0.23 0.216 0.231 0.204 0.0013 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 18800490 rs4627050 A G 0.492 0.392 0.424 0.426 0.622 0.657 0.425 0.0043 0.0969 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) 11 20247844 rs1520896 A G 0.436 0.369 0.357 0.383 0.356 0.373 0.397 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 11 20492179 rs80315173 G C 0.026 0.018 0.013 0.061 0.068 0.049 0.031 0.0089 0 0.0289 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 11 21873268 rs4922945 A G 0 0.023 0.013 0.043 0.005 0.037 0.013 0.0218 0 0.0169 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 11 21875334 rs11026318 T C 0.322 0.318 0.304 0.339 0.347 0.357 0.31 0 0.0011 0.0011 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 11 22503808 rs1514092 A G 0.368 0.367 0.355 0.326 0.327 0.298 0.347 0 0.0015 0.0025 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 11 25990646 rs4086865 A G 0.424 0.332 0.406 0.311 0.381 0.402 0.446 0.0184 0 0.006 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 11 27484407 rs12786130 C T 0.401 0.369 0.348 0.347 0.396 0.426 0.344 0.0017 0.0051 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 27501639 rs10835188 T G 0.39 0.455 0.518 0.457 0.441 0.439 0.46 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 27538197 rs10767646 T C 0.564 0.478 0.464 0.496 0.373 0.4 0.496 0 0.0258 0.0017 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 27658369 rs6265 T C 0 0.005 0 0 0.005 0 0.009 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/20418890 Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Smoking behavior 11 27658369 rs6265 T C 0 0.005 0 0 0.005 0 0.009 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 11 27658369 rs6265 T C 0 0.005 0 0 0.005 0 0.009 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 11 27658369 rs6265 T C 0 0.005 0 0 0.005 0 0.009 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 11 27658369 rs6265 T C 0 0.005 0 0 0.005 0 0.009 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 11 27662970 rs11030104 G A 0 0.005 0 0 0.014 0 0.009 0.0013 0.0009 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 11 27662970 rs11030104 G A 0 0.005 0 0 0.014 0 0.009 0.0013 0.0009 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 11 27662970 rs11030104 G A 0 0.005 0 0 0.014 0 0.009 0.0013 0.0009 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 11 27701787 rs56133711 A G 0.068 0.077 0.085 0.061 0.086 0.094 0.075 0.0016 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 11 33017547 rs4755351 G A 0.055 0.095 0.112 0.135 0.18 0.119 0.12 0 0.0017 0.0125 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 11 44347927 rs3853291 A G 0.259 0.27 0.313 0.37 0.194 0.225 0.274 0.043 0.0272 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 46381302 rs35324223 A G 0.09 0.12 0.095 0.132 0.099 0.07 0.093 0.0084 0.0025 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 11 47325389 rs11039183 A G 0.03 0.045 0.054 0.035 0.05 0.045 0.062 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 47629441 rs3817334 T C 0.233 0.259 0.196 0.211 0.236 0.24 0.252 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 11 47629441 rs3817334 T C 0.233 0.259 0.196 0.211 0.236 0.24 0.252 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 11 48093537 rs3942852 T C 0.406 0.311 0.406 0.487 0.387 0.336 0.389 0.0344 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 11 58292720 rs12289961 C T 0.5 0.441 0.46 0.517 0.427 0.414 0.474 0.0095 0.0087 0 www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 11 58315137 rs113196862 T C 0.004 0 0 0.004 0 0 0 0.0031 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 11 58580292 rs948562 G A 0.055 0.06 0.081 0.078 0.104 0.091 0.08 0 0.0023 0.0023 www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 11 61510774 rs751984 C T 0.144 0.206 0.147 0.274 0.3 0.302 0.199 0 0.0022 0.049 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 11 61510774 rs751984 C T 0.144 0.206 0.147 0.274 0.3 0.302 0.199 0 0.0022 0.049 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 11 61785208 rs174537 T G 0.017 0.014 0.004 0.035 0.09 0.049 0.027 0 0.0216 0.0254 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 11 61785208 rs174537 T G 0.017 0.014 0.004 0.035 0.09 0.049 0.027 0 0.0216 0.0254 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 11 61785208 rs174537 T G 0.017 0.014 0.004 0.035 0.09 0.049 0.027 0 0.0216 0.0254 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 11 61803910 rs174549 A G 0.008 0 0.004 0.039 0.063 0.033 0.013 0.0075 0 0.0517 www.ncbi.nlm.nih.gov/pubmed/25194280 Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Laryngeal squamous cell carcinoma 11 61830500 rs1535 G A 0.11 0.108 0.094 0.196 0.212 0.103 0.093 0.0258 0 0.0356 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 11 61837495 rs2072113 T C 0.11 0.15 0.112 0.114 0.176 0.119 0.098 0 0.0021 0.0005 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 11 62126500 rs7937840 T C 0.06 0.054 0.126 0.101 0.055 0.05 0.134 0.0033 0.0147 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 64095140 rs11231693 A G 0.256 0.27 0.261 0.257 0.342 0.312 0.226 0 0.0114 0.0017 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 11 64340005 rs479777 C T 0.052 0.043 0.086 0.04 0.293 0.235 0.068 0 0.1823 0.0102 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 11 65815595 rs3903072 T G 0.123 0.135 0.094 0.13 0.077 0.082 0.084 0.0053 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 11 65815595 rs3903072 T G 0.123 0.135 0.094 0.13 0.077 0.082 0.084 0.0053 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 11 65815595 rs3903072 T G 0.123 0.135 0.094 0.13 0.077 0.082 0.084 0.0053 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 67633095 rs11227870 A G 0.216 0.205 0.268 0.209 0.122 0.09 0.201 0 0.0482 0.0012 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 11 68164294 rs4930561 G A 0.377 0.455 0.482 0.435 0.279 0.344 0.438 0 0.0336 0.0005 www.ncbi.nlm.nih.gov/pubmed/29059430 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. Breast cancer in childhood cancer survivors 11 69211113 rs11228565 A G 0.085 0.099 0.045 0.083 0.041 0.029 0.013 0.0108 0.0135 0 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 11 69227030 rs7931342 T G 0.161 0.131 0.147 0.117 0.117 0.115 0.164 0.0001 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 11 69227030 rs7931342 T G 0.161 0.131 0.147 0.117 0.117 0.115 0.164 0.0001 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 11 69227030 rs7931342 T G 0.161 0.131 0.147 0.117 0.117 0.115 0.164 0.0001 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 11 69227030 rs7931342 T G 0.161 0.131 0.147 0.117 0.117 0.115 0.164 0.0001 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/24740154 Genome-wide association scan for variants associated with early-onset prostate cancer. Prostate cancer (early onset) 11 69227200 rs10896449 A G 0.278 0.241 0.225 0.204 0.214 0.217 0.297 0.0029 0 0.0074 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 11 69227200 rs10896449 A G 0.278 0.241 0.225 0.204 0.214 0.217 0.297 0.0029 0 0.0074 www.ncbi.nlm.nih.gov/pubmed/18264096 Multiple loci identified in a genome-wide association study of prostate cancer. Prostate cancer 11 69228491 rs7130881 G A 0.195 0.207 0.219 0.152 0.185 0.201 0.155 0.0046 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 11 69228491 rs7130881 G A 0.195 0.207 0.219 0.152 0.185 0.201 0.155 0.0046 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 11 69244226 rs376592364 A T 0.432 0.389 0.392 0.335 0.257 0.315 0.463 0 0.0112 0.0284 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 11 69492927 rs537626 C G 0.275 0.296 0.326 0.364 0.167 0.156 0.301 0.0427 0.0848 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 11 69513996 rs614367 T C 0.114 0.099 0.143 0.14 0.095 0.094 0.124 0.0036 0.0054 0 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 11 69513996 rs614367 T C 0.114 0.099 0.143 0.14 0.095 0.094 0.124 0.0036 0.0054 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 11 69513996 rs614367 T C 0.114 0.099 0.143 0.14 0.095 0.094 0.124 0.0036 0.0054 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 11 69552350 rs498136 A C 0.144 0.198 0.196 0.161 0.099 0.088 0.199 0 0.0279 0.0058 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 11 69552350 rs498136 A C 0.144 0.198 0.196 0.161 0.099 0.088 0.199 0 0.0279 0.0058 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 11 69552350 rs498136 A C 0.144 0.198 0.196 0.161 0.099 0.088 0.199 0 0.0279 0.0058 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 11 69642525 rs1352075 T C 0.182 0.176 0.228 0.157 0.149 0.164 0.208 0.0006 0 0.0054 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 11 70153146 rs3781663 G A 0.356 0.374 0.268 0.329 0.266 0.307 0.345 0 0.0028 0.0015 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 11 71813131 rs190164515 C A 0.056 0.036 0.032 0.064 0.005 0.029 0.019 0.0209 0.0138 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 11 73601207 rs10751226 C T 0.444 0.536 0.428 0.374 0.364 0.346 0.465 0 0.0015 0.0262 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 11 74634505 rs3824999 G T 0.123 0.126 0.098 0.087 0.059 0.119 0.089 0.0004 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 11 74634505 rs3824999 G T 0.123 0.126 0.098 0.087 0.059 0.119 0.089 0.0004 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/22634755 "Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk." Colorectal cancer 11 74634505 rs3824999 G T 0.123 0.126 0.098 0.087 0.059 0.119 0.089 0.0004 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 11 74634505 rs3824999 G T 0.123 0.126 0.098 0.087 0.059 0.119 0.089 0.0004 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 11 75537412 rs606460 G A 0.424 0.432 0.406 0.496 0.491 0.451 0.456 0.0045 0 0.0065 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 11 76549500 rs11290954 A C 0.157 0.176 0.192 0.17 0.176 0.197 0.212 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 11 82100187 rs11607499 C T 0.008 0.014 0.009 0.004 0.036 0.054 0.018 0.002 0.0254 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 11 86933347 rs1350171 C T 0.309 0.333 0.371 0.47 0.286 0.252 0.372 0.0661 0.0323 0 www.ncbi.nlm.nih.gov/pubmed/26870257 Nine susceptibility loci for hepatitis B virus-related hepatocellular carcinoma identified by a pilot two-stage genome-wide association study. Hepatocellular carcinoma in hepatitis B infection 11 88824823 rs10831496 A G 0.165 0.135 0.143 0.109 0.32 0.25 0.137 0.0171 0.0775 0 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 11 89178528 rs1042602 A C 0 0.005 0 0.017 0 0 0 0.0351 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/17952075 "Genetic determinants of hair, eye and skin pigmentation in Europeans." Freckles 11 89178528 rs1042602 A C 0 0.005 0 0.017 0 0 0 0.0351 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/17999355 A genomewide association study of skin pigmentation in a South Asian population. Skin pigmentation 11 89178528 rs1042602 A C 0 0.005 0 0.017 0 0 0 0.0351 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/30166351 Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Skin pigmentation traits 11 89272085 rs1847134 C A 0.195 0.234 0.188 0.254 0.122 0.18 0.189 0.0193 0.0162 0 www.ncbi.nlm.nih.gov/pubmed/24980573 Identification of a melanoma susceptibility locus and somatic mutation in TET2. Melanoma 11 89284793 rs1126809 A G 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 11 89284793 rs1126809 A G 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/27424798 Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Cutaneous squamous cell carcinoma 11 89284793 rs1126809 A G 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Low tan response 11 89284793 rs1126809 A G 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/30166351 Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Skin pigmentation traits 11 89284793 rs1126809 A G 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/26829030 Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. Squamous cell carcinoma 11 89284793 rs1126809 A G 0 0.005 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/23548203 Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. Tanning 11 89294875 rs10830253 G T 0.301 0.365 0.286 0.372 0.194 0.242 0.292 0.0261 0.0372 0 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 11 92245852 rs12786200 T C 0.191 0.23 0.179 0.235 0.248 0.182 0.195 0.0018 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/25710658 Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia 11 92556568 rs586699 A G 0.386 0.432 0.451 0.404 0.368 0.41 0.473 0 0.0014 0.0016 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 11 93058934 rs7120482 A G 0.051 0.054 0.036 0.048 0.014 0.025 0.049 0.0014 0.0118 0 www.ncbi.nlm.nih.gov/pubmed/23719583 Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. Adverse response to radiation therapy 11 93676282 rs11020478 G A 0.004 0.023 0.045 0.053 0.072 0.082 0.062 0 0.0093 0.0129 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 11 94612336 rs7942260 G A 0.072 0.068 0.067 0.078 0.023 0.057 0.075 0.0027 0.0098 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 11 96162388 rs115019323 A G 0.025 0.023 0.022 0.026 0 0.004 0.004 0.0095 0.0197 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 11 96198321 rs479825 C T 0.348 0.32 0.342 0.265 0.221 0.262 0.311 0 0.0032 0.0156 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 11 96266936 rs7115578 A G 0.492 0.464 0.429 0.387 0.423 0.439 0.428 0.0062 0 0.0049 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 11 96938030 rs1944782 G A 0.059 0.032 0.071 0.066 0.167 0.098 0.071 0 0.029 0.0078 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 96947703 rs1944788 C T 0.056 0.032 0.071 0.066 0.11 0.071 0.071 0 0.0042 0.0032 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 96970814 rs17275283 C T 0.051 0.027 0.058 0.061 0.099 0.079 0.062 0 0.0076 0.005 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 11 101284141 rs7941595 A G 0.14 0.131 0.121 0.13 0.189 0.135 0.133 0 0.0017 0.0008 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 11 101538407 rs11224824 A G 0.218 0.225 0.161 0.162 0.173 0.168 0.23 0.002 0 0.0056 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 11 102530930 rs11568818 C T 0.381 0.464 0.46 0.465 0.455 0.504 0.447 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 11 102530930 rs11568818 C T 0.381 0.464 0.46 0.465 0.455 0.504 0.447 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 11 103547430 rs716274 G A 0.466 0.455 0.411 0.404 0.473 0.471 0.407 0.003 0.0042 0 www.ncbi.nlm.nih.gov/pubmed/21118971 Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients. Small-cell lung cancer (survival) 11 103813371 rs148883465 G A 0.013 0.032 0 0.009 0 0 0 0.002 0.0097 0 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 11 104170883 rs7930114 C T 0.153 0.159 0.103 0.165 0.063 0.123 0.104 0.0122 0.0117 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 11 106436144 rs1512436 T C 0.325 0.275 0.27 0.33 0.296 0.353 0.297 0.0007 0 0.002 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 11 108272729 rs1800057 G C 0 0.005 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 11 108304735 rs1801516 A G 0 0.005 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 11 108304735 rs1801516 A G 0 0.005 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 11 108486410 rs74911261 A G 0 0.005 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer 11 108486410 rs74911261 A G 0 0.005 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 11 108486410 rs74911261 A G 0 0.005 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast Cancer in BRCA1 mutation carriers 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/18372901 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Colorectal cancer 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/21761138 Meta-analysis of new genome-wide association studies of colorectal cancer risk. Colorectal cancer 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 11 111300984 rs3802842 C A 0.352 0.318 0.388 0.374 0.46 0.455 0.354 0 0.0182 0.0055 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 11 111302186 rs6589219 G C 0.36 0.324 0.392 0.374 0.559 0.553 0.354 0 0.0792 0.0082 www.ncbi.nlm.nih.gov/pubmed/28960316 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. Colorectal cancer 11 111378886 rs7111520 A G 0.356 0.323 0.29 0.39 0.347 0.326 0.261 0.0124 0 0.0088 www.ncbi.nlm.nih.gov/pubmed/30194254 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. Hodgkins lymphoma 11 111636465 rs505372 C A 0.246 0.209 0.275 0.261 0.196 0.238 0.248 0.001 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 113936459 rs11214775 A G 0.343 0.284 0.308 0.364 0.2 0.221 0.225 0.0323 0.0322 0 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 11 113936459 rs11214775 A G 0.343 0.284 0.308 0.364 0.2 0.221 0.225 0.0323 0.0322 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 11 114123783 rs238896 G A 0.083 0.073 0.076 0.044 0.09 0.083 0.089 0.0122 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 11 115151684 rs12286929 A G 0.297 0.423 0.41 0.46 0.338 0.373 0.447 0.016 0.0061 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 11 115151684 rs12286929 A G 0.297 0.423 0.41 0.46 0.338 0.373 0.447 0.016 0.0061 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 11 116439398 rs11215932 C T 0.357 0.352 0.284 0.383 0.22 0.3 0.305 0.0182 0.0176 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 11 117214494 rs77683187 C A 0.106 0.176 0.149 0.139 0.171 0.176 0.066 0 0.0059 0.0041 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 118254910 rs1056562 T C 0.265 0.311 0.263 0.332 0.324 0.258 0.314 0.0029 0 0.0014 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 11 118391991 rs61900932 T C 0.004 0 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 11 118871133 rs4938573 C T 0.318 0.302 0.29 0.239 0.419 0.361 0.232 0.0166 0.036 0 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 11 122838470 rs3134425 T C 0.271 0.207 0.237 0.304 0.18 0.164 0.261 0.0257 0.0295 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 11 123095918 rs7121616 A G 0.288 0.239 0.308 0.222 0.275 0.271 0.317 0.0094 0 0.005 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 123268252 rs7927484 T C 0.318 0.336 0.41 0.309 0.347 0.361 0.323 0.002 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 11 123393934 rs1943466 C A 0.428 0.455 0.424 0.395 0.451 0.488 0.42 0.0048 0.0049 0 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer (hypertension) (bevacizumab) 11 123393934 rs1943466 C A 0.428 0.455 0.424 0.395 0.451 0.488 0.42 0.0048 0.0049 0 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 11 123484683 rs35923643 G A 0.025 0.041 0.045 0.009 0.054 0.033 0.018 0.0156 0.0028 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 11 123484683 rs35923643 G A 0.025 0.041 0.045 0.009 0.054 0.033 0.018 0.0156 0.0028 0 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 11 123490689 rs735665 A G 0.025 0.041 0.045 0.004 0.054 0.033 0.013 0.0219 0.0035 0 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 11 123490689 rs735665 A G 0.025 0.041 0.045 0.004 0.054 0.033 0.013 0.0219 0.0035 0 www.ncbi.nlm.nih.gov/pubmed/22700719 Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Chronic lymphocytic leukemia 11 123490689 rs735665 A G 0.025 0.041 0.045 0.004 0.054 0.033 0.013 0.0219 0.0035 0 www.ncbi.nlm.nih.gov/pubmed/18758461 A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 11 123490689 rs735665 A G 0.025 0.041 0.045 0.004 0.054 0.033 0.013 0.0219 0.0035 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 11 123490689 rs735665 A G 0.025 0.041 0.045 0.004 0.054 0.033 0.013 0.0219 0.0035 0 www.ncbi.nlm.nih.gov/pubmed/20639881 Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Follicular lymphoma 11 126175935 rs7105310 G C 0.175 0.146 0.162 0.117 0.063 0.127 0.195 0 0.0047 0.0177 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 11 127775792 rs10790917 A G 0.017 0.014 0.013 0.074 0.009 0.02 0.013 0.0784 0 0.0231 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 11 128222597 rs71479994 A G 0.013 0.014 0.031 0.022 0.05 0.066 0.013 0 0.021 0.0075 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 11 128622844 rs4937362 C T 0.407 0.297 0.357 0.357 0.351 0.393 0.261 0 0.0014 0.0014 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 11 129360950 rs7102494 T C 0.299 0.319 0.323 0.341 0.433 0.356 0.333 0 0.0075 0.0044 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 129591121 rs11822830 A G 0.123 0.14 0.152 0.183 0.122 0.123 0.147 0.0109 0.0027 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 129591276 rs11820646 T C 0.165 0.194 0.171 0.204 0.273 0.258 0.168 0 0.0163 0.0102 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 11 129591276 rs11820646 T C 0.165 0.194 0.171 0.204 0.273 0.258 0.168 0 0.0163 0.0102 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 11 129591276 rs11820646 T C 0.165 0.194 0.171 0.204 0.273 0.258 0.168 0 0.0163 0.0102 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 11 129591276 rs11820646 T C 0.165 0.194 0.171 0.204 0.273 0.258 0.168 0 0.0163 0.0102 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 11 129591276 rs11820646 T C 0.165 0.194 0.171 0.204 0.273 0.258 0.168 0 0.0163 0.0102 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 11 132887775 rs1027796 A C 0.148 0.131 0.121 0.157 0.149 0.172 0.12 0 0.0004 0.0024 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 11 134396478 rs878987 G A 0.195 0.194 0.165 0.278 0.288 0.234 0.226 0.0086 0 0.0207 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 12 866782 rs12309274 G T 0.136 0.117 0.13 0.157 0.149 0.107 0.111 0.0029 0 0.0019 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 12 946864 rs12822733 G C 0.188 0.14 0.165 0.13 0.185 0.115 0.159 0.0018 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 12 955272 rs10849605 C T 0.453 0.392 0.401 0.451 0.373 0.455 0.447 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22899653 Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Lung cancer 12 1982091 rs11062040 C T 0.284 0.302 0.344 0.326 0.392 0.353 0.367 0 0.0029 0.0011 www.ncbi.nlm.nih.gov/pubmed/22142827 A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Response to gemcitabine in pancreatic cancer 12 1982091 rs11062040 C T 0.284 0.302 0.344 0.326 0.392 0.353 0.367 0 0.0029 0.0011 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 12 4296223 rs3217901 G A 0.072 0.054 0.086 0.087 0.054 0.053 0.089 0.0023 0.0048 0 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12 4296223 rs3217901 G A 0.072 0.054 0.086 0.087 0.054 0.053 0.089 0.0023 0.0048 0 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 12 4315956 rs10849033 G A 0.521 0.55 0.487 0.365 0.559 0.471 0.504 0.056 0 0.01 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 12 6276561 rs10849432 C T 0.308 0.315 0.313 0.317 0.257 0.299 0.314 0 0.0011 0.0003 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 12 6276561 rs10849432 C T 0.308 0.315 0.313 0.317 0.257 0.299 0.314 0 0.0011 0.0003 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 12 6872998 rs11064437 T C 0.343 0.306 0.326 0.209 0.365 0.291 0.327 0.0409 0 0.0062 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 12 7059368 rs7962738 A T 0.013 0 0.013 0.035 0.05 0.008 0.009 0.0114 0 0.0232 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in never smokers 12 8552873 rs10770857 A T 0.36 0.353 0.356 0.403 0.376 0.384 0.306 0.0036 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Response to radiotherapy in prostate cancer (overall toxicity) 12 11394598 rs2900174 G A 0.432 0.423 0.388 0.378 0.306 0.336 0.398 0 0.0105 0.0064 www.ncbi.nlm.nih.gov/pubmed/22142827 A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Response to gemcitabine in pancreatic cancer 12 11394598 rs2900174 G A 0.432 0.423 0.388 0.378 0.306 0.336 0.398 0 0.0105 0.0064 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 12 11809639 rs7314811 T C 0.496 0.464 0.415 0.574 0.446 0.475 0.455 0.0319 0 0.0066 www.ncbi.nlm.nih.gov/pubmed/29942513 Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses. Mucinous adenocarcinoma in colorectal cancer 12 11856807 rs2238126 G A 0.216 0.248 0.17 0.144 0.225 0.23 0.19 0.0191 0.0025 0 www.ncbi.nlm.nih.gov/pubmed/27145994 Common genetic variation in ETV6 is associated with colorectal cancer susceptibility. Colorectal cancer 12 12922268 rs2111398 A G 0.448 0.423 0.473 0.513 0.446 0.434 0.474 0.0084 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 12 13383212 rs78791096 A G 0.077 0.054 0.058 0.109 0.036 0.061 0.044 0.0276 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 12 14257551 rs17221259 C T 0 0 0 0.013 0 0.008 0 0.0229 0 0.0252 www.ncbi.nlm.nih.gov/pubmed/24143190 Genome-wide association study of breast cancer in the Japanese population. Breast cancer 12 14260997 rs12422552 C G 0.432 0.532 0.42 0.47 0.572 0.516 0.394 0 0.0146 0.0057 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 12 14260997 rs12422552 C G 0.432 0.532 0.42 0.47 0.572 0.516 0.394 0 0.0146 0.0057 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 12 14260997 rs12422552 C G 0.432 0.532 0.42 0.47 0.572 0.516 0.394 0 0.0146 0.0057 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 12 14263984 rs10845938 G A 0.411 0.293 0.46 0.342 0.277 0.348 0.447 0 0.0038 0.0131 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 12 14263984 rs10845938 G A 0.411 0.293 0.46 0.342 0.277 0.348 0.447 0 0.0038 0.0131 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) 12 14263984 rs10845938 G A 0.411 0.293 0.46 0.342 0.277 0.348 0.447 0 0.0038 0.0131 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (early onset) 12 16602438 rs9651873 C A 0.034 0.009 0.022 0.057 0.099 0.082 0.031 0 0.0165 0.0361 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 12 17291799 rs2965667 A T 0.025 0.05 0.054 0.096 0.018 0.02 0.031 0.0586 0.0161 0 www.ncbi.nlm.nih.gov/pubmed/25781442 Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. Colorectal cancer (aspirin and/or NSAID use interaction) 12 20383437 rs4326884 A G 0.068 0.153 0.08 0.152 0.036 0.058 0.155 0.0295 0.049 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 12 20423940 rs12369136 G A 0.004 0.005 0.004 0.004 0 0.008 0.004 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 12 21168436 rs10841753 C T 0.199 0.185 0.131 0.184 0.162 0.131 0.147 0.0015 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone conjugates/estrone ratio in resected early stage estrogen-receptor positive breast cancer 12 21178615 rs4149056 C T 0 0.005 0 0.004 0.009 0.004 0.004 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer 12 21215863 rs2900478 A T 0 0.005 0 0.004 0.009 0.004 0.004 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer 12 26318431 rs10842707 T C 0 0.014 0.018 0.022 0.041 0.025 0.027 0 0.0036 0.0037 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 12 26318431 rs10842707 T C 0 0.014 0.018 0.022 0.041 0.025 0.027 0 0.0036 0.0037 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 12 28002147 rs10771399 G A 0.013 0.027 0.027 0.018 0.005 0.02 0.027 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 12 28002147 rs10771399 G A 0.013 0.027 0.027 0.018 0.005 0.02 0.027 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 12 28002147 rs10771399 G A 0.013 0.027 0.027 0.018 0.005 0.02 0.027 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 12 28002147 rs10771399 G A 0.013 0.027 0.027 0.018 0.005 0.02 0.027 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 12 28002147 rs10771399 G A 0.013 0.027 0.027 0.018 0.005 0.02 0.027 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/24325915 Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. "Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)" 12 28002147 rs10771399 G A 0.013 0.027 0.027 0.018 0.005 0.02 0.027 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 12 28002147 rs10771399 G A 0.013 0.027 0.027 0.018 0.005 0.02 0.027 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/23544013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. Breast Cancer in BRCA1 mutation carriers 12 28021884 rs7297051 T C 0.051 0.099 0.147 0.13 0.122 0.139 0.128 0.0001 0 0.002 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 12 28021884 rs7297051 T C 0.051 0.099 0.147 0.13 0.122 0.139 0.128 0.0001 0 0.002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 12 28021884 rs7297051 T C 0.051 0.099 0.147 0.13 0.122 0.139 0.128 0.0001 0 0.002 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 12 28021884 rs7297051 T C 0.051 0.099 0.147 0.13 0.122 0.139 0.128 0.0001 0 0.002 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 12 28021884 rs7297051 T C 0.051 0.099 0.147 0.13 0.122 0.139 0.128 0.0001 0 0.002 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast Cancer in BRCA1 mutation carriers 12 29680396 rs2052678 A G 0.239 0.176 0.237 0.352 0.239 0.303 0.239 0.0366 0 0.0286 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 12 29797945 rs302359 C T 0.436 0.428 0.41 0.444 0.365 0.376 0.385 0.0032 0.0061 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 12 30822535 rs7134911 C A 0.479 0.441 0.423 0.43 0.347 0.365 0.42 0 0.0125 0.0026 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 12 32283475 rs708224 G A 0.407 0.414 0.321 0.339 0.288 0.258 0.358 0 0.0159 0.0088 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 12 32962886 rs4346053 A T 0.343 0.293 0.375 0.333 0.327 0.369 0.394 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer 12 41385180 rs1902910 G A 0.068 0.095 0.094 0.144 0.077 0.078 0.08 0.0266 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 12 43590425 rs77464658 A C 0 0 0.009 0.009 0 0 0.004 0.0064 0.0052 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 12 48016734 rs6580649 T C 0.157 0.186 0.147 0.148 0.099 0.123 0.137 0 0.0056 0.0021 www.ncbi.nlm.nih.gov/pubmed/27393504 Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung cancer 12 49251457 rs11168936 T C 0.274 0.296 0.214 0.311 0.261 0.279 0.235 0.0058 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 12 49282227 rs10875943 T C 0.297 0.27 0.259 0.287 0.293 0.344 0.319 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 12 49282227 rs10875943 T C 0.297 0.27 0.259 0.287 0.293 0.344 0.319 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer 12 49282227 rs10875943 T C 0.297 0.27 0.259 0.287 0.293 0.344 0.319 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 12 49853685 rs7138803 A G 0.097 0.1 0.126 0.113 0.212 0.205 0.147 0 0.0332 0.0014 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 12 49853685 rs7138803 A G 0.097 0.1 0.126 0.113 0.212 0.205 0.147 0 0.0332 0.0014 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 12 49853685 rs7138803 A G 0.097 0.1 0.126 0.113 0.212 0.205 0.147 0 0.0332 0.0014 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 12 50185615 rs12817211 T C 0 0.005 0 0.026 0 0 0 0.0582 0 0.0166 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 12 50761880 rs11169552 T C 0.042 0.023 0.054 0.078 0.149 0.09 0.031 0 0.0187 0.0388 www.ncbi.nlm.nih.gov/pubmed/20972440 "Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33." Colorectal cancer 12 51216581 rs7399018 T C 0.348 0.3 0.259 0.241 0.302 0.246 0.23 0.0023 0 0.0023 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 12 51955287 rs11610143 G C 0.017 0.009 0.004 0.074 0.027 0.02 0.009 0.0811 0 0.0531 www.ncbi.nlm.nih.gov/pubmed/26732429 Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Adenocarcinoma 12 51955287 rs11610143 G C 0.017 0.009 0.004 0.074 0.027 0.02 0.009 0.0811 0 0.0531 www.ncbi.nlm.nih.gov/pubmed/26732429 Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Lung cancer 12 52880120 rs902774 A G 0.125 0.082 0.071 0.048 0.014 0.045 0.071 0 0.0077 0.0197 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 12 52880120 rs902774 A G 0.125 0.082 0.071 0.048 0.014 0.045 0.071 0 0.0077 0.0197 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 12 52880120 rs902774 A G 0.125 0.082 0.071 0.048 0.014 0.045 0.071 0 0.0077 0.0197 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 12 52918828 rs73110464 T C 0.201 0.173 0.136 0.192 0.113 0.113 0.164 0.0071 0.019 0 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 12 53200654 rs11574532 T C 0.051 0.045 0.018 0.043 0.027 0.029 0.027 0.0005 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. "Response to radiotherapy in prostate cancer (toxicity, urinary frequency)" 12 53765493 rs7969151 A G 0.428 0.491 0.397 0.283 0.423 0.447 0.397 0.0584 0 0.0063 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 12 53948900 rs1443512 C A 0.411 0.419 0.335 0.364 0.396 0.426 0.35 0.0006 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 12 53948900 rs1443512 C A 0.411 0.419 0.335 0.364 0.396 0.426 0.35 0.0006 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 12 53955989 rs10783615 A G 0.377 0.374 0.272 0.326 0.387 0.348 0.31 0 0.001 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 12 53955989 rs10783615 A G 0.377 0.374 0.272 0.326 0.387 0.348 0.31 0 0.001 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 12 54025136 rs754133 A G 0.094 0.059 0.04 0.074 0.115 0.07 0.08 0 0.0013 0.0013 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 12 56009793 rs772921 T C 0.076 0.063 0.076 0.083 0.032 0.049 0.08 0.0036 0.0123 0 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 12 56009793 rs772921 T C 0.076 0.063 0.076 0.083 0.032 0.049 0.08 0.0036 0.0123 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 12 56080595 rs3741499 T C 0.435 0.455 0.464 0.434 0.409 0.463 0.46 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 12 56080696 rs4759229 A G 0.331 0.378 0.402 0.387 0.288 0.34 0.363 0.0023 0.0073 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 12 58440252 rs3847711 G A 0.479 0.478 0.576 0.439 0.432 0.475 0.496 0.0035 0 0.0078 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 12 64619044 rs7968403 C T 0.114 0.123 0.116 0.126 0.144 0.142 0.13 0 0.0004 0.0004 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 12 65598856 rs11175834 T C 0.461 0.464 0.428 0.402 0.427 0.458 0.319 0.0003 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 12 65598856 rs11175834 T C 0.461 0.464 0.428 0.402 0.427 0.458 0.319 0.0003 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Papillary thyroid cancer 12 65966384 rs7970350 T C 0.261 0.311 0.369 0.355 0.225 0.279 0.314 0.0105 0.0149 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 12 65966384 rs7970350 T C 0.261 0.311 0.369 0.355 0.225 0.279 0.314 0.0105 0.0149 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 12 69004009 rs57514780 C T 0.141 0.126 0.13 0.132 0.095 0.094 0.124 0 0.0049 0.0002 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 12 69405910 rs10878977 C T 0.205 0.225 0.25 0.316 0.324 0.258 0.239 0.0094 0 0.0187 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 12 73596057 rs1154865 G C 0.205 0.213 0.185 0.171 0.203 0.202 0.168 0.0001 0.0001 0 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 12 77335605 rs1402279 C T 0.178 0.153 0.14 0.25 0.113 0.143 0.137 0.0516 0.004 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 12 81995345 rs11115148 G T 0.051 0.05 0.045 0.083 0.032 0.066 0.054 0.0105 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 12 89666809 rs17249754 A G 0.097 0.126 0.152 0.126 0.234 0.135 0.133 0 0.011 0.0012 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 12 89666809 rs17249754 A G 0.097 0.126 0.152 0.126 0.234 0.135 0.133 0 0.011 0.0012 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 12 90637859 rs77028233 A G 0 0 0 0.004 0 0.004 0 0.0061 0 0.008 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 12 90683731 rs1847461 A G 0.072 0.059 0.045 0.035 0.005 0.025 0.058 0 0.0127 0.0107 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 12 95096472 rs12310399 T C 0.483 0.514 0.549 0.409 0.509 0.537 0.487 0.027 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) 12 95633983 rs17356907 G A 0.144 0.194 0.152 0.178 0.104 0.156 0.146 0.0026 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 12 95633983 rs17356907 G A 0.144 0.194 0.152 0.178 0.104 0.156 0.146 0.0026 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 12 95633983 rs17356907 G A 0.144 0.194 0.152 0.178 0.104 0.156 0.146 0.0026 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 12 95633983 rs17356907 G A 0.144 0.194 0.152 0.178 0.104 0.156 0.146 0.0026 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 12 95633983 rs17356907 G A 0.144 0.194 0.152 0.178 0.104 0.156 0.146 0.0026 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 12 95633983 rs17356907 G A 0.144 0.194 0.152 0.178 0.104 0.156 0.146 0.0026 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 12 95633983 rs17356907 G A 0.144 0.194 0.152 0.178 0.104 0.156 0.146 0.0026 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 12 100426307 rs12296850 G A 0.14 0.122 0.103 0.139 0.167 0.176 0.089 0 0.0069 0.0079 www.ncbi.nlm.nih.gov/pubmed/23341777 Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. Squamous cell carcinoma 12 108305255 rs1878022 C T 0.141 0.158 0.112 0.184 0.158 0.156 0.111 0.0071 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/21483023 Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. Response to platinum-based chemotherapy in non-small-cell lung cancer 12 108373556 rs10861905 A C 0.14 0.126 0.107 0.167 0.131 0.115 0.102 0.0096 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 12 108387767 rs803567 G A 0.165 0.149 0.176 0.161 0.104 0.112 0.137 0.0009 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 12 111446804 rs3184504 T C 0 0.009 0 0.017 0.005 0 0 0.0231 0 0.008 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 12 111621753 rs11065979 T C 0 0.014 0 0.017 0.005 0 0 0.0187 0 0.0036 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 12 112767698 rs7294822 A C 0.289 0.3 0.241 0.254 0.314 0.321 0.292 0.0027 0.0048 0 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 12 114228397 rs10774740 G T 0.275 0.212 0.21 0.309 0.232 0.246 0.286 0.0119 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 12 114247766 rs1270884 A G 0.131 0.113 0.116 0.226 0.108 0.066 0.159 0.0682 0.0245 0 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 12 114247766 rs1270884 A G 0.131 0.113 0.116 0.226 0.108 0.066 0.159 0.0682 0.0245 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 12 114366775 rs3782464 C A 0.188 0.171 0.198 0.178 0.104 0.127 0.165 0 0.0156 0.0003 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 12 114430333 rs1265507 A G 0.407 0.423 0.451 0.478 0.382 0.35 0.482 0.0085 0.0182 0 www.ncbi.nlm.nih.gov/pubmed/22532574 Identification of a novel percent mammographic density locus at 12q24. Percent mammographic density 12 115114632 rs35444 G A 0.466 0.383 0.411 0.444 0.342 0.365 0.434 0.003 0.0128 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 12 115114632 rs35444 G A 0.466 0.383 0.411 0.444 0.342 0.365 0.434 0.003 0.0128 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 12 115179836 rs55922880 C T 0.123 0.099 0.125 0.122 0.153 0.23 0.168 0.0004 0.0167 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 12 115398717 rs1292011 G A 0.555 0.455 0.406 0.439 0.432 0.479 0.425 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 12 115398717 rs1292011 G A 0.555 0.455 0.406 0.439 0.432 0.479 0.425 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 12 115398717 rs1292011 G A 0.555 0.455 0.406 0.439 0.432 0.479 0.425 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 12 115453598 rs7315438 C T 0.162 0.162 0.201 0.274 0.332 0.262 0.168 0 0.0003 0.0471 www.ncbi.nlm.nih.gov/pubmed/21761138 Meta-analysis of new genome-wide association studies of colorectal cancer risk. Colorectal cancer 12 116564853 rs2089222 A G 0.318 0.302 0.255 0.304 0.225 0.205 0.261 0.0045 0.0168 0 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 12 116702884 rs10850703 C A 0.18 0.198 0.147 0.226 0.176 0.18 0.15 0.0097 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/28039263 Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. Cisplatin-induced ototoxicity 12 117072747 rs11068315 T C 0 0.005 0 0 0.005 0 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27670397 Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Pre-treatment pain in head and neck squamous cell carcinoma 12 120394343 rs206966 T C 0.208 0.122 0.165 0.257 0.194 0.201 0.195 0.02 0 0.0122 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 12 120987058 rs7310409 A G 0.335 0.409 0.299 0.32 0.216 0.176 0.297 0 0.0481 0.0028 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 12 121016819 rs1182933 T C 0.03 0.05 0.049 0.083 0.045 0.02 0.035 0.0268 0.0007 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 12 123920171 rs12317176 T C 0.406 0.505 0.432 0.452 0.284 0.434 0.385 0.0031 0.0124 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 12 123920171 rs12317176 T C 0.406 0.505 0.432 0.452 0.284 0.434 0.385 0.0031 0.0124 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 12 123955563 rs4765219 A C 0.301 0.275 0.304 0.344 0.314 0.279 0.31 0.0039 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 12 123955563 rs4765219 A C 0.301 0.275 0.304 0.344 0.314 0.279 0.31 0.0039 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 12 124020897 rs863750 T C 0.453 0.35 0.415 0.409 0.374 0.398 0.443 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 12 125314817 rs1666839 G A 0.051 0.068 0.054 0.07 0.113 0.115 0.049 0 0.0173 0.0084 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 12 125326510 rs550677 A G 0.102 0.104 0.146 0.127 0.162 0.152 0.106 0 0.0041 0.0034 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 12 128297477 rs11059635 T C 0.098 0.104 0.08 0.07 0.077 0.041 0.111 0 0.0028 0.0073 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) 12 129452215 rs4759570 A G 0 0 0 0.004 0 0.004 0 0.006 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 13 20476436 rs7989332 A C 0.237 0.151 0.17 0.178 0.176 0.164 0.124 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 13 23719720 rs753955 G A 0.114 0.077 0.076 0.109 0.114 0.115 0.125 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21725308 A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Lung cancer 13 23847637 rs76248362 C G 0 0 0 0.017 0.023 0.012 0.009 0.0077 0 0.0234 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 13 23857670 rs74657221 C G 0 0 0 0.013 0.014 0.004 0.009 0.0072 0 0.0107 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 13 25800908 rs1326116 G A 0.096 0.072 0.111 0.071 0.07 0.075 0.106 0.0004 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 13 27623299 rs7097 T C 0.034 0.041 0.027 0.039 0.05 0.029 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21471979 Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Large B-cell lymphoma 13 27902841 rs9554197 T C 0.208 0.198 0.165 0.117 0.15 0.193 0.093 0.0106 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 13 27919860 rs9581943 A G 0.089 0.068 0.049 0.087 0.077 0.09 0.044 0.0011 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 13 27919860 rs9581943 A G 0.089 0.068 0.049 0.087 0.077 0.09 0.044 0.0011 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 13 27919860 rs9581943 A G 0.089 0.068 0.049 0.087 0.077 0.09 0.044 0.0011 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/25086665 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Pancreatic cancer 13 28590646 rs9579199 G A 0.123 0.131 0.165 0.244 0.077 0.07 0.115 0.0948 0.0459 0 www.ncbi.nlm.nih.gov/pubmed/24080446 Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study. Breast cancer (menopausal hormone therapy interaction) 13 29543880 rs9578106 C T 0.154 0.194 0.174 0.113 0.108 0.074 0.111 0 0.0054 0.0148 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 13 30740318 rs3885907 C A 0.407 0.286 0.415 0.43 0.455 0.434 0.35 0 0.0009 0.0121 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) 13 31124157 rs912294 A G 0.11 0.149 0.143 0.122 0.171 0.18 0.128 0.0012 0.0081 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in microsatellite instability low/stable colorectal cancer 13 36459278 rs9315420 G A 0.394 0.41 0.384 0.391 0.401 0.312 0.353 0 0.0004 0.0003 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 13 36848378 rs511674 C T 0.182 0.131 0.201 0.083 0.207 0.271 0.181 0.06 0.0279 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 13 44053652 rs17065323 T C 0.208 0.171 0.126 0.187 0.122 0.12 0.159 0.0047 0.0123 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 13 47795595 rs7999699 A G 0.525 0.464 0.527 0.461 0.496 0.504 0.491 0.0014 0 0.0012 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 13 48892795 rs1449572 T G 0.165 0.158 0.14 0.13 0.099 0.082 0.164 0 0.0124 0.0072 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 13 50521772 rs9562987 A G 0.435 0.458 0.412 0.505 0.51 0.513 0.414 0.0008 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 13 53528071 rs12429545 A G 0.017 0.018 0.009 0.013 0.014 0.02 0.027 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 13 53528071 rs12429545 A G 0.017 0.018 0.009 0.013 0.014 0.02 0.027 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 13 55584874 rs9527419 T A 0.195 0.212 0.183 0.296 0.27 0.217 0.223 0.0185 0 0.0169 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 13 55804290 rs2997105 C T 0.25 0.225 0.161 0.265 0.186 0.201 0.208 0.0119 0.0017 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 13 60686390 rs1576377 T C 0.216 0.189 0.143 0.265 0.329 0.312 0.21 0 0.0156 0.035 www.ncbi.nlm.nih.gov/pubmed/28112199 "Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci." "B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)" 13 62709905 rs116571008 G C 0.115 0.099 0.121 0.233 0.146 0.103 0.112 0.0688 0 0.0222 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 13 63164591 rs73505772 A T 0.191 0.179 0.142 0.222 0.179 0.14 0.181 0.0105 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 13 63490455 rs1340490 T G 0.081 0.072 0.095 0.053 0.045 0.041 0.062 0 0.0023 0.0067 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 13 63548486 rs9539806 G A 0.419 0.414 0.371 0.263 0.333 0.324 0.398 0.028 0 0.0307 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 13 63564941 rs2218400 A C 0.478 0.432 0.473 0.297 0.368 0.34 0.478 0.0316 0 0.0535 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 13 63567780 rs1000589 T G 0.526 0.477 0.505 0.366 0.509 0.488 0.528 0.0478 0 0.0117 www.ncbi.nlm.nih.gov/pubmed/23180869 Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Pancreatic cancer 13 63567780 rs1000589 T G 0.526 0.477 0.505 0.366 0.509 0.488 0.528 0.0478 0 0.0117 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 13 65907683 rs1585440 T G 0.083 0.136 0.101 0.096 0.093 0.088 0.131 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 13 66383401 rs9529055 A G 0.114 0.095 0.134 0.062 0.068 0.094 0.093 0.0067 0 0.0098 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 13 66767643 rs1885949 C T 0.038 0.023 0.031 0.065 0.05 0.042 0.04 0.0092 0 0.0088 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 13 73154002 rs9600079 G T 0.423 0.449 0.423 0.561 0.459 0.454 0.464 0.0324 0 0.0108 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 13 73154002 rs9600079 G T 0.423 0.449 0.423 0.561 0.459 0.454 0.464 0.0324 0 0.0108 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 13 73232845 rs12870942 C T 0.009 0.005 0.009 0.035 0.005 0.013 0 0.038 0 0.0185 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 13 73232845 rs12870942 C T 0.009 0.005 0.009 0.035 0.005 0.013 0 0.038 0 0.0185 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 13 73232845 rs12870942 C T 0.009 0.005 0.009 0.035 0.005 0.013 0 0.038 0 0.0185 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 13 73238004 rs7981863 C T 0.5 0.509 0.469 0.632 0.36 0.398 0.473 0.0873 0.0516 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 13 73238004 rs7981863 C T 0.5 0.509 0.469 0.632 0.36 0.398 0.473 0.0873 0.0516 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 13 73240754 rs11841589 G T 0.513 0.518 0.487 0.657 0.387 0.414 0.486 0.0962 0.0459 0 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial cancer 13 73240754 rs11841589 G T 0.513 0.518 0.487 0.657 0.387 0.414 0.486 0.0962 0.0459 0 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial endometrioid carcinoma 13 73334709 rs9573163 G C 0.047 0.059 0.08 0.165 0.05 0.07 0.071 0.0832 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 13 73342491 rs9543325 T C 0.017 0.005 0.004 0.109 0.009 0.037 0.031 0.1389 0 0.0606 www.ncbi.nlm.nih.gov/pubmed/20101243 "A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33." Pancreatic cancer 13 73342491 rs9543325 T C 0.017 0.005 0.004 0.109 0.009 0.037 0.031 0.1389 0 0.0606 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 13 73342491 rs9543325 T C 0.017 0.005 0.004 0.109 0.009 0.037 0.031 0.1389 0 0.0606 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 13 73342491 rs9543325 T C 0.017 0.005 0.004 0.109 0.009 0.037 0.031 0.1389 0 0.0606 www.ncbi.nlm.nih.gov/pubmed/25086665 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Pancreatic cancer 13 73357977 rs1886449 T C 0.214 0.207 0.205 0.257 0.081 0.094 0.186 0.042 0.0836 0 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 13 73383544 rs6562760 A G 0.314 0.306 0.304 0.283 0.329 0.357 0.367 0.0047 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 13 73383544 rs6562760 A G 0.314 0.306 0.304 0.283 0.329 0.357 0.367 0.0047 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 13 73383544 rs6562760 A G 0.314 0.306 0.304 0.283 0.329 0.357 0.367 0.0047 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 13 73383544 rs6562760 A G 0.314 0.306 0.304 0.283 0.329 0.357 0.367 0.0047 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast Cancer in BRCA1 mutation carriers 13 79725587 rs2039553 A G 0.342 0.311 0.38 0.355 0.418 0.41 0.425 0.0003 0.0045 0 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 13 83706928 rs9602270 T A 0.153 0.171 0.153 0.191 0.144 0.082 0.097 0.0172 0.0096 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 13 83804984 rs9593831 T C 0.449 0.419 0.469 0.509 0.374 0.336 0.469 0.0199 0.0325 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 13 83861212 rs17077369 G A 0.445 0.4 0.446 0.491 0.341 0.311 0.407 0.0257 0.0363 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 13 91792975 rs2352028 C T 0.449 0.396 0.288 0.409 0.432 0.357 0.362 0.0005 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/20304703 Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lung cancer 13 95123178 rs16950650 T C 0.136 0.126 0.125 0.139 0.176 0.168 0.142 0 0.0033 0.0021 www.ncbi.nlm.nih.gov/pubmed/23478653 A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy. Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer 13 95222702 rs1926657 T C 0.301 0.3 0.317 0.3 0.419 0.426 0.389 0.006 0.0267 0 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 13 99389484 rs7335046 G C 0.373 0.464 0.315 0.3 0.396 0.307 0.358 0.0101 0 0.0072 www.ncbi.nlm.nih.gov/pubmed/21700618 Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma. Basal cell carcinoma 13 101398739 rs9557635 A G 0.021 0.032 0.036 0.035 0.05 0.045 0.009 0 0.0036 0.0043 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 13 103214754 rs912969 T C 0.53 0.468 0.446 0.43 0.455 0.508 0.46 0.0036 0 0.0005 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 13 103275657 rs1529276 A T 0.047 0.063 0.031 0.087 0.072 0.066 0.031 0.0108 0 0.0167 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Prostate cancer 13 104707293 rs323473 A G 0.11 0.082 0.094 0.104 0.164 0.16 0.111 0 0.0153 0.0034 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 13 107138053 rs35669975 G C 0.237 0.234 0.29 0.4 0.18 0.143 0.248 0.1124 0.0587 0 www.ncbi.nlm.nih.gov/pubmed/25963547 Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort. Obesity in adult survivors of childhood cancer exposed to cranial radiation 13 107290084 rs9558996 T C 0.008 0.036 0.013 0.03 0.108 0.143 0.013 0 0.0895 0.0359 www.ncbi.nlm.nih.gov/pubmed/29367611 Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer. Carboplatin disposition in epthelial ovarian cancer 13 108630682 rs9583269 T C 0.415 0.414 0.402 0.322 0.5 0.513 0.344 0.0308 0.0435 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 13 109708437 rs75823044 T C 0.052 0.065 0.032 0.028 0.023 0.017 0.04 0 0.0028 0.0073 www.ncbi.nlm.nih.gov/pubmed/29117387 Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. Prostate cancer 13 111451555 rs118166185 T G 0.008 0.005 0 0.03 0.005 0.004 0 0.0442 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 13 113004794 rs4907479 A G 0.144 0.135 0.138 0.187 0.342 0.332 0.111 0 0.092 0.0498 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 13 113165471 rs3024737 G A 0.064 0.018 0.022 0.013 0.072 0.066 0.027 0.0135 0.0197 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 13 114294254 rs112998813 C T 0.097 0.041 0.027 0.057 0.073 0.062 0.045 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nodular sclerosis Hodgkin lymphoma 14 22010722 rs11846015 T G 0.034 0.068 0.072 0.054 0.036 0.058 0.072 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in estrogen receptor negative breast cancer 14 22468664 rs12589282 A C 0.407 0.405 0.428 0.421 0.486 0.55 0.419 0 0.0209 0.0023 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) 14 23116124 rs4982731 C T 0.453 0.423 0.397 0.396 0.419 0.389 0.412 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23512250 Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. Acute lymphoblastic leukemia (childhood) 14 23119848 rs2239633 A G 0.161 0.144 0.112 0.139 0.171 0.193 0.131 0 0.0058 0.0014 www.ncbi.nlm.nih.gov/pubmed/23996088 Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Acute lymphoblastic leukemia (B-cell precursor) 14 23119848 rs2239633 A G 0.161 0.144 0.112 0.139 0.171 0.193 0.131 0 0.0058 0.0014 www.ncbi.nlm.nih.gov/pubmed/29348612 GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Acute lymphoblastic leukemia (childhood) 14 23119848 rs2239633 A G 0.161 0.144 0.112 0.139 0.171 0.193 0.131 0 0.0058 0.0014 www.ncbi.nlm.nih.gov/pubmed/19684604 "Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia." Acute lymphoblastic leukemia (childhood) 14 23119848 rs2239633 A G 0.161 0.144 0.112 0.139 0.171 0.193 0.131 0 0.0058 0.0014 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 14 23119848 rs2239633 A G 0.161 0.144 0.112 0.139 0.171 0.193 0.131 0 0.0058 0.0014 www.ncbi.nlm.nih.gov/pubmed/29632299 Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia in childhood (B cell precursor) 14 24401845 rs7160316 G A 0.127 0.146 0.121 0.083 0.171 0.164 0.124 0.0193 0.0112 0 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in estrogen receptor positive breast cancer 14 27284333 rs75870332 A T 0.097 0.072 0.076 0.101 0.077 0.115 0.066 0.0009 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 14 29267632 rs12885454 A C 0.06 0.063 0.103 0.07 0.059 0.025 0.089 0 0.0089 0.0023 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 14 29267632 rs12885454 A C 0.06 0.063 0.103 0.07 0.059 0.025 0.089 0 0.0089 0.0023 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 14 33189539 rs912855 T C 0.297 0.314 0.311 0.33 0.277 0.369 0.279 0.0003 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 14 33545815 rs10146472 G A 0.411 0.446 0.469 0.422 0.414 0.385 0.491 0 0.0023 0.0028 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 14 34894698 rs17102823 C A 0.174 0.158 0.138 0.2 0.23 0.197 0.23 0 0.0015 0.002 www.ncbi.nlm.nih.gov/pubmed/28779025 Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Colorectal carcinoma in primary sclerosing cholangitis 14 36063370 rs368187 G C 0.178 0.159 0.188 0.165 0.14 0.176 0.168 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28195142 A genome-wide association study yields five novel thyroid cancer risk loci. Thyroid cancer 14 36090325 rs34081947 T C 0.178 0.153 0.183 0.162 0.14 0.152 0.164 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Differentiated thyroid cancer 14 36090325 rs34081947 T C 0.178 0.153 0.183 0.162 0.14 0.152 0.164 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/28703219 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. Papillary thyroid cancer 14 36180040 rs944289 T C 0.148 0.108 0.147 0.13 0.104 0.107 0.15 0 0.0022 0.0019 www.ncbi.nlm.nih.gov/pubmed/19198613 Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Thyroid cancer 14 36663564 rs2236007 A G 0.034 0.05 0.036 0.052 0.185 0.119 0.031 0 0.0729 0.0257 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 14 36663564 rs2236007 A G 0.034 0.05 0.036 0.052 0.185 0.119 0.031 0 0.0729 0.0257 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 14 36663564 rs2236007 A G 0.034 0.05 0.036 0.052 0.185 0.119 0.031 0 0.0729 0.0257 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 36680588 rs17104988 A G 0.14 0.144 0.107 0.139 0.077 0.061 0.089 0.0079 0.0223 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 14 36808438 rs848087 A G 0.182 0.167 0.185 0.196 0.207 0.201 0.17 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 36888207 rs17177725 C T 0.008 0 0.009 0 0.005 0.012 0 0.0028 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 14 42934256 rs11157317 T C 0.229 0.162 0.201 0.178 0.248 0.225 0.183 0.0018 0.0061 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 14 44734273 rs712419 C A 0.415 0.455 0.491 0.378 0.252 0.262 0.429 0 0.0532 0.0292 www.ncbi.nlm.nih.gov/pubmed/28044437 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Body mass index (change over time) in lung cancer 14 46625443 rs360178 A G 0.03 0.045 0.049 0.048 0.027 0.016 0.035 0.0032 0.0072 0 www.ncbi.nlm.nih.gov/pubmed/30068317 Genome-wide association study of lung function and clinical implication in heavy smokers. Post bronchodilator FEV1/FVC ratio in smoking 14 46766242 rs11848063 A G 0.445 0.369 0.317 0.442 0.41 0.369 0.362 0.0079 0 0.0044 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 14 51819674 rs35072154 T C 0.093 0.068 0.045 0.135 0.072 0.066 0.035 0.042 0 0.0154 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 51899056 rs1316298 G A 0.267 0.293 0.255 0.296 0.252 0.168 0.217 0.0089 0.0117 0 www.ncbi.nlm.nih.gov/pubmed/24658283 A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility. Lung cancer (smoking interaction) 14 52905612 rs8008270 T C 0.263 0.324 0.32 0.27 0.338 0.312 0.283 0.0022 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 14 52905612 rs8008270 T C 0.263 0.324 0.32 0.27 0.338 0.312 0.283 0.0022 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 14 53944201 rs4444235 C T 0.369 0.341 0.29 0.363 0.225 0.203 0.27 0.0186 0.0428 0 www.ncbi.nlm.nih.gov/pubmed/19011631 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Colorectal cancer 14 53944201 rs4444235 C T 0.369 0.341 0.29 0.363 0.225 0.203 0.27 0.0186 0.0428 0 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 14 53944201 rs4444235 C T 0.369 0.341 0.29 0.363 0.225 0.203 0.27 0.0186 0.0428 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 14 53952388 rs35107139 A C 0.453 0.469 0.514 0.396 0.413 0.467 0.54 0.012 0 0.0147 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 14 57140349 rs7144018 T C 0.14 0.144 0.121 0.174 0.225 0.086 0.137 0.0033 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 14 58186796 rs9323328 A G 0.322 0.401 0.304 0.317 0.194 0.193 0.323 0 0.0498 0.0046 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 14 58186796 rs9323328 A G 0.322 0.401 0.304 0.317 0.194 0.193 0.323 0 0.0498 0.0046 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 14 58722643 rs17094983 A G 0.148 0.14 0.147 0.13 0.099 0.119 0.128 0 0.0016 0.0016 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 14 58722643 rs17094983 A G 0.148 0.14 0.147 0.13 0.099 0.119 0.128 0 0.0016 0.0016 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 14 60655808 rs7153648 C G 0.424 0.419 0.455 0.417 0.464 0.5 0.394 0 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 14 61262775 rs76788097 G A 0.004 0.009 0.004 0.009 0.023 0.016 0.004 0 0.005 0.0041 www.ncbi.nlm.nih.gov/pubmed/25569183 A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Marginal zone lymphoma 14 64227194 rs58262369 T C 0.055 0.036 0.071 0.039 0.059 0.074 0.044 0.002 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 14 65317086 rs73278043 G C 0.055 0.041 0.036 0.078 0.009 0.012 0.049 0.0361 0.0406 0 www.ncbi.nlm.nih.gov/pubmed/29195075 An Unexpectedly Complex Architecture for Skin Pigmentation in Africans. Tanning 14 68193711 rs2588809 T C 0.377 0.347 0.317 0.235 0.478 0.373 0.323 0.0528 0.0297 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 14 68193711 rs2588809 T C 0.377 0.347 0.317 0.235 0.478 0.373 0.323 0.0528 0.0297 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 14 68193711 rs2588809 T C 0.377 0.347 0.317 0.235 0.478 0.373 0.323 0.0528 0.0297 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 68214759 rs1744947 T C 0.303 0.248 0.219 0.2 0.275 0.23 0.232 0.0066 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 68232877 rs1314913 T C 0.093 0.086 0.054 0.083 0.045 0.041 0.058 0.0034 0.0102 0 www.ncbi.nlm.nih.gov/pubmed/23001122 Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Breast cancer (male) 14 68283210 rs3784099 G A 0.097 0.105 0.085 0.158 0.198 0.19 0.155 0 0.0094 0.0215 www.ncbi.nlm.nih.gov/pubmed/22232737 Novel genetic markers of breast cancer survival identified by a genome-wide association study. Breast cancer (survival) 14 68513118 rs11624333 C T 0 0 0 0.017 0.005 0 0 0.0381 0 0.0249 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 68559662 rs11844632 A G 0.14 0.133 0.174 0.195 0.314 0.3 0.159 0 0.0524 0.0279 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 14 68567965 rs999737 T C 0 0 0 0.017 0.005 0 0 0.0381 0 0.0249 www.ncbi.nlm.nih.gov/pubmed/19330030 A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Breast cancer 14 68567965 rs999737 T C 0 0 0 0.017 0.005 0 0 0.0381 0 0.0249 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 14 68567965 rs999737 T C 0 0 0 0.017 0.005 0 0 0.0381 0 0.0249 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 14 68567965 rs999737 T C 0 0 0 0.017 0.005 0 0 0.0381 0 0.0249 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 68567965 rs999737 T C 0 0 0 0.017 0.005 0 0 0.0381 0 0.0249 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 14 68660027 rs7141529 T C 0.381 0.414 0.46 0.5 0.469 0.434 0.416 0.0101 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 14 68660027 rs7141529 T C 0.381 0.414 0.46 0.5 0.469 0.434 0.416 0.0101 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 14 68941980 rs2268983 G A 0.188 0.167 0.112 0.17 0.171 0.123 0.089 0.0015 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 14 69336483 rs1275679 A G 0.271 0.227 0.21 0.252 0.342 0.332 0.297 0 0.017 0.0013 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 14 70452982 rs8014252 C T 0.373 0.365 0.411 0.448 0.4 0.348 0.35 0.0124 0 0.0024 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Plasma estrone levels in resected estrogen-receptor positive breast cancer 14 70625539 rs8014671 G A 0.397 0.405 0.429 0.417 0.365 0.393 0.363 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 14 70625539 rs8014671 G A 0.397 0.405 0.429 0.417 0.365 0.393 0.363 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 14 71047446 rs2286313 G A 0.013 0.009 0.005 0.035 0.005 0 0.004 0.042 0.0022 0 www.ncbi.nlm.nih.gov/pubmed/27207650 Genome-wide association study of colorectal cancer in Hispanics. Colorectal cancer 14 74899026 rs732765 A G 0.407 0.441 0.402 0.417 0.27 0.32 0.434 0 0.0344 0.0005 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 14 78068563 rs3850370 T G 0.5 0.5 0.513 0.404 0.509 0.48 0.482 0.0202 0 0.0051 www.ncbi.nlm.nih.gov/pubmed/22872573 Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Response to platinum-based chemotherapy in non-small-cell lung cancer 14 79433111 rs7141420 C T 0.369 0.385 0.414 0.47 0.46 0.471 0.398 0.0029 0 0.0139 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 14 79433111 rs7141420 C T 0.369 0.385 0.414 0.47 0.46 0.471 0.398 0.0029 0 0.0139 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 14 79944098 rs8010717 C T 0.271 0.225 0.248 0.228 0.25 0.275 0.248 0.0002 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/25189868 Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. Blood pressure (smoking interaction) 14 87829256 rs4322600 A G 0.174 0.162 0.201 0.148 0.095 0.116 0.217 0 0.0135 0.0131 www.ncbi.nlm.nih.gov/pubmed/22923054 A genome-wide association study of breast cancer in women of African ancestry. Breast cancer 14 88218732 rs17124276 T C 0.097 0.136 0.081 0.113 0.05 0.029 0.089 0.0107 0.0385 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 14 89201573 rs77216150 T C 0.026 0.018 0.009 0.022 0.014 0.008 0 0.0013 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 14 89569888 rs243192 G A 0.034 0.041 0.04 0 0.014 0.016 0.031 0.0178 0 0.0155 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 14 89834691 rs12100561 A G 0.542 0.487 0.491 0.474 0.437 0.439 0.469 0 0.0032 0.0032 www.ncbi.nlm.nih.gov/pubmed/21105107 Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma. Hepatocellular carcinoma 14 90698719 rs1742101 T C 0 0 0 0.022 0.072 0.025 0.004 0 0.0087 0.0613 www.ncbi.nlm.nih.gov/pubmed/28120872 Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer. Response to platinum-based neoadjuvant chemotherapy in cervical cancer 14 91374725 rs941764 A G 0.216 0.266 0.196 0.244 0.23 0.236 0.208 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 14 91374725 rs941764 A G 0.216 0.266 0.196 0.244 0.23 0.236 0.208 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 14 91374725 rs941764 A G 0.216 0.266 0.196 0.244 0.23 0.236 0.208 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 91962066 rs2160077 G A 0.398 0.342 0.446 0.391 0.644 0.623 0.412 0.005 0.1236 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 14 91962066 rs2160077 G A 0.398 0.342 0.446 0.391 0.644 0.623 0.412 0.005 0.1236 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 14 92637727 rs11627032 C T 0.097 0.054 0.089 0.07 0.05 0.098 0.08 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 14 92637727 rs11627032 C T 0.097 0.054 0.089 0.07 0.05 0.098 0.08 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 92637727 rs11627032 C T 0.097 0.054 0.089 0.07 0.05 0.098 0.08 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 14 95476110 rs11622887 A C 0.352 0.311 0.317 0.344 0.401 0.43 0.438 0.0009 0.0084 0 www.ncbi.nlm.nih.gov/pubmed/23478653 A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy. Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer 14 95627510 rs115169421 A G 0.004 0.032 0.014 0.018 0 0 0 0.0091 0.018 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 14 96587587 rs17280262 T C 0.025 0 0.004 0.013 0.036 0.053 0.018 0 0.0195 0.0054 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer 14 96637470 rs17094273 A G 0.329 0.305 0.25 0.259 0.282 0.277 0.302 0.0013 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 14 97356528 rs234439 A G 0.131 0.146 0.17 0.168 0.153 0.098 0.126 0.0034 0.0023 0 www.ncbi.nlm.nih.gov/pubmed/29356057 Genetic risk of prostate cancer in Ugandan men. Prostate cancer 14 97836994 rs1471356 G A 0.394 0.333 0.348 0.404 0.432 0.439 0.389 0 0.0038 0.0057 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 14 98188794 rs1381274 C T 0.487 0.419 0.496 0.452 0.306 0.328 0.513 0 0.0493 0.0083 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 14 100851974 rs2295389 G C 0.055 0.086 0.049 0.065 0.135 0.123 0.071 0 0.0237 0.0033 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 14 101629499 rs11621975 G A 0.119 0.095 0.09 0.136 0.189 0.156 0.103 0 0.0093 0.0138 www.ncbi.nlm.nih.gov/pubmed/28935272 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin 14 103018488 rs751837 T C 0.359 0.373 0.384 0.391 0.306 0.291 0.509 0 0.0225 0.0036 www.ncbi.nlm.nih.gov/pubmed/21471979 Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Large B-cell lymphoma 14 104637421 rs116039120 C T 0.042 0.054 0.05 0.039 0.054 0.042 0.058 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 14 104776883 rs2498796 A G 0.305 0.266 0.348 0.235 0.455 0.429 0.362 0.0446 0.0544 0 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial cancer 14 104776883 rs2498796 A G 0.305 0.266 0.348 0.235 0.455 0.429 0.362 0.0446 0.0544 0 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial endometrioid carcinoma 15 27799396 rs11074306 A G 0.064 0.095 0.058 0.109 0.068 0.061 0.075 0.0114 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/28781888 A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus. Uveal melanoma 15 28090674 rs4778138 A G 0.288 0.293 0.295 0.326 0.131 0.168 0.199 0.0345 0.0672 0 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 15 28090674 rs4778138 A G 0.288 0.293 0.295 0.326 0.131 0.168 0.199 0.0345 0.0672 0 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 15 28111713 rs1129038 T C 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/30166351 Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Skin pigmentation traits 15 28120472 rs12913832 G A 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 15 28120472 rs12913832 G A 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Low tan response 15 28120472 rs12913832 G A 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/25963972 Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up. Perceived skin darkness 15 28120472 rs12913832 G A 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/30166351 Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Skin pigmentation traits 15 28120472 rs12913832 G A 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/23548203 Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. Tanning 15 28165345 rs12916300 T C 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 15 28165345 rs12916300 T C 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 15 28165345 rs12916300 T C 0 0 0 0.009 0 0.004 0.004 0.0083 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/26829030 Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. Squamous cell carcinoma 15 28243742 rs8028689 C T 0.398 0.441 0.438 0.252 0.432 0.43 0.385 0.078 0 0.0045 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 15 28285036 rs1667394 T C 0.064 0.059 0.041 0.144 0.027 0.033 0.031 0.1062 0.0047 0 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Low tan response 15 32702555 rs4779584 C T 0.377 0.351 0.335 0.339 0.514 0.479 0.341 0.003 0.0496 0 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 15 32702555 rs4779584 C T 0.377 0.351 0.335 0.339 0.514 0.479 0.341 0.003 0.0496 0 www.ncbi.nlm.nih.gov/pubmed/18372905 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Colorectal cancer 15 32702555 rs4779584 C T 0.377 0.351 0.335 0.339 0.514 0.479 0.341 0.003 0.0496 0 www.ncbi.nlm.nih.gov/pubmed/21761138 Meta-analysis of new genome-wide association studies of colorectal cancer risk. Colorectal cancer 15 32702555 rs4779584 C T 0.377 0.351 0.335 0.339 0.514 0.479 0.341 0.003 0.0496 0 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 15 32718211 rs2293582 A G 0.13 0.126 0.151 0.136 0.092 0.103 0.18 0 0.0077 0.0025 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 15 32720301 rs73376930 G A 0.331 0.341 0.357 0.278 0.338 0.357 0.381 0.0126 0 0.0035 www.ncbi.nlm.nih.gov/pubmed/24737748 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Colorectal cancer 15 32720301 rs73376930 G A 0.331 0.341 0.357 0.278 0.338 0.357 0.381 0.0126 0 0.0035 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 15 32834253 rs1258767 G A 0 0 0 0.013 0 0.012 0 0.0193 0 0.0283 www.ncbi.nlm.nih.gov/pubmed/24662972 Genome-wide interaction study of smoking and bladder cancer risk. Bladder cancer (smoking interaction) 15 33272281 rs8035094 C T 0.248 0.243 0.241 0.32 0.284 0.238 0.252 0.0129 0 0.0061 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer 15 37837578 rs10152207 A G 0.095 0.082 0.111 0.118 0.236 0.127 0.112 0 0.0209 0.0089 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 15 40029923 rs937213 C T 0.073 0.068 0.077 0.061 0.023 0.029 0.075 0 0.0186 0.0028 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 15 40029923 rs937213 C T 0.073 0.068 0.077 0.061 0.023 0.029 0.075 0 0.0186 0.0028 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial cancer 15 40029923 rs937213 C T 0.073 0.068 0.077 0.061 0.023 0.029 0.075 0 0.0186 0.0028 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 15 40029923 rs937213 C T 0.073 0.068 0.077 0.061 0.023 0.029 0.075 0 0.0186 0.0028 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial endometrioid carcinoma 15 40121915 rs8023845 T G 0.144 0.149 0.144 0.171 0.144 0.127 0.173 0.0013 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 42040418 rs7172971 T C 0.064 0.063 0.045 0.026 0.077 0.045 0.045 0.0106 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 15 43267033 rs748404 C T 0.051 0.059 0.032 0.104 0.09 0.103 0.044 0.0111 0 0.0331 www.ncbi.nlm.nih.gov/pubmed/19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Lung cancer 15 43492277 rs2439831 C T 0.225 0.306 0.241 0.257 0.255 0.256 0.239 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 46347610 rs4775302 A G 0.369 0.432 0.38 0.457 0.396 0.48 0.425 0.0026 0 0.0045 www.ncbi.nlm.nih.gov/pubmed/22130093 New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort. Prostate cancer 15 46564730 rs4775602 C A 0.444 0.481 0.531 0.5 0.427 0.429 0.442 0.0027 0.0059 0 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Response to radiotherapy in prostate cancer (overall toxicity) 15 47383458 rs12910916 T C 0.297 0.27 0.259 0.291 0.314 0.275 0.306 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 15 48099968 rs1834640 A G 0.008 0.005 0.009 0.113 0.063 0.033 0.022 0.1238 0 0.1195 www.ncbi.nlm.nih.gov/pubmed/17999355 A genomewide association study of skin pigmentation in a South Asian population. Skin pigmentation 15 48108002 rs2675345 A G 0.008 0.005 0.013 0.113 0.054 0.033 0.022 0.1258 0 0.1066 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 15 48141297 rs2470102 A G 0.008 0.005 0.009 0.113 0.054 0.033 0.022 0.1299 0 0.1133 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 15 48608389 rs1876206 C T 0.051 0.055 0.098 0.048 0.046 0.067 0.027 0 0 0 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 15 49038657 rs79040073 T C 0.008 0.014 0.013 0.043 0.018 0.004 0.009 0.0346 0 0.0094 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 49186829 rs7169304 A G 0.114 0.082 0.108 0.096 0.151 0.121 0.112 0.0007 0.0044 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 49186829 rs7169304 A G 0.114 0.082 0.108 0.096 0.151 0.121 0.112 0.0007 0.0044 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 15 49186829 rs7169304 A G 0.114 0.082 0.108 0.096 0.151 0.121 0.112 0.0007 0.0044 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 49314101 rs11632038 G A 0 0.005 0.004 0.017 0.009 0 0.009 0.0119 0 0.0039 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 49448874 rs17400427 C T 0.089 0.072 0.081 0.076 0.081 0.061 0.111 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 49667937 rs28516445 G A 0.021 0.023 0.032 0.017 0.018 0.02 0.022 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 50016753 rs8033655 A G 0.119 0.095 0.117 0.135 0.162 0.148 0.133 0 0.0028 0.0028 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 15 50402109 rs4774565 A G 0.386 0.457 0.473 0.443 0.583 0.538 0.451 0 0.0285 0.001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 15 51261712 rs17601876 A G 0.097 0.131 0.085 0.139 0.068 0.07 0.111 0.0144 0.0159 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer 15 51261712 rs17601876 A G 0.097 0.131 0.085 0.139 0.068 0.07 0.111 0.0144 0.0159 0 www.ncbi.nlm.nih.gov/pubmed/30093612 Identification of nine new susceptibility loci for endometrial cancer. Endometrial cancer (endometrioid histology) 15 51261712 rs17601876 A G 0.097 0.131 0.085 0.139 0.068 0.07 0.111 0.0144 0.0159 0 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 15 51456413 rs3736485 G A 0.388 0.417 0.38 0.388 0.282 0.292 0.454 0 0.0287 0.0053 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 15 51456413 rs3736485 G A 0.388 0.417 0.38 0.388 0.282 0.292 0.454 0 0.0287 0.0053 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 15 56090097 rs16976734 G A 0.089 0.09 0.058 0.091 0.045 0.054 0.097 0.0026 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 56483399 rs11636802 G A 0.03 0.009 0.027 0.031 0.055 0.053 0.004 0 0.0116 0.0122 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 56488569 rs72742684 T C 0.03 0.009 0.027 0.03 0.05 0.053 0.004 0 0.0103 0.0111 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 61410580 rs3884558 A G 0.203 0.15 0.17 0.145 0.236 0.139 0.15 0.0019 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 15 61525012 rs532282237 C T 0.008 0.009 0 0 0.009 0 0 0.001 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 15 63719606 rs79503123 C T 0.009 0.009 0.022 0.013 0.009 0.004 0.009 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 15 66027468 rs61310892 A G 0.097 0.072 0.054 0.057 0.086 0.12 0.066 0.0037 0.0085 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 15 66072882 rs7164067 A G 0.252 0.293 0.311 0.313 0.284 0.32 0.192 0.0023 0 0.0053 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 15 66740813 rs1440372 T C 0.128 0.086 0.094 0.165 0.135 0.086 0.106 0.019 0 0.0065 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 15 66862731 rs4589502 T C 0.441 0.432 0.446 0.478 0.365 0.475 0.412 0.0038 0 0 www.ncbi.nlm.nih.gov/pubmed/24658283 A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility. Lung cancer (smoking interaction) 15 67163292 rs56062135 T C 0.038 0.077 0.094 0.022 0.108 0.09 0.04 0.029 0.0168 0 www.ncbi.nlm.nih.gov/pubmed/28195142 A genome-wide association study yields five novel thyroid cancer risk loci. Thyroid cancer 15 67199963 rs7166081 G A 0.184 0.257 0.21 0.152 0.259 0.254 0.146 0.0155 0.0167 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 15 67199963 rs7166081 G A 0.184 0.257 0.21 0.152 0.259 0.254 0.146 0.0155 0.0167 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 15 67784830 rs16951275 C T 0.432 0.347 0.46 0.409 0.414 0.373 0.403 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 15 67784830 rs16951275 C T 0.432 0.347 0.46 0.409 0.414 0.373 0.403 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 15 67967670 rs338389 G A 0.263 0.248 0.25 0.191 0.212 0.24 0.263 0.0073 0 0.0075 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in rectal cancer 15 69726651 rs7176508 A G 0.208 0.236 0.174 0.187 0.162 0.205 0.226 0 0.0004 0.0004 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 69726651 rs7176508 A G 0.208 0.236 0.174 0.187 0.162 0.205 0.226 0 0.0004 0.0004 www.ncbi.nlm.nih.gov/pubmed/22700719 Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 69726651 rs7176508 A G 0.208 0.236 0.174 0.187 0.162 0.205 0.226 0 0.0004 0.0004 www.ncbi.nlm.nih.gov/pubmed/18758461 A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 69726651 rs7176508 A G 0.208 0.236 0.174 0.187 0.162 0.205 0.226 0 0.0004 0.0004 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 15 70139434 rs11855650 T G 0.411 0.32 0.433 0.352 0.275 0.303 0.394 0 0.0139 0.0088 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 72801650 rs7164727 T C 0.316 0.225 0.32 0.237 0.329 0.269 0.259 0.006 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 15 72801650 rs7164727 T C 0.316 0.225 0.32 0.237 0.329 0.269 0.259 0.006 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 15 73936469 rs4886782 A G 0.004 0.023 0.054 0.043 0.041 0.029 0.013 0.0042 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 15 73936469 rs4886782 A G 0.004 0.023 0.054 0.043 0.041 0.029 0.013 0.0042 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 15 73936469 rs4886782 A G 0.004 0.023 0.054 0.043 0.041 0.029 0.013 0.0042 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 15 74300521 rs12904134 A G 0 0.005 0 0.013 0 0 0.004 0.0184 0.0007 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 15 74619987 rs11543198 A G 0.038 0.018 0.023 0.013 0.027 0.045 0.041 0.0069 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/25281661 Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population. Bladder cancer 15 74763478 rs79149102 T C 0.021 0.036 0.022 0.052 0.032 0.016 0.035 0.0108 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 15 74785026 rs1378942 A C 0 0.009 0.004 0.03 0.045 0.016 0.004 0.0123 0 0.039 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 15 74785026 rs1378942 A C 0 0.009 0.004 0.03 0.045 0.016 0.004 0.0123 0 0.039 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 15 74833304 rs6495122 C A 0.214 0.288 0.185 0.196 0.27 0.265 0.162 0.0023 0.0101 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 15 74833304 rs6495122 C A 0.214 0.288 0.185 0.196 0.27 0.265 0.162 0.0023 0.0101 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 15 74839978 rs936229 A G 0.492 0.41 0.455 0.5 0.332 0.393 0.464 0.0128 0.0269 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 15 74843920 rs6938 G C 0.051 0.073 0.041 0.109 0.108 0.057 0.084 0.0114 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 15 75157333 rs4886670 G T 0.17 0.236 0.203 0.257 0.309 0.244 0.261 0 0.0023 0.0065 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) 15 75637650 rs79604958 C G 0 0 0.004 0.009 0 0 0.004 0.009 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Response to radiotherapy in prostate cancer (overall toxicity) 15 75637960 rs67079557 A TAATAAG 0.483 0.464 0.469 0.575 0.377 0.398 0.54 0.0372 0.0385 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 15 78510527 rs9788721 C T 0.356 0.423 0.339 0.348 0.35 0.422 0.315 0.0001 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/29631575 The genetics of smoking in individuals with chronic obstructive pulmonary disease. Cotinine levels in smokers with chronic obstructive pulmonary disease 15 78510527 rs9788721 C T 0.356 0.423 0.339 0.348 0.35 0.422 0.315 0.0001 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/27669027 Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Emphysema distribution in smoking 15 78513681 rs8034191 C T 0.157 0.171 0.112 0.165 0.126 0.148 0.071 0.0034 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Lung cancer 15 78513681 rs8034191 C T 0.157 0.171 0.112 0.165 0.126 0.148 0.071 0.0034 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/18385676 Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Lung cancer 15 78513681 rs8034191 C T 0.157 0.171 0.112 0.165 0.126 0.148 0.071 0.0034 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/18780872 Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. Lung cancer 15 78513681 rs8034191 C T 0.157 0.171 0.112 0.165 0.126 0.148 0.071 0.0034 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/18385738 A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Lung cancer 15 78521704 rs10519203 G A 0.348 0.36 0.317 0.391 0.284 0.336 0.257 0.0138 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/25551457 "No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects." "Fibrinogen levels (smoking status, alcohol consumption or body mass index interaction)" 15 78559273 rs2036527 A G 0.184 0.234 0.174 0.29 0.2 0.189 0.173 0.0341 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/22832964 Genome-wide meta-analyses of smoking behaviors in African Americans. Smoking behavior 15 78565597 rs55853698 G T 0.013 0.041 0.023 0.057 0.027 0.049 0.022 0.0113 0 0.0128 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 15 78565644 rs55781567 G C 0.237 0.273 0.259 0.357 0.302 0.361 0.248 0.0112 0 0.0266 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 78565644 rs55781567 G C 0.237 0.273 0.259 0.357 0.302 0.361 0.248 0.0112 0 0.0266 www.ncbi.nlm.nih.gov/pubmed/27393504 Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung cancer 15 78565644 rs55781567 G C 0.237 0.273 0.259 0.357 0.302 0.361 0.248 0.0112 0 0.0266 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 15 78565644 rs55781567 G C 0.237 0.273 0.259 0.357 0.302 0.361 0.248 0.0112 0 0.0266 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 78571130 rs667282 C T 0.352 0.374 0.313 0.352 0.23 0.256 0.288 0.0055 0.0243 0 www.ncbi.nlm.nih.gov/pubmed/22832964 Genome-wide meta-analyses of smoking behaviors in African Americans. Smoking behavior 15 78601997 rs1051730 A G 0.072 0.086 0.103 0.113 0.045 0.078 0.106 0.0067 0.01 0 www.ncbi.nlm.nih.gov/pubmed/19836008 A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Lung adenocarcinoma 15 78601997 rs1051730 A G 0.072 0.086 0.103 0.113 0.045 0.078 0.106 0.0067 0.01 0 www.ncbi.nlm.nih.gov/pubmed/18978790 Lung cancer susceptibility locus at 5p15.33. Lung cancer 15 78601997 rs1051730 A G 0.072 0.086 0.103 0.113 0.045 0.078 0.106 0.0067 0.01 0 www.ncbi.nlm.nih.gov/pubmed/30104567 Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Lung cancer 15 78601997 rs1051730 A G 0.072 0.086 0.103 0.113 0.045 0.078 0.106 0.0067 0.01 0 www.ncbi.nlm.nih.gov/pubmed/30104567 Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Lung cancer in ever smokers 15 78601997 rs1051730 A G 0.072 0.086 0.103 0.113 0.045 0.078 0.106 0.0067 0.01 0 www.ncbi.nlm.nih.gov/pubmed/20418889 Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Smoking behavior 15 78601997 rs1051730 A G 0.072 0.086 0.103 0.113 0.045 0.078 0.106 0.0067 0.01 0 www.ncbi.nlm.nih.gov/pubmed/20418888 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Smoking behavior 15 78601997 rs1051730 A G 0.072 0.086 0.103 0.113 0.045 0.078 0.106 0.0067 0.01 0 www.ncbi.nlm.nih.gov/pubmed/20418890 Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Smoking behavior 15 78618839 rs8040868 C T 0.274 0.288 0.36 0.352 0.356 0.385 0.407 0 0.0011 0.0011 www.ncbi.nlm.nih.gov/pubmed/29924316 Genome-Wide Association Study of Familial Lung Cancer. Familial lung cancer 15 78618839 rs8040868 C T 0.274 0.288 0.36 0.352 0.356 0.385 0.407 0 0.0011 0.0011 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 15 78623530 rs55958997 A C 0.206 0.236 0.25 0.162 0.222 0.25 0.274 0.0201 0 0.0048 www.ncbi.nlm.nih.gov/pubmed/25072098 Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide. Exhaled carbon monoxide levels 15 78674313 rs11639372 T C 0.11 0.086 0.147 0.187 0.189 0.157 0.134 0.0081 0 0.0198 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 78674313 rs11639372 T C 0.11 0.086 0.147 0.187 0.189 0.157 0.134 0.0081 0 0.0198 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 15 78674313 rs11639372 T C 0.11 0.086 0.147 0.187 0.189 0.157 0.134 0.0081 0 0.0198 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 78675059 rs12902602 G A 0.004 0.014 0.018 0.03 0.045 0.02 0.018 0.0011 0 0.0099 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (smoking interaction) 15 78675059 rs12902602 G A 0.004 0.014 0.018 0.03 0.045 0.02 0.018 0.0011 0 0.0099 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 15 78675059 rs12902602 G A 0.004 0.014 0.018 0.03 0.045 0.02 0.018 0.0011 0 0.0099 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 15 78764427 rs1809420 C T 0.009 0.05 0.022 0.022 0.056 0.038 0.027 0.0003 0.0055 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 15 78764427 rs1809420 C T 0.009 0.05 0.022 0.022 0.056 0.038 0.027 0.0003 0.0055 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 15 78892838 rs28408315 A G 0.17 0.234 0.201 0.226 0.257 0.221 0.155 0 0.0013 0.0052 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 15 78892838 rs28408315 A G 0.17 0.234 0.201 0.226 0.257 0.221 0.155 0 0.0013 0.0052 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 15 78892838 rs28408315 A G 0.17 0.234 0.201 0.226 0.257 0.221 0.155 0 0.0013 0.0052 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 79696844 rs12591436 G T 0 0.009 0 0.009 0.005 0 0 0.0045 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Response to radiotherapy in prostate cancer (overall toxicity) 15 81937658 rs16973225 C A 0.064 0.046 0.117 0.093 0.063 0.074 0.076 0.0009 0.0005 0 www.ncbi.nlm.nih.gov/pubmed/25781442 Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. Colorectal cancer (aspirin and/or NSAID use interaction) 15 83845538 rs7162542 C G 0.28 0.36 0.272 0.148 0.176 0.172 0.239 0.0188 0 0.0555 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 15 83845538 rs7162542 C G 0.28 0.36 0.272 0.148 0.176 0.172 0.239 0.0188 0 0.0555 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 15 85533958 rs2279168 G A 0.144 0.216 0.161 0.2 0.149 0.168 0.093 0.0066 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 15 85919621 rs4262906 T C 0.153 0.136 0.214 0.187 0.159 0.103 0.21 0.0017 0.0099 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) 15 85919621 rs4262906 T C 0.153 0.136 0.214 0.187 0.159 0.103 0.21 0.0017 0.0099 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) 15 87509536 rs11853542 A G 0.089 0.095 0.098 0.148 0.185 0.156 0.146 0 0.004 0.014 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 15 88493060 rs4932397 C G 0.047 0.036 0.032 0.039 0.054 0.025 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28662289 Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma. Familial hepatitis B virus-related hepatocellular carcinoma 15 88871064 rs1879529 T G 0.275 0.323 0.326 0.335 0.268 0.287 0.319 0.0022 0.0033 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 15 88871064 rs1879529 T G 0.275 0.323 0.326 0.335 0.268 0.287 0.319 0.0022 0.0033 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 15 88883704 rs17791430 C T 0.047 0.036 0.063 0.087 0.059 0.074 0.071 0.0061 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 89326435 rs2074885 A G 0.22 0.225 0.304 0.287 0.296 0.295 0.393 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30787463 Genome-wide association study of germline variants and breast cancer-specific mortality. Breast cancer specific mortality in estrogen receptor negative breast cancer 15 90595866 rs16944613 G A 0.479 0.405 0.428 0.461 0.332 0.384 0.416 0.0051 0.0159 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 15 90968837 rs2290203 A G 0.525 0.486 0.5 0.443 0.393 0.417 0.429 0 0.0049 0.0079 www.ncbi.nlm.nih.gov/pubmed/25038754 "Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1." Breast cancer 15 90968837 rs2290203 A G 0.525 0.486 0.5 0.443 0.393 0.417 0.429 0 0.0049 0.0079 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 15 92114143 rs207954 T C 0.448 0.478 0.442 0.482 0.482 0.525 0.438 0 0.0022 0.0025 www.ncbi.nlm.nih.gov/pubmed/22076464 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 15 92188429 rs11074046 A G 0.085 0.086 0.103 0.139 0.117 0.135 0.115 0.0042 0 0.0077 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 15 92316651 rs1871438 G A 0.369 0.359 0.295 0.297 0.532 0.443 0.332 0.0168 0.0615 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 15 92567899 rs28510890 A G 0.457 0.428 0.487 0.439 0.505 0.458 0.509 0.0005 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 15 94038713 rs12101726 A C 0.33 0.382 0.409 0.403 0.36 0.435 0.505 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 15 96315180 rs4310804 G C 0.059 0.072 0.098 0.1 0.063 0.127 0.106 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 15 96315180 rs4310804 G C 0.059 0.072 0.098 0.1 0.063 0.127 0.106 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 15 96565598 rs2139953 C A 0.03 0.023 0.018 0.066 0.108 0.053 0.031 0 0.0006 0.0367 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 15 98660872 rs8027457 T C 0.18 0.095 0.167 0.1 0.149 0.197 0.137 0.0148 0.0061 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 15 100147762 rs4246302 G A 0.14 0.182 0.122 0.175 0.127 0.128 0.112 0.0064 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 16 696611 rs11861214 T G 0.161 0.171 0.207 0.159 0.176 0.132 0.182 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 16 699057 rs4984916 G A 0.098 0.118 0.108 0.196 0.072 0.074 0.155 0.052 0.0281 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 16 1434454 rs61743495 C T 0.17 0.186 0.144 0.144 0.105 0.096 0.116 0 0.0096 0.0023 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 16 4056787 rs11076805 A C 0.195 0.14 0.189 0.148 0.218 0.213 0.142 0.003 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer 16 4056787 rs11076805 A C 0.195 0.14 0.189 0.148 0.218 0.213 0.142 0.003 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 16 4951379 rs9635542 G A 0.068 0.055 0.08 0.061 0.009 0.02 0.053 0.0046 0.0326 0 www.ncbi.nlm.nih.gov/pubmed/22637743 Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. Lung cancer (asbestos exposure interaction) 16 5379576 rs476605 A C 0.051 0.045 0.067 0.117 0.095 0.074 0.093 0.0158 0 0.0133 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 16 5621791 rs7202041 T A 0.244 0.167 0.205 0.187 0.302 0.23 0.208 0.0031 0.012 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 16 7093498 rs12103267 A G 0.119 0.135 0.125 0.139 0.077 0.107 0.115 0.0029 0.0067 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 16 7693745 rs917543 G T 0.127 0.117 0.147 0.265 0.153 0.152 0.133 0.0709 0 0.0281 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 16 7786295 rs3112740 A C 0.102 0.09 0.041 0.057 0.063 0.045 0.062 0 0.0005 0.0014 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 16 7882576 rs75728418 T G 0.124 0.171 0.147 0.144 0.122 0.098 0.102 0.0005 0.0025 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 16 9301482 rs4780973 T C 0.141 0.158 0.174 0.23 0.131 0.119 0.097 0.0426 0.0012 0 www.ncbi.nlm.nih.gov/pubmed/28470677 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Survival in pancreatic cancer 16 9344835 rs40129 G T 0.322 0.333 0.281 0.387 0.243 0.169 0.248 0.0483 0.044 0 www.ncbi.nlm.nih.gov/pubmed/25194280 Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Laryngeal squamous cell carcinoma 16 9535210 rs4141488 T C 0.35 0.338 0.339 0.342 0.55 0.5 0.394 0.004 0.0671 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (smoking interaction) 16 10079891 rs7192140 C T 0.441 0.482 0.432 0.457 0.396 0.447 0.474 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 16 10079891 rs7192140 C T 0.441 0.482 0.432 0.457 0.396 0.447 0.474 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 16 10647125 rs78442819 C G 0 0 0 0.004 0.005 0 0 0.006 0 0.0079 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 16 11808105 rs7194099 A G 0.038 0.045 0.081 0.139 0.108 0.094 0.035 0.038 0 0.0548 www.ncbi.nlm.nih.gov/pubmed/30219690 GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort. Depression in smokers 16 12389189 rs67119854 G C 0 0.009 0 0.026 0.005 0 0.022 0.024 0.0052 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 16 16864058 rs7186128 G A 0.33 0.316 0.362 0.298 0.363 0.37 0.336 0.0051 0.0034 0 www.ncbi.nlm.nih.gov/pubmed/23478653 A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy. Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer 16 19263230 rs75774303 A T 0.136 0.113 0.103 0.061 0.063 0.086 0.133 0.0076 0 0.0184 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 16 19924067 rs12446632 A G 0.059 0.099 0.054 0.074 0.108 0.074 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 16 19924067 rs12446632 A G 0.059 0.099 0.054 0.074 0.108 0.074 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 16 19924067 rs12446632 A G 0.059 0.099 0.054 0.074 0.108 0.074 0.097 0 0 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 16 23050620 rs72772480 A C 0.008 0.009 0.009 0.004 0 0.004 0 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 16 26527941 rs35874699 A C 0.458 0.419 0.397 0.36 0.473 0.414 0.394 0.0103 0.0023 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 16 30004016 rs4787491 A G 0.453 0.437 0.433 0.417 0.609 0.594 0.473 0.0119 0.0612 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 16 30004016 rs4787491 A G 0.453 0.437 0.433 0.417 0.609 0.594 0.473 0.0119 0.0612 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 16 30163605 rs6565176 T C 0.225 0.176 0.17 0.178 0.182 0.153 0.15 0 0 0 www.ncbi.nlm.nih.gov/pubmed/30194254 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. Hodgkins lymphoma 16 30714927 rs8058578 T C 0.522 0.518 0.441 0.513 0.455 0.421 0.451 0.0034 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 16 31118574 rs9925964 G A 0.051 0.072 0.05 0.117 0.099 0.05 0.089 0.0187 0 0.0082 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 16 31118574 rs9925964 G A 0.051 0.072 0.05 0.117 0.099 0.05 0.089 0.0187 0 0.0082 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 16 49830880 rs2047937 C T 0.492 0.514 0.46 0.465 0.414 0.385 0.446 0 0.0097 0.0028 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 16 49830880 rs2047937 C T 0.492 0.514 0.46 0.465 0.414 0.385 0.446 0 0.0097 0.0028 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 16 50069823 rs4785204 T C 0.097 0.104 0.098 0.17 0.036 0.078 0.084 0.0545 0.0237 0 www.ncbi.nlm.nih.gov/pubmed/22960999 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Esophageal cancer (squamous cell) 16 51681964 rs1381451 A G 0.148 0.135 0.13 0.1 0.171 0.213 0.12 0.012 0.0206 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 16 52532542 rs2193094 T G 0.017 0.041 0.036 0.039 0.041 0.016 0.013 0.0009 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/25956309 Genome-wide association study of susceptibility loci for breast cancer in Sardinian population. Breast cancer 16 52541995 rs4784223 G A 0.411 0.368 0.415 0.496 0.356 0.388 0.425 0.0271 0.0047 0 www.ncbi.nlm.nih.gov/pubmed/24493630 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Breast cancer (early onset) 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/24143190 Genome-wide association study of breast cancer in the Japanese population. Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/20453838 Genome-wide association study identifies five new breast cancer susceptibility loci. Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/20872241 A combined analysis of genome-wide association studies in breast cancer. Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/19330030 A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/17529974 Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/17529967 Genome-wide association study identifies novel breast cancer susceptibility loci. Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/23001122 Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Breast cancer (male) 16 52552429 rs3803662 G A 0.386 0.487 0.478 0.368 0.396 0.41 0.412 0.0059 0 0.0073 www.ncbi.nlm.nih.gov/pubmed/23544012 Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. Breast cancer in BRCA2 mutation carriers 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/30323354 "BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts." BRCA1/2-negative high-risk breast cancer 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/25327703 Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. Breast cancer 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/20585626 Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. Breast cancer 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 16 52565276 rs4784227 T C 0.013 0.023 0.018 0.061 0.018 0.033 0.022 0.0323 0 0.0162 www.ncbi.nlm.nih.gov/pubmed/28864454 Genome-Wide Testing of Exonic Variants and Breast Cancer Risk in the California Teachers Study. Breast cancer (estrogen-receptor positive) 16 52601088 rs12922061 T C 0.017 0.027 0.027 0.035 0.009 0.02 0.027 0.0036 0.0036 0 www.ncbi.nlm.nih.gov/pubmed/24143190 Genome-wide association study of breast cancer in the Japanese population. Breast cancer 16 52601252 rs3112612 A G 0.415 0.446 0.402 0.37 0.419 0.409 0.416 0.0033 0 0.0019 www.ncbi.nlm.nih.gov/pubmed/21263130 Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. Breast cancer 16 53768582 rs11642015 T C 0.042 0.06 0.036 0.039 0.027 0.029 0.063 0 0.0025 0.0025 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) 16 53768582 rs11642015 T C 0.042 0.06 0.036 0.039 0.027 0.029 0.063 0 0.0025 0.0025 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) 16 53768582 rs11642015 T C 0.042 0.06 0.036 0.039 0.027 0.029 0.063 0 0.0025 0.0025 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 16 53768582 rs11642015 T C 0.042 0.06 0.036 0.039 0.027 0.029 0.063 0 0.0025 0.0025 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 16 53769311 rs62048402 A G 0.042 0.059 0.036 0.039 0.036 0.033 0.08 0 0.0012 0.002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 16 53769662 rs1558902 A T 0.038 0.055 0.036 0.035 0.032 0.033 0.072 0 0.0007 0.0019 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 16 53769662 rs1558902 A T 0.038 0.055 0.036 0.035 0.032 0.033 0.072 0 0.0007 0.0019 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 16 53769662 rs1558902 A T 0.038 0.055 0.036 0.035 0.032 0.033 0.072 0 0.0007 0.0019 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 16 53779455 rs17817449 G T 0.441 0.427 0.375 0.313 0.344 0.373 0.42 0.0138 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 16 53779455 rs17817449 G T 0.441 0.427 0.375 0.313 0.344 0.373 0.42 0.0138 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 16 53779455 rs17817449 G T 0.441 0.427 0.375 0.313 0.344 0.373 0.42 0.0138 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 16 53779455 rs17817449 G T 0.441 0.427 0.375 0.313 0.344 0.373 0.42 0.0138 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 16 53779455 rs17817449 G T 0.441 0.427 0.375 0.313 0.344 0.373 0.42 0.0138 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 16 53779455 rs17817449 G T 0.441 0.427 0.375 0.313 0.344 0.373 0.42 0.0138 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 16 53779455 rs17817449 G T 0.441 0.427 0.375 0.313 0.344 0.373 0.42 0.0138 0 0.0174 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 16 53821379 rs11075995 A T 0.188 0.158 0.13 0.157 0.241 0.225 0.226 0.0033 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 16 53821379 rs11075995 A T 0.188 0.158 0.13 0.157 0.241 0.225 0.226 0.0033 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 16 53821379 rs11075995 A T 0.188 0.158 0.13 0.157 0.241 0.225 0.226 0.0033 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 16 53821379 rs11075995 A T 0.188 0.158 0.13 0.157 0.241 0.225 0.226 0.0033 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 16 53821379 rs11075995 A T 0.188 0.158 0.13 0.157 0.241 0.225 0.226 0.0033 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 16 53821379 rs11075995 A T 0.188 0.158 0.13 0.157 0.241 0.225 0.226 0.0033 0.0134 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 16 54080912 rs16953002 A G 0.229 0.186 0.174 0.174 0.099 0.189 0.199 0 0.0043 0.0042 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 16 54080912 rs16953002 A G 0.229 0.186 0.174 0.174 0.099 0.189 0.199 0 0.0043 0.0042 www.ncbi.nlm.nih.gov/pubmed/23455637 A variant in FTO shows association with melanoma risk not due to BMI. Melanoma 16 54081917 rs12596638 A G 0.244 0.186 0.191 0.175 0.093 0.167 0.21 0 0.0116 0.0086 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 16 57620664 rs11863709 T C 0.03 0.023 0.022 0.026 0.023 0.033 0.031 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 16 57620664 rs11863709 T C 0.03 0.023 0.022 0.026 0.023 0.033 0.031 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) 16 59753666 rs1392502 T G 0 0.009 0 0 0 0.004 0 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 16 61744191 rs8048207 T C 0.376 0.387 0.415 0.448 0.374 0.377 0.376 0.0088 0.0002 0 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 16 62453185 rs1834077 C T 0.106 0.117 0.089 0.139 0.225 0.168 0.12 0 0.0192 0.0149 www.ncbi.nlm.nih.gov/pubmed/27670397 Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Pre-treatment pain in head and neck squamous cell carcinoma 16 67301066 rs16957304 G A 0.22 0.275 0.232 0.285 0.275 0.262 0.19 0.0038 0 0.0068 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 16 67301066 rs16957304 G A 0.22 0.275 0.232 0.285 0.275 0.262 0.19 0.0038 0 0.0068 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 16 68787043 rs9929218 A G 0.284 0.275 0.306 0.338 0.324 0.287 0.341 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/19011631 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Colorectal cancer 16 68787043 rs9929218 A G 0.284 0.275 0.306 0.338 0.324 0.287 0.341 0.001 0 0.001 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 16 69940643 rs3748387 G A 0.53 0.509 0.464 0.439 0.541 0.475 0.443 0.0057 0.0013 0 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 16 71475893 rs8050871 C G 0.403 0.441 0.505 0.425 0.383 0.363 0.428 0 0.0067 0.0033 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 16 71997071 rs12597458 T G 0.28 0.23 0.223 0.196 0.23 0.242 0.177 0.002 0.0001 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 16 72171772 rs72791114 C T 0 0 0 0.013 0.009 0 0 0.022 0 0.0247 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 16 72173898 rs3812984 C T 0.301 0.232 0.259 0.178 0.153 0.205 0.217 0.0029 0 0.0179 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 16 72191288 rs16970670 T A 0 0.005 0.005 0.017 0.009 0 0 0.0195 0 0.0115 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 16 72916569 rs4788676 C T 0.136 0.113 0.121 0.152 0.173 0.154 0.105 0 0.0013 0.0066 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 16 72916569 rs4788676 C T 0.136 0.113 0.121 0.152 0.173 0.154 0.105 0 0.0013 0.0066 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 16 72916569 rs4788676 C T 0.136 0.113 0.121 0.152 0.173 0.154 0.105 0 0.0013 0.0066 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 16 73405456 rs9934948 T C 0.492 0.423 0.446 0.417 0.41 0.459 0.535 0.0028 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/22232737 Novel genetic markers of breast cancer survival identified by a genome-wide association study. Breast cancer (survival) 16 74438798 rs10871290 T C 0.47 0.455 0.527 0.461 0.428 0.455 0.54 0 0.0019 0.0034 www.ncbi.nlm.nih.gov/pubmed/18463975 A pilot genome-wide association study of early-onset breast cancer. Breast cancer 16 74630845 rs7193541 T C 0.394 0.455 0.473 0.452 0.568 0.516 0.478 0 0.0158 0.0013 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 16 75229763 rs7190458 A G 0.237 0.297 0.313 0.313 0.189 0.225 0.354 0.0042 0.0262 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 16 75229763 rs7190458 A G 0.237 0.297 0.313 0.313 0.189 0.225 0.354 0.0042 0.0262 0 www.ncbi.nlm.nih.gov/pubmed/25086665 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Pancreatic cancer 16 78042662 rs11150038 A G 0.009 0.005 0.005 0.009 0.032 0.051 0.005 0 0.0289 0.0114 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 16 78597897 rs2859631 G A 0.203 0.199 0.239 0.196 0.248 0.281 0.252 0.0043 0.0073 0 www.ncbi.nlm.nih.gov/pubmed/20923822 Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Radiation response 16 80616908 rs13329835 A G 0.292 0.225 0.219 0.257 0.311 0.256 0.283 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 16 80616908 rs13329835 A G 0.292 0.225 0.219 0.257 0.311 0.256 0.283 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 16 80616908 rs13329835 A G 0.292 0.225 0.219 0.257 0.311 0.256 0.283 0 0.0002 0.0002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 16 81501185 rs2925979 T C 0.318 0.286 0.299 0.261 0.284 0.291 0.357 0.0038 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 16 81741193 rs12446319 C T 0.318 0.36 0.277 0.342 0.324 0.303 0.297 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) 16 82119933 rs34638657 C A 0.03 0.023 0.018 0.074 0.041 0.053 0.018 0.0282 0 0.034 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 16 82612728 rs3844412 A G 0.291 0.356 0.259 0.303 0.315 0.353 0.301 0 0.0006 0.0006 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) 16 82753448 rs8056064 G A 0.094 0.149 0.174 0.161 0.122 0.172 0.124 0.0008 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 16 83292454 rs11644424 A C 0.178 0.14 0.152 0.274 0.153 0.207 0.217 0.0372 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) 16 83591958 rs8060632 A C 0.28 0.252 0.306 0.235 0.23 0.279 0.279 0.0025 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/28317148 Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients. Bortezomib-induced peripheral neuropathy in multiple myeloma 16 83706502 rs1364121 C T 0.25 0.207 0.324 0.226 0.252 0.316 0.327 0.0072 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/28120872 Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer. Response to platinum-based neoadjuvant chemotherapy in cervical cancer 16 84192073 rs8049634 A G 0.208 0.266 0.304 0.387 0.469 0.475 0.257 0 0.0332 0.0799 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Small cell lung carcinoma 16 85894208 rs391023 C T 0.161 0.225 0.156 0.239 0.108 0.123 0.181 0.0298 0.0314 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 16 85895015 rs391855 A T 0.218 0.239 0.149 0.202 0.131 0.124 0.189 0.0014 0.0197 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 16 85895015 rs391855 A T 0.218 0.239 0.149 0.202 0.131 0.124 0.189 0.0014 0.0197 0 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 16 85910833 rs391525 G A 0.42 0.428 0.446 0.483 0.509 0.512 0.385 0 0.0036 0.0134 www.ncbi.nlm.nih.gov/pubmed/21131588 Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Chronic lymphocytic leukemia 16 85922065 rs1044873 T C 0.457 0.482 0.531 0.422 0.541 0.521 0.451 0.0136 0.0097 0 www.ncbi.nlm.nih.gov/pubmed/24292274 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 16 85942053 rs305061 C T 0.103 0.114 0.121 0.113 0.1 0.111 0.089 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22700719 Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Chronic lymphocytic leukemia 16 86220445 rs847208 C A 0.102 0.095 0.058 0.117 0.189 0.143 0.066 0 0.0179 0.0215 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 16 86270655 rs7191751 A G 0.445 0.505 0.482 0.552 0.469 0.5 0.443 0.013 0 0.0061 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 16 86400840 rs1728400 C A 0.009 0.005 0.005 0.013 0.05 0.041 0.004 0 0.0282 0.0177 www.ncbi.nlm.nih.gov/pubmed/25526632 A genome wide meta-analysis study for identification of common variation associated with breast cancer prognosis. Breast cancer (survival) 16 86487884 rs9929215 C G 0.242 0.266 0.241 0.177 0.198 0.209 0.221 0.0064 0 0.0095 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 16 86662114 rs16941835 C G 0.216 0.203 0.255 0.165 0.203 0.184 0.232 0.0062 0 0.0082 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 16 87051631 rs4496150 A C 0.025 0.032 0.022 0.07 0.05 0.09 0.071 0.0022 0 0.014 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 16 89382255 rs3096299 G A 0.462 0.464 0.496 0.636 0.417 0.427 0.491 0.0834 0.0153 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 16 89404838 rs2086824 C A 0.004 0.014 0.014 0.075 0 0 0.004 0.1328 0 0.0129 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 16 89600929 rs154659 T C 0.487 0.469 0.505 0.409 0.5 0.587 0.46 0.022 0.0168 0 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 16 89689495 rs258322 A G 0.275 0.239 0.188 0.161 0.223 0.168 0.226 0.009 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 16 89689495 rs258322 A G 0.275 0.239 0.188 0.161 0.223 0.168 0.226 0.009 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/24980573 Identification of a melanoma susceptibility locus and somatic mutation in TET2. Melanoma 16 89689495 rs258322 A G 0.275 0.239 0.188 0.161 0.223 0.168 0.226 0.009 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 16 89689495 rs258322 A G 0.275 0.239 0.188 0.161 0.223 0.168 0.226 0.009 0 0.0113 www.ncbi.nlm.nih.gov/pubmed/19578364 Genome-wide association study identifies three loci associated with melanoma risk. Melanoma 16 89961218 rs8063761 T A 0.403 0.459 0.415 0.47 0.391 0.471 0.474 0.0003 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/26908436 A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants. Squamous cell carcinoma 16 90000528 rs4785763 A C 0.25 0.315 0.263 0.283 0.364 0.402 0.31 0 0.0229 0.0009 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 16 90000528 rs4785763 A C 0.25 0.315 0.263 0.283 0.364 0.402 0.31 0 0.0229 0.0009 www.ncbi.nlm.nih.gov/pubmed/19578364 Genome-wide association study identifies three loci associated with melanoma risk. Melanoma 16 90000776 rs73283869 A G 0.047 0.086 0.054 0.057 0.032 0.098 0.04 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 16 90018153 rs11648785 T C 0.185 0.11 0.132 0.161 0.17 0.118 0.073 0.0027 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 17 715725 rs684232 T C 0.233 0.239 0.277 0.296 0.455 0.43 0.292 0 0.0637 0.0189 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 17 715725 rs684232 T C 0.233 0.239 0.277 0.296 0.455 0.43 0.292 0 0.0637 0.0189 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 17 2268343 rs17761864 A C 0.114 0.095 0.138 0.1 0.108 0.074 0.097 0 0.0005 0.0005 www.ncbi.nlm.nih.gov/pubmed/22960999 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Esophageal cancer (squamous cell) 17 3883613 rs758642 A G 0.369 0.423 0.414 0.333 0.383 0.393 0.363 0.0063 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 17 5039881 rs10445262 G A 0.021 0.014 0.018 0.022 0.032 0.049 0.013 0 0.0074 0.0046 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 17 5489769 rs1805465 T C 0.059 0.027 0.04 0.026 0.014 0.033 0.044 0 0.0006 0.0037 www.ncbi.nlm.nih.gov/pubmed/25987655 Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Asparaginase hypersensitivity in acute lymphoblastic leukemia 17 6384826 rs8075565 T C 0.379 0.338 0.329 0.304 0.365 0.414 0.339 0.0077 0.0072 0 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Response to radiotherapy in prostate cancer (overall toxicity) 17 7654516 rs1642764 T C 0.241 0.255 0.266 0.15 0.212 0.22 0.277 0.0281 0 0.0196 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 17 7899800 rs28441558 C T 0.021 0.041 0.049 0.039 0.117 0.152 0.035 0 0.067 0.0144 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 17 7899800 rs28441558 C T 0.021 0.041 0.049 0.039 0.117 0.152 0.035 0 0.067 0.0144 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 17 7922377 rs9912317 T C 0 0.027 0.045 0.013 0.095 0.086 0.027 0.0005 0.0513 0.0012 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 17 9186907 rs3785982 T C 0 0 0 0.004 0.014 0 0 0.0025 0 0.0114 www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 17 10208841 rs28452431 T C 0.246 0.144 0.17 0.222 0.141 0.164 0.208 0.0061 0.0091 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 17 10617383 rs8079868 T C 0.504 0.481 0.509 0.541 0.414 0.376 0.478 0.0147 0.031 0 www.ncbi.nlm.nih.gov/pubmed/30068317 Genome-wide association study of lung function and clinical implication in heavy smokers. Post bronchodilator percent predicted FEV1 in smoking 17 14614150 rs12600394 T C 0.195 0.216 0.165 0.196 0.126 0.107 0.128 0.0062 0.02 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 17 16861664 rs7210837 A G 0.095 0.071 0.114 0.142 0.15 0.134 0.093 0.0028 0 0.0141 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 17 16916785 rs57968458 A G 0.212 0.207 0.228 0.2 0.176 0.148 0.192 0 0.0048 0.0021 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma 17 16916785 rs57968458 A G 0.212 0.207 0.228 0.2 0.176 0.148 0.192 0 0.0048 0.0021 www.ncbi.nlm.nih.gov/pubmed/26007630 Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Multiple myeloma and monoclonal gammopathy 17 16939677 rs34562254 A G 0.097 0.117 0.094 0.13 0.108 0.082 0.15 0.0019 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 17 16945825 rs4273077 G A 0.114 0.117 0.112 0.122 0.243 0.213 0.137 0 0.0421 0.0049 www.ncbi.nlm.nih.gov/pubmed/23955597 "Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk." Multiple myeloma 17 18850557 rs4924935 C T 0.165 0.122 0.223 0.191 0.212 0.225 0.173 0 0.0034 0.0034 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 17 27214252 rs4795519 A C 0.373 0.351 0.339 0.387 0.266 0.221 0.345 0.0127 0.0409 0 www.ncbi.nlm.nih.gov/pubmed/21540461 A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. Chronic myeloid leukemia 17 30689342 rs8081187 A G 0 0 0 0.017 0.005 0.008 0 0.0287 0 0.0343 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 30920697 rs3760318 A G 0.492 0.441 0.428 0.47 0.491 0.492 0.456 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 17 30920697 rs3760318 A G 0.492 0.441 0.428 0.47 0.491 0.492 0.456 0 0.0007 0.0007 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 17 32362795 rs9896320 G A 0.457 0.356 0.35 0.483 0.323 0.381 0.366 0.0322 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 17 32550640 rs225190 C T 0.104 0.108 0.092 0.123 0.141 0.121 0.089 0 0.001 0.0033 www.ncbi.nlm.nih.gov/pubmed/20686608 Genome-wide association study of pancreatic cancer in Japanese population. Pancreatic cancer 17 33158862 rs72819126 A G 0.004 0.005 0.005 0.009 0.014 0.012 0 0 0.0018 0.0043 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 17 35565049 rs2840044 G A 0.436 0.374 0.326 0.43 0.369 0.414 0.341 0.0046 0 0.0046 www.ncbi.nlm.nih.gov/pubmed/24785509 A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. Response to radiotherapy in cancer (late toxicity) 17 37529428 rs763512 A G 0.068 0.072 0.076 0.104 0.077 0.057 0.075 0.0079 0 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 17 37714971 rs11649743 A G 0.038 0.032 0.04 0.057 0.162 0.094 0.027 0 0.0473 0.0284 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 17 37717865 rs12951345 C A 0.047 0.05 0.045 0.117 0.135 0.045 0.075 0.0198 0 0.0267 www.ncbi.nlm.nih.gov/pubmed/30541042 Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer. Pancreatic ductal adenocarcinoma 17 37718512 rs4795218 A G 0.008 0.009 0.004 0.026 0.081 0.025 0.013 0 0.0161 0.0268 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 17 37736310 rs2005705 G A 0.479 0.414 0.451 0.391 0.32 0.353 0.438 0 0.0116 0.0142 www.ncbi.nlm.nih.gov/pubmed/24740154 Genome-wide association scan for variants associated with early-onset prostate cancer. Prostate cancer (early onset) 17 37738049 rs4430796 A G 0.335 0.286 0.308 0.226 0.207 0.25 0.259 0.0027 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/21499250 Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Endometrial cancer 17 37738049 rs4430796 A G 0.335 0.286 0.308 0.226 0.207 0.25 0.259 0.0027 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/26443449 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Prostate cancer 17 37738049 rs4430796 A G 0.335 0.286 0.308 0.226 0.207 0.25 0.259 0.0027 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/18264096 Multiple loci identified in a genome-wide association study of prostate cancer. Prostate cancer 17 37738049 rs4430796 A G 0.335 0.286 0.308 0.226 0.207 0.25 0.259 0.0027 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 17 37738049 rs4430796 A G 0.335 0.286 0.308 0.226 0.207 0.25 0.259 0.0027 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/17603485 "Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes." Prostate cancer 17 37738049 rs4430796 A G 0.335 0.286 0.308 0.226 0.207 0.25 0.259 0.0027 0 0.0142 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 17 37741165 rs7501939 C T 0.424 0.333 0.429 0.522 0.509 0.467 0.443 0.0127 0 0.0254 www.ncbi.nlm.nih.gov/pubmed/20676098 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Prostate cancer 17 37741165 rs7501939 C T 0.424 0.333 0.429 0.522 0.509 0.467 0.443 0.0127 0 0.0254 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 17 37741165 rs7501939 C T 0.424 0.333 0.429 0.522 0.509 0.467 0.443 0.0127 0 0.0254 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 17 37741165 rs7501939 C T 0.424 0.333 0.429 0.522 0.509 0.467 0.443 0.0127 0 0.0254 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 17 37741165 rs7501939 C T 0.424 0.333 0.429 0.522 0.509 0.467 0.443 0.0127 0 0.0254 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 17 37741642 rs12601991 T G 0 0 0.004 0.004 0.005 0.004 0 0.0005 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer 17 37741642 rs12601991 T G 0 0 0.004 0.004 0.005 0.004 0 0.0005 0 0.0015 www.ncbi.nlm.nih.gov/pubmed/27197191 "Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations." Cancer (pleiotropy) 17 37742390 rs11651052 G A 0.348 0.306 0.33 0.413 0.266 0.283 0.305 0.0335 0.0127 0 www.ncbi.nlm.nih.gov/pubmed/27008869 GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer. Endometrial cancer 17 37742390 rs11651052 G A 0.348 0.306 0.33 0.413 0.266 0.283 0.305 0.0335 0.0127 0 www.ncbi.nlm.nih.gov/pubmed/30410027 Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA. Prostate cancer 17 37742390 rs11651052 G A 0.348 0.306 0.33 0.413 0.266 0.283 0.305 0.0335 0.0127 0 www.ncbi.nlm.nih.gov/pubmed/27262462 Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. Prostate cancer 17 37743574 rs11263763 G A 0.407 0.496 0.353 0.404 0.246 0.234 0.389 0 0.0698 0 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial cancer 17 37743574 rs11263763 G A 0.407 0.496 0.353 0.404 0.246 0.234 0.389 0 0.0698 0 www.ncbi.nlm.nih.gov/pubmed/27135401 Five endometrial cancer risk loci identified through genome-wide association analysis. Endometrial endometrioid carcinoma 17 37743574 rs11263763 G A 0.407 0.496 0.353 0.404 0.246 0.234 0.389 0 0.0698 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 17 39909987 rs2290400 C T 0.431 0.455 0.388 0.452 0.627 0.549 0.55 0.0007 0.037 0 www.ncbi.nlm.nih.gov/pubmed/29348612 GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Acute lymphoblastic leukemia (childhood) 17 40023239 rs2302777 G A 0.021 0.018 0.004 0.044 0.106 0.02 0.027 0 0.0052 0.026 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 17 41094871 rs150537328 C T 0 0 0 0.009 0 0 0.004 0.0131 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 41741012 rs6503659 A T 0.025 0.023 0.032 0.043 0.059 0.033 0.018 0.0007 0 0.007 www.ncbi.nlm.nih.gov/pubmed/22960999 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Esophageal cancer (squamous cell) 17 45394123 rs4763 A G 0.038 0.054 0.058 0.03 0.09 0.082 0.031 0.0053 0.0189 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 46175102 rs2532263 A G 0 0 0 0.017 0.014 0.008 0 0.0235 0 0.0395 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 46770948 rs3809857 T G 0.008 0.005 0 0.026 0.009 0.008 0 0.0277 0 0.0202 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 17 46788237 rs199498 C T 0.055 0.081 0.045 0.061 0.104 0.094 0.084 0.0001 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 48536888 rs76525880 T A 0.004 0.005 0.004 0.013 0.014 0.004 0 0.0049 0 0.0064 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 17 49267824 rs11650494 A G 0.326 0.311 0.286 0.248 0.135 0.184 0.279 0 0.0362 0.0195 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 17 49267824 rs11650494 A G 0.326 0.311 0.286 0.248 0.135 0.184 0.279 0 0.0362 0.0195 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 17 49359387 rs7210100 A G 0.11 0.099 0.076 0.044 0.041 0.033 0.08 0 0.0014 0.0219 www.ncbi.nlm.nih.gov/pubmed/21602798 Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Prostate cancer 17 50196930 rs2075555 T G 0.305 0.302 0.266 0.3 0.383 0.361 0.301 0 0.0116 0.0022 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 17 54979110 rs6504950 A G 0.381 0.365 0.393 0.461 0.297 0.339 0.345 0.032 0.0136 0 www.ncbi.nlm.nih.gov/pubmed/19330027 Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Breast cancer 17 54979110 rs6504950 A G 0.381 0.365 0.393 0.461 0.297 0.339 0.345 0.032 0.0136 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 17 54979110 rs6504950 A G 0.381 0.365 0.393 0.461 0.297 0.339 0.345 0.032 0.0136 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 17 57153267 rs17833789 A C 0.119 0.054 0.089 0.135 0.351 0.279 0.155 0 0.1252 0.0388 www.ncbi.nlm.nih.gov/pubmed/29895819 Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations. Freckles 17 57581872 rs16958559 G T 0.496 0.495 0.405 0.303 0.5 0.426 0.478 0.0688 0 0.0136 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 17 58163947 rs16942732 T G 0.119 0.135 0.183 0.1 0.082 0.111 0.195 0.0011 0 0.0167 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 17 58165213 rs1468574 T C 0.111 0.131 0.176 0.096 0.081 0.112 0.188 0.0019 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/28429243 SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+Ębreast cancer: genome-wide association studies of the estrone pathway. Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer 17 58378759 rs2680708 G A 0.28 0.284 0.33 0.183 0.387 0.373 0.239 0.0562 0.0415 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 17 61617277 rs2040609 C T 0.349 0.347 0.314 0.367 0.243 0.201 0.31 0.0148 0.043 0 www.ncbi.nlm.nih.gov/pubmed/28081215 Genome-Wide Association Studies of Multiple Keratinocyte Cancers. Multiple keratinocyte cancers 17 66986976 rs8070529 A C 0.197 0.179 0.179 0.135 0.131 0.131 0.186 0.0003 0 0.0105 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 17 67902693 rs7216064 A G 0.144 0.171 0.179 0.184 0.135 0.135 0.124 0.0049 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/27501781 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. EGFR mutation-positive lung adenocarcinoma 17 67902693 rs7216064 A G 0.144 0.171 0.179 0.184 0.135 0.135 0.124 0.0049 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/22797724 A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Lung adenocarcinoma 17 67902693 rs7216064 A G 0.144 0.171 0.179 0.184 0.135 0.135 0.124 0.0049 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/23143601 Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Lung cancer 17 69121547 rs997781 A G 0.072 0.104 0.071 0.039 0.104 0.111 0.102 0.0257 0.0048 0 www.ncbi.nlm.nih.gov/pubmed/26183928 Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung. MGMT methylation in smokers 17 70457204 rs8066985 A G 0.288 0.35 0.362 0.25 0.288 0.336 0.357 0.0163 0 0.0086 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 17 70665494 rs12602300 C T 0.119 0.123 0.094 0.101 0.054 0.041 0.102 0 0.024 0.0008 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 17 71110733 rs17765344 A G 0.093 0.077 0.071 0.075 0.086 0.07 0.075 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 17 71111532 rs8071558 C G 0.093 0.095 0.077 0.075 0.095 0.079 0.089 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 17 71112612 rs1859962 G T 0.199 0.221 0.257 0.217 0.216 0.184 0.281 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 17 71112612 rs1859962 G T 0.199 0.221 0.257 0.217 0.216 0.184 0.281 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 17 71112612 rs1859962 G T 0.199 0.221 0.257 0.217 0.216 0.184 0.281 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/17603485 "Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes." Prostate cancer 17 71112612 rs1859962 G T 0.199 0.221 0.257 0.217 0.216 0.184 0.281 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 17 71112612 rs1859962 G T 0.199 0.221 0.257 0.217 0.216 0.184 0.281 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 17 71112612 rs1859962 G T 0.199 0.221 0.257 0.217 0.216 0.184 0.281 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 17 71440368 rs11651604 C G 0.025 0.032 0.031 0.035 0.018 0.033 0.018 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059430 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. Breast cancer in childhood cancer survivors treated with less than 10 gray radiotherapy 17 72303817 rs17181550 G T 0.182 0.18 0.214 0.184 0.392 0.32 0.235 0.0043 0.0698 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 17 72303817 rs17181550 G T 0.182 0.18 0.214 0.184 0.392 0.32 0.235 0.0043 0.0698 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 17 72404025 rs11655237 T C 0.25 0.315 0.174 0.196 0.167 0.205 0.221 0 0.0009 0.0067 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 17 72405335 rs7214041 T C 0.25 0.324 0.174 0.196 0.162 0.201 0.221 0 0.0016 0.0083 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 17 72983988 rs4969001 G T 0.093 0.099 0.071 0.104 0.171 0.086 0.066 0 0.0044 0.0062 www.ncbi.nlm.nih.gov/pubmed/30323354 "BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts." BRCA1/2-negative high-risk breast cancer 17 74776908 rs62084913 T C 0.017 0.027 0.022 0.057 0.023 0.008 0.009 0.0357 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 76934284 rs4789378 T C 0.314 0.369 0.415 0.335 0.338 0.335 0.381 0.0001 0 0.0011 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 17 79807926 rs745570 A G 0.161 0.167 0.167 0.158 0.189 0.201 0.201 0.001 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 17 79807926 rs745570 A G 0.161 0.167 0.167 0.158 0.189 0.201 0.201 0.001 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 17 79807926 rs745570 A G 0.161 0.167 0.167 0.158 0.189 0.201 0.201 0.001 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 79807926 rs745570 A G 0.161 0.167 0.167 0.158 0.189 0.201 0.201 0.001 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 17 79807926 rs745570 A G 0.161 0.167 0.167 0.158 0.189 0.201 0.201 0.001 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/30643258 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Smoking status (ever vs never smokers) 17 80288362 rs17857135 C T 0.458 0.459 0.41 0.421 0.586 0.579 0.464 0.0084 0.047 0 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 17 80641771 rs12940622 G A 0.47 0.432 0.402 0.478 0.351 0.344 0.392 0.0155 0.0215 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 17 80641771 rs12940622 G A 0.47 0.432 0.402 0.478 0.351 0.344 0.392 0.0155 0.0215 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 17 82447676 rs3751913 C T 0.237 0.201 0.216 0.222 0.381 0.248 0.203 0 0.0224 0.0038 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 17 82597601 rs62079673 C T 0.286 0.336 0.356 0.36 0.359 0.381 0.321 0 0.001 0.0027 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 17 82946434 rs898097 T C 0.301 0.338 0.392 0.496 0.365 0.373 0.363 0.0511 0 0.017 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 514471 rs62091368 A G 0.106 0.059 0.094 0.07 0.099 0.09 0.031 0 0.0016 0.0004 www.ncbi.nlm.nih.gov/pubmed/27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. "Response to radiotherapy in prostate cancer (toxicity, decreased urine stream)" 18 612819 rs9947236 C T 0.296 0.206 0.228 0.171 0.338 0.36 0.274 0.0418 0.0411 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 18 1839910 rs60764613 T G 0.483 0.482 0.442 0.426 0.338 0.387 0.438 0 0.0127 0.0077 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 18 2280389 rs631644 G A 0.381 0.365 0.396 0.347 0.455 0.426 0.447 0.0101 0.0069 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 18 2498055 rs1879352 C T 0.03 0.027 0.027 0.013 0.018 0.033 0.018 0.0017 0 0.0007 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 18 4772808 rs8089250 C T 0.182 0.176 0.192 0.204 0.293 0.238 0.168 0 0.0148 0.0076 www.ncbi.nlm.nih.gov/pubmed/27143689 Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer 18 5893150 rs12457278 T C 0.444 0.454 0.473 0.689 0.432 0.418 0.518 0.1426 0.0091 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 18 8556718 rs12604637 T C 0 0.005 0.004 0.013 0.009 0.017 0.004 0.0025 0 0.0088 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 18 8716323 rs2111836 G A 0.28 0.252 0.205 0.226 0.189 0.225 0.266 0 0.002 0.002 www.ncbi.nlm.nih.gov/pubmed/25824743 A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia. Breast cancer 18 9701785 rs674617 T C 0.085 0.069 0.063 0.147 0.063 0.078 0.066 0.0442 0 0.0095 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 18 10899030 rs11080466 G A 0.271 0.27 0.263 0.217 0.293 0.295 0.208 0.0066 0.007 0 www.ncbi.nlm.nih.gov/pubmed/21866343 The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations. Non-small cell lung cancer 18 11451677 rs74791047 A T 0.089 0.086 0.078 0.088 0.05 0.057 0.076 0.0012 0.0064 0 www.ncbi.nlm.nih.gov/pubmed/29195075 An Unexpectedly Complex Architecture for Skin Pigmentation in Africans. Tanning 18 12821594 rs2847281 G A 0.076 0.063 0.085 0.096 0.081 0.061 0.084 0.0012 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/22960999 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Esophageal cancer (squamous cell) 18 13298944 rs62097350 G A 0.225 0.261 0.2 0.2 0.212 0.197 0.27 0.0008 0 0.0031 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 18 13366863 rs12456874 G A 0.025 0.027 0.031 0.052 0.009 0.008 0.018 0.0268 0.0174 0 www.ncbi.nlm.nih.gov/pubmed/23180869 Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Pancreatic cancer 18 13954110 rs35505947 C T 0.047 0.054 0.058 0.013 0.041 0.037 0.058 0.0175 0 0.0094 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 18 22897971 rs12962334 C G 0.314 0.356 0.366 0.448 0.275 0.373 0.385 0.029 0.0036 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 23047728 rs9675999 A G 0.013 0.052 0.005 0.076 0.108 0.109 0.046 0 0.0124 0.0523 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 23141009 rs11082304 T G 0.165 0.185 0.165 0.18 0.248 0.246 0.257 0.0015 0.0098 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 18 23151966 rs4239436 A G 0.119 0.126 0.076 0.052 0.105 0.082 0.071 0.0134 0 0.0039 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 18 23151966 rs4239436 A G 0.119 0.126 0.076 0.052 0.105 0.082 0.071 0.0134 0 0.0039 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 18 23151966 rs4239436 A G 0.119 0.126 0.076 0.052 0.105 0.082 0.071 0.0134 0 0.0039 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI in smokers 18 23196687 rs11082321 A G 0.261 0.248 0.229 0.226 0.435 0.381 0.248 0.0058 0.0715 0 www.ncbi.nlm.nih.gov/pubmed/25038754 "Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1." Breast cancer 18 23524924 rs1808579 T C 0.483 0.5 0.446 0.443 0.367 0.404 0.487 0 0.0103 0.0074 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 18 26576054 rs7240205 C T 0.197 0.158 0.228 0.213 0.207 0.164 0.195 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 26757460 rs527616 C G 0.098 0.063 0.104 0.104 0.045 0.045 0.097 0.0071 0.022 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 18 26757460 rs527616 C G 0.098 0.063 0.104 0.104 0.045 0.045 0.097 0.0071 0.022 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 18 26757460 rs527616 C G 0.098 0.063 0.104 0.104 0.045 0.045 0.097 0.0071 0.022 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 26990703 rs1436904 G T 0.162 0.18 0.201 0.209 0.255 0.18 0.248 0 0 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 18 26990703 rs1436904 G T 0.162 0.18 0.201 0.209 0.255 0.18 0.248 0 0 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 18 26990703 rs1436904 G T 0.162 0.18 0.201 0.209 0.255 0.18 0.248 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 27826891 rs9959491 T C 0.288 0.324 0.397 0.391 0.194 0.295 0.363 0.0182 0.035 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 31461771 rs3794924 A G 0.11 0.113 0.071 0.135 0.117 0.119 0.084 0.0045 0 0.0062 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer 18 36114157 rs1050631 A G 0.17 0.198 0.183 0.2 0.131 0.148 0.183 0.0031 0.0091 0 www.ncbi.nlm.nih.gov/pubmed/23644492 Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma. Esophageal squamous cell cancer (length of survival) 18 41723663 rs4890355 A G 0.419 0.514 0.527 0.539 0.446 0.41 0.553 0.0079 0.0174 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 18 44319280 rs12957236 T G 0.085 0.059 0.08 0.157 0.14 0.131 0.111 0.0142 0 0.0288 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 18 44819625 rs6507583 G A 0.373 0.392 0.357 0.36 0.491 0.459 0.371 0.0024 0.0243 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 18 44819625 rs6507583 G A 0.373 0.392 0.357 0.36 0.491 0.459 0.371 0.0024 0.0243 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 45285245 rs11082438 T G 0.178 0.171 0.152 0.13 0.198 0.172 0.208 0.009 0 0.0004 www.ncbi.nlm.nih.gov/pubmed/25279986 Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Follicular lymphoma 18 45308832 rs9952980 T C 0.038 0.032 0.009 0.057 0.018 0.012 0.013 0.029 0.0023 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 45737001 rs7238033 T C 0.326 0.338 0.326 0.4 0.351 0.365 0.385 0.0045 0 0.0035 www.ncbi.nlm.nih.gov/pubmed/21824976 "A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3." Bladder cancer 18 45737317 rs10775480 T C 0.321 0.329 0.327 0.392 0.338 0.356 0.368 0.0049 0 0.0032 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 18 48019814 rs7227917 G A 0.335 0.318 0.29 0.347 0.355 0.233 0.317 0.0027 0.002 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 18 48845622 rs4939821 T C 0.009 0.014 0.018 0.026 0.077 0.078 0.018 0 0.0406 0.0216 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 18 48924606 rs7229639 A G 0.233 0.207 0.201 0.222 0.329 0.252 0.217 0 0.0124 0.0027 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 18 48924606 rs7229639 A G 0.233 0.207 0.201 0.222 0.329 0.252 0.217 0 0.0124 0.0027 www.ncbi.nlm.nih.gov/pubmed/24448986 Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians. Colorectal cancer 18 48924606 rs7229639 A G 0.233 0.207 0.201 0.222 0.329 0.252 0.217 0 0.0124 0.0027 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 18 48924606 rs7229639 A G 0.233 0.207 0.201 0.222 0.329 0.252 0.217 0 0.0124 0.0027 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 18 48925503 rs4939567 A G 0.399 0.421 0.358 0.446 0.454 0.415 0.419 0.0017 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 18 48926786 rs11874392 A T 0.487 0.455 0.558 0.465 0.46 0.451 0.416 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27207650 Genome-wide association study of colorectal cancer in Hispanics. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/17934461 A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/18372901 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/18372905 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/21761138 Meta-analysis of new genome-wide association studies of colorectal cancer risk. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 18 48927093 rs4939827 T C 0.237 0.288 0.29 0.361 0.396 0.373 0.279 0 0.0022 0.0282 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 18 48927559 rs12953717 T C 0.25 0.227 0.321 0.211 0.126 0.18 0.191 0 0.0164 0.0105 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 18 48927678 rs7226855 A G 0.492 0.46 0.558 0.417 0.428 0.434 0.434 0.0034 0 0.0084 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 18 49157384 rs72923818 C A 0.004 0 0.004 0.009 0.018 0 0 0.0015 0 0.0052 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 18 50317164 rs1036935 A G 0.331 0.309 0.366 0.325 0.302 0.213 0.336 0 0.0127 0.0025 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 18 50482070 rs9960150 T C 0.114 0.141 0.161 0.148 0.105 0.176 0.127 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 18 52420925 rs17748074 G A 0.356 0.338 0.268 0.36 0.153 0.164 0.274 0.0339 0.0918 0 www.ncbi.nlm.nih.gov/pubmed/28317148 Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients. Bortezomib-induced peripheral neuropathy in multiple myeloma 18 53580709 rs1442089 C A 0.428 0.446 0.442 0.504 0.469 0.459 0.339 0.0098 0 0.0132 www.ncbi.nlm.nih.gov/pubmed/26586795 Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis. Survival in colorectal cancer (distant metastatic) 18 53590462 rs1372474 G A 0.056 0.095 0.08 0.144 0.05 0.053 0.076 0.0477 0.0123 0 www.ncbi.nlm.nih.gov/pubmed/26586795 Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis. Survival in colorectal cancer (distant metastatic) 18 54246103 rs8093601 C G 0.182 0.171 0.214 0.317 0.25 0.217 0.235 0.0366 0 0.0208 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 18 55287190 rs1262463 G A 0.339 0.347 0.344 0.257 0.275 0.312 0.332 0.0094 0 0.0126 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 18 55997051 rs1978503 G A 0.216 0.22 0.229 0.148 0.18 0.141 0.146 0.0035 0 0.0087 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 18 59079083 rs12956892 T G 0.275 0.302 0.277 0.296 0.338 0.336 0.336 0 0.0018 0.0007 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 18 59165543 rs10503023 A G 0.068 0.064 0.076 0.087 0.077 0.061 0.075 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/30068317 Genome-wide association study of lung function and clinical implication in heavy smokers. Post bronchodilator FEV1/FVC ratio in smoking 18 59211042 rs1517037 T C 0.301 0.303 0.336 0.361 0.365 0.426 0.33 0 0.005 0.009 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 18 59211042 rs1517037 T C 0.301 0.303 0.336 0.361 0.365 0.426 0.33 0 0.005 0.009 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 18 59212979 rs57791062 T C 0.393 0.333 0.406 0.422 0.374 0.43 0.403 0.0009 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/30541042 Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer. Pancreatic ductal adenocarcinoma 18 59216087 rs7243357 G T 0.108 0.099 0.122 0.148 0.122 0.127 0.093 0.0053 0 0.0058 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 18 59216087 rs7243357 G T 0.108 0.099 0.122 0.148 0.122 0.127 0.093 0.0053 0 0.0058 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 18 59955055 rs4368253 T C 0.339 0.309 0.326 0.278 0.455 0.418 0.292 0.0128 0.0425 0 www.ncbi.nlm.nih.gov/pubmed/23770605 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 18 59955055 rs4368253 T C 0.339 0.309 0.326 0.278 0.455 0.418 0.292 0.0128 0.0425 0 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 18 63178058 rs4940575 T C 0.322 0.318 0.306 0.426 0.32 0.322 0.301 0.033 0 0.0091 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 63178651 rs12454712 C T 0.242 0.207 0.13 0.145 0.198 0.193 0.199 0.0084 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 18 63509033 rs2032224 A C 0.22 0.149 0.189 0.244 0.167 0.189 0.239 0.009 0.0028 0 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) 18 64751208 rs17073641 C A 0.297 0.315 0.335 0.265 0.288 0.287 0.286 0.002 0 0.002 www.ncbi.nlm.nih.gov/pubmed/23577725 Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. Age-related macular degeneration (smoking status interaction) 18 65231430 rs637644 G A 0.389 0.338 0.411 0.509 0.523 0.43 0.437 0.0129 0 0.0259 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) 18 69220817 rs17080623 G A 0.301 0.324 0.366 0.261 0.306 0.32 0.345 0.0101 0 0.006 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 18 72554745 rs694339 G A 0.186 0.198 0.21 0.254 0.225 0.213 0.221 0.0049 0 0.0042 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 18 75305279 rs12970291 A G 0.034 0.023 0.004 0.022 0 0.008 0.004 0.0044 0.0096 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 18 75324210 rs10460109 T C 0.322 0.383 0.348 0.413 0.473 0.533 0.407 0 0.0269 0.0163 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 18 76776324 rs2406342 T G 0.415 0.396 0.487 0.383 0.351 0.336 0.474 0 0.0065 0.0146 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) 18 79013973 rs7241993 C T 0.398 0.401 0.42 0.452 0.347 0.414 0.42 0.0056 0.0027 0 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 18 79013973 rs7241993 C T 0.398 0.401 0.42 0.452 0.347 0.414 0.42 0.0056 0.0027 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 19 348743 rs6510725 C T 0.352 0.311 0.295 0.252 0.437 0.385 0.323 0.0269 0.0306 0 www.ncbi.nlm.nih.gov/pubmed/23144319 Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Non-small cell lung cancer 19 1650135 rs1860661 A G 0.064 0.059 0.077 0.08 0.05 0.033 0.085 0.0031 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/29196614 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Hodgkins lymphoma 19 1650135 rs1860661 A G 0.064 0.059 0.077 0.08 0.05 0.033 0.085 0.0031 0.0103 0 www.ncbi.nlm.nih.gov/pubmed/24920014 A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Hodgkins lymphoma 19 3353624 rs34466956 T C 0.356 0.342 0.284 0.252 0.329 0.266 0.297 0.0081 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/30429480 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nevus count or cutaneous melanoma 19 4069121 rs7254272 G A 0.22 0.259 0.237 0.2 0.302 0.246 0.243 0.0075 0.0051 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 19 4837475 rs10425559 A G 0.08 0.145 0.179 0.204 0.171 0.142 0.173 0.012 0 0.0063 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 19 7252745 rs4247374 T C 0.004 0 0 0.004 0.063 0.045 0.009 0 0.0518 0.017 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 19 7252745 rs4247374 T C 0.004 0 0 0.004 0.063 0.045 0.009 0 0.0518 0.017 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 19 8577276 rs4542783 T C 0.432 0.355 0.308 0.361 0.414 0.439 0.381 0.0005 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 19 8577276 rs4542783 T C 0.432 0.355 0.308 0.361 0.414 0.439 0.381 0.0005 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 19 10879653 rs12710258 T C 0 0.005 0 0 0 0.016 0.004 0.0002 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 19 12388576 rs10407238 A G 0.081 0.081 0.125 0.083 0.063 0.107 0.089 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 19 14901422 rs4594370 G A 0.055 0.063 0.089 0.065 0.045 0.049 0.084 0 0.0024 0.002 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 17103263 rs11666569 T C 0.462 0.414 0.344 0.461 0.428 0.439 0.381 0.004 0 0.0048 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 19 17103263 rs11666569 T C 0.462 0.414 0.344 0.461 0.428 0.439 0.381 0.004 0 0.0048 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (early onset) 19 17278895 rs8170 A G 0.157 0.193 0.167 0.229 0.124 0.165 0.144 0.0219 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/20852631 A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Breast cancer 19 17278895 rs8170 A G 0.157 0.193 0.167 0.229 0.124 0.165 0.144 0.0219 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 19 17278895 rs8170 A G 0.157 0.193 0.167 0.229 0.124 0.165 0.144 0.0219 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 19 17278895 rs8170 A G 0.157 0.193 0.167 0.229 0.124 0.165 0.144 0.0219 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 19 17278895 rs8170 A G 0.157 0.193 0.167 0.229 0.124 0.165 0.144 0.0219 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 19 17278895 rs8170 A G 0.157 0.193 0.167 0.229 0.124 0.165 0.144 0.0219 0.0026 0 www.ncbi.nlm.nih.gov/pubmed/23544013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. Breast Cancer in BRCA1 mutation carriers 19 17282085 rs8100241 A G 0.394 0.342 0.406 0.368 0.383 0.361 0.367 0 0 0 www.ncbi.nlm.nih.gov/pubmed/22976474 A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Breast cancer 19 17283116 rs56069439 A C 0.199 0.239 0.167 0.268 0.14 0.203 0.195 0.0227 0.0055 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 19 17283116 rs56069439 A C 0.199 0.239 0.167 0.268 0.14 0.203 0.195 0.0227 0.0055 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 17283116 rs56069439 A C 0.199 0.239 0.167 0.268 0.14 0.203 0.195 0.0227 0.0055 0 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer (estrogen-receptor negative) 19 17283315 rs2363956 G T 0.487 0.414 0.571 0.491 0.464 0.447 0.504 0 0.0009 0.0009 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 19 17283315 rs2363956 G T 0.487 0.414 0.571 0.491 0.464 0.447 0.504 0 0.0009 0.0009 www.ncbi.nlm.nih.gov/pubmed/24325915 Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. "Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)" 19 17290595 rs67397200 G C 0.235 0.333 0.205 0.313 0.176 0.213 0.237 0.0218 0.0184 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 17290595 rs67397200 G C 0.235 0.333 0.205 0.313 0.176 0.213 0.237 0.0218 0.0184 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 19 17290595 rs67397200 G C 0.235 0.333 0.205 0.313 0.176 0.213 0.237 0.0218 0.0184 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast Cancer in BRCA1 mutation carriers 19 18278325 rs12608504 A G 0.326 0.427 0.415 0.378 0.32 0.275 0.412 0 0.0178 0.0037 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 19 18278325 rs12608504 A G 0.326 0.427 0.415 0.378 0.32 0.275 0.412 0 0.0178 0.0037 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 19 18278325 rs12608504 A G 0.326 0.427 0.415 0.378 0.32 0.275 0.412 0 0.0178 0.0037 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 19 18278325 rs12608504 A G 0.326 0.427 0.415 0.378 0.32 0.275 0.412 0 0.0178 0.0037 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 19 18344015 rs17724992 G A 0.059 0.073 0.045 0.035 0.027 0.025 0.063 0 0.0029 0.0096 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 19 18344015 rs17724992 G A 0.059 0.073 0.045 0.035 0.027 0.025 0.063 0 0.0029 0.0096 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 19 18422832 rs7258465 T C 0.22 0.257 0.293 0.274 0.18 0.246 0.261 0.002 0.0058 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 18460331 rs4808801 A G 0.25 0.27 0.284 0.309 0.203 0.25 0.274 0.0081 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 19 18460331 rs4808801 A G 0.25 0.27 0.284 0.309 0.203 0.25 0.274 0.0081 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 19 18460331 rs4808801 A G 0.25 0.27 0.284 0.309 0.203 0.25 0.274 0.0081 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 18460331 rs4808801 A G 0.25 0.27 0.284 0.309 0.203 0.25 0.274 0.0081 0.0083 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 19 18522945 rs172032 T C 0.136 0.171 0.219 0.2 0.122 0.164 0.208 0.0027 0.0071 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 18522945 rs172032 T C 0.136 0.171 0.219 0.2 0.122 0.164 0.208 0.0027 0.0071 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 19 19434887 rs2965183 G A 0.314 0.275 0.38 0.348 0.189 0.203 0.363 0.0087 0.0577 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 19535463 rs2304098 T C 0.318 0.284 0.375 0.365 0.194 0.225 0.358 0.0139 0.0525 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 19925367 rs10411195 C T 0.22 0.266 0.286 0.261 0.171 0.244 0.226 0.0011 0.0043 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior 19 21569009 rs11085466 C G 0.318 0.36 0.299 0.322 0.266 0.237 0.283 0.0008 0.0101 0 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 19 22611884 rs11671104 C A 0.252 0.23 0.214 0.257 0.139 0.116 0.214 0.015 0.0491 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 19 28375689 rs995834 A G 0.312 0.347 0.401 0.339 0.279 0.295 0.358 0 0.0066 0.0028 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) 19 29805946 rs8102137 C T 0.021 0.014 0.004 0.061 0.032 0.033 0.013 0.0369 0 0.0373 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 19 29805946 rs8102137 C T 0.021 0.014 0.004 0.061 0.032 0.033 0.013 0.0369 0 0.0373 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 19 30446936 rs33428 A G 0.225 0.18 0.212 0.144 0.189 0.217 0.142 0.0095 0.001 0 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) 19 31960836 rs8103940 A G 0.017 0.018 0.018 0.078 0.045 0.021 0.018 0.0559 0 0.0369 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 19 33041394 rs10411210 T C 0.556 0.509 0.42 0.47 0.518 0.504 0.5 0.0003 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 19 33041394 rs10411210 T C 0.556 0.509 0.42 0.47 0.518 0.504 0.5 0.0003 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 19 33041394 rs10411210 T C 0.556 0.509 0.42 0.47 0.518 0.504 0.5 0.0003 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/19011631 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Colorectal cancer 19 33041394 rs10411210 T C 0.556 0.509 0.42 0.47 0.518 0.504 0.5 0.0003 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 19 33084158 rs7252505 G A 0.175 0.144 0.203 0.281 0.227 0.184 0.183 0.032 0 0.0179 www.ncbi.nlm.nih.gov/pubmed/28295283 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. Colorectal cancer 19 33334040 rs4081724 A G 0 0 0 0.013 0.005 0 0.004 0.0185 0 0.01 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 19 33505500 rs11665716 A G 0.102 0.1 0.131 0.063 0.064 0.037 0.072 0 0.0034 0.0139 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 19 33818627 rs29941 A G 0.144 0.112 0.131 0.135 0.093 0.104 0.133 0.0003 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 19 33818627 rs29941 A G 0.144 0.112 0.131 0.135 0.093 0.104 0.133 0.0003 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 19 34277685 rs28541881 T C 0.174 0.261 0.228 0.294 0.173 0.182 0.248 0.0257 0.016 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 19 34426795 rs2965280 T C 0.186 0.275 0.246 0.304 0.171 0.186 0.257 0.0259 0.0223 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 19 38244973 rs8102476 T C 0.144 0.189 0.156 0.113 0.266 0.328 0.181 0.0311 0.0718 0 www.ncbi.nlm.nih.gov/pubmed/19767754 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Prostate cancer 19 38244973 rs8102476 T C 0.144 0.189 0.156 0.113 0.266 0.328 0.181 0.0311 0.0718 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 19 39323213 rs8108034 G T 0.343 0.398 0.263 0.408 0.239 0.262 0.341 0.0299 0.0322 0 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 19 40685488 rs13343737 A G 0.106 0.068 0.121 0.07 0.113 0.115 0.155 0.0108 0 0.0017 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma 19 40689265 rs66500423 C T 0.153 0.176 0.161 0.135 0.162 0.146 0.159 0.0008 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 19 40689265 rs66500423 C T 0.153 0.176 0.161 0.135 0.162 0.146 0.159 0.0008 0 0.0008 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 19 40804666 rs3733829 G A 0.004 0.032 0 0.03 0.005 0.012 0.004 0.0174 0 0.0033 www.ncbi.nlm.nih.gov/pubmed/20418890 Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Smoking behavior 19 40811274 rs185308415 A G 0.233 0.213 0.35 0.25 0.243 0.254 0.239 0 0 0 www.ncbi.nlm.nih.gov/pubmed/27488534 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. nicotine metabolite ratio in current smokers 19 40818275 rs2545770 A C 0.457 0.414 0.42 0.491 0.514 0.458 0.429 0.0019 0 0.0071 www.ncbi.nlm.nih.gov/pubmed/27488534 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. nicotine metabolite ratio in current smokers 19 40824274 rs7507400 T G 0.319 0.342 0.348 0.25 0.405 0.353 0.257 0.0218 0.0161 0 www.ncbi.nlm.nih.gov/pubmed/27488534 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. nicotine metabolite ratio in current smokers 19 40825304 rs111825958 A C 0.17 0.126 0.138 0.152 0.122 0.079 0.075 0.0053 0.0068 0 www.ncbi.nlm.nih.gov/pubmed/28921760 Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences. nicotine metabolite ratio in current smokers 19 40827379 rs11878604 C T 0.263 0.239 0.237 0.204 0.221 0.184 0.195 0 0.0003 0.0013 www.ncbi.nlm.nih.gov/pubmed/27488534 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. nicotine metabolite ratio in current smokers 19 40847202 rs56113850 C T 0.392 0.374 0.358 0.292 0.346 0.355 0.362 0.0121 0 0.0066 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 19 40847202 rs56113850 C T 0.392 0.374 0.358 0.292 0.346 0.355 0.362 0.0121 0 0.0066 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer 19 40847202 rs56113850 C T 0.392 0.374 0.358 0.292 0.346 0.355 0.362 0.0121 0 0.0066 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung cancer in ever smokers 19 40847202 rs56113850 C T 0.392 0.374 0.358 0.292 0.346 0.355 0.362 0.0121 0 0.0066 www.ncbi.nlm.nih.gov/pubmed/27488534 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. nicotine metabolite ratio in current smokers 19 40847202 rs56113850 C T 0.392 0.374 0.358 0.292 0.346 0.355 0.362 0.0121 0 0.0066 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Squamous cell lung carcinoma 19 40855903 rs111645190 A G 0.004 0 0 0.004 0 0 0 0.0031 0.0011 0 www.ncbi.nlm.nih.gov/pubmed/28921760 Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences. nicotine metabolite ratio in current smokers 19 40857860 rs8102683 T C 0.233 0.194 0.246 0.303 0.194 0.258 0.266 0.015 0 0.0014 www.ncbi.nlm.nih.gov/pubmed/23049750 Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. Smoking behavior 19 40866570 rs7247903 G A 0.246 0.202 0.22 0.292 0.291 0.26 0.282 0.0035 0 0.0059 www.ncbi.nlm.nih.gov/pubmed/27488534 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. nicotine metabolite ratio in current smokers 19 40901969 rs73931391 G A 0.081 0.054 0.067 0.074 0.073 0.033 0.071 0.0004 0.0014 0 www.ncbi.nlm.nih.gov/pubmed/27488534 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. nicotine metabolite ratio in current smokers 19 41015733 rs7260329 A G 0.089 0.086 0.117 0.078 0.099 0.103 0.146 0.0028 0 0.0026 www.ncbi.nlm.nih.gov/pubmed/20418888 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Smoking behavior 19 41354391 rs1800469 A G 0.254 0.243 0.232 0.213 0.185 0.211 0.221 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/27145994 Common genetic variation in ETV6 is associated with colorectal cancer susceptibility. Colorectal cancer 19 41354391 rs1800469 A G 0.254 0.243 0.232 0.213 0.185 0.211 0.221 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 19 41354391 rs1800469 A G 0.254 0.243 0.232 0.213 0.185 0.211 0.221 0 0.0017 0.0017 www.ncbi.nlm.nih.gov/pubmed/24836286 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Colorectal cancer 19 41479679 rs11672691 G A 0.085 0.081 0.098 0.104 0.032 0.053 0.106 0.0073 0.0253 0 www.ncbi.nlm.nih.gov/pubmed/23065704 A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Prostate cancer 19 41479679 rs11672691 G A 0.085 0.081 0.098 0.104 0.032 0.053 0.106 0.0073 0.0253 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 19 41589873 rs2006209 T C 0.352 0.324 0.306 0.439 0.383 0.533 0.327 0 0.0009 0.0399 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 19 42196795 rs61088131 T C 0.085 0.126 0.098 0.135 0.081 0.074 0.133 0.0075 0.0107 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 19 42196795 rs61088131 T C 0.085 0.126 0.098 0.135 0.081 0.074 0.133 0.0075 0.0107 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) 19 43779080 rs1685191 C T 0.47 0.431 0.445 0.469 0.527 0.555 0.465 0 0.0121 0.0035 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 43782361 rs3760982 G A 0.5 0.505 0.509 0.53 0.436 0.48 0.536 0.0018 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 19 43782361 rs3760982 G A 0.5 0.505 0.509 0.53 0.436 0.48 0.536 0.0018 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 19 43782361 rs3760982 G A 0.5 0.505 0.509 0.53 0.436 0.48 0.536 0.0018 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 43782361 rs3760982 G A 0.5 0.505 0.509 0.53 0.436 0.48 0.536 0.0018 0.0065 0 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 19 43919418 rs375066 C T 0.284 0.27 0.317 0.37 0.279 0.332 0.336 0.0103 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 19 44007237 rs2191566 T G 0.539 0.537 0.482 0.447 0.404 0.422 0.549 0 0.0051 0.0219 www.ncbi.nlm.nih.gov/pubmed/19684603 Germline genomic variants associated with childhood acute lymphoblastic leukemia. Acute lymphoblastic leukemia (childhood) 19 44892362 rs2075650 G A 0.119 0.099 0.116 0.1 0.146 0.135 0.133 0.0019 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 19 44892362 rs2075650 G A 0.119 0.099 0.116 0.1 0.146 0.135 0.133 0.0019 0.0031 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 19 45698914 rs2287019 T C 0.123 0.095 0.089 0.123 0.117 0.123 0.106 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 19 45698914 rs2287019 T C 0.123 0.095 0.089 0.123 0.117 0.123 0.106 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 19 45818249 rs56848936 G A 0.089 0.082 0.046 0.092 0.059 0.042 0.084 0.0047 0.009 0 www.ncbi.nlm.nih.gov/pubmed/28295283 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. Colon cancer 19 45818249 rs56848936 G A 0.089 0.082 0.046 0.092 0.059 0.042 0.084 0.0047 0.009 0 www.ncbi.nlm.nih.gov/pubmed/28295283 Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. Colorectal cancer 19 46470746 rs7248888 T C 0.161 0.18 0.18 0.187 0.153 0.078 0.142 0.006 0.0162 0 www.ncbi.nlm.nih.gov/pubmed/24743840 Genome-wide diet-gene interaction analyses for risk of colorectal cancer. Colorectal cancer (diet interaction) 19 46673495 rs874460 A C 0.051 0.036 0.027 0.03 0.009 0.029 0.035 0 0.0022 0.0022 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia 19 46704397 rs11083846 A G 0.03 0.041 0.049 0.048 0.045 0.02 0.044 0.0003 0.0003 0 www.ncbi.nlm.nih.gov/pubmed/18758461 A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 19 46980665 rs10164289 A G 0.076 0.081 0.076 0.07 0.059 0.078 0.084 0 0 0 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (cisplatin) 19 47065746 rs3810291 A G 0.059 0.095 0.076 0.087 0.063 0.053 0.102 0.0005 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 19 47065746 rs3810291 A G 0.059 0.095 0.076 0.087 0.063 0.053 0.102 0.0005 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI in smokers 19 47065746 rs3810291 A G 0.059 0.095 0.076 0.087 0.063 0.053 0.102 0.0005 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 19 47065746 rs3810291 A G 0.059 0.095 0.076 0.087 0.063 0.053 0.102 0.0005 0.0038 0 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 19 48703205 rs681343 T C 0.487 0.41 0.496 0.513 0.487 0.459 0.469 0.0024 0 0.0019 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 19 50861367 rs2735839 A G 0.314 0.359 0.371 0.417 0.36 0.373 0.323 0.0098 0 0.007 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 19 50861367 rs2735839 A G 0.314 0.359 0.371 0.417 0.36 0.373 0.323 0.0098 0 0.007 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer 19 50861367 rs2735839 A G 0.314 0.359 0.371 0.417 0.36 0.373 0.323 0.0098 0 0.007 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 19 51869723 rs10411161 T C 0.318 0.311 0.295 0.404 0.266 0.316 0.301 0.03 0 0.0009 www.ncbi.nlm.nih.gov/pubmed/21424380 Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. Breast cancer 19 51942133 rs8113308 C T 0.445 0.464 0.536 0.622 0.324 0.446 0.509 0.0753 0.0441 0 www.ncbi.nlm.nih.gov/pubmed/25964295 Polymorphism at 19q13.41 Predicts Breast Cancer Survival Specifically after Endocrine Therapy. Survival in endocrine treated breast cancer (estrogen-receptor positive) 19 54293995 rs103294 T C 0.081 0.081 0.089 0.104 0.073 0.041 0.035 0.0123 0.0041 0 www.ncbi.nlm.nih.gov/pubmed/23023329 Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Prostate cancer 19 54662761 rs1654668 C T 0.504 0.432 0.451 0.474 0.441 0.471 0.482 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 19 54667327 rs11574583 A G 0.089 0.095 0.103 0.065 0.059 0.054 0.075 0 0.0019 0.0055 www.ncbi.nlm.nih.gov/pubmed/21844884 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Response to platinum-based chemotherapy (carboplatin) 19 55368504 rs1126757 T C 0.004 0.005 0 0.027 0.018 0 0 0.0335 0 0.0276 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 19 55368504 rs1126757 T C 0.004 0.005 0 0.027 0.018 0 0 0.0335 0 0.0276 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 19 55521344 rs639436 A G 0.199 0.203 0.214 0.14 0.113 0.09 0.199 0 0.0142 0.026 www.ncbi.nlm.nih.gov/pubmed/28604730 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Lung adenocarcinoma 19 57067709 rs9676308 A G 0.038 0.009 0.022 0.017 0.05 0.049 0.035 0.0025 0.0097 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 19 57291543 rs36032958 A G 0.004 0 0 0.009 0 0 0 0.0129 0 0.0013 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 20 778672 rs6117615 G A 0.064 0.077 0.077 0.065 0.059 0.067 0.115 0 0.0005 0.0011 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) 20 2281891 rs6082600 C T 0.051 0.036 0.054 0.035 0.064 0.041 0.04 0.0001 0.0001 0 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 20 2301324 rs214782 A G 0.309 0.401 0.362 0.444 0.446 0.447 0.403 0.0017 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/24403052 Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Basal cell carcinoma 20 2301324 rs214782 A G 0.309 0.401 0.362 0.444 0.446 0.447 0.403 0.0017 0 0.0143 www.ncbi.nlm.nih.gov/pubmed/25855136 New basal cell carcinoma susceptibility loci. Basal cell carcinoma 20 2302811 rs214785 T C 0.309 0.401 0.353 0.439 0.446 0.447 0.398 0.0007 0 0.0148 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 20 4586042 rs6076699 G A 0.248 0.23 0.203 0.164 0.126 0.141 0.164 0 0.0067 0.014 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 20 4586042 rs6076699 G A 0.248 0.23 0.203 0.164 0.126 0.141 0.164 0 0.0067 0.014 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (smoking interaction) 20 5791630 rs73077323 A G 0.013 0.014 0.009 0.017 0.005 0.004 0.009 0.0034 0.0047 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 20 6423634 rs961253 A C 0.356 0.329 0.371 0.4 0.347 0.393 0.327 0.0036 0 0.0036 www.ncbi.nlm.nih.gov/pubmed/28960316 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. Colorectal cancer 20 6423634 rs961253 A C 0.356 0.329 0.371 0.4 0.347 0.393 0.327 0.0036 0 0.0036 www.ncbi.nlm.nih.gov/pubmed/19011631 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Colorectal cancer 20 6423634 rs961253 A C 0.356 0.329 0.371 0.4 0.347 0.393 0.327 0.0036 0 0.0036 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 20 6423634 rs961253 A C 0.356 0.329 0.371 0.4 0.347 0.393 0.327 0.0036 0 0.0036 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 20 6632185 rs1884897 A G 0.496 0.532 0.527 0.391 0.46 0.475 0.535 0.0274 0 0.0221 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 20 6632185 rs1884897 A G 0.496 0.532 0.527 0.391 0.46 0.475 0.535 0.0274 0 0.0221 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 20 6642727 rs979012 T C 0.305 0.296 0.317 0.27 0.302 0.246 0.385 0.0014 0 0.0071 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 20 6709454 rs1015563 T C 0.073 0.095 0.094 0.135 0.117 0.086 0.084 0.0108 0 0.0075 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 20 6718948 rs4813802 G T 0.068 0.069 0.054 0.109 0.054 0.029 0.058 0.0298 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 20 6718948 rs4813802 G T 0.068 0.069 0.054 0.109 0.054 0.029 0.058 0.0298 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 20 6718948 rs4813802 G T 0.068 0.069 0.054 0.109 0.054 0.029 0.058 0.0298 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 20 7771719 rs6077251 T C 0.182 0.118 0.147 0.189 0.275 0.156 0.168 0 0.0037 0.0076 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) 20 8294998 rs62195918 G A 0.257 0.196 0.202 0.252 0.229 0.319 0.203 0 0.003 0.0067 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 20 8915129 rs115205687 T G 0.085 0.086 0.165 0.048 0.09 0.131 0.12 0.0292 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 20 8915129 rs115205687 T G 0.085 0.086 0.165 0.048 0.09 0.131 0.12 0.0292 0 0.0047 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 20 9650739 rs2224610 C T 0.233 0.252 0.255 0.228 0.185 0.19 0.235 0 0.0055 0.0029 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 20 10981287 rs62185668 A C 0.034 0.041 0.054 0.048 0.068 0.041 0.054 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24861552 Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. Urinary bladder cancer 20 10988382 rs1327235 G A 0.496 0.441 0.514 0.43 0.427 0.463 0.509 0.0028 0 0.0055 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 20 10988382 rs1327235 G A 0.496 0.441 0.514 0.43 0.427 0.463 0.509 0.0028 0 0.0055 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 20 11007451 rs6104690 G A 0.424 0.441 0.491 0.444 0.446 0.357 0.42 0 0.0021 0.0008 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 20 13248679 rs6105057 G A 0.39 0.365 0.375 0.365 0.405 0.434 0.332 0 0.0047 0.0008 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer 20 16208618 rs2327990 T C 0.322 0.3 0.371 0.43 0.32 0.303 0.288 0.0349 0 0.0034 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 20 19772894 rs4814894 A G 0.094 0.081 0.058 0.087 0.05 0.107 0.089 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 20 23001450 rs11696756 A G 0.081 0.09 0.107 0.057 0.059 0.061 0.084 0.0018 0 0.0071 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 20 23918358 rs1741629 G T 0.052 0.032 0.068 0.009 0.065 0.041 0.036 0.0265 0 0.0006 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 20 24077771 rs6049375 C T 0.411 0.455 0.433 0.509 0.414 0.459 0.434 0.0117 0 0.0035 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment 20 24451198 rs2050203 T C 0.127 0.118 0.13 0.152 0.167 0.098 0.146 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/28935272 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin 20 32752994 rs6087988 C T 0.487 0.487 0.432 0.465 0.464 0.57 0.416 0 0.0054 0.002 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 20 34000289 rs2284378 T C 0.102 0.086 0.103 0.078 0.194 0.238 0.097 0.0038 0.0688 0 www.ncbi.nlm.nih.gov/pubmed/22976474 A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Breast cancer 20 34116821 rs6142102 G C 0.318 0.383 0.353 0.339 0.41 0.422 0.398 0.0028 0.0081 0 www.ncbi.nlm.nih.gov/pubmed/28300201 Identification of a novel locus associated with skin colour in African-admixed populations. Skin pigmentation 20 34141638 rs4911414 T G 0.081 0.073 0.085 0.07 0.134 0.16 0.098 0.0031 0.0251 0 www.ncbi.nlm.nih.gov/pubmed/23548203 Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. Tanning 20 37388937 rs754626 G T 0.346 0.355 0.329 0.274 0.282 0.254 0.326 0.0003 0 0.0118 www.ncbi.nlm.nih.gov/pubmed/26908436 A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants. Squamous cell carcinoma 20 39992814 rs6071887 G A 0.308 0.365 0.326 0.351 0.386 0.418 0.323 0 0.0073 0.0041 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 20 44458008 rs6073450 A G 0.42 0.486 0.433 0.382 0.455 0.455 0.487 0.0118 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/26098869 "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer." Pancreatic cancer 20 44458008 rs6073450 A G 0.42 0.486 0.433 0.382 0.455 0.455 0.487 0.0118 0 0.0027 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 20 45878897 rs4812973 A G 0.085 0.054 0.076 0.078 0.099 0.09 0.093 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 20 46073481 rs2425752 T C 0.004 0 0 0.031 0.009 0.012 0 0.0454 0 0.0459 www.ncbi.nlm.nih.gov/pubmed/30194254 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. Hodgkins lymphoma 20 46930192 rs6090583 G A 0.263 0.297 0.29 0.183 0.176 0.157 0.301 0 0.0011 0.0415 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 20 46930192 rs6090583 G A 0.263 0.297 0.29 0.183 0.176 0.157 0.301 0 0.0011 0.0415 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) 20 47579861 rs6125048 T G 0.013 0.027 0.018 0.048 0.014 0 0.018 0.0329 0.0127 0 www.ncbi.nlm.nih.gov/pubmed/19176441 Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. Response to treatment for acute lymphoblastic leukemia 20 48723580 rs6066825 A G 0.203 0.241 0.25 0.202 0.306 0.213 0.266 0.0049 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/26151821 Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Colorectal cancer 20 48723580 rs6066825 A G 0.203 0.241 0.25 0.202 0.306 0.213 0.266 0.0049 0.0015 0 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 20 48738472 rs6066835 C T 0.081 0.123 0.086 0.113 0.095 0.086 0.128 0.0001 0.0001 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 20 48914749 rs6012558 G A 0.432 0.451 0.482 0.535 0.414 0.447 0.562 0.0116 0.0094 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (adjusted for smoking behaviour) 20 48914749 rs6012558 G A 0.432 0.451 0.482 0.535 0.414 0.447 0.562 0.0116 0.0094 0 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) 20 49374264 rs142605642 T C 0 0 0.009 0.017 0.032 0.029 0 0 0.0025 0.0333 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 20 50826118 rs6020772 C T 0.225 0.23 0.17 0.274 0.122 0.197 0.223 0.0243 0.0176 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 20 50911385 rs12480328 C T 0.148 0.122 0.107 0.078 0.159 0.115 0.107 0.0133 0.0016 0 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer 20 51419700 rs6021191 T A 0.195 0.167 0.161 0.135 0.239 0.234 0.186 0.0146 0.0179 0 www.ncbi.nlm.nih.gov/pubmed/25987655 Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Asparaginase hypersensitivity in acute lymphoblastic leukemia 20 52471323 rs6091540 T C 0.186 0.189 0.156 0.248 0.243 0.258 0.152 0.0031 0 0.0239 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." BMI (adjusted for smoking behaviour) 20 52471323 rs6091540 T C 0.186 0.189 0.156 0.248 0.243 0.258 0.152 0.0031 0 0.0239 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Body mass index (joint analysis main effects and smoking interaction) 20 53838666 rs6091758 G A 0.386 0.408 0.415 0.377 0.545 0.521 0.394 0.0067 0.0441 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 20 53838666 rs6091758 G A 0.386 0.408 0.415 0.377 0.545 0.521 0.394 0.0067 0.0441 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) 20 53838666 rs6091758 G A 0.386 0.408 0.415 0.377 0.545 0.521 0.394 0.0067 0.0441 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (early onset) 20 54200178 rs964293 C A 0.369 0.423 0.432 0.333 0.545 0.533 0.46 0.0417 0.0498 0 www.ncbi.nlm.nih.gov/pubmed/26766742 CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk. Colorectal cancer (oestrogen-progestogen hormone therapy interaction) 20 58831013 rs76473307 C A 0.123 0.138 0.107 0.11 0.114 0.098 0.125 0 0 0 www.ncbi.nlm.nih.gov/pubmed/26956414 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Chronic lymphocytic leukemia 20 59176062 rs6015450 G A 0.211 0.259 0.225 0.262 0.274 0.228 0.273 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Diastolic blood pressure (cigarette smoking interaction) 20 59176062 rs6015450 G A 0.211 0.259 0.225 0.262 0.274 0.228 0.273 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29455858 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Systolic blood pressure (cigarette smoking interaction) 20 60847915 rs4812219 T C 0.186 0.221 0.219 0.183 0.36 0.336 0.274 0.0173 0.0532 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer 20 62345988 rs4925386 C T 0.123 0.131 0.17 0.165 0.177 0.153 0.128 0.0002 0 0.0018 www.ncbi.nlm.nih.gov/pubmed/20972440 "Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33." Colorectal cancer 20 62381861 rs6061231 A C 0.335 0.369 0.277 0.378 0.279 0.258 0.261 0.0196 0.0094 0 www.ncbi.nlm.nih.gov/pubmed/26965516 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Colorectal cancer 20 62394395 rs2427308 T C 0.295 0.302 0.246 0.304 0.342 0.248 0.208 0.0015 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/29471430 GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. Colorectal cancer 20 62394395 rs2427308 T C 0.295 0.302 0.246 0.304 0.342 0.248 0.208 0.0015 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/25990418 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Colorectal cancer 20 62394395 rs2427308 T C 0.295 0.302 0.246 0.304 0.342 0.248 0.208 0.0015 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/24737748 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Colorectal cancer 20 62394395 rs2427308 T C 0.295 0.302 0.246 0.304 0.342 0.248 0.208 0.0015 0 0.0025 www.ncbi.nlm.nih.gov/pubmed/29917119 Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Colorectal cancer 20 62440555 rs2427345 C T 0.441 0.432 0.527 0.483 0.5 0.496 0.478 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 20 62440555 rs2427345 C T 0.441 0.432 0.527 0.483 0.5 0.496 0.478 0 0.0001 0.0001 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 20 63638397 rs75691080 T C 0.15 0.115 0.081 0.088 0.041 0.049 0.097 0 0.0209 0.0075 www.ncbi.nlm.nih.gov/pubmed/26237428 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Cutaneous malignant melanoma 20 63731211 rs6062509 G T 0.085 0.072 0.04 0.052 0.059 0.09 0.022 0 0.0019 0.0004 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer 20 63731211 rs6062509 G T 0.085 0.072 0.04 0.052 0.059 0.09 0.022 0 0.0019 0.0004 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 20 63775533 rs3810496 C T 0.436 0.505 0.522 0.444 0.329 0.351 0.469 0 0.0321 0.0118 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) 20 63775533 rs3810496 C T 0.436 0.505 0.522 0.444 0.329 0.351 0.469 0 0.0321 0.0118 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 20 64247978 rs6062356 G T 0.087 0.099 0.126 0.133 0.105 0.066 0.121 0.0058 0.0058 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 21 15148511 rs2823093 G A 0.432 0.496 0.505 0.57 0.427 0.484 0.58 0.0169 0.0085 0 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 21 15148511 rs2823093 G A 0.432 0.496 0.505 0.57 0.427 0.484 0.58 0.0169 0.0085 0 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 21 15148511 rs2823093 G A 0.432 0.496 0.505 0.57 0.427 0.484 0.58 0.0169 0.0085 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 21 16396204 rs2823779 G A 0.212 0.185 0.237 0.212 0.155 0.25 0.188 0 0 0 www.ncbi.nlm.nih.gov/pubmed/24785509 A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. Response to radiotherapy in cancer (late toxicity) 21 17368480 rs11700530 G A 0.291 0.234 0.219 0.257 0.248 0.225 0.252 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 21 20043380 rs2825968 C T 0.131 0.135 0.13 0.109 0.135 0.107 0.12 0.0001 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 21 23048180 rs4816890 G T 0.31 0.366 0.326 0.218 0.229 0.265 0.317 0.0129 0 0.0288 www.ncbi.nlm.nih.gov/pubmed/26621817 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Colorectal or endometrial cancer 21 29345416 rs372883 T C 0.363 0.342 0.347 0.248 0.23 0.291 0.341 0.0075 0 0.0251 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 21 29773850 rs455804 A C 0.445 0.46 0.464 0.43 0.333 0.369 0.469 0 0.0181 0.0066 www.ncbi.nlm.nih.gov/pubmed/22807686 GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. Hepatocellular carcinoma 21 29805194 rs458685 G A 0.059 0.072 0.063 0.126 0.131 0.131 0.058 0.005 0 0.0362 www.ncbi.nlm.nih.gov/pubmed/17903305 A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study. Breast cancer 21 31028811 rs28456019 A G 0.239 0.236 0.272 0.222 0.182 0.227 0.183 0 0.0004 0.0004 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers 21 34145184 rs12627687 T C 0.021 0.027 0.013 0.017 0.014 0.025 0.004 0 0 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 21 34738904 rs16992204 C T 0.034 0.059 0.04 0.109 0.135 0.111 0.053 0.0023 0 0.0487 www.ncbi.nlm.nih.gov/pubmed/27354352 Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. Breast cancer 21 34985564 rs2014300 G A 0.492 0.505 0.478 0.474 0.387 0.385 0.473 0 0.0178 0.0032 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 21 37299116 rs16994935 T C 0.237 0.255 0.205 0.206 0.203 0.16 0.204 0 0.0026 0.0026 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers 21 38801604 rs1209950 T C 0.127 0.099 0.094 0.148 0.05 0.049 0.106 0.0288 0.0402 0 www.ncbi.nlm.nih.gov/pubmed/21079520 Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. Non-small cell lung cancer (survival) 21 40043117 rs9981861 C T 0.267 0.275 0.344 0.413 0.387 0.258 0.261 0.0357 0 0.0187 www.ncbi.nlm.nih.gov/pubmed/21079520 Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. Non-small cell lung cancer (survival) 21 41374154 rs45430 T C 0.038 0.108 0.045 0.13 0.032 0.025 0.044 0.072 0.0258 0 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 21 41374154 rs45430 T C 0.038 0.108 0.045 0.13 0.032 0.025 0.044 0.072 0.0258 0 www.ncbi.nlm.nih.gov/pubmed/21983787 Genome-wide association study identifies three new melanoma susceptibility loci. Melanoma 21 41668857 rs2776353 A T 0.47 0.417 0.4 0.325 0.518 0.471 0.432 0.0435 0.0182 0 www.ncbi.nlm.nih.gov/pubmed/27539887 Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Basal cell carcinoma 21 41668857 rs2776353 A T 0.47 0.417 0.4 0.325 0.518 0.471 0.432 0.0435 0.0182 0 www.ncbi.nlm.nih.gov/pubmed/29739929 "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure." Non-melanoma skin cancer 21 41672041 rs2838088 T C 0.17 0.136 0.241 0.204 0.176 0.269 0.246 0 0.0003 0.0003 www.ncbi.nlm.nih.gov/pubmed/24025145 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) 21 41807559 rs7279297 A G 0.453 0.545 0.455 0.517 0.478 0.463 0.456 0.0021 0 0.0003 www.ncbi.nlm.nih.gov/pubmed/19340012 Genome-wide association study of tanning phenotype in a population of European ancestry. Tanning 21 42358786 rs1547374 G A 0.287 0.323 0.348 0.339 0.409 0.504 0.301 0 0.0393 0.0093 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 22 17313079 rs5749032 G A 0.292 0.288 0.299 0.204 0.246 0.221 0.261 0.0083 0 0.0146 www.ncbi.nlm.nih.gov/pubmed/30738427 A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) 22 27576518 rs9613472 G A 0.06 0.091 0.089 0.096 0.104 0.117 0.058 0 0.0027 0.0049 www.ncbi.nlm.nih.gov/pubmed/30643251 Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Smoking initiation (ever regular vs never regular) (MTAG) 22 27978955 rs78554043 C G 0.017 0.018 0.018 0.013 0.005 0 0.027 0 0.0098 0.0014 www.ncbi.nlm.nih.gov/pubmed/29117387 Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. Prostate cancer 22 28796682 rs2239815 T C 0.275 0.302 0.237 0.254 0.135 0.123 0.155 0.0085 0.051 0 www.ncbi.nlm.nih.gov/pubmed/22960999 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Esophageal cancer (squamous cell) 22 28796682 rs2239815 T C 0.275 0.302 0.237 0.254 0.135 0.123 0.155 0.0085 0.051 0 www.ncbi.nlm.nih.gov/pubmed/25129146 Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Esophageal squamous cell carcinoma 22 28904318 rs16986825 T C 0.021 0.005 0.009 0.022 0.009 0 0.018 0.0062 0.0078 0 www.ncbi.nlm.nih.gov/pubmed/29422604 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Pancreatic cancer 22 28904318 rs16986825 T C 0.021 0.005 0.009 0.022 0.009 0 0.018 0.0062 0.0078 0 www.ncbi.nlm.nih.gov/pubmed/25086665 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Pancreatic cancer 22 29053489 rs2294239 G A 0.105 0.122 0.162 0.161 0.176 0.186 0.167 0 0.0028 0.0032 www.ncbi.nlm.nih.gov/pubmed/28443625 "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) 22 29225488 rs132390 C T 0.089 0.072 0.086 0.035 0.05 0.115 0.058 0.0182 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 22 29225488 rs132390 C T 0.089 0.072 0.086 0.035 0.05 0.115 0.058 0.0182 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 22 29225488 rs132390 C T 0.089 0.072 0.086 0.035 0.05 0.115 0.058 0.0182 0 0.0001 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 22 29941597 rs36600 T C 0.055 0.072 0.063 0.117 0.018 0.066 0.066 0.0361 0.0098 0 www.ncbi.nlm.nih.gov/pubmed/21725308 A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Lung cancer 22 30743331 rs926340 A G 0.453 0.464 0.433 0.447 0.365 0.377 0.394 0.0011 0.0092 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 22 31442532 rs5753618 T C 0.055 0.036 0.098 0.096 0.023 0.033 0.106 0.0167 0.0341 0 www.ncbi.nlm.nih.gov/pubmed/29228715 Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. Colorectal cancer 22 36121884 rs1476029 T C 0 0 0 0.009 0 0.004 0 0.0154 0 0.015 www.ncbi.nlm.nih.gov/pubmed/23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) 22 38148291 rs2284063 A G 0.436 0.455 0.477 0.378 0.396 0.479 0.549 0.0162 0 0.0125 www.ncbi.nlm.nih.gov/pubmed/28212542 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. Melanoma 22 38148291 rs2284063 A G 0.436 0.455 0.477 0.378 0.396 0.479 0.549 0.0162 0 0.0125 www.ncbi.nlm.nih.gov/pubmed/19578364 Genome-wide association study identifies three loci associated with melanoma risk. Melanoma 22 38936618 rs1014971 T C 0.432 0.423 0.362 0.43 0.266 0.266 0.389 0.0117 0.0547 0 www.ncbi.nlm.nih.gov/pubmed/24163127 Genome-wide association study identifies multiple loci associated with bladder cancer risk. Bladder cancer 22 38936618 rs1014971 T C 0.432 0.423 0.362 0.43 0.266 0.266 0.389 0.0117 0.0547 0 www.ncbi.nlm.nih.gov/pubmed/20972438 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Bladder cancer 22 39123191 rs139371 T C 0.017 0.027 0.022 0.043 0.027 0.004 0.022 0.0135 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (hyperdiploidy) 22 39123191 rs139371 T C 0.017 0.027 0.022 0.043 0.027 0.004 0.022 0.0135 0.0024 0 www.ncbi.nlm.nih.gov/pubmed/23502783 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Multiple myeloma (IgH translocation) 22 39146287 rs877529 A G 0.509 0.418 0.438 0.592 0.342 0.373 0.394 0.0872 0.0336 0 www.ncbi.nlm.nih.gov/pubmed/23955597 "Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk." Multiple myeloma 22 39150140 rs139402 C T 0.509 0.414 0.441 0.557 0.342 0.376 0.394 0.0555 0.0299 0 www.ncbi.nlm.nih.gov/pubmed/27363682 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Multiple myeloma 22 40040969 rs11704416 C G 0.237 0.311 0.25 0.33 0.257 0.23 0.208 0.0204 0 0.0016 www.ncbi.nlm.nih.gov/pubmed/23065704 A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Prostate cancer 22 40056115 rs9623117 T C 0.095 0.11 0.133 0.136 0.156 0.119 0.105 0.0002 0 0.0022 www.ncbi.nlm.nih.gov/pubmed/19117981 Sequence variants at 22q13 are associated with prostate cancer risk. Prostate cancer 22 40480230 rs6001930 C T 0.174 0.198 0.089 0.196 0.35 0.221 0.103 0 0.0372 0.033 www.ncbi.nlm.nih.gov/pubmed/23535733 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Breast cancer 22 40480230 rs6001930 C T 0.174 0.198 0.089 0.196 0.35 0.221 0.103 0 0.0372 0.033 www.ncbi.nlm.nih.gov/pubmed/25751625 "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer." Breast cancer 22 40480230 rs6001930 C T 0.174 0.198 0.089 0.196 0.35 0.221 0.103 0 0.0372 0.033 www.ncbi.nlm.nih.gov/pubmed/23535729 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Breast cancer 22 40480230 rs6001930 C T 0.174 0.198 0.089 0.196 0.35 0.221 0.103 0 0.0372 0.033 www.ncbi.nlm.nih.gov/pubmed/27117709 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Breast cancer 22 40480230 rs6001930 C T 0.174 0.198 0.089 0.196 0.35 0.221 0.103 0 0.0372 0.033 www.ncbi.nlm.nih.gov/pubmed/29059683 Association analysis identifies 65 new breast cancer risk loci. Breast cancer 22 40480230 rs6001930 C T 0.174 0.198 0.089 0.196 0.35 0.221 0.103 0 0.0372 0.033 www.ncbi.nlm.nih.gov/pubmed/29058716 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Breast cancer (estrogen-receptor negative) 22 43104206 rs5759167 T G 0.154 0.167 0.143 0.2 0.259 0.184 0.168 0 0.0029 0.0101 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer 22 43104206 rs5759167 T G 0.154 0.167 0.143 0.2 0.259 0.184 0.168 0 0.0029 0.0101 www.ncbi.nlm.nih.gov/pubmed/26034056 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Prostate cancer 22 43104206 rs5759167 T G 0.154 0.167 0.143 0.2 0.259 0.184 0.168 0 0.0029 0.0101 www.ncbi.nlm.nih.gov/pubmed/19767753 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Prostate cancer 22 43104206 rs5759167 T G 0.154 0.167 0.143 0.2 0.259 0.184 0.168 0 0.0029 0.0101 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer 22 43122269 rs742134 A G 0.14 0.14 0.183 0.191 0.221 0.123 0.208 0.0002 0 0.0002 www.ncbi.nlm.nih.gov/pubmed/21743057 Genome-wide association study identifies new prostate cancer susceptibility loci. Prostate cancer 22 43928847 rs738409 G C 0.097 0.09 0.13 0.139 0.18 0.152 0.113 0 0.0051 0.0101 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 22 43928850 rs738408 T C 0.097 0.091 0.134 0.14 0.18 0.152 0.111 0 0.0047 0.0099 www.ncbi.nlm.nih.gov/pubmed/28090653 Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) 22 43937814 rs2896019 G T 0.17 0.149 0.241 0.145 0.09 0.119 0.221 0 0.013 0.018 www.ncbi.nlm.nih.gov/pubmed/29385134 Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers. Nonalcoholic steatohepatitis-derived hepatocellular carcinoma 22 43995806 rs2143571 A G 0.453 0.41 0.406 0.378 0.302 0.343 0.42 0 0.0112 0.0104 www.ncbi.nlm.nih.gov/pubmed/29385134 Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers. Nonalcoholic steatohepatitis-derived hepatocellular carcinoma 22 44080184 rs130318 T C 0.153 0.135 0.161 0.174 0.194 0.139 0.12 0.0014 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer (hypertension) (bevacizumab) 22 44080184 rs130318 T C 0.153 0.135 0.161 0.174 0.194 0.139 0.12 0.0014 0 0.0021 www.ncbi.nlm.nih.gov/pubmed/25117820 Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) 22 46016089 rs28520003 G A 0.392 0.387 0.401 0.444 0.422 0.396 0.366 0.0038 0 0.0038 www.ncbi.nlm.nih.gov/pubmed/30595370 Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Smoking status 22 46016089 rs28520003 G A 0.392 0.387 0.401 0.444 0.422 0.396 0.366 0.0038 0 0.0038 www.ncbi.nlm.nih.gov/pubmed/30271922 Genome-wide association study for risk taking propensity indicates shared pathways with body mass index. Smoking status (ever vs never smokers) 22 48345986 rs4407 G A 0.106 0.095 0.058 0.174 0.167 0.148 0.12 0.0134 0 0.0326 www.ncbi.nlm.nih.gov/pubmed/24096698 Genome-wide association study of endometrial cancer in E2C2. Endometrial cancer 22 48533757 rs5768709 G A 0.302 0.324 0.362 0.313 0.288 0.258 0.314 0 0.0035 0.0022 www.ncbi.nlm.nih.gov/pubmed/22158540 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Pancreatic cancer 22 50532837 rs140522 C T 0.436 0.473 0.428 0.53 0.409 0.398 0.474 0.0229 0.0108 0 www.ncbi.nlm.nih.gov/pubmed/28165464 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia X 4330060 rs17219051 T C 0.026 0.027 0.018 0.078 0.009 0.008 0.027 0.0709 0.0144 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers X 9846095 rs2405942 G A 0.195 0.324 0.232 0.252 0.127 0.23 0.177 0.0038 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/23535732 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Prostate cancer X 9846095 rs2405942 G A 0.195 0.324 0.232 0.252 0.127 0.23 0.177 0.0038 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer X 11321091 rs2788524 A G 0.11 0.063 0.063 0.148 0.045 0.09 0.089 0.037 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer X 11321091 rs2788524 A G 0.11 0.063 0.063 0.148 0.045 0.09 0.089 0.037 0.0008 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) X 11464514 rs17321482 T C 0.017 0.018 0.009 0.052 0 0 0 0.0721 0.0146 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer X 11464514 rs17321482 T C 0.017 0.018 0.009 0.052 0 0 0 0.0721 0.0146 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer (advanced) X 19186106 rs139545172 A G 0.042 0.063 0.08 0.148 0.099 0.066 0.142 0.03 0 0.0066 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers X 22873960 rs5925696 A G 0.136 0.146 0.134 0.183 0.108 0.107 0.15 0.0141 0.0105 0 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment X 25835497 rs5944185 T C 0.267 0.234 0.179 0.298 0.136 0.172 0.266 0.03 0.0378 0 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment X 28214936 rs5971305 G A 0.154 0.207 0.161 0.165 0.153 0.107 0.168 0 0.0046 0.0017 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment X 30044474 rs10126910 G T 0.076 0.09 0.116 0.104 0.036 0.082 0.089 0.0033 0.0095 0 www.ncbi.nlm.nih.gov/pubmed/29594489 Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. Clostridium difficile infection in multiple myeloma X 37995474 rs872690 C T 0.203 0.162 0.134 0.096 0.135 0.115 0.177 0.0119 0 0.0176 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment X 43747786 rs3027409 G T 0.263 0.252 0.268 0.209 0.342 0.377 0.257 0.0199 0.0373 0 www.ncbi.nlm.nih.gov/pubmed/19247474 Genome-wide and candidate gene association study of cigarette smoking behaviors. Smoking behavior X 51498820 rs5945619 C T 0.353 0.315 0.33 0.33 0.391 0.369 0.336 0 0.003 0.0004 www.ncbi.nlm.nih.gov/pubmed/18264097 Multiple newly identified loci associated with prostate cancer susceptibility. Prostate cancer X 51498820 rs5945619 C T 0.353 0.315 0.33 0.33 0.391 0.369 0.336 0 0.003 0.0004 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer X 52867918 rs2807031 C T 0.18 0.207 0.188 0.139 0.297 0.369 0.239 0.0365 0.0688 0 www.ncbi.nlm.nih.gov/pubmed/25939597 Two susceptibility loci identified for prostate cancer aggressiveness. Prostate cancer X 52867918 rs2807031 C T 0.18 0.207 0.188 0.139 0.297 0.369 0.239 0.0365 0.0688 0 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer X 52867918 rs2807031 C T 0.18 0.207 0.188 0.139 0.297 0.369 0.239 0.0365 0.0688 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer X 66386851 rs5965182 A T 0.462 0.46 0.429 0.409 0.36 0.377 0.443 0 0.0055 0.0071 www.ncbi.nlm.nih.gov/pubmed/20932654 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Erectile dysfunction and prostate cancer treatment X 67801708 rs5919432 T C 0.316 0.27 0.313 0.226 0.405 0.512 0.266 0.0361 0.0911 0 www.ncbi.nlm.nih.gov/pubmed/21743467 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Prostate cancer X 67801708 rs5919432 T C 0.316 0.27 0.313 0.226 0.405 0.512 0.266 0.0361 0.0911 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer X 71188133 rs4844289 A G 0.229 0.246 0.279 0.278 0.162 0.189 0.283 0.0062 0.0261 0 www.ncbi.nlm.nih.gov/pubmed/25217961 "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer." Prostate cancer X 71188133 rs4844289 A G 0.229 0.246 0.279 0.278 0.162 0.189 0.283 0.0062 0.0261 0 www.ncbi.nlm.nih.gov/pubmed/29892016 "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci." Prostate cancer X 119130439 rs5957117 T C 0.305 0.333 0.236 0.174 0.189 0.258 0.248 0.0207 0 0.0223 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers X 127519376 rs723557 G T 0.034 0.045 0.054 0.078 0.072 0.066 0.062 0.0039 0 0.0067 www.ncbi.nlm.nih.gov/pubmed/26307654 Genome-wide association study of prostate cancer-specific survival. Prostate cancer (survival) X 136051802 rs150889544 A G 0.12 0.117 0.09 0.052 0.018 0.033 0.053 0 0.0158 0.0227 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxy-1-methylpropylmercapturic acid levels in smokers X 143165510 rs139618469 C T 0.076 0.027 0.08 0.053 0.027 0.008 0.053 0.0005 0.022 0 www.ncbi.nlm.nih.gov/pubmed/26053186 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 3-hydroxypropylmercapturic acid levels in smokers X 149380542 rs17325431 C T 0.102 0.063 0.116 0.104 0.063 0.066 0.133 0.0003 0.0089 0 www.ncbi.nlm.nih.gov/pubmed/25866641 A genome wide association study on Newfoundland colorectal cancer patients survival outcomes. Survival in colon cancer